ISMARA results: mef2aa+mef2ab

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for mef2aa+mef2ab

Z-value: 2.89

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Transcription factors associated with mef2aa+mef2ab

Gene Symbol	Gene ID	Gene Info
mef2aa NCBI UniProt	ENSDARG00000031756	myocyte enhancer factor 2aa
mef2ab NCBI UniProt	ENSDARG00000057527	myocyte enhancer factor 2ab
mef2ab NCBI UniProt	ENSDARG00000110771	myocyte enhancer factor 2ab

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
mef2aa	dr11_v1_chr18_+_23249519_23249519	0.80	7.2e-22	Click!
mef2ab	dr11_v1_chr7_+_15677196_15677196	0.23	2.4e-02	Click!

Activity profile of mef2aa+mef2ab motif

Sorted Z-values of mef2aa+mef2ab motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_-_61205711 Show fit	78.08	ENSDART00000055062	pvalb1 NCBI UniProt Show fit	parvalbumin 1
chr25_+_31264155 Show fit	68.42	ENSDART00000012256	tnni2a.3 NCBI UniProt Show fit	troponin I type 2a (skeletal, fast), tandem duplicate 3
chr3_+_32526263 Show fit	60.37	ENSDART00000150897	si:ch73-367p23.2 NCBI UniProt Show fit	si:ch73-367p23.2
chr12_-_26064105 Show fit	58.95	ENSDART00000168825	ldb3b NCBI UniProt Show fit	LIM domain binding 3b
chr5_-_72125551 Show fit	52.59	ENSDART00000149412	smyd1a NCBI UniProt Show fit	SET and MYND domain containing 1a
chr21_+_20383837 Show fit	51.01	ENSDART00000026430	hspb11 NCBI UniProt Show fit	heat shock protein, alpha-crystallin-related, b11
chr6_-_18199062 Show fit	49.70	ENSDART00000167513	ppp1r27b NCBI UniProt Show fit	protein phosphatase 1, regulatory subunit 27b
chr8_-_11112058 Show fit	47.93	ENSDART00000042755	ampd1 NCBI UniProt Show fit	adenosine monophosphate deaminase 1 (isoform M)
chr12_-_17712393 Show fit	46.75	ENSDART00000143534 ENSDART00000010144	pvalb2 NCBI UniProt Show fit	parvalbumin 2
chr7_+_7048245 Show fit	46.75	ENSDART00000001649	actn3b NCBI UniProt Show fit	actinin alpha 3b

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of mef2aa+mef2ab

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	163.1	GO:0061061	muscle structure development(GO:0061061)
6.5	148.9	GO:0031033	myosin filament organization(GO:0031033)
2.8	119.3	GO:0003009	skeletal muscle contraction(GO:0003009)
0.1	53.4	GO:0016567	protein ubiquitination(GO:0016567)
3.7	52.2	GO:0032264	IMP salvage(GO:0032264)
2.3	49.7	GO:0010923	negative regulation of phosphatase activity(GO:0010923)
8.6	42.8	GO:0090200	regulation of mitochondrial membrane potential(GO:0051881) regulation of release of cytochrome c from mitochondria(GO:0090199) positive regulation of release of cytochrome c from mitochondria(GO:0090200)
3.1	40.3	GO:0006603	phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
4.4	39.3	GO:0051694	pointed-end actin filament capping(GO:0051694)
8.8	35.1	GO:0001778	plasma membrane repair(GO:0001778) chondrocyte differentiation involved in endochondral bone morphogenesis(GO:0003413) growth plate cartilage chondrocyte differentiation(GO:0003418)

Showing 1 to 10 of 101 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.1	134.0	GO:0005861	troponin complex(GO:0005861)
2.7	127.4	GO:0031941	filamentous actin(GO:0031941)
4.6	96.8	GO:0031430	M band(GO:0031430)
0.0	76.7	GO:0005634	nucleus(GO:0005634)
0.1	60.8	GO:0015630	microtubule cytoskeleton(GO:0015630)
2.6	39.3	GO:0036379	striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.9	35.1	GO:0042470	melanosome(GO:0042470) pigment granule(GO:0048770)
0.4	29.0	GO:0034707	chloride channel complex(GO:0034707)
0.7	27.3	GO:0016605	PML body(GO:0016605)
2.1	24.9	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)

Showing 1 to 10 of 50 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	229.4	GO:0005509	calcium ion binding(GO:0005509)
6.4	127.4	GO:0051393	muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
2.5	54.0	GO:0005523	tropomyosin binding(GO:0005523)
0.8	52.6	GO:0018024	histone-lysine N-methyltransferase activity(GO:0018024)
4.7	52.2	GO:0047623	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
3.0	45.4	GO:0051879	Hsp90 protein binding(GO:0051879)
0.5	42.7	GO:0019902	phosphatase binding(GO:0019902)
3.1	40.3	GO:0016775	creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.7	35.1	GO:0001786	phosphatidylserine binding(GO:0001786)
0.7	34.6	GO:0042826	histone deacetylase binding(GO:0042826)

Showing 1 to 10 of 84 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	47.7	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.6	22.4	NABA COLLAGENS	Genes encoding collagen proteins
0.3	16.0	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.3	15.8	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.3	11.5	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.2	8.6	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.3	7.8	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.3	6.9	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.2	4.6	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.2	3.7	PID EPHA FWDPATHWAY	EPHA forward signaling

Showing 1 to 10 of 18 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.8	47.9	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
1.0	28.9	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.5	22.4	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
1.0	19.8	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.9	18.2	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
1.0	11.5	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.7	10.7	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.4	8.8	REACTOME GLUCAGON TYPE LIGAND RECEPTORS	Genes involved in Glucagon-type ligand receptors
1.1	8.6	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2	6.9	REACTOME MYOGENESIS	Genes involved in Myogenesis

Showing 1 to 10 of 22 entries

Results for mef2aa+mef2ab

Z-value: 2.89

Motif logo

Transcription factors associated with mef2aa+mef2ab

Activity-expression correlation:

Activity profile of mef2aa+mef2ab motif

Sorted Z-values of mef2aa+mef2ab motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of mef2aa+mef2ab

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: