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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for mafaa

Z-value: 0.67

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Transcription factors associated with mafaa

Gene Symbol Gene ID Gene Info
mafaa
ENSDARG00000044155 v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Aa

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
mafaadr11_v1_chr6_-_32703317_32703317-0.241.8e-02Click!

Activity profile of mafaa motif

Sorted Z-values of mafaa motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_39313027 12.98 ENSDART00000012644
krt4
keratin 4
chr13_+_4671698 10.83 ENSDART00000164617
ENSDART00000128494
ENSDART00000165776
pla2g12b
phospholipase A2, group XIIB
chr2_-_22688651 10.75 ENSDART00000013863
agxtb
alanine-glyoxylate aminotransferase b
chr4_-_8030583 8.92 ENSDART00000113628
si:ch211-240l19.8
si:ch211-240l19.8
chr25_+_31264155 8.48 ENSDART00000012256
tnni2a.3
troponin I type 2a (skeletal, fast), tandem duplicate 3
chr10_+_19596214 8.10 ENSDART00000183110
CABZ01059626.1

chr8_-_50482781 6.87 ENSDART00000056361
ido1
indoleamine 2,3-dioxygenase 1
chr7_+_6969909 6.48 ENSDART00000189886
actn3b
actinin alpha 3b
chr7_+_27603211 6.46 ENSDART00000148782
cyp2r1
cytochrome P450, family 2, subfamily R, polypeptide 1
chr1_+_59090743 5.26 ENSDART00000100199
mfap4
microfibril associated protein 4
chr1_+_59090583 5.21 ENSDART00000150658
mfap4
microfibril associated protein 4
chr10_-_57270 5.18 ENSDART00000058411
hlcs
holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
chr1_+_59090972 4.99 ENSDART00000171497
mfap4
microfibril associated protein 4
chr3_-_1388936 4.03 ENSDART00000171278
ddx47
DEAD (Asp-Glu-Ala-Asp) box polypeptide 47
chr8_+_50534948 3.90 ENSDART00000174435
PEBP4
phosphatidylethanolamine binding protein 4
chr16_-_46567344 3.87 ENSDART00000127721
si:dkey-152b24.7
si:dkey-152b24.7
chr2_-_37465517 3.72 ENSDART00000139983
si:dkey-57k2.6
si:dkey-57k2.6
chr24_+_6353394 3.39 ENSDART00000165118
CR352329.1

chr20_-_22476255 3.24 ENSDART00000103510
pdgfra
platelet-derived growth factor receptor, alpha polypeptide
chr11_+_6115621 3.24 ENSDART00000165031
ENSDART00000027666
ENSDART00000161458
nr2f6b
nuclear receptor subfamily 2, group F, member 6b
chr4_-_8040436 3.12 ENSDART00000113033
si:ch211-240l19.6
si:ch211-240l19.6
chr6_+_42475730 3.10 ENSDART00000150226
mst1ra
macrophage stimulating 1 receptor a
chr20_-_23440955 2.92 ENSDART00000153386
slc10a4
solute carrier family 10, member 4
chr5_-_23795688 2.89 ENSDART00000099084
gbgt1l4
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 4
chr25_-_27842654 2.86 ENSDART00000154852
ENSDART00000156906
asb15a
ankyrin repeat and SOCS box containing 15a
chr19_-_5332784 2.78 ENSDART00000010373
krt1-19d
keratin, type 1, gene 19d
chr22_+_635813 2.75 ENSDART00000179067
CU856139.1

chr5_-_33230794 2.54 ENSDART00000144273
kank1b
KN motif and ankyrin repeat domains 1b
chr14_+_40641350 2.52 ENSDART00000074506
tnmd
tenomodulin
chr1_+_52392511 2.50 ENSDART00000144025
si:ch211-217k17.8
si:ch211-217k17.8
chr25_+_3217419 2.47 ENSDART00000104859
rccd1
RCC1 domain containing 1
chr24_+_80653 2.37 ENSDART00000158473
ENSDART00000129135
reck
reversion-inducing-cysteine-rich protein with kazal motifs
chr22_+_21305682 2.28 ENSDART00000023521
odf3l2
outer dense fiber of sperm tails 3-like 2
chr24_-_6029314 2.20 ENSDART00000136155
ftr60
finTRIM family, member 60
chr19_-_3777217 2.13 ENSDART00000160510
si:dkey-206d17.15
si:dkey-206d17.15
chr2_+_38161318 2.13 ENSDART00000044264
mmp14b
matrix metallopeptidase 14b (membrane-inserted)
chr20_+_54323218 2.00 ENSDART00000191096
CABZ01077555.1

chr3_-_10677890 2.00 ENSDART00000155382
ENSDART00000171319
si:ch1073-144j5.2
si:ch1073-144j5.2
chr3_-_62417677 1.98 ENSDART00000101888
sstr2b
somatostatin receptor 2b
chr16_+_42465518 1.91 ENSDART00000058699
si:ch211-215k15.4
si:ch211-215k15.4
chr13_-_28272299 1.81 ENSDART00000006393
tlx1
T cell leukemia homeobox 1
chr24_+_37709191 1.81 ENSDART00000066558
decr2
2,4-dienoyl CoA reductase 2, peroxisomal
chr19_-_48010490 1.80 ENSDART00000159938
FBXL19
zgc:158376
chr21_-_1642739 1.75 ENSDART00000151118
zgc:152948
zgc:152948
chr13_-_301309 1.71 ENSDART00000131747
chs1
chitin synthase 1
chr5_-_5326010 1.55 ENSDART00000161946
pbx3a
pre-B-cell leukemia homeobox 3a
chr12_-_11649690 1.55 ENSDART00000149713
btbd16
BTB (POZ) domain containing 16
chr23_+_3538463 1.53 ENSDART00000172758
si:dkey-9l20.3
si:dkey-9l20.3
chr6_-_33913184 1.53 ENSDART00000146373
nasp
nuclear autoantigenic sperm protein (histone-binding)
chr9_-_1639884 1.51 ENSDART00000062850
ENSDART00000150947
agps
alkylglycerone phosphate synthase
chr21_+_18885258 1.48 ENSDART00000169078
si:dkey-65l23.2
si:dkey-65l23.2
chr4_+_56422336 1.48 ENSDART00000159185
si:dkey-65l23.2
si:dkey-65l23.2
chr8_+_43078044 1.48 ENSDART00000147872
si:dkey-65l23.2
si:dkey-65l23.2
chr25_-_3217115 1.45 ENSDART00000032390
gtf2h1
general transcription factor IIH, polypeptide 1
chr6_-_131401 1.44 ENSDART00000151251
LRRC8E
si:zfos-323e3.4
chr22_-_27709692 1.39 ENSDART00000172458
CR547131.1

chr13_-_50463938 1.36 ENSDART00000083857
ccnj
cyclin J
chr22_+_19283978 1.31 ENSDART00000131487
ENSDART00000143589
si:dkey-21e2.14
si:dkey-21e2.14
chr20_-_14321359 1.28 ENSDART00000145104
dlgap2b
discs, large (Drosophila) homolog-associated protein 2b
chr8_+_52479026 1.26 ENSDART00000162885
FO704661.1
Danio rerio gamma-glutamyl hydrolase (LOC553228), mRNA.
chr15_-_17138640 1.23 ENSDART00000080777
mrpl28
mitochondrial ribosomal protein L28
chr19_-_28788466 1.23 ENSDART00000151793
sox4a
SRY (sex determining region Y)-box 4a
chr3_-_34055745 1.22 ENSDART00000151652
ighv2-2
immunoglobulin heavy variable 2-2
chr4_-_50926767 1.22 ENSDART00000183430
si:ch211-208f21.3
si:ch211-208f21.3
chr14_+_146857 1.16 ENSDART00000122521
CABZ01088229.1

chr17_-_42798332 1.15 ENSDART00000189885
prkd3
protein kinase D3
chr21_+_45841731 1.14 ENSDART00000038657
faxdc2
fatty acid hydroxylase domain containing 2
chr6_-_25371196 1.10 ENSDART00000187291
PKN2 (1 of many)
zgc:153916
chr15_+_26940569 1.00 ENSDART00000189636
ENSDART00000077172
bcas3
breast carcinoma amplified sequence 3
chr4_-_72468168 1.00 ENSDART00000182995
ENSDART00000174067
CR788316.1

chr23_+_42652877 0.91 ENSDART00000035654
cyp2ae1
cytochrome P450, family 2, subfamily AE, polypeptide 1
chr11_+_25276748 0.88 ENSDART00000126211
cyldb
cylindromatosis (turban tumor syndrome), b
chr18_-_48745517 0.87 ENSDART00000097259
st3gal4
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
chr20_-_39391833 0.87 ENSDART00000135149
si:dkey-217m5.8
si:dkey-217m5.8
chr4_-_14486822 0.86 ENSDART00000048821
plxnb2a
plexin b2a
chr8_-_3336273 0.84 ENSDART00000081160
zgc:173737
zgc:173737
chr2_-_57707039 0.80 ENSDART00000097685
CABZ01060891.1

chr6_+_58508420 0.77 ENSDART00000153740
chrna4a
cholinergic receptor, nicotinic, alpha 4a
chr13_+_6295173 0.64 ENSDART00000163855
angpt2a
angiopoietin 2a
chr21_-_17037907 0.64 ENSDART00000101263
ube2g1b
ubiquitin-conjugating enzyme E2G 1b (UBC7 homolog, yeast)
chr3_+_26322596 0.57 ENSDART00000172700
si:ch211-156b7.5
si:ch211-156b7.5
chr4_+_19700308 0.51 ENSDART00000027919
pax4
paired box 4
chr22_+_10606863 0.50 ENSDART00000147975
rad54l2
RAD54 like 2
chr3_+_8826905 0.48 ENSDART00000167474
ENSDART00000168088
si:dkeyp-30d6.2
si:dkeyp-30d6.2
chr23_+_12916062 0.46 ENSDART00000144268
si:dkey-150i13.2
si:dkey-150i13.2
chr16_+_4658250 0.42 ENSDART00000006212
LIN28A
si:ch1073-284b18.2
chr17_-_20202725 0.38 ENSDART00000133650
ecd
ecdysoneless homolog (Drosophila)
chr12_-_19119176 0.30 ENSDART00000149180
aco2
aconitase 2, mitochondrial
chr2_-_37896965 0.28 ENSDART00000129852
hbl1
hexose-binding lectin 1
chr24_-_41312459 0.23 ENSDART00000041349
crygn2
crystallin, gamma N2
chr7_-_7493758 0.17 ENSDART00000036703
pfdn2
prefoldin subunit 2
chr8_-_2591654 0.07 ENSDART00000049109
seta
SET nuclear proto-oncogene a

Network of associatons between targets according to the STRING database.

First level regulatory network of mafaa

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 10.7 GO:0006545 glycine biosynthetic process(GO:0006545)
1.1 6.5 GO:0070640 vitamin D3 metabolic process(GO:0070640) cellular response to vitamin D(GO:0071305)
1.0 15.5 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.9 6.9 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
0.8 2.4 GO:1905048 regulation of metallopeptidase activity(GO:1905048)
0.8 10.8 GO:0032309 icosanoid secretion(GO:0032309) arachidonic acid secretion(GO:0050482) acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328) arachidonate transport(GO:1903963)
0.6 3.2 GO:0003261 cardiac muscle progenitor cell migration to the midline involved in heart field formation(GO:0003261)
0.5 1.5 GO:0046504 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.5 2.5 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.4 1.5 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.3 1.7 GO:0006031 chitin biosynthetic process(GO:0006031) glucosamine-containing compound biosynthetic process(GO:1901073)
0.2 2.1 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.2 2.9 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.2 2.0 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.2 1.1 GO:0089700 protein kinase D signaling(GO:0089700)
0.2 3.1 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.2 2.9 GO:0030259 lipid glycosylation(GO:0030259)
0.2 8.5 GO:0003009 skeletal muscle contraction(GO:0003009)
0.2 0.6 GO:0048014 Tie signaling pathway(GO:0048014)
0.1 1.4 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.1 0.9 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.1 1.3 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity(GO:0098962)
0.1 0.8 GO:0035094 response to nicotine(GO:0035094)
0.0 1.2 GO:0045879 negative regulation of smoothened signaling pathway(GO:0045879)
0.0 1.1 GO:0016126 sterol biosynthetic process(GO:0016126)
0.0 2.5 GO:0030837 negative regulation of actin filament polymerization(GO:0030837) negative regulation of protein polymerization(GO:0032272)
0.0 1.4 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 1.2 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.5 GO:1990798 pancreas regeneration(GO:1990798)
0.0 3.6 GO:0006364 rRNA processing(GO:0006364)
0.0 0.9 GO:0009247 glycolipid biosynthetic process(GO:0009247)
0.0 4.6 GO:0016570 histone modification(GO:0016570)
0.0 3.2 GO:0000122 negative regulation of transcription from RNA polymerase II promoter(GO:0000122)
0.0 1.5 GO:0007160 cell-matrix adhesion(GO:0007160)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 13.0 GO:0045095 keratin filament(GO:0045095)
0.6 2.4 GO:1990909 Wnt signalosome(GO:1990909)
0.2 1.7 GO:0030428 cell septum(GO:0030428)
0.2 1.4 GO:0000439 core TFIIH complex(GO:0000439)
0.2 8.5 GO:0005861 troponin complex(GO:0005861)
0.1 3.1 GO:0009925 basal plasma membrane(GO:0009925)
0.1 14.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 2.8 GO:0005882 intermediate filament(GO:0005882)
0.0 1.4 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 1.2 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.2 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.2 GO:0016272 prefoldin complex(GO:0016272)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 6.9 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.8 3.2 GO:0048407 platelet-derived growth factor-activated receptor activity(GO:0005017) platelet-derived growth factor binding(GO:0048407)
0.5 2.9 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.4 10.8 GO:0004623 phospholipase A2 activity(GO:0004623)
0.4 10.7 GO:0008483 transaminase activity(GO:0008483)
0.2 2.0 GO:0004994 somatostatin receptor activity(GO:0004994)
0.2 16.7 GO:0003823 antigen binding(GO:0003823)
0.2 1.7 GO:0004100 chitin synthase activity(GO:0004100)
0.2 2.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.2 1.1 GO:0000254 C-4 methylsterol oxidase activity(GO:0000254)
0.1 6.8 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.1 0.3 GO:0003994 aconitate hydratase activity(GO:0003994)
0.1 5.2 GO:0016879 ligase activity, forming carbon-nitrogen bonds(GO:0016879)
0.1 1.8 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.1 0.9 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 4.0 GO:0003724 RNA helicase activity(GO:0003724)
0.0 1.1 GO:0004697 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.0 0.8 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 1.5 GO:0071949 FAD binding(GO:0071949)
0.0 3.1 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 3.2 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.0 3.9 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 1.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.6 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.9 GO:0008373 sialyltransferase activity(GO:0008373)
0.0 2.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.2 GO:0044183 protein binding involved in protein folding(GO:0044183)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.2 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.1 15.5 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 6.9 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.2 6.5 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.1 1.5 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 1.4 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 2.4 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 0.3 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)