ISMARA results: maza+mazb

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for maza+mazb

Z-value: 4.15

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Transcription factors associated with maza+mazb

Gene Symbol	Gene ID	Gene Info
mazb NCBI UniProt	ENSDARG00000063555	si_ch211-166g5.4
maza NCBI UniProt	ENSDARG00000087330	MYC-associated zinc finger protein a (purine-binding transcription factor)

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
maza	dr11_v1_chr3_-_21106093_21106093	0.63	1.2e-11	Click!
si:ch211-166g5.4	dr11_v1_chr12_-_3778848_3778848	0.55	1.0e-08	Click!

Activity profile of maza+mazb motif

Sorted Z-values of maza+mazb motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr14_-_30642819 Show fit	97.86	ENSDART00000078154	npas4a NCBI UniProt Show fit	neuronal PAS domain protein 4a
chr16_-_17207754 Show fit	69.80	ENSDART00000063804	wu:fj39g12 NCBI UniProt Show fit	wu:fj39g12
chr3_+_32425202 Show fit	69.34	ENSDART00000156464	prr12b NCBI UniProt Show fit	proline rich 12b
chr24_-_4973765 Show fit	69.12	ENSDART00000127597	zic1 NCBI UniProt Show fit	zic family member 1 (odd-paired homolog, Drosophila)
chr1_-_39943596 Show fit	69.07	ENSDART00000149730	stox2a NCBI UniProt Show fit	storkhead box 2a
chr21_+_26697536 Show fit	65.75	ENSDART00000004109	gng3 NCBI UniProt Show fit	guanine nucleotide binding protein (G protein), gamma 3
chr19_-_5254699 Show fit	62.27	ENSDART00000081951	stx1b NCBI UniProt Show fit	syntaxin 1B
chr25_+_37366698 Show fit	62.02	ENSDART00000165400 ENSDART00000192589	slc1a2b NCBI UniProt Show fit	solute carrier family 1 (glial high affinity glutamate transporter), member 2b
chr2_-_9646857 Show fit	56.36	ENSDART00000056901	zgc:153615 NCBI UniProt Show fit	zgc:153615
chr14_+_22172047 Show fit	55.83	ENSDART00000114750 ENSDART00000148259	gabrb2 NCBI UniProt Show fit	gamma-aminobutyric acid (GABA) A receptor, beta 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of maza+mazb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
7.9	173.8	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.7	161.2	GO:0070588	calcium ion transmembrane transport(GO:0070588)
1.6	141.6	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.4	101.4	GO:0007018	microtubule-based movement(GO:0007018)
19.6	97.9	GO:0060080	inhibitory postsynaptic potential(GO:0060080)
0.5	94.9	GO:0006813	potassium ion transport(GO:0006813)
3.4	77.2	GO:0051489	regulation of filopodium assembly(GO:0051489)
2.8	69.8	GO:0007168	receptor guanylyl cyclase signaling pathway(GO:0007168)
1.0	69.8	GO:1902476	chloride transmembrane transport(GO:1902476)
9.9	69.1	GO:0021534	cell proliferation in hindbrain(GO:0021534)

Showing 1 to 10 of 214 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	213.5	GO:0005887	integral component of plasma membrane(GO:0005887)
0.0	204.6	GO:0016021	integral component of membrane(GO:0016021)
0.3	180.0	GO:0030054	cell junction(GO:0030054)
0.1	158.1	GO:0005829	cytosol(GO:0005829)
2.8	150.4	GO:0098839	postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
4.9	142.2	GO:0048788	cytoskeleton of presynaptic active zone(GO:0048788)
0.0	131.9	GO:0005634	nucleus(GO:0005634)
0.8	83.0	GO:0043025	neuronal cell body(GO:0043025)
2.3	78.1	GO:1902710	GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
4.4	70.8	GO:0071564	npBAF complex(GO:0071564)

Showing 1 to 10 of 84 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	281.9	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
2.7	154.2	GO:0044325	ion channel binding(GO:0044325)
0.3	122.0	GO:0005096	GTPase activator activity(GO:0005096)
4.2	120.5	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.4	99.1	GO:0008017	microtubule binding(GO:0008017)
1.8	83.6	GO:0008013	beta-catenin binding(GO:0008013)
2.3	78.1	GO:0004890	GABA-A receptor activity(GO:0004890)
1.9	77.8	GO:0017075	syntaxin-1 binding(GO:0017075)
6.3	75.7	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
0.8	73.3	GO:0008201	heparin binding(GO:0008201)

Showing 1 to 10 of 155 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.9	42.4	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
1.0	41.9	PID ILK PATHWAY	Integrin-linked kinase signaling
2.3	37.5	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.7	35.6	PID INSULIN PATHWAY	Insulin Pathway
1.7	31.2	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.3	24.8	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.5	24.4	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.4	20.0	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
0.5	19.1	PID MET PATHWAY	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.3	12.7	PID AP1 PATHWAY	AP-1 transcription factor network

Showing 1 to 10 of 27 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.7	101.0	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
5.3	90.5	REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	Genes involved in Thromboxane signalling through TP receptor
4.5	86.2	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
4.4	62.3	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
1.8	40.4	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
3.7	36.5	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
3.1	33.6	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
2.1	29.9	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.6	28.3	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
2.0	26.4	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors

Showing 1 to 10 of 47 entries

Results for maza+mazb

Z-value: 4.15

Motif logo

Transcription factors associated with maza+mazb

Activity-expression correlation:

Activity profile of maza+mazb motif

Sorted Z-values of maza+mazb motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of maza+mazb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: