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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for mafb+mafba+nrl
Z-value: 2.26
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Transcription factors associated with mafb+mafba+nrl
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSDARG00000017121 | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Ba | |
| ENSDARG00000076520 | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog b (paralog b) | |
| ENSDARG00000100466 | neural retina leucine zipper |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| mafba | dr11_v1_chr23_-_3408777_3408777 | 0.46 | 3.8e-06 | Click! |
| mafb | dr11_v1_chr25_+_36674715_36674715 | -0.25 | 1.6e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_1291012 Show fit | 29.66 |
ENSDART00000158390
|
ATPase plasma membrane Ca2+ transporting 2 |
|
| chr6_-_60147517 Show fit | 27.91 |
ENSDART00000083453
|
solute carrier family 32 (GABA vesicular transporter), member 1 |
|
| chr8_-_14052349 Show fit | 23.98 |
ENSDART00000135811
|
ATPase plasma membrane Ca2+ transporting 3a |
|
| chr19_-_5254699 Show fit | 19.78 |
ENSDART00000081951
|
syntaxin 1B |
|
| chr10_-_7858553 Show fit | 19.06 |
ENSDART00000182010
|
inositol polyphosphate-5-phosphatase Ja |
|
| chr24_-_4973765 Show fit | 17.72 |
ENSDART00000127597
|
zic family member 1 (odd-paired homolog, Drosophila) |
|
| chr25_-_3503164 Show fit | 16.47 |
ENSDART00000191477
ENSDART00000186345 ENSDART00000180199 |
si:ch211-272n13.7 |
|
| chr6_+_58543336 Show fit | 15.31 |
ENSDART00000157018
|
stathmin-like 3 |
|
| chr7_-_26087807 Show fit | 15.29 |
ENSDART00000052989
|
acetylcholinesterase |
|
| chr9_-_296169 Show fit | 15.12 |
ENSDART00000165228
|
kinesin family member 5A, a |
Network of associatons between targets according to the STRING database.
First level regulatory network of mafb+mafba+nrl
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 71.5 | GO:0070588 | calcium ion transmembrane transport(GO:0070588) |
| 0.2 | 34.3 | GO:0006814 | sodium ion transport(GO:0006814) |
| 0.6 | 30.2 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 4.3 | 30.1 | GO:0098935 | dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971) |
| 3.5 | 27.9 | GO:0098700 | neurotransmitter loading into synaptic vesicle(GO:0098700) |
| 0.2 | 21.3 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 1.5 | 21.0 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
| 0.7 | 20.8 | GO:0007212 | dopamine receptor signaling pathway(GO:0007212) |
| 4.0 | 19.8 | GO:0098967 | exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967) |
| 2.5 | 19.8 | GO:0033137 | negative regulation of peptidyl-serine phosphorylation(GO:0033137) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 65.7 | GO:0099634 | postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634) |
| 0.1 | 61.7 | GO:0043005 | neuron projection(GO:0043005) |
| 0.6 | 54.6 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.2 | 39.5 | GO:0070382 | exocytic vesicle(GO:0070382) |
| 1.9 | 27.9 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.2 | 25.7 | GO:0045202 | synapse(GO:0045202) |
| 1.0 | 25.2 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 0.3 | 23.1 | GO:0001726 | ruffle(GO:0001726) |
| 0.4 | 22.1 | GO:0030426 | growth cone(GO:0030426) |
| 0.3 | 21.4 | GO:0045211 | postsynaptic membrane(GO:0045211) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 80.9 | GO:0000987 | core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159) |
| 0.9 | 54.0 | GO:0044325 | ion channel binding(GO:0044325) |
| 1.9 | 53.7 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.6 | 44.6 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.1 | 35.7 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.6 | 29.2 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 2.1 | 27.9 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 0.3 | 23.8 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.7 | 22.9 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.1 | 21.8 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 17.3 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.6 | 15.9 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.6 | 15.5 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.2 | 11.7 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.3 | 10.4 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.2 | 7.8 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.3 | 6.8 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.3 | 6.2 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.1 | 4.6 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 4.1 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 33.5 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 2.0 | 27.9 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 1.6 | 27.4 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 1.4 | 19.8 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 1.0 | 15.4 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.6 | 13.0 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 3.1 | 12.3 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.6 | 9.9 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.5 | 7.9 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.2 | 7.2 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |