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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for mecp2

Z-value: 1.66

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Transcription factors associated with mecp2

Gene Symbol Gene ID Gene Info
mecp2
ENSDARG00000014218 methyl CpG binding protein 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
mecp2dr11_v1_chr8_-_7637626_76376400.541.4e-08Click!

Activity profile of mecp2 motif

Sorted Z-values of mecp2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr9_-_31278048 20.38 ENSDART00000022204
zic5
zic family member 5 (odd-paired homolog, Drosophila)
chr22_+_11535131 17.16 ENSDART00000113930
npb
neuropeptide B
chr16_+_32559821 16.72 ENSDART00000093250
pou3f2b
POU class 3 homeobox 2b
chr5_+_64739762 16.29 ENSDART00000161112
ENSDART00000135610
ENSDART00000002908
olfm1a
olfactomedin 1a
chr8_+_16004154 16.11 ENSDART00000134787
ENSDART00000172510
ENSDART00000141173
elavl4
ELAV like neuron-specific RNA binding protein 4
chr8_+_16004551 14.74 ENSDART00000165141
elavl4
ELAV like neuron-specific RNA binding protein 4
chr5_-_13685047 14.65 ENSDART00000018351
zgc:65851
zgc:65851
chr8_+_31119548 13.94 ENSDART00000136578
syn1
synapsin I
chr19_+_5072918 13.59 ENSDART00000037126
eno2
enolase 2
chr1_+_31864404 13.06 ENSDART00000075260
inab
internexin neuronal intermediate filament protein, alpha b
chr1_+_12766351 13.02 ENSDART00000165785
pcdh10a
protocadherin 10a
chr12_-_29624638 12.67 ENSDART00000126744
nrg3b
neuregulin 3b
chr25_-_19443421 12.15 ENSDART00000067362
cart2
cocaine- and amphetamine-regulated transcript 2
chr4_+_19534833 12.06 ENSDART00000140028
lrrc4.1
leucine rich repeat containing 4.1
chr20_-_45661049 11.40 ENSDART00000124582
ENSDART00000131251
napbb
N-ethylmaleimide-sensitive factor attachment protein, beta b
chr8_-_25422186 11.19 ENSDART00000113492
ENSDART00000131736
kcnq2a
potassium voltage-gated channel, KQT-like subfamily, member 2a
chr3_+_35005062 11.04 ENSDART00000181163
prkcbb
protein kinase C, beta b
chr3_-_13068189 10.64 ENSDART00000167180
prkar1b
protein kinase, cAMP-dependent, regulatory, type I, beta
chr1_-_20911297 10.26 ENSDART00000078271
cpe
carboxypeptidase E
chr13_-_40120252 10.16 ENSDART00000157852
crtac1b
cartilage acidic protein 1b
chr17_-_6759006 9.99 ENSDART00000184692
ENSDART00000180530
vsnl1b
visinin-like 1b
chr20_-_47704973 9.94 ENSDART00000174808
tfap2b
transcription factor AP-2 beta
chr4_-_1360495 9.61 ENSDART00000164623
ptn
pleiotrophin
chr10_-_22845485 9.51 ENSDART00000079454
vamp2
vesicle-associated membrane protein 2
chr1_+_54908895 9.39 ENSDART00000145652
golga7ba
golgin A7 family, member Ba
chr19_+_232536 9.31 ENSDART00000137880
syngap1a
synaptic Ras GTPase activating protein 1a
chr10_-_22057001 9.23 ENSDART00000016575
tlx3b
T cell leukemia homeobox 3b
chr7_+_19552381 9.16 ENSDART00000169060
si:ch211-212k18.5
si:ch211-212k18.5
chr9_+_27411502 9.07 ENSDART00000143994
si:dkey-193n17.9
si:dkey-193n17.9
chr13_-_36911118 9.06 ENSDART00000048739
trim9
tripartite motif containing 9
chr7_-_24699985 8.89 ENSDART00000052802
calb2b
calbindin 2b
chr11_-_762721 8.74 ENSDART00000166465
syn2b
synapsin IIb
chr1_-_23557877 8.71 ENSDART00000145942
fam184b
family with sequence similarity 184, member B
chr1_-_40994259 8.55 ENSDART00000101562
adra2c
adrenoceptor alpha 2C
chr14_-_2355833 8.44 ENSDART00000157677
PCDHGC3 (1 of many)
si:ch73-233f7.6
chr13_-_36545258 8.22 ENSDART00000186171
FP103009.1

chr8_+_23165749 7.98 ENSDART00000063057
dnajc5aa
DnaJ (Hsp40) homolog, subfamily C, member 5aa
chr3_+_46724528 7.94 ENSDART00000181358
pde4a
phosphodiesterase 4A, cAMP-specific
chr9_-_18877597 7.88 ENSDART00000099446
kctd4
potassium channel tetramerization domain containing 4
chr8_+_47897734 7.87 ENSDART00000140266
mfn2
mitofusin 2
chr15_+_40188076 7.86 ENSDART00000063779
efhd1
EF-hand domain family, member D1
chr17_-_19022990 7.81 ENSDART00000154186
flrt2
fibronectin leucine rich transmembrane protein 2
chr25_-_34156152 7.68 ENSDART00000125036
foxb1a
forkhead box B1a
chr18_-_46881108 7.60 ENSDART00000190084
gramd1bb
GRAM domain containing 1Bb
chr24_+_5208171 7.46 ENSDART00000155926
ENSDART00000154464
si:ch73-206p6.1
si:ch73-206p6.1
chr15_+_28685892 7.31 ENSDART00000155815
ENSDART00000060244
nova2
neuro-oncological ventral antigen 2
chr22_-_13544244 7.30 ENSDART00000110136
cntnap5b
contactin associated protein-like 5b
chr16_-_29458806 7.25 ENSDART00000047931
lingo4b
leucine rich repeat and Ig domain containing 4b
chr6_+_41554794 7.16 ENSDART00000165424
srgap3
SLIT-ROBO Rho GTPase activating protein 3
chr25_-_12203952 7.07 ENSDART00000158204
ENSDART00000091727
ntrk3a
neurotrophic tyrosine kinase, receptor, type 3a
chr1_+_25783801 7.05 ENSDART00000102455
gucy1a1
guanylate cyclase 1 soluble subunit alpha 1
chr17_-_28198099 7.02 ENSDART00000156143
htr1d
5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
chr9_+_24159725 7.01 ENSDART00000137756
hecw2a
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2a
chr25_+_8063455 6.99 ENSDART00000073919
kcnc1b
potassium voltage-gated channel, Shaw-related subfamily, member 1b
chr8_+_21146262 6.98 ENSDART00000045684
porcn
porcupine O-acyltransferase
chr12_+_33038757 6.90 ENSDART00000153146
rbfox3a
RNA binding fox-1 homolog 3a
chr16_-_31188715 6.81 ENSDART00000058829
scrt1b
scratch family zinc finger 1b
chr20_+_22666548 6.81 ENSDART00000147520
lnx1
ligand of numb-protein X 1
chr6_+_39222598 6.77 ENSDART00000154991
b4galnt1b
beta-1,4-N-acetyl-galactosaminyl transferase 1b
chr14_-_2196267 6.66 ENSDART00000161674
ENSDART00000125674
pcdh2ab8
pcdh2ab9
protocadherin 2 alpha b 8
protocadherin 2 alpha b 9
chr21_+_28728030 6.64 ENSDART00000097307
puraa
purine-rich element binding protein Aa
chr21_-_42100471 6.53 ENSDART00000166148
gabra1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr20_-_31905968 6.52 ENSDART00000142806
stxbp5a
syntaxin binding protein 5a (tomosyn)
chr16_+_34528409 6.51 ENSDART00000144718
paqr7b
progestin and adipoQ receptor family member VII, b
chr15_+_39096736 6.48 ENSDART00000129511
ENSDART00000014877
robo2
roundabout, axon guidance receptor, homolog 2 (Drosophila)
chr19_-_9503473 6.48 ENSDART00000091615
iffo1a
intermediate filament family orphan 1a
chr7_+_19882066 6.16 ENSDART00000111144
TMEM151A
transmembrane protein 151A
chr14_-_2050057 6.13 ENSDART00000112875
PCDHB15
protocadherin beta 15
chr9_+_17787864 6.08 ENSDART00000013111
dgkh
diacylglycerol kinase, eta
chr2_+_34572690 6.00 ENSDART00000077216
astn1
astrotactin 1
chr21_-_10446405 5.96 ENSDART00000167948
hcn1
hyperpolarization activated cyclic nucleotide-gated potassium channel 1
chr4_-_9764767 5.90 ENSDART00000164328
ENSDART00000147699
mical3b
microtubule associated monooxygenase, calponin and LIM domain containing 3b
chr4_-_12102025 5.88 ENSDART00000048391
ENSDART00000023894
braf
B-Raf proto-oncogene, serine/threonine kinase
chr2_+_23222939 5.87 ENSDART00000026800
kifap3b
kinesin-associated protein 3b
chr3_-_35602233 5.82 ENSDART00000055269
gng13b
guanine nucleotide binding protein (G protein), gamma 13b
chr11_-_23322182 5.76 ENSDART00000111289
kiss1
KiSS-1 metastasis-suppressor
chr23_+_2361184 5.75 ENSDART00000184469
CABZ01048666.1

chr5_-_28606916 5.74 ENSDART00000026107
ENSDART00000137717
tnc
tenascin C
chr22_-_38607504 5.58 ENSDART00000164609
si:ch211-126j24.1
si:ch211-126j24.1
chr3_-_27880229 5.51 ENSDART00000151404
abat
4-aminobutyrate aminotransferase
chr2_+_50391331 5.49 ENSDART00000098108
viml
vimentin like
chr24_+_24461558 5.48 ENSDART00000182424
bhlhe22
basic helix-loop-helix family, member e22
chr19_+_32979331 5.35 ENSDART00000078066
spire1a
spire-type actin nucleation factor 1a
chr7_-_26389908 5.31 ENSDART00000109268
si:dkey-3k24.5
si:dkey-3k24.5
chr2_+_39108339 5.21 ENSDART00000085675
clstn2
calsyntenin 2
chr17_+_24318753 5.20 ENSDART00000064083
otx1
orthodenticle homeobox 1
chr24_+_792429 5.20 ENSDART00000082523
impa2
inositol(myo)-1(or 4)-monophosphatase 2
chr2_+_23823622 5.18 ENSDART00000099581
si:dkey-24c2.9
si:dkey-24c2.9
chr23_+_28128453 5.16 ENSDART00000182618
c1galt1a
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1a
chr5_-_24712405 5.15 ENSDART00000033630
si:ch211-106a19.1
si:ch211-106a19.1
chr15_-_30815826 5.12 ENSDART00000156160
ENSDART00000145918
msi2b
musashi RNA-binding protein 2b
chr7_-_35708450 5.05 ENSDART00000193886
irx5a
iroquois homeobox 5a
chr20_-_47732703 5.05 ENSDART00000193975
tfap2d
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr11_-_27917730 4.83 ENSDART00000173219
eif4g3a
eukaryotic translation initiation factor 4 gamma, 3a
chr4_+_23223881 4.77 ENSDART00000133056
ENSDART00000089126
trhde.1
thyrotropin releasing hormone degrading enzyme, tandem duplicate 1
chr25_-_20381271 4.75 ENSDART00000142665
kctd15a
potassium channel tetramerization domain containing 15a
chr15_+_28685625 4.68 ENSDART00000188797
ENSDART00000166036
nova2
neuro-oncological ventral antigen 2
chr2_-_32501501 4.63 ENSDART00000181309
faim2a
Fas apoptotic inhibitory molecule 2a
chr14_-_9199968 4.62 ENSDART00000146113
arhgef9b
Cdc42 guanine nucleotide exchange factor (GEF) 9b
chr20_-_47731768 4.56 ENSDART00000031167
tfap2d
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr18_+_28564640 4.55 ENSDART00000016983
spon1a
spondin 1a
chr2_-_50372467 4.51 ENSDART00000108900
cntnap2b
contactin associated protein like 2b
chr17_+_52300018 4.39 ENSDART00000190302
esrrb
estrogen-related receptor beta
chr18_-_27897217 4.37 ENSDART00000175259
iqcg
IQ motif containing G
chr13_-_31296358 4.34 ENSDART00000030946
prdm8
PR domain containing 8
chr12_+_22680115 4.24 ENSDART00000152879
ablim2
actin binding LIM protein family, member 2
chr17_+_28882977 4.11 ENSDART00000153937
prkd1
protein kinase D1
chr3_+_13637383 4.10 ENSDART00000166000
si:ch211-194b1.1
si:ch211-194b1.1
chr17_-_21441464 4.09 ENSDART00000031490
vax1
ventral anterior homeobox 1
chr16_-_12914288 4.07 ENSDART00000184221
cacng8b
calcium channel, voltage-dependent, gamma subunit 8b
chr2_-_44406125 4.06 ENSDART00000056375
pih1d3
PIH1 domain containing 3
chr20_+_474288 4.02 ENSDART00000026794
nt5dc1
5'-nucleotidase domain containing 1
chr5_-_29488245 3.97 ENSDART00000047719
ENSDART00000141154
ENSDART00000171165
cacna1ba
calcium channel, voltage-dependent, N type, alpha 1B subunit, a
chr23_+_40908583 3.89 ENSDART00000180933
LO017845.1

chr21_-_18824434 3.87 ENSDART00000156333
si:dkey-112m2.1
si:dkey-112m2.1
chr6_+_58406014 3.85 ENSDART00000044241
kcnq2b
potassium voltage-gated channel, KQT-like subfamily, member 2b
chr24_-_20808283 3.83 ENSDART00000143759
vipr1b
vasoactive intestinal peptide receptor 1b
chr12_+_25640480 3.82 ENSDART00000105608
prkcea
protein kinase C, epsilon a
chr16_+_50006145 3.73 ENSDART00000049375
ube2e2
ubiquitin-conjugating enzyme E2E 2
chr1_-_26293203 3.67 ENSDART00000180140
cxxc4
CXXC finger 4
chr5_-_52277643 3.63 ENSDART00000010757
rgmb
repulsive guidance molecule family member b
chr22_-_20166660 3.62 ENSDART00000085913
ENSDART00000188241
btbd2a
BTB (POZ) domain containing 2a
chr21_+_10021823 3.61 ENSDART00000163995
herc7
hect domain and RLD 7
chr21_-_33995213 3.60 ENSDART00000140184
EBF1 (1 of many)
si:ch211-51e8.2
chr25_+_17589906 3.59 ENSDART00000167750
vac14
vac14 homolog (S. cerevisiae)
chr10_+_26118122 3.53 ENSDART00000079207
trim47
tripartite motif containing 47
chr8_-_30979494 3.49 ENSDART00000138959
si:ch211-251j10.3
si:ch211-251j10.3
chr13_-_44782462 3.48 ENSDART00000141298
ENSDART00000099990
btbd9
BTB (POZ) domain containing 9
chr13_+_51853716 3.47 ENSDART00000175341
ENSDART00000187855
LT631684.1

chr15_+_31471808 3.47 ENSDART00000110078
or102-3
odorant receptor, family C, subfamily 102, member 3
chr14_+_5936996 3.45 ENSDART00000097144
ENSDART00000126777
kctd8
potassium channel tetramerization domain containing 8
chr18_-_16590056 3.43 ENSDART00000143744
mgat4c
mgat4 family, member C
chr4_-_24019711 3.42 ENSDART00000077926
celf2
cugbp, Elav-like family member 2
chr7_-_33829824 3.39 ENSDART00000074729
uacab
uveal autoantigen with coiled-coil domains and ankyrin repeats b
chr2_+_25657958 3.38 ENSDART00000161407
tnika
TRAF2 and NCK interacting kinase a
chr21_+_45904956 3.38 ENSDART00000135034
ENSDART00000159841
ENSDART00000188242
slc22a21
solute carrier family 22 (organic cation transporter), member 21
chr24_-_33276139 3.35 ENSDART00000128943
nrbp2b
nuclear receptor binding protein 2b
chr11_-_3334248 3.33 ENSDART00000154314
ENSDART00000121861
prph
peripherin
chr23_+_43668756 3.32 ENSDART00000112598
otud4
OTU deubiquitinase 4
chr3_+_17806213 3.32 ENSDART00000055890
znf385c
zinc finger protein 385C
chr5_+_59397739 3.27 ENSDART00000148659
clip2
CAP-GLY domain containing linker protein 2
chr25_-_20381107 3.23 ENSDART00000067454
kctd15a
potassium channel tetramerization domain containing 15a
chr18_-_46881682 3.17 ENSDART00000189653
gramd1bb
GRAM domain containing 1Bb
chr3_-_23596532 3.16 ENSDART00000124921
ube2z
ubiquitin-conjugating enzyme E2Z
chr18_+_5917625 3.14 ENSDART00000169100
glg1b
golgi glycoprotein 1b
chr17_+_28883353 3.14 ENSDART00000110322
prkd1
protein kinase D1
chr2_+_40294313 3.14 ENSDART00000037292
epha4b
eph receptor A4b
chr18_+_45228691 3.14 ENSDART00000127953
large2
LARGE xylosyl- and glucuronyltransferase 2
chr16_-_11986321 3.13 ENSDART00000148666
ENSDART00000029121
usp5
ubiquitin specific peptidase 5 (isopeptidase T)
chr10_+_20128267 3.08 ENSDART00000064615
dmtn
dematin actin binding protein
chr15_-_18138607 3.08 ENSDART00000176690
CR385077.1

chr2_-_30324297 3.07 ENSDART00000099078
jph1b
junctophilin 1b
chr19_-_47587719 3.07 ENSDART00000111108
CABZ01071972.1

chr17_-_15382704 3.07 ENSDART00000005313
zgc:85722
zgc:85722
chr11_-_21363834 3.06 ENSDART00000080051
RASSF5
si:dkey-85p17.3
chr2_+_25658112 3.06 ENSDART00000051234
tnika
TRAF2 and NCK interacting kinase a
chr1_-_58036509 3.05 ENSDART00000081122
COLGALT1
si:ch211-114l13.7
chr1_-_53407448 3.03 ENSDART00000160033
ENSDART00000172322
elmod2
ELMO/CED-12 domain containing 2
chr21_-_11820379 3.02 ENSDART00000126640
RHOBTB3
si:dkey-6b12.5
chr3_+_31396149 3.00 ENSDART00000151423
ENSDART00000193580
c1ql3b
complement component 1, q subcomponent-like 3b
chr3_-_13461056 2.99 ENSDART00000137678
fbxw9
F-box and WD repeat domain containing 9
chr17_-_50010121 2.99 ENSDART00000122747
tmem30aa
transmembrane protein 30Aa
chr19_+_14454306 2.97 ENSDART00000161965
zdhhc18b
zinc finger, DHHC-type containing 18b
chr3_+_23707691 2.95 ENSDART00000025449
hoxb5a
homeobox B5a
chr12_-_13966184 2.92 ENSDART00000066368
klhl11
kelch-like family member 11
chr18_-_20560007 2.91 ENSDART00000141367
ENSDART00000090186
si:ch211-238n5.4
si:ch211-238n5.4
chr16_+_1353894 2.89 ENSDART00000148426
celf3b
cugbp, Elav-like family member 3b
chr20_+_32523576 2.88 ENSDART00000147319
scml4
Scm polycomb group protein like 4
chr21_-_25613249 2.85 ENSDART00000137896
fibpb
fibroblast growth factor (acidic) intracellular binding protein b
chr22_-_876506 2.84 ENSDART00000137522
cept1b
choline/ethanolamine phosphotransferase 1b
chr25_+_4581214 2.84 ENSDART00000185552
CABZ01068600.1

chr24_-_3477103 2.80 ENSDART00000143723
idi1
isopentenyl-diphosphate delta isomerase 1
chr11_+_2687395 2.76 ENSDART00000082510
b3galt6
UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6
chr6_+_48664275 2.76 ENSDART00000161184
FAM19A3
si:dkey-238f9.1
chr2_+_38147761 2.73 ENSDART00000135307
sall2
spalt-like transcription factor 2
chr15_+_23208042 2.72 ENSDART00000006085
cbl
Cbl proto-oncogene, E3 ubiquitin protein ligase
chr5_-_31035198 2.67 ENSDART00000086534
cyb5d2
cytochrome b5 domain containing 2
chr4_-_789645 2.66 ENSDART00000164441
mapre3b
microtubule-associated protein, RP/EB family, member 3b
chr25_-_19134489 2.63 ENSDART00000193629
abhd2b
abhydrolase domain containing 2b
chr3_+_60957512 2.62 ENSDART00000044096
helz
helicase with zinc finger
chr10_-_43392667 2.61 ENSDART00000183033
edil3b
EGF-like repeats and discoidin I-like domains 3b
chr4_+_20263097 2.61 ENSDART00000138820
lrtm2a
leucine-rich repeats and transmembrane domains 2a
chr21_-_2042037 2.60 ENSDART00000171131
ENSDART00000160144
add1
adducin 1 (alpha)
chr20_-_36227500 2.59 ENSDART00000166054
BX255920.1

chr19_+_3056450 2.57 ENSDART00000141324
ENSDART00000082353
hsf1
heat shock transcription factor 1
chr19_+_13994563 2.56 ENSDART00000164696
tmem222b
transmembrane protein 222b
chr15_-_37921998 2.54 ENSDART00000193597
ENSDART00000181443
ENSDART00000168790
si:dkey-238d18.5
si:dkey-238d18.5
chr21_-_37790727 2.54 ENSDART00000162907
gabrb4
gamma-aminobutyric acid (GABA) A receptor, beta 4
chr8_-_14484599 2.51 ENSDART00000057644
lhx4
LIM homeobox 4
chr6_+_6802142 2.50 ENSDART00000065566
dtd1
D-tyrosyl-tRNA deacylase 1
chr4_-_8611841 2.49 ENSDART00000067322
fbxl14b
F-box and leucine-rich repeat protein 14b
chr3_+_17653784 2.48 ENSDART00000159984
ENSDART00000157682
ENSDART00000187937
kat2a
K(lysine) acetyltransferase 2A
chr20_-_22484621 2.46 ENSDART00000063601
gsx2
GS homeobox 2
chr19_-_677713 2.44 ENSDART00000025146
slc6a19a.1
solute carrier family 6 (neutral amino acid transporter), member 19a, tandem duplicate 1
chr10_+_39476600 2.44 ENSDART00000135756
kirrel3a
kirre like nephrin family adhesion molecule 3a
chr8_+_48966165 2.43 ENSDART00000165425
aak1a
AP2 associated kinase 1a
chr22_-_4398069 2.37 ENSDART00000181893
kdm4b
lysine (K)-specific demethylase 4B
chr20_-_24122881 2.36 ENSDART00000131857
bach2b
BTB and CNC homology 1, basic leucine zipper transcription factor 2b
chr19_+_37458610 2.36 ENSDART00000103151
dlgap3
discs, large (Drosophila) homolog-associated protein 3
chr25_+_3994823 2.34 ENSDART00000154020
eps8l2
EPS8 like 2

Network of associatons between targets according to the STRING database.

First level regulatory network of mecp2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 20.4 GO:0033278 cell proliferation in midbrain(GO:0033278)
2.9 11.4 GO:0010807 regulation of synaptic vesicle priming(GO:0010807)
2.3 7.0 GO:0061355 Wnt protein secretion(GO:0061355)
2.2 8.9 GO:0099509 regulation of presynaptic cytosolic calcium ion concentration(GO:0099509) regulation of long-term synaptic potentiation(GO:1900271)
1.9 5.7 GO:0014814 regulation of synaptic growth at neuromuscular junction(GO:0008582) axon regeneration at neuromuscular junction(GO:0014814) positive regulation of synaptic growth at neuromuscular junction(GO:0045887)
1.8 16.3 GO:0061075 positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868)
1.7 8.6 GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway(GO:0071881)
1.5 7.7 GO:0021855 axon target recognition(GO:0007412) hypothalamus cell migration(GO:0021855)
1.5 12.2 GO:0008343 adult feeding behavior(GO:0008343)
1.3 6.5 GO:0070208 protein heterotrimerization(GO:0070208)
1.3 5.2 GO:0016267 O-glycan processing, core 1(GO:0016267)
1.2 7.3 GO:1901490 protein kinase D signaling(GO:0089700) regulation of lymphangiogenesis(GO:1901490)
1.2 3.5 GO:0008344 adult locomotory behavior(GO:0008344)
1.1 3.4 GO:1901223 negative regulation of NIK/NF-kappaB signaling(GO:1901223)
1.1 7.9 GO:0048662 regulation of smooth muscle cell proliferation(GO:0048660) negative regulation of smooth muscle cell proliferation(GO:0048662)
1.1 8.9 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
1.1 5.5 GO:0009450 gamma-aminobutyric acid catabolic process(GO:0009450)
0.9 4.5 GO:0071205 protein localization to juxtaparanode region of axon(GO:0071205) protein localization to axon(GO:0099612)
0.9 7.1 GO:0090594 inflammatory response to wounding(GO:0090594)
0.9 7.0 GO:2000650 negative regulation of sodium ion transmembrane transporter activity(GO:2000650)
0.9 3.5 GO:0045217 cell-cell junction maintenance(GO:0045217)
0.9 2.6 GO:0045601 regulation of endothelial cell differentiation(GO:0045601)
0.8 3.3 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659) negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.8 13.0 GO:0097324 melanocyte migration(GO:0097324)
0.8 17.2 GO:0007631 feeding behavior(GO:0007631)
0.8 2.3 GO:0061187 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
0.7 2.1 GO:2000378 negative regulation of reactive oxygen species metabolic process(GO:2000378)
0.7 5.3 GO:0033206 meiotic cytokinesis(GO:0033206) polar body extrusion after meiotic divisions(GO:0040038)
0.7 10.6 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.7 9.8 GO:0035493 SNARE complex assembly(GO:0035493)
0.6 6.5 GO:0050975 sensory perception of touch(GO:0050975)
0.6 7.0 GO:0050795 regulation of behavior(GO:0050795)
0.6 4.4 GO:0007288 sperm axoneme assembly(GO:0007288)
0.6 1.8 GO:0071470 cellular response to osmotic stress(GO:0071470)
0.6 2.3 GO:0061549 sympathetic ganglion development(GO:0061549)
0.6 2.8 GO:0046490 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate metabolic process(GO:0046490)
0.5 6.0 GO:0035677 posterior lateral line neuromast hair cell development(GO:0035677)
0.5 5.8 GO:0050909 sensory perception of taste(GO:0050909)
0.5 2.6 GO:0051792 medium-chain fatty acid biosynthetic process(GO:0051792)
0.5 6.8 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.5 4.1 GO:0090259 regulation of retinal ganglion cell axon guidance(GO:0090259)
0.5 5.0 GO:0072498 embryonic skeletal joint development(GO:0072498)
0.5 4.4 GO:0060579 ventral spinal cord interneuron fate commitment(GO:0060579)
0.5 3.4 GO:0015697 quaternary ammonium group transport(GO:0015697)
0.5 2.7 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.4 3.1 GO:0070571 negative regulation of axon regeneration(GO:0048681) negative regulation of neuron projection regeneration(GO:0070571)
0.4 1.3 GO:0060063 Spemann organizer formation at the embryonic shield(GO:0060063)
0.4 2.5 GO:0007613 memory(GO:0007613)
0.4 5.2 GO:0006020 inositol metabolic process(GO:0006020)
0.4 7.1 GO:1990090 response to nerve growth factor(GO:1990089) cellular response to nerve growth factor stimulus(GO:1990090)
0.4 2.3 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.4 9.3 GO:0030032 lamellipodium assembly(GO:0030032)
0.4 1.1 GO:0042373 vitamin K metabolic process(GO:0042373)
0.4 1.4 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.4 2.1 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.3 5.8 GO:0033555 multicellular organismal response to stress(GO:0033555)
0.3 12.4 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.3 6.0 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.3 5.2 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.3 1.2 GO:0071871 response to monoamine(GO:0071867) response to catecholamine(GO:0071869) response to epinephrine(GO:0071871)
0.3 2.7 GO:1904825 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)
0.3 1.2 GO:0032790 ribosome disassembly(GO:0032790)
0.3 5.8 GO:0006198 cAMP catabolic process(GO:0006198)
0.3 4.6 GO:0021988 olfactory bulb development(GO:0021772) olfactory lobe development(GO:0021988)
0.3 1.7 GO:0001839 neural plate morphogenesis(GO:0001839)
0.3 25.2 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.3 2.2 GO:0035479 angioblast cell migration from lateral mesoderm to midline(GO:0035479)
0.3 6.1 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.3 1.9 GO:0097010 eukaryotic translation initiation factor 4F complex assembly(GO:0097010)
0.3 0.8 GO:0006747 FAD biosynthetic process(GO:0006747) FAD metabolic process(GO:0046443) flavin adenine dinucleotide metabolic process(GO:0072387) flavin adenine dinucleotide biosynthetic process(GO:0072388)
0.2 1.0 GO:0031507 heterochromatin assembly(GO:0031507)
0.2 11.1 GO:0001885 endothelial cell development(GO:0001885)
0.2 4.1 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.2 2.8 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.2 1.9 GO:0045338 farnesyl diphosphate metabolic process(GO:0045338)
0.2 7.5 GO:0017121 phospholipid scrambling(GO:0017121)
0.2 1.1 GO:0097355 protein localization to heterochromatin(GO:0097355)
0.2 0.6 GO:0006585 dopamine biosynthetic process from tyrosine(GO:0006585) dopamine biosynthetic process(GO:0042416)
0.2 3.1 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.2 0.9 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.2 0.8 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.2 0.7 GO:0006740 NADPH regeneration(GO:0006740)
0.2 23.9 GO:0051260 protein homooligomerization(GO:0051260)
0.2 1.6 GO:0055015 ventricular cardiac muscle cell development(GO:0055015)
0.2 10.1 GO:0051781 positive regulation of cell division(GO:0051781)
0.2 0.9 GO:0035279 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.2 1.9 GO:0046548 retinal rod cell development(GO:0046548)
0.2 2.2 GO:1990504 dense core granule exocytosis(GO:1990504)
0.2 19.2 GO:0007269 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
0.2 4.6 GO:0046847 filopodium assembly(GO:0046847)
0.2 1.3 GO:0019405 alditol catabolic process(GO:0019405)
0.2 2.3 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.2 1.5 GO:0046850 regulation of bone remodeling(GO:0046850)
0.2 11.0 GO:0050853 B cell receptor signaling pathway(GO:0050853)
0.1 1.9 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.1 0.6 GO:0019401 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.1 0.3 GO:0065001 specification of axis polarity(GO:0065001)
0.1 0.4 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 3.3 GO:0001556 oocyte maturation(GO:0001556)
0.1 0.7 GO:0039694 viral genome replication(GO:0019079) negative stranded viral RNA replication(GO:0039689) viral RNA genome replication(GO:0039694) RNA replication(GO:0039703) multi-organism biosynthetic process(GO:0044034)
0.1 0.4 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.1 3.4 GO:0007520 myoblast fusion(GO:0007520)
0.1 1.1 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.1 2.5 GO:0098508 endothelial to hematopoietic transition(GO:0098508)
0.1 2.4 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity(GO:0098962)
0.1 0.8 GO:0000393 spliceosomal conformational changes to generate catalytic conformation(GO:0000393)
0.1 2.3 GO:0018095 protein polyglutamylation(GO:0018095)
0.1 0.4 GO:1902803 regulation of synaptic vesicle transport(GO:1902803)
0.1 4.3 GO:0014003 oligodendrocyte development(GO:0014003)
0.1 2.9 GO:0009408 response to heat(GO:0009408)
0.1 3.7 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.1 2.2 GO:0001966 thigmotaxis(GO:0001966)
0.1 0.9 GO:0070475 rRNA base methylation(GO:0070475)
0.1 1.2 GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902254)
0.1 33.6 GO:0008380 RNA splicing(GO:0008380)
0.1 0.7 GO:0098971 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.1 0.6 GO:0031087 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.1 0.9 GO:0061074 regulation of neural retina development(GO:0061074)
0.1 3.0 GO:0045332 phospholipid translocation(GO:0045332)
0.1 0.6 GO:0048742 regulation of myotube differentiation(GO:0010830) regulation of skeletal muscle fiber development(GO:0048742)
0.1 1.3 GO:0045116 protein neddylation(GO:0045116)
0.1 2.7 GO:0009648 photoperiodism(GO:0009648)
0.1 1.5 GO:1902667 regulation of axon guidance(GO:1902667)
0.1 1.6 GO:0034453 microtubule anchoring(GO:0034453)
0.1 6.9 GO:0017157 regulation of exocytosis(GO:0017157)
0.1 5.9 GO:0030042 actin filament depolymerization(GO:0030042)
0.1 3.3 GO:0045104 intermediate filament-based process(GO:0045103) intermediate filament cytoskeleton organization(GO:0045104)
0.1 7.8 GO:0008360 regulation of cell shape(GO:0008360)
0.1 4.1 GO:0007416 synapse assembly(GO:0007416)
0.1 18.3 GO:0034765 regulation of ion transmembrane transport(GO:0034765)
0.1 1.3 GO:0021884 forebrain neuron development(GO:0021884)
0.1 0.8 GO:0060294 cilium movement involved in cell motility(GO:0060294)
0.1 3.4 GO:0006661 phosphatidylinositol biosynthetic process(GO:0006661)
0.1 14.8 GO:0006869 lipid transport(GO:0006869)
0.1 1.8 GO:0006406 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.1 1.6 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 1.5 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.1 0.3 GO:0061157 RNA destabilization(GO:0050779) mRNA destabilization(GO:0061157)
0.1 3.3 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.1 0.2 GO:0010898 regulation of triglyceride catabolic process(GO:0010896) positive regulation of triglyceride catabolic process(GO:0010898)
0.0 0.4 GO:0008105 asymmetric protein localization(GO:0008105) apical protein localization(GO:0045176)
0.0 0.3 GO:0043649 dicarboxylic acid catabolic process(GO:0043649)
0.0 0.5 GO:0070932 histone H3 deacetylation(GO:0070932)
0.0 1.2 GO:0050821 protein stabilization(GO:0050821)
0.0 1.8 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 8.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.6 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 2.6 GO:0050919 negative chemotaxis(GO:0050919)
0.0 2.3 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 4.1 GO:0006413 translational initiation(GO:0006413)
0.0 2.1 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 1.5 GO:0006024 glycosaminoglycan biosynthetic process(GO:0006024)
0.0 3.8 GO:0046578 regulation of Ras protein signal transduction(GO:0046578)
0.0 0.8 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.0 0.2 GO:0032469 endoplasmic reticulum calcium ion homeostasis(GO:0032469)
0.0 0.1 GO:0061055 myotome development(GO:0061055)
0.0 0.8 GO:0043523 regulation of neuron apoptotic process(GO:0043523)
0.0 0.6 GO:0051125 regulation of actin nucleation(GO:0051125)
0.0 2.4 GO:0035725 sodium ion transmembrane transport(GO:0035725)
0.0 6.0 GO:0043087 regulation of GTPase activity(GO:0043087)
0.0 8.8 GO:0048812 neuron projection morphogenesis(GO:0048812)
0.0 2.4 GO:0048511 rhythmic process(GO:0048511)
0.0 2.9 GO:0006399 tRNA metabolic process(GO:0006399)
0.0 1.4 GO:0042472 inner ear morphogenesis(GO:0042472)
0.0 3.4 GO:0007018 microtubule-based movement(GO:0007018)
0.0 0.9 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 1.2 GO:0006006 glucose metabolic process(GO:0006006)
0.0 0.3 GO:0016925 protein sumoylation(GO:0016925)
0.0 1.3 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 2.1 GO:0051216 cartilage development(GO:0051216)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 11.4 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
2.6 13.1 GO:0005883 neurofilament(GO:0005883)
2.1 15.0 GO:0043194 axon initial segment(GO:0043194)
1.2 10.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
1.1 8.9 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.7 31.5 GO:0043204 perikaryon(GO:0043204)
0.7 2.6 GO:0097524 sperm plasma membrane(GO:0097524)
0.6 4.5 GO:0033010 paranodal junction(GO:0033010)
0.6 9.4 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.6 3.1 GO:0030314 junctional membrane complex(GO:0030314)
0.6 3.5 GO:0005913 cell-cell adherens junction(GO:0005913) zonula adherens(GO:0005915)
0.6 1.7 GO:0031213 RSF complex(GO:0031213)
0.5 7.9 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306)
0.5 7.0 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.4 3.6 GO:0035032 extrinsic component of vacuolar membrane(GO:0000306) phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.4 0.9 GO:0005845 mRNA cap binding complex(GO:0005845)
0.4 8.9 GO:0043195 terminal bouton(GO:0043195)
0.4 13.4 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.3 25.3 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.3 5.1 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.3 30.0 GO:0005882 intermediate filament(GO:0005882)
0.3 9.1 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.3 1.8 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.2 5.2 GO:0036126 sperm flagellum(GO:0036126)
0.2 4.8 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.2 5.9 GO:0035371 microtubule plus-end(GO:0035371)
0.2 1.0 GO:1990513 CLOCK-BMAL transcription complex(GO:1990513)
0.2 2.3 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.2 5.9 GO:0035869 ciliary transition zone(GO:0035869)
0.2 1.3 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.2 3.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 1.2 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.1 1.1 GO:0016586 RSC complex(GO:0016586)
0.1 0.6 GO:0071203 WASH complex(GO:0071203)
0.1 3.4 GO:0043186 P granule(GO:0043186)
0.1 1.5 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.1 0.8 GO:0033061 DNA recombinase mediator complex(GO:0033061)
0.1 3.9 GO:0098978 glutamatergic synapse(GO:0098978)
0.1 4.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 6.7 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.1 5.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 3.7 GO:0032587 ruffle membrane(GO:0032587)
0.1 1.1 GO:0045335 phagocytic vesicle(GO:0045335)
0.1 0.9 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.1 0.8 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.1 1.0 GO:0044545 NSL complex(GO:0044545)
0.1 1.9 GO:0000145 exocyst(GO:0000145)
0.1 1.3 GO:0002116 semaphorin receptor complex(GO:0002116)
0.1 0.3 GO:0071005 U2-type precatalytic spliceosome(GO:0071005)
0.1 1.7 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 4.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 6.5 GO:0014069 postsynaptic density(GO:0014069)
0.1 13.2 GO:0045202 synapse(GO:0045202)
0.1 0.7 GO:0005686 U2 snRNP(GO:0005686)
0.1 4.8 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.2 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 3.1 GO:0031201 SNARE complex(GO:0031201)
0.0 1.0 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 2.3 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 1.6 GO:0005758 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0 1.9 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 7.0 GO:0030425 dendrite(GO:0030425)
0.0 4.7 GO:0030424 axon(GO:0030424)
0.0 1.6 GO:0016592 mediator complex(GO:0016592)
0.0 5.5 GO:0030659 cytoplasmic vesicle membrane(GO:0030659)
0.0 0.7 GO:0000421 autophagosome membrane(GO:0000421)
0.0 8.1 GO:0000139 Golgi membrane(GO:0000139)
0.0 3.1 GO:0005681 spliceosomal complex(GO:0005681)
0.0 1.0 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 26.6 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 0.2 GO:0070449 elongin complex(GO:0070449)
0.0 1.2 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.0 0.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 20.9 GO:0005576 extracellular region(GO:0005576)
0.0 0.1 GO:0031415 NatA complex(GO:0031415)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 11.4 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
1.7 5.2 GO:0052833 inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
1.6 11.0 GO:0035173 histone kinase activity(GO:0035173)
1.5 10.6 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
1.4 8.6 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
1.3 5.2 GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263) beta-1,3-galactosyltransferase activity(GO:0048531)
1.2 8.6 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
1.2 7.1 GO:0005030 neurotrophin receptor activity(GO:0005030)
1.1 8.9 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.9 2.7 GO:0047690 aspartyltransferase activity(GO:0047690)
0.8 2.5 GO:0051499 D-aminoacyl-tRNA deacylase activity(GO:0051499) D-tyrosyl-tRNA(Tyr) deacylase activity(GO:0051500)
0.6 3.8 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.6 1.9 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.6 7.5 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.6 2.8 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142) ethanolaminephosphotransferase activity(GO:0004307)
0.6 6.1 GO:0030552 cAMP binding(GO:0030552)
0.5 1.6 GO:1901612 cardiolipin binding(GO:1901612)
0.5 13.4 GO:0004698 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.5 3.4 GO:0015651 quaternary ammonium group transmembrane transporter activity(GO:0015651)
0.5 22.0 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.5 6.5 GO:0022851 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.4 2.6 GO:0008126 acetylesterase activity(GO:0008126)
0.4 6.8 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.4 2.8 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.4 7.1 GO:0004383 guanylate cyclase activity(GO:0004383)
0.4 1.2 GO:0070097 delta-catenin binding(GO:0070097)
0.4 2.3 GO:0008502 melatonin receptor activity(GO:0008502)
0.4 10.3 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.3 0.9 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
0.3 7.2 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.3 12.2 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.3 7.0 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.3 3.9 GO:0008327 methyl-CpG binding(GO:0008327)
0.3 5.8 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.3 1.9 GO:0034057 RNA strand annealing activity(GO:0033592) RNA strand-exchange activity(GO:0034057)
0.3 12.4 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.3 3.1 GO:0042285 xylosyltransferase activity(GO:0042285)
0.3 6.0 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.3 0.8 GO:0003919 FMN adenylyltransferase activity(GO:0003919)
0.3 5.2 GO:0019894 kinesin binding(GO:0019894)
0.3 6.1 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.2 5.8 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.2 5.8 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.2 9.5 GO:0017075 syntaxin-1 binding(GO:0017075)
0.2 5.7 GO:0000339 RNA cap binding(GO:0000339)
0.2 1.7 GO:0001222 transcription corepressor binding(GO:0001222)
0.2 9.3 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.2 7.5 GO:0051010 microtubule plus-end binding(GO:0051010)
0.2 3.3 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.2 2.8 GO:0035250 UDP-galactosyltransferase activity(GO:0035250)
0.2 12.7 GO:0045499 chemorepellent activity(GO:0045499)
0.2 2.3 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.2 4.0 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.2 3.6 GO:0015026 coreceptor activity(GO:0015026)
0.2 5.1 GO:0015248 sterol transporter activity(GO:0015248)
0.2 5.5 GO:0008483 transaminase activity(GO:0008483)
0.2 0.7 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.2 3.1 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.2 1.6 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.2 2.3 GO:0070739 protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)
0.2 2.6 GO:0048495 Roundabout binding(GO:0048495)
0.2 7.8 GO:0044325 ion channel binding(GO:0044325)
0.2 6.8 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.1 1.0 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 2.6 GO:0033691 sialic acid binding(GO:0033691)
0.1 0.4 GO:1990715 mRNA CDS binding(GO:1990715)
0.1 2.5 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 0.6 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.1 6.1 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 1.1 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 3.6 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 5.9 GO:0071949 FAD binding(GO:0071949)
0.1 9.1 GO:0008201 heparin binding(GO:0008201)
0.1 1.2 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.1 8.0 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 1.2 GO:0034595 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439) phosphatidylinositol phosphate 5-phosphatase activity(GO:0034595)
0.1 0.8 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.1 1.3 GO:0031386 protein tag(GO:0031386)
0.1 0.5 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 2.1 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 3.7 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.1 0.3 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.1 12.8 GO:0001664 G-protein coupled receptor binding(GO:0001664)
0.1 1.5 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 1.3 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 1.0 GO:0002039 p53 binding(GO:0002039)
0.1 0.3 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 1.1 GO:0048038 quinone binding(GO:0048038)
0.1 6.4 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.1 2.6 GO:0005178 integrin binding(GO:0005178)
0.0 0.5 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 5.4 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 15.2 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 2.2 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.7 GO:0045159 myosin II binding(GO:0045159)
0.0 0.1 GO:0070259 tyrosyl-DNA phosphodiesterase activity(GO:0070259)
0.0 39.3 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.5 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.1 GO:0030882 lipid antigen binding(GO:0030882)
0.0 5.6 GO:0042393 histone binding(GO:0042393)
0.0 13.0 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 9.1 GO:0051015 actin filament binding(GO:0051015)
0.0 4.4 GO:0005516 calmodulin binding(GO:0005516)
0.0 1.2 GO:0051087 chaperone binding(GO:0051087)
0.0 25.3 GO:0003723 RNA binding(GO:0003723)
0.0 0.4 GO:0032190 acrosin binding(GO:0032190)
0.0 0.4 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0 1.1 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.3 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 6.5 GO:0003779 actin binding(GO:0003779)
0.0 6.8 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.5 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 9.7 GO:0008270 zinc ion binding(GO:0008270)
0.0 0.3 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.0 2.2 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.7 GO:0030170 pyridoxal phosphate binding(GO:0030170)
0.0 0.3 GO:0004707 MAP kinase activity(GO:0004707)
0.0 28.8 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 2.0 GO:0035091 phosphatidylinositol binding(GO:0035091)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 12.4 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.6 9.6 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.6 5.7 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.5 9.6 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.3 3.0 ST G ALPHA S PATHWAY G alpha s Pathway
0.3 12.2 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.2 7.3 ST GA13 PATHWAY G alpha 13 Pathway
0.2 5.4 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.2 2.7 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.1 1.5 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.1 7.0 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.1 2.1 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 5.2 PID NOTCH PATHWAY Notch signaling pathway
0.1 1.6 PID MYC PATHWAY C-MYC pathway
0.1 1.0 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 1.0 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.1 0.5 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.2 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 1.2 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.5 PID INSULIN PATHWAY Insulin Pathway
0.0 1.2 PID P73PATHWAY p73 transcription factor network
0.0 0.2 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.5 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.7 23.5 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
1.2 7.0 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.8 10.6 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.6 12.2 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.6 8.6 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.5 5.5 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.5 8.9 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.5 1.9 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.4 6.5 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.4 15.4 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.3 3.6 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.3 2.6 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.3 21.3 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.3 2.3 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.2 6.9 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.2 2.5 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.2 6.1 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.2 1.5 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.2 4.7 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.2 3.6 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.1 1.1 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 1.3 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 3.4 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 2.8 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.1 1.7 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.1 0.7 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 1.2 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 6.1 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.1 0.7 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 13.2 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 5.5 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 0.7 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 1.0 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.6 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.4 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.8 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.8 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.4 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins