Project

PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

Navigation
Downloads

Results for mbd2

Z-value: 0.99

Motif logo

logo of

Transcription factors associated with mbd2

Gene Symbol Gene ID Gene Info
mbd2
ENSDARG00000075952 methyl-CpG binding domain protein 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
mbd2dr11_v1_chr5_-_1047222_10472220.094.0e-01Click!

Activity profile of mbd2 motif

Sorted Z-values of mbd2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr21_+_26697536 8.51 ENSDART00000004109
gng3
guanine nucleotide binding protein (G protein), gamma 3
chr23_-_3681026 7.77 ENSDART00000192128
ENSDART00000040086
pacsin1a
protein kinase C and casein kinase substrate in neurons 1a
chr20_+_16743056 6.79 ENSDART00000050308
calm1b
calmodulin 1b
chr18_-_46464501 6.77 ENSDART00000040669
sphkap
SPHK1 interactor, AKAP domain containing
chr11_-_762721 6.64 ENSDART00000166465
syn2b
synapsin IIb
chr25_+_34407529 6.62 ENSDART00000156751
OTUD7A
si:dkey-37f18.2
chr10_+_16225870 6.59 ENSDART00000164647
slc12a2
solute carrier family 12 (sodium/potassium/chloride transporter), member 2
chr22_-_12862415 6.47 ENSDART00000145156
ENSDART00000137280
glsa
glutaminase a
chr8_-_54223316 6.33 ENSDART00000018054
trh
thyrotropin-releasing hormone
chr24_-_35699595 5.97 ENSDART00000167990
mapre2
microtubule-associated protein, RP/EB family, member 2
chr20_-_40717900 5.69 ENSDART00000181663
cx43
connexin 43
chr24_-_35699444 4.99 ENSDART00000166567
mapre2
microtubule-associated protein, RP/EB family, member 2
chr16_-_45058919 4.92 ENSDART00000177134
gapdhs
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr7_+_30867008 4.71 ENSDART00000193106
apba2b
amyloid beta (A4) precursor protein-binding, family A, member 2b
chr6_+_39222598 4.58 ENSDART00000154991
b4galnt1b
beta-1,4-N-acetyl-galactosaminyl transferase 1b
chr2_-_56635744 4.43 ENSDART00000167790
ENSDART00000168160
pip5k1cb
phosphatidylinositol-4-phosphate 5-kinase, type I, gamma b
chr19_-_27966526 4.42 ENSDART00000141896
ube2ql1
ubiquitin-conjugating enzyme E2Q family-like 1
chr20_+_54738210 4.40 ENSDART00000151399
pak7
p21 protein (Cdc42/Rac)-activated kinase 7
chr22_-_3564563 4.21 ENSDART00000145114
ptprsa
protein tyrosine phosphatase, receptor type, s, a
chr20_+_40457599 4.08 ENSDART00000017553
serinc1
serine incorporator 1
chr18_-_46763170 4.03 ENSDART00000171880
dner
delta/notch-like EGF repeat containing
chr13_-_40120252 3.99 ENSDART00000157852
crtac1b
cartilage acidic protein 1b
chr21_+_28728030 3.93 ENSDART00000097307
puraa
purine-rich element binding protein Aa
chr14_-_3032016 3.88 ENSDART00000183461
ENSDART00000183035
ndst1a
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1a
chr14_-_3031810 3.87 ENSDART00000090213
ndst1a
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1a
chr22_-_2929127 3.79 ENSDART00000123730
ENSDART00000046678
pak2b
p21 protein (Cdc42/Rac)-activated kinase 2b
chr21_-_12272543 3.66 ENSDART00000081510
ENSDART00000151297
celf4
CUGBP, Elav-like family member 4
chr16_+_5678071 3.64 ENSDART00000011166
ENSDART00000134198
ENSDART00000131575
zgc:158689
zgc:158689
chr5_+_457729 3.57 ENSDART00000025183
ift74
intraflagellar transport 74
chr4_-_24019711 3.47 ENSDART00000077926
celf2
cugbp, Elav-like family member 2
chr15_+_404891 3.46 ENSDART00000155682
nipsnap2
nipsnap homolog 2
chr13_-_44782462 3.29 ENSDART00000141298
ENSDART00000099990
btbd9
BTB (POZ) domain containing 9
chr12_-_3756405 3.26 ENSDART00000150839
fam57bb
family with sequence similarity 57, member Bb
chr9_+_2452672 3.24 ENSDART00000193993
chn1
chimerin 1
chr13_-_1349922 3.22 ENSDART00000140970
si:ch73-52p7.1
si:ch73-52p7.1
chr14_-_24251057 3.21 ENSDART00000114169
bnip1a
BCL2 interacting protein 1a
chr2_-_689047 3.19 ENSDART00000122732
foxc1a
forkhead box C1a
chr19_-_27966780 3.19 ENSDART00000110016
ube2ql1
ubiquitin-conjugating enzyme E2Q family-like 1
chr5_+_393738 3.17 ENSDART00000161456
june
JunE proto-oncogene, AP-1 transcription factor subunit
chr2_-_57891504 3.15 ENSDART00000139948
zgc:92789
zgc:92789
chr1_+_32521469 3.12 ENSDART00000113818
ENSDART00000152580
nlgn4a
neuroligin 4a
chr2_-_32738535 3.04 ENSDART00000135293
nrbp2a
nuclear receptor binding protein 2a
chr2_+_23823622 3.03 ENSDART00000099581
si:dkey-24c2.9
si:dkey-24c2.9
chr16_-_27161410 3.02 ENSDART00000177503
LO017771.1

chr17_-_26604549 2.63 ENSDART00000174773
fam149b1
family with sequence similarity 149, member B1
chr5_+_32009956 2.57 ENSDART00000188482
scai
suppressor of cancer cell invasion
chr9_+_53725294 2.52 ENSDART00000165991
cnmd
chondromodulin
chr24_-_21404367 2.46 ENSDART00000152093
atp8a2
ATPase phospholipid transporting 8A2
chr12_-_11457625 2.45 ENSDART00000012318
htra1b
HtrA serine peptidase 1b
chr15_+_36966369 2.40 ENSDART00000163622
kirrel3l
kirre like nephrin family adhesion molecule 3, like
chr12_-_287633 2.32 ENSDART00000113335
map2k4b
mitogen-activated protein kinase kinase 4b
chr22_-_506522 2.28 ENSDART00000106645
ENSDART00000067637
dstyk
dual serine/threonine and tyrosine protein kinase
chr9_+_53725128 2.26 ENSDART00000169062
cnmd
chondromodulin
chr17_+_53250802 2.26 ENSDART00000143819
VASH1
vasohibin 1
chr5_-_12560569 2.14 ENSDART00000133587
wsb2
WD repeat and SOCS box containing 2
chr4_+_11439511 2.13 ENSDART00000150485
pcloa
piccolo presynaptic cytomatrix protein a
chr23_-_9807546 2.10 ENSDART00000136740
ENSDART00000004474
mapre1b
microtubule-associated protein, RP/EB family, member 1b
chr19_-_25427255 2.09 ENSDART00000036854
glcci1a
glucocorticoid induced 1a
chr16_-_42238120 2.09 ENSDART00000084730
zgc:162160
zgc:162160
chr12_+_25600685 2.08 ENSDART00000077157
six3b
SIX homeobox 3b
chr17_-_50010121 2.03 ENSDART00000122747
tmem30aa
transmembrane protein 30Aa
chr8_-_53926228 2.02 ENSDART00000015554
ubiad1
UbiA prenyltransferase domain containing 1
chr8_+_54013199 1.98 ENSDART00000158497
CABZ01079663.1

chr25_+_21833287 1.94 ENSDART00000187606
ckmt1
creatine kinase, mitochondrial 1
chr9_-_5046315 1.91 ENSDART00000179087
ENSDART00000109954
nr4a2a
nuclear receptor subfamily 4, group A, member 2a
chr1_-_30689004 1.90 ENSDART00000018827
dachc
dachshund c
chr10_+_16225553 1.79 ENSDART00000129844
slc12a2
solute carrier family 12 (sodium/potassium/chloride transporter), member 2
chr9_-_21936841 1.77 ENSDART00000144843
lmo7a
LIM domain 7a
chr23_-_17450746 1.75 ENSDART00000145399
ENSDART00000136457
ENSDART00000133125
ENSDART00000145719
ENSDART00000147524
ENSDART00000005366
ENSDART00000104680
tpd52l2b
tumor protein D52-like 2b
chr23_-_7052362 1.70 ENSDART00000127702
ENSDART00000192468
prpf6
PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)
chr11_-_270210 1.66 ENSDART00000005217
ENSDART00000172779
alas1
aminolevulinate, delta-, synthase 1
chr16_+_27564270 1.61 ENSDART00000140460
tmem67
transmembrane protein 67
chr19_-_42045372 1.59 ENSDART00000144275
trioa
trio Rho guanine nucleotide exchange factor a
chr17_-_52636937 1.58 ENSDART00000084268
fam98b
family with sequence similarity 98, member B
chr21_+_1143141 1.58 ENSDART00000178294
CABZ01086139.1

chr2_+_35854242 1.56 ENSDART00000134918
dhx9
DEAH (Asp-Glu-Ala-His) box helicase 9
chr10_+_16036246 1.55 ENSDART00000141586
ENSDART00000135868
ENSDART00000065037
ENSDART00000124502
lmnb1
lamin B1
chr9_+_1365747 1.54 ENSDART00000140917
ENSDART00000036605
prkra
protein kinase, interferon-inducible double stranded RNA dependent activator
chr14_-_30983011 1.54 ENSDART00000014095
rap2c
RAP2C, member of RAS oncogene family
chr18_+_3579829 1.52 ENSDART00000158763
ENSDART00000182850
ENSDART00000162754
ENSDART00000178789
ENSDART00000172656
lrch3
leucine-rich repeats and calponin homology (CH) domain containing 3
chr20_+_18943406 1.47 ENSDART00000193590
mtmr9
myotubularin related protein 9
chr9_+_24159725 1.45 ENSDART00000137756
hecw2a
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2a
chr15_+_11693624 1.45 ENSDART00000193630
ENSDART00000161930
strn4
striatin, calmodulin binding protein 4
chr25_+_34407740 1.37 ENSDART00000012677
OTUD7A
si:dkey-37f18.2
chr13_-_51922290 1.35 ENSDART00000168648
srfb
serum response factor b
chr23_+_45584223 1.33 ENSDART00000149367
si:ch73-290k24.5
si:ch73-290k24.5
chr10_-_26999482 1.30 ENSDART00000146085
si:dkey-88p24.11
si:dkey-88p24.11
chr14_+_556501 1.30 ENSDART00000181289
nudt6
nudix (nucleoside diphosphate linked moiety X)-type motif 6
chr2_+_50062165 1.29 ENSDART00000097939
ENSDART00000138214
zcchc2
zinc finger, CCHC domain containing 2
chr21_-_5393125 1.20 ENSDART00000146061
psmd5
proteasome 26S subunit, non-ATPase 5
chr7_+_53754653 1.14 ENSDART00000163261
ENSDART00000158160
neo1a
neogenin 1a
chr22_-_36829006 1.13 ENSDART00000170256
ENSDART00000086064
map1sa
microtubule-associated protein 1Sa
chr20_-_36227500 1.11 ENSDART00000166054
BX255920.1

chr18_+_38749547 1.10 ENSDART00000143735
si:ch211-215d8.2
si:ch211-215d8.2
chr14_+_14992909 1.04 ENSDART00000182203
BX119314.1

chr6_-_1874664 1.03 ENSDART00000007972
dlgap4b
discs, large (Drosophila) homolog-associated protein 4b
chr11_-_575786 1.02 ENSDART00000019997
mkrn2
makorin, ring finger protein, 2
chr3_-_17716322 1.00 ENSDART00000192664
CABZ01018956.1

chr19_+_5480327 0.98 ENSDART00000148794
jupb
junction plakoglobin b
chr8_+_25900049 0.96 ENSDART00000124300
ENSDART00000127618
ENSDART00000024009
rhoab
ras homolog gene family, member Ab
chr22_+_110158 0.94 ENSDART00000143698
prkar2ab
protein kinase, cAMP-dependent, regulatory, type II, alpha, B
chr6_-_19665114 0.93 ENSDART00000168985
usp43a
ubiquitin specific peptidase 43a
chr20_-_45062514 0.89 ENSDART00000183529
ENSDART00000182955
klhl29
kelch-like family member 29
chr7_+_53755054 0.87 ENSDART00000181629
neo1a
neogenin 1a
chr6_+_51932563 0.84 ENSDART00000181778
angpt4
angiopoietin 4
chr4_+_279669 0.82 ENSDART00000184884
CABZ01085275.1

chr15_-_3940671 0.81 ENSDART00000189741
mindy4b
MINDY family member 4B
chr8_+_1148876 0.76 ENSDART00000148651
avp
arginine vasopressin
chr17_-_6382392 0.73 ENSDART00000188051
ENSDART00000192560
ENSDART00000137389
ENSDART00000115389
txlnbb
taxilin beta b
chr4_+_27018663 0.72 ENSDART00000180778
CR749777.1

chr1_-_65017 0.70 ENSDART00000168609
si:zfos-1011f11.2
si:zfos-1011f11.2
chr12_-_11294979 0.69 ENSDART00000148850
get4
golgi to ER traffic protein 4 homolog (S. cerevisiae)
chr19_-_45534392 0.68 ENSDART00000163920
trps1
trichorhinophalangeal syndrome I
chr4_-_77979432 0.66 ENSDART00000049170
zgc:85975
zgc:85975
chr1_-_64829 0.64 ENSDART00000180269
si:zfos-1011f11.2
si:zfos-1011f11.2
chr6_-_19664848 0.62 ENSDART00000159749
usp43a
ubiquitin specific peptidase 43a
chr14_+_6962271 0.61 ENSDART00000148447
ENSDART00000149114
ENSDART00000149492
ENSDART00000148394
hnrnpaba
heterogeneous nuclear ribonucleoprotein A/Ba
chr21_+_22833905 0.58 ENSDART00000111150
birc2
baculoviral IAP repeat containing 2
chr18_-_127558 0.55 ENSDART00000149556
trpm7
transient receptor potential cation channel, subfamily M, member 7
chr6_-_31336317 0.54 ENSDART00000193927
dnajc6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr3_-_25813426 0.52 ENSDART00000039482
ntn1b
netrin 1b
chr11_+_575665 0.52 ENSDART00000122133
mkrn2os.1
MKRN2 opposite strand, tandem duplicate 1
chr12_+_27462225 0.44 ENSDART00000105661
meox1
mesenchyme homeobox 1
chr14_+_44860335 0.41 ENSDART00000091620
ENSDART00000173043
ENSDART00000091625
atp8a1
ATPase phospholipid transporting 8A1
chr11_-_27738489 0.38 ENSDART00000181612
fam120a
family with sequence similarity 120A
chr17_-_8673278 0.38 ENSDART00000171850
ENSDART00000017337
ENSDART00000148504
ENSDART00000148808
ctbp2a
C-terminal binding protein 2a
chr13_-_27620815 0.36 ENSDART00000139904
kcnq5a
potassium voltage-gated channel, KQT-like subfamily, member 5a
chr22_+_9060699 0.34 ENSDART00000133993
BX248395.1

chr3_+_32341917 0.34 ENSDART00000055299
prl
prolactin
chr15_-_35224173 0.30 ENSDART00000014415
mrpl44
mitochondrial ribosomal protein L44
chr4_+_16885854 0.29 ENSDART00000017726
etnk1
ethanolamine kinase 1
chr15_-_35224481 0.28 ENSDART00000099600
mrpl44
mitochondrial ribosomal protein L44
chr7_+_28612671 0.27 ENSDART00000019991
slc7a6os
solute carrier family 7, member 6 opposite strand
chr10_+_16036573 0.25 ENSDART00000188757
lmnb1
lamin B1
chr23_+_39331216 0.19 ENSDART00000160957
kcng1
potassium voltage-gated channel, subfamily G, member 1
chr7_-_9556354 0.17 ENSDART00000127974
lrrk1
leucine-rich repeat kinase 1
chr9_+_31222026 0.15 ENSDART00000145573
clybl
citrate lyase beta like
chr1_+_52792439 0.13 ENSDART00000123972
smarca5
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
chr8_+_2878756 0.11 ENSDART00000168107
crb2b
crumbs family member 2b
chr1_-_21204114 0.10 ENSDART00000141077
si:dkey-253i9.4
si:dkey-253i9.4
chr22_+_35275206 0.05 ENSDART00000112234
rubcn
RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein
chr12_+_763051 0.04 ENSDART00000152579
abcc3
ATP-binding cassette, sub-family C (CFTR/MRP), member 3
chr3_+_26081343 0.02 ENSDART00000134647
atp2a1
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1

Network of associatons between targets according to the STRING database.

First level regulatory network of mbd2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.3 GO:1903792 histamine metabolic process(GO:0001692) negative regulation of anion transport(GO:1903792)
1.5 13.1 GO:0035372 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)
1.3 4.0 GO:0014014 negative regulation of gliogenesis(GO:0014014)
1.1 3.3 GO:0008344 adult locomotory behavior(GO:0008344)
1.0 4.8 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.8 3.2 GO:0021557 oculomotor nerve development(GO:0021557)
0.8 6.5 GO:0006543 glutamate biosynthetic process(GO:0006537) glutamine catabolic process(GO:0006543)
0.8 3.2 GO:0072314 regulation of platelet-derived growth factor receptor signaling pathway(GO:0010640) platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790) glomerular visceral epithelial cell fate commitment(GO:0072149) glomerular epithelial cell fate commitment(GO:0072314) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583)
0.7 7.8 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.7 2.0 GO:0042373 vitamin K metabolic process(GO:0042373) cellular response to fluid shear stress(GO:0071498)
0.6 8.4 GO:0048796 swim bladder maturation(GO:0048796) swim bladder inflation(GO:0048798)
0.5 3.6 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735) pronephric proximal tubule development(GO:0035776)
0.4 3.6 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.4 4.6 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.3 7.8 GO:1900006 positive regulation of dendrite development(GO:1900006)
0.3 2.1 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.3 4.2 GO:0099560 synaptic membrane adhesion(GO:0099560)
0.3 1.7 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.3 2.3 GO:0060036 notochord cell vacuolation(GO:0060036)
0.2 4.1 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.2 2.1 GO:1904071 presynaptic active zone assembly(GO:1904071)
0.2 1.9 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.2 2.1 GO:0021631 optic nerve morphogenesis(GO:0021631)
0.2 3.7 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.2 1.0 GO:0002159 desmosome assembly(GO:0002159)
0.2 1.5 GO:2000650 negative regulation of sodium ion transmembrane transporter activity(GO:2000650)
0.2 0.5 GO:0021960 anterior commissure morphogenesis(GO:0021960)
0.2 1.5 GO:0032486 Rap protein signal transduction(GO:0032486)
0.1 1.9 GO:0046314 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.1 0.6 GO:0060547 negative regulation of necroptotic process(GO:0060546) negative regulation of necrotic cell death(GO:0060547)
0.1 4.9 GO:0045332 phospholipid translocation(GO:0045332)
0.1 1.0 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.1 4.6 GO:0072015 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.1 0.5 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.1 2.3 GO:0007257 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.1 3.5 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 1.7 GO:0046501 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.1 1.2 GO:0043248 proteasome assembly(GO:0043248)
0.1 4.9 GO:0006096 glycolytic process(GO:0006096)
0.1 3.2 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 2.0 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.1 1.5 GO:0010507 negative regulation of autophagy(GO:0010507)
0.1 1.0 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity(GO:0098962)
0.1 0.9 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 0.4 GO:0070073 clustering of voltage-gated calcium channels(GO:0070073)
0.0 0.4 GO:0061056 sclerotome development(GO:0061056)
0.0 1.1 GO:0031114 regulation of microtubule depolymerization(GO:0031114)
0.0 0.7 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.0 3.8 GO:0032147 activation of protein kinase activity(GO:0032147)
0.0 5.2 GO:0099643 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
0.0 7.4 GO:0000209 protein polyubiquitination(GO:0000209)
0.0 0.8 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 1.6 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.0 0.3 GO:0048532 anatomical structure arrangement(GO:0048532)
0.0 0.2 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.0 4.4 GO:0046488 phosphatidylinositol metabolic process(GO:0046488)
0.0 1.5 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 1.6 GO:0009615 response to virus(GO:0009615)
0.0 0.3 GO:0033555 multicellular organismal response to stress(GO:0033555)
0.0 4.9 GO:0042127 regulation of cell proliferation(GO:0042127)
0.0 1.8 GO:0030155 regulation of cell adhesion(GO:0030155)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 13.1 GO:0035371 microtubule plus-end(GO:0035371)
0.5 8.5 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.2 1.6 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.2 2.1 GO:0098982 GABA-ergic synapse(GO:0098982)
0.2 3.6 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 0.9 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 1.6 GO:0036038 MKS complex(GO:0036038)
0.1 0.7 GO:0071818 BAT3 complex(GO:0071818)
0.1 10.7 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 1.5 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 6.6 GO:0030173 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.1 7.1 GO:0030141 secretory granule(GO:0030141)
0.1 6.6 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 1.7 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.1 5.7 GO:0044309 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.0 3.2 GO:0031201 SNARE complex(GO:0031201)
0.0 1.0 GO:0098978 glutamatergic synapse(GO:0098978)
0.0 1.3 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 8.3 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.1 GO:0016589 NURF complex(GO:0016589)
0.0 1.0 GO:0016342 catenin complex(GO:0016342)
0.0 5.6 GO:0000139 Golgi membrane(GO:0000139)
0.0 10.2 GO:0031410 cytoplasmic vesicle(GO:0031410)
0.0 1.8 GO:0005882 intermediate filament(GO:0005882)
0.0 1.7 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 2.2 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 2.6 GO:0030425 dendrite(GO:0030425)
0.0 11.4 GO:0005739 mitochondrion(GO:0005739)
0.0 8.7 GO:1990904 ribonucleoprotein complex(GO:1990904)
0.0 11.3 GO:0005829 cytosol(GO:0005829)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.9 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
1.0 7.8 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.9 8.4 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.9 3.6 GO:0048487 beta-tubulin binding(GO:0048487)
0.7 6.5 GO:0004359 glutaminase activity(GO:0004359)
0.6 3.9 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.6 1.7 GO:0016748 succinyltransferase activity(GO:0016748)
0.5 2.3 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.4 8.5 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.4 13.1 GO:0051010 microtubule plus-end binding(GO:0051010)
0.3 2.0 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.3 1.3 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.2 1.5 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.2 6.8 GO:0051018 protein kinase A binding(GO:0051018)
0.2 4.7 GO:0001540 beta-amyloid binding(GO:0001540)
0.2 1.9 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 1.9 GO:0004111 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.1 7.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 0.6 GO:0032296 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.1 0.8 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.1 0.9 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1 4.4 GO:0016307 phosphatidylinositol phosphate kinase activity(GO:0016307)
0.1 2.1 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.1 1.0 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 4.6 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.1 2.5 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 2.3 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 0.6 GO:0043028 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.1 2.1 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 1.3 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.1 0.2 GO:0047777 (3S)-citramalyl-CoA lyase activity(GO:0047777)
0.0 7.4 GO:0005179 hormone activity(GO:0005179)
0.0 3.2 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 3.5 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.8 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 2.9 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 2.9 GO:0000287 magnesium ion binding(GO:0000287)
0.0 3.7 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 6.6 GO:0005543 phospholipid binding(GO:0005543)
0.0 2.2 GO:0008134 transcription factor binding(GO:0008134)
0.0 0.7 GO:0019905 syntaxin binding(GO:0019905)
0.0 3.6 GO:0003682 chromatin binding(GO:0003682)
0.0 0.5 GO:0030276 clathrin binding(GO:0030276)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.4 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 2.6 PID RHOA PATHWAY RhoA signaling pathway
0.1 3.2 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.1 1.5 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.1 2.4 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 2.3 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.8 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.3 PID ERBB4 PATHWAY ErbB4 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 8.5 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.3 4.4 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.2 4.9 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.2 4.0 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 1.7 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 0.8 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.1 2.4 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 6.3 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 6.3 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 2.9 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.7 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.8 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 1.2 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.3 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 3.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.3 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 1.6 REACTOME MRNA SPLICING Genes involved in mRNA Splicing