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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for mef2b

Z-value: 1.39

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Transcription factors associated with mef2b

Gene Symbol Gene ID Gene Info
mef2b
ENSDARG00000093170 myocyte enhancer factor 2b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
mef2bdr11_v1_chr22_+_18187857_181878570.331.0e-03Click!

Activity profile of mef2b motif

Sorted Z-values of mef2b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_61205711 32.68 ENSDART00000055062
pvalb1
parvalbumin 1
chr8_+_22930627 20.82 ENSDART00000187860
sypa
synaptophysin a
chr11_+_11201096 20.57 ENSDART00000171916
ENSDART00000171521
ENSDART00000087105
ENSDART00000159603
myom2a
myomesin 2a
chr5_-_31926906 18.64 ENSDART00000187340
ssh1b
slingshot protein phosphatase 1b
chr5_+_64368770 17.57 ENSDART00000162246
plpp7
phospholipid phosphatase 7 (inactive)
chr3_-_32818607 17.16 ENSDART00000075465
mylpfa
myosin light chain, phosphorylatable, fast skeletal muscle a
chr1_+_45080897 17.00 ENSDART00000129819
si:ch211-151p13.8
si:ch211-151p13.8
chr6_-_40722480 15.65 ENSDART00000188187
kbtbd12
kelch repeat and BTB (POZ) domain containing 12
chr25_+_29160102 15.13 ENSDART00000162854
pkmb
pyruvate kinase M1/2b
chr23_+_22658700 14.85 ENSDART00000192248
eno1a
enolase 1a, (alpha)
chr19_-_31035155 14.56 ENSDART00000161882
bzw2
basic leucine zipper and W2 domains 2
chr9_-_33107237 14.27 ENSDART00000013918
casq2
calsequestrin 2
chr25_-_13381854 13.80 ENSDART00000164621
ENSDART00000169129
ndrg4
NDRG family member 4
chr16_+_29663809 13.45 ENSDART00000191336
tmod4
tropomodulin 4 (muscle)
chr6_-_40722200 13.34 ENSDART00000035101
kbtbd12
kelch repeat and BTB (POZ) domain containing 12
chr5_+_51597677 13.32 ENSDART00000048210
ENSDART00000184797
ckmt2b
creatine kinase, mitochondrial 2b (sarcomeric)
chr14_+_24215046 13.25 ENSDART00000079215
stc2a
stanniocalcin 2a
chr6_-_14139503 13.11 ENSDART00000089577
cacnb4b
calcium channel, voltage-dependent, beta 4b subunit
chr7_-_23745984 12.98 ENSDART00000048050
ITGB1BP2
zgc:92429
chr10_-_22845485 12.60 ENSDART00000079454
vamp2
vesicle-associated membrane protein 2
chr5_-_72125551 12.22 ENSDART00000149412
smyd1a
SET and MYND domain containing 1a
chr24_+_25471196 12.06 ENSDART00000066625
smpx
small muscle protein, X-linked
chr23_-_39849155 11.95 ENSDART00000115330
ppp1r14c
protein phosphatase 1, regulatory (inhibitor) subunit 14C
chr17_-_12336987 11.72 ENSDART00000172001
snap25b
synaptosomal-associated protein, 25b
chr19_-_31035325 11.71 ENSDART00000147504
bzw2
basic leucine zipper and W2 domains 2
chr1_-_25936677 11.48 ENSDART00000146488
ENSDART00000136321
myoz2b
myozenin 2b
chr10_-_8033468 10.89 ENSDART00000140476
atp6v0a2a
ATPase H+ transporting V0 subunit a2a
chr10_-_24371312 10.76 ENSDART00000149362
pitpnab
phosphatidylinositol transfer protein, alpha b
chr1_+_8601935 10.25 ENSDART00000152367
si:ch211-160d14.6
si:ch211-160d14.6
chr6_-_35472923 9.85 ENSDART00000185907
rgs8
regulator of G protein signaling 8
chr10_-_8032885 9.84 ENSDART00000188619
atp6v0a2a
ATPase H+ transporting V0 subunit a2a
chr6_-_10780698 9.40 ENSDART00000151714
gpr155b
G protein-coupled receptor 155b
chr25_-_29363934 9.13 ENSDART00000166889
nptna
neuroplastin a
chr20_-_26001288 8.98 ENSDART00000136518
ENSDART00000063177
capn3b
calpain 3b
chr7_-_52334840 8.80 ENSDART00000174173
CR938716.1

chr18_+_7264961 8.78 ENSDART00000188461
CABZ01015105.1

chr20_+_41549200 8.72 ENSDART00000135715
fam184a
family with sequence similarity 184, member A
chr1_-_21483832 8.63 ENSDART00000102790
glrba
glycine receptor, beta a
chr6_+_36942966 8.42 ENSDART00000028895
negr1
neuronal growth regulator 1
chr20_-_26042070 7.99 ENSDART00000140255
si:dkey-12h9.6
si:dkey-12h9.6
chr14_-_32405387 7.88 ENSDART00000184647
fgf13a
fibroblast growth factor 13a
chr10_+_37145007 7.79 ENSDART00000131777
cuedc1a
CUE domain containing 1a
chr4_-_23908802 7.69 ENSDART00000138873
celf2
cugbp, Elav-like family member 2
chr6_-_42003780 7.58 ENSDART00000032527
cav3
caveolin 3
chr17_-_14671098 7.39 ENSDART00000037371
ppp1r13ba
protein phosphatase 1, regulatory subunit 13Ba
chr13_+_9432501 7.39 ENSDART00000058064
zgc:123321
zgc:123321
chr21_+_11684830 7.38 ENSDART00000147473
pcsk1
proprotein convertase subtilisin/kexin type 1
chr12_+_6002715 7.30 ENSDART00000114961
si:ch211-131k2.3
si:ch211-131k2.3
chr23_-_32157865 7.24 ENSDART00000000876
nr4a1
nuclear receptor subfamily 4, group A, member 1
chr5_-_51819027 6.84 ENSDART00000164267
homer1b
homer scaffolding protein 1b
chr21_-_27185915 6.54 ENSDART00000135052
slc8a4a
solute carrier family 8 (sodium/calcium exchanger), member 4a
chr5_-_10946232 6.51 ENSDART00000163139
ENSDART00000031265
rtn4r
reticulon 4 receptor
chr19_+_41169996 6.11 ENSDART00000048438
asb4
ankyrin repeat and SOCS box containing 4
chr13_-_27767330 6.09 ENSDART00000131631
ENSDART00000112553
ENSDART00000189911
rims1a
regulating synaptic membrane exocytosis 1a
chr13_+_1944451 6.06 ENSDART00000125914
hmgcll1
3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1
chr25_+_3677650 5.98 ENSDART00000154348
prnprs3
prion protein, related sequence 3
chr12_-_26430507 5.95 ENSDART00000153214
synpo2lb
synaptopodin 2-like b
chr21_+_11685009 5.88 ENSDART00000014668
pcsk1
proprotein convertase subtilisin/kexin type 1
chr12_+_41697664 5.69 ENSDART00000162302
bnip3
BCL2 interacting protein 3
chr1_-_6494384 5.55 ENSDART00000109356
klf7a
Kruppel-like factor 7a
chr3_+_32425202 5.54 ENSDART00000156464
prr12b
proline rich 12b
chr19_+_24394560 5.48 ENSDART00000142506
si:dkey-81h8.1
si:dkey-81h8.1
chr10_-_2522588 5.28 ENSDART00000081926
CU856539.1

chr21_-_12272543 5.24 ENSDART00000081510
ENSDART00000151297
celf4
CUGBP, Elav-like family member 4
chr1_-_17569793 5.08 ENSDART00000125125
acsl1a
acyl-CoA synthetase long chain family member 1a
chr9_+_31795343 4.87 ENSDART00000139584
itgbl1
integrin, beta-like 1
chr6_-_46403475 4.86 ENSDART00000154148
camk1a
calcium/calmodulin-dependent protein kinase Ia
chr21_+_19070921 4.75 ENSDART00000029874
nkx6.1
NK6 homeobox 1
chr2_+_19777146 4.74 ENSDART00000038648
ptbp2b
polypyrimidine tract binding protein 2b
chr10_-_41450367 4.70 ENSDART00000122682
ENSDART00000189549
cabp1b
calcium binding protein 1b
chr10_+_29698467 4.68 ENSDART00000163402
dlg2
discs, large homolog 2 (Drosophila)
chr12_+_42400277 4.67 ENSDART00000166590
si:ch211-221j21.3
si:ch211-221j21.3
chr17_-_5769196 4.58 ENSDART00000113885
si:dkey-100n19.2
si:dkey-100n19.2
chr21_+_43559123 4.50 ENSDART00000151212
gpr185a
G protein-coupled receptor 185 a
chr17_-_10025234 4.43 ENSDART00000008355
cfl2
cofilin 2 (muscle)
chr7_-_27686021 4.36 ENSDART00000079112
ENSDART00000100989
calca
calcitonin/calcitonin-related polypeptide, alpha
chr11_-_18253111 4.34 ENSDART00000125984
mustn1b
musculoskeletal, embryonic nuclear protein 1b
chr7_+_21859337 4.27 ENSDART00000159626
si:dkey-85k7.7
si:dkey-85k7.7
chr2_-_6182098 4.24 ENSDART00000156167
si:ch73-182a11.2
si:ch73-182a11.2
chr9_-_48937240 4.22 ENSDART00000075627
cers6
ceramide synthase 6
chr16_+_25245857 4.21 ENSDART00000155220
klhl38b
kelch-like family member 38b
chr19_+_30990129 4.19 ENSDART00000052169
ENSDART00000193376
sync
syncoilin, intermediate filament protein
chr5_+_51227147 4.17 ENSDART00000083340
ubac1
UBA domain containing 1
chr21_+_39432248 4.16 ENSDART00000179938
pafah1b1b
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1b
chr7_-_49646251 4.08 ENSDART00000193674
hrasb
-Ha-ras Harvey rat sarcoma viral oncogene homolog b
chr10_-_2527342 4.01 ENSDART00000184168
CU856539.1

chr12_+_8373525 3.94 ENSDART00000152180
arid5b
AT-rich interaction domain 5B
chr24_-_28333029 3.93 ENSDART00000149015
ENSDART00000129174
prkag2a
protein kinase, AMP-activated, gamma 2 non-catalytic subunit a
chr25_-_27722614 3.87 ENSDART00000190154
zgc:153935
zgc:153935
chr15_-_14552101 3.82 ENSDART00000171169
numbl
numb homolog (Drosophila)-like
chr7_+_39006837 3.73 ENSDART00000173735
dgkza
diacylglycerol kinase, zeta a
chr14_+_30285613 3.55 ENSDART00000173090
mtus1a
microtubule associated tumor suppressor 1a
chr23_+_6077503 3.54 ENSDART00000081714
ENSDART00000139834
mybpha
myosin binding protein Ha
chr8_-_26388090 3.53 ENSDART00000147912
si:dkey-20d21.12
si:dkey-20d21.12
chr19_-_7321221 3.50 ENSDART00000092375
oxr1b
oxidation resistance 1b
chr13_+_11439486 3.46 ENSDART00000138312
zbtb18
zinc finger and BTB domain containing 18
chr4_+_5180650 3.43 ENSDART00000067390
fgf6b
fibroblast growth factor 6b
chr9_-_48281941 3.39 ENSDART00000099787
klhl41a
kelch-like family member 41a
chr12_-_34035364 3.38 ENSDART00000087065
timp2a
TIMP metallopeptidase inhibitor 2a
chr20_+_34455645 3.38 ENSDART00000135789
mettl11b
methyltransferase like 11B
chr12_+_27022517 3.35 ENSDART00000152975
msl1b
male-specific lethal 1 homolog b (Drosophila)
chr2_+_1202347 3.16 ENSDART00000075837
CABZ01084566.1

chr18_+_26719787 3.15 ENSDART00000141672
alpk3a
alpha-kinase 3a
chr25_-_29988352 3.13 ENSDART00000067059
fam19a5b
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5b
chr9_-_23894392 3.09 ENSDART00000133417
asb18
ankyrin repeat and SOCS box containing 18
chr11_-_18601955 3.00 ENSDART00000180565
zmynd8
zinc finger, MYND-type containing 8
chr9_+_32178374 2.92 ENSDART00000078576
coq10b
coenzyme Q10B
chr4_-_5018705 2.92 ENSDART00000154025
strip2
striatin interacting protein 2
chr5_-_50781623 2.91 ENSDART00000114950
zgc:194908
zgc:194908
chr23_+_20110086 2.86 ENSDART00000054664
tnnc1b
troponin C type 1b (slow)
chr23_+_17417539 2.86 ENSDART00000182605
BX649300.2

chr24_-_12745222 2.84 ENSDART00000151836
si:ch211-196f5.9
si:ch211-196f5.9
chr1_-_17570013 2.79 ENSDART00000146946
acsl1a
acyl-CoA synthetase long chain family member 1a
chr12_+_34119439 2.77 ENSDART00000032821
cyth1b
cytohesin 1b
chr7_-_31938938 2.72 ENSDART00000132353
bdnf
brain-derived neurotrophic factor
chr19_-_41069573 2.63 ENSDART00000111982
ENSDART00000193142
sgce
sarcoglycan, epsilon
chr13_-_36581875 2.57 ENSDART00000113204
lgals3a
lectin, galactoside binding soluble 3a
chr7_+_31379528 2.42 ENSDART00000187370
ctdspl2b
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2b
chr4_-_4261673 2.36 ENSDART00000150694
cd9b
CD9 molecule b
chr4_+_13449775 2.35 ENSDART00000172552
dyrk2
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
chr18_+_3169579 2.33 ENSDART00000164724
ENSDART00000186340
ENSDART00000181247
ENSDART00000168056
pak1
p21 protein (Cdc42/Rac)-activated kinase 1
chr23_-_3721444 2.28 ENSDART00000141682
nudt3a
nudix (nucleoside diphosphate linked moiety X)-type motif 3a
chr20_+_45620076 2.21 ENSDART00000113806
hnrnpa0l
heterogeneous nuclear ribonucleoprotein A0, like
chr14_-_24332786 2.18 ENSDART00000173164
fam13b
family with sequence similarity 13, member B
chr5_+_61657702 2.12 ENSDART00000134387
ENSDART00000171248
ap2b1
adaptor-related protein complex 2, beta 1 subunit
chr5_-_31875645 2.03 ENSDART00000098160
tmem119b
transmembrane protein 119b
chr12_+_30563550 1.97 ENSDART00000126064
si:ch211-28p3.4
si:ch211-28p3.4
chr21_-_25669820 1.96 ENSDART00000148236
tmem179b
transmembrane protein 179B
chr5_+_64842730 1.95 ENSDART00000144732
lrrc8ab
leucine rich repeat containing 8 VRAC subunit Ab
chr8_+_17987215 1.93 ENSDART00000113605
lrriq3
leucine-rich repeats and IQ motif containing 3
chr25_-_19486399 1.88 ENSDART00000155076
ENSDART00000156016
zgc:193812
zgc:193812
chr18_+_17959681 1.75 ENSDART00000142700
znf423
zinc finger protein 423
chr23_-_36670369 1.68 ENSDART00000006881
zbtb39
zinc finger and BTB domain containing 39
chr9_+_29040425 1.66 ENSDART00000150201
MRAS
si:ch73-116o1.2
chr25_-_27722309 1.66 ENSDART00000148121
zgc:153935
zgc:153935
chr6_-_46768040 1.57 ENSDART00000154071
igfn1.2
immunoglobulin-like and fibronectin type III domain containing 1, tandem duplicate 2
chr23_-_7826849 1.55 ENSDART00000157612
myt1b
myelin transcription factor 1b
chr22_+_2861734 1.52 ENSDART00000140578
si:dkey-20i20.2
si:dkey-20i20.2
chr17_-_50234004 1.49 ENSDART00000058706
fosaa
v-fos FBJ murine osteosarcoma viral oncogene homolog Aa
chr9_-_48184823 1.43 ENSDART00000180264
klhl23
kelch-like family member 23
chr19_+_44039849 1.42 ENSDART00000086040
lrrc14b
leucine rich repeat containing 14B
chr4_+_14343706 1.37 ENSDART00000142845
prl2
prolactin 2
chr5_-_18911114 1.33 ENSDART00000014434
bri3bp
bri3 binding protein
chr5_+_61658282 1.32 ENSDART00000188878
ap2b1
adaptor-related protein complex 2, beta 1 subunit
chr3_+_26135502 1.24 ENSDART00000146979
atp2a1
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
chr5_-_30151815 1.18 ENSDART00000156048
zbtb44
zinc finger and BTB domain containing 44
chr24_+_8736497 1.17 ENSDART00000181904
tmem14ca
transmembrane protein 14Ca
chr9_+_21793565 1.17 ENSDART00000134915
rev1
REV1, polymerase (DNA directed)
chr8_+_7097929 1.15 ENSDART00000188955
ENSDART00000184772
ENSDART00000109581
abtb1
ankyrin repeat and BTB (POZ) domain containing 1
chr7_+_39679944 1.15 ENSDART00000133420
tbc1d14
TBC1 domain family, member 14
chr23_-_38497705 1.13 ENSDART00000109493
tshz2
teashirt zinc finger homeobox 2
chr13_+_42011287 1.04 ENSDART00000131147
cyp1b1
cytochrome P450, family 1, subfamily B, polypeptide 1
chr6_+_14301214 0.94 ENSDART00000129491
tmem182b
transmembrane protein 182b
chr13_-_24825691 0.92 ENSDART00000142745
slka
STE20-like kinase a
chr18_+_49248389 0.84 ENSDART00000059285
ENSDART00000142004
ENSDART00000132751
yif1b
Yip1 interacting factor homolog B (S. cerevisiae)
chr15_-_14755236 0.81 ENSDART00000166880
ENSDART00000160302
p4ha3
prolyl 4-hydroxylase, alpha polypeptide III
chr2_+_37975026 0.77 ENSDART00000034802
si:rp71-1g18.13
si:rp71-1g18.13
chr9_+_32178050 0.77 ENSDART00000169526
coq10b
coenzyme Q10B
chr23_-_25050329 0.72 ENSDART00000140216
avpr2aa
arginine vasopressin receptor 2a, duplicate a
chr1_-_45662774 0.66 ENSDART00000042158
serhl
serine hydrolase-like
chr3_+_17456428 0.65 ENSDART00000090676
ENSDART00000182082
si:ch211-210g13.5
si:ch211-210g13.5
chr24_+_9178064 0.64 ENSDART00000142971
dlgap1b
discs, large (Drosophila) homolog-associated protein 1b
chr23_+_23485858 0.55 ENSDART00000114067
agrn
agrin
chr4_+_77060861 0.54 ENSDART00000174271
ENSDART00000174393
ENSDART00000150450
si:dkey-240n22.8
si:dkey-240n22.8
chr23_+_3721042 0.53 ENSDART00000143323
smim29
small integral membrane protein 29
chr16_-_30655980 0.46 ENSDART00000146508
ldlrad4b
low density lipoprotein receptor class A domain containing 4b
chr6_+_46697710 0.45 ENSDART00000154969
tespa1
thymocyte expressed, positive selection associated 1
chr9_-_28399071 0.45 ENSDART00000104317
ENSDART00000064343
klf7b
Kruppel-like factor 7b
chr19_-_32518556 0.41 ENSDART00000103410
zbtb8b
zinc finger and BTB domain containing 8B
chr8_+_44420108 0.39 ENSDART00000075381
CU571323.1

chr8_-_53166975 0.37 ENSDART00000114683
rbsn
rabenosyn, RAB effector
chr10_-_17170086 0.36 ENSDART00000020122
ywhah
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
chr15_+_20543770 0.35 ENSDART00000092357
sgsm2
small G protein signaling modulator 2
chr25_+_32530976 0.28 ENSDART00000156190
ENSDART00000103324
scaper
S-phase cyclin A-associated protein in the ER
chr20_-_24443680 0.27 ENSDART00000191337
CR385053.3

chr17_+_1992495 0.26 ENSDART00000192937
CABZ01062996.1

chr7_-_7420301 0.24 ENSDART00000102620
six7
SIX homeobox 7
chr3_+_31717291 0.24 ENSDART00000058221
dcaf7
ddb1 and cul4 associated factor 7
chr5_-_25236340 0.23 ENSDART00000162774
abca2
ATP-binding cassette, sub-family A (ABC1), member 2
chr5_+_16580739 0.22 ENSDART00000135140
htr7c
5-hydroxytryptamine (serotonin) receptor 7c
chr5_+_67390645 0.19 ENSDART00000014822
ebf2
early B cell factor 2
chr5_+_67390115 0.16 ENSDART00000193255
ebf2
early B cell factor 2
chr9_+_24065855 0.16 ENSDART00000161468
ENSDART00000171577
ENSDART00000172743
ENSDART00000159324
ENSDART00000079689
ENSDART00000023196
ENSDART00000101577
lrrfip1a
leucine rich repeat (in FLII) interacting protein 1a
chr16_-_26435431 0.12 ENSDART00000187526
megf8
multiple EGF-like-domains 8
chr8_-_17980317 0.04 ENSDART00000129148
tnni3k
TNNI3 interacting kinase

Network of associatons between targets according to the STRING database.

First level regulatory network of mef2b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 14.3 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
3.0 9.0 GO:0097264 self proteolysis(GO:0097264)
2.5 9.9 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
1.8 25.5 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
1.6 8.0 GO:0023041 neuronal signal transduction(GO:0023041)
1.5 12.3 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
1.5 6.1 GO:0046951 ketone body biosynthetic process(GO:0046951)
1.5 13.5 GO:0051694 pointed-end actin filament capping(GO:0051694)
1.5 20.7 GO:0051452 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
1.5 4.4 GO:0030043 actin filament fragmentation(GO:0030043)
1.2 12.2 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
1.2 6.0 GO:0021731 trigeminal motor nucleus development(GO:0021731)
1.1 3.4 GO:0006480 N-terminal protein amino acid methylation(GO:0006480)
1.0 4.2 GO:0051012 microtubule sliding(GO:0051012)
1.0 13.3 GO:0046314 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
1.0 6.8 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.9 13.3 GO:0016486 peptide hormone processing(GO:0016486)
0.9 4.3 GO:0035988 chondrocyte proliferation(GO:0035988)
0.8 7.6 GO:0046716 muscle cell cellular homeostasis(GO:0046716)
0.8 12.6 GO:0035493 SNARE complex assembly(GO:0035493)
0.8 7.2 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.7 10.3 GO:1901642 nucleoside transport(GO:0015858) nucleoside transmembrane transport(GO:1901642)
0.7 2.0 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.6 5.7 GO:0097345 mitochondrial outer membrane permeabilization(GO:0097345)
0.6 8.6 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.6 3.4 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.6 7.9 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.5 6.5 GO:0042044 fluid transport(GO:0042044)
0.5 7.3 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.5 2.3 GO:1901906 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.4 3.9 GO:0060612 adipose tissue development(GO:0060612)
0.4 6.3 GO:0003310 pancreatic A cell differentiation(GO:0003310)
0.4 2.3 GO:0003232 bulbus arteriosus development(GO:0003232)
0.3 12.9 GO:0006376 mRNA splice site selection(GO:0006376)
0.3 3.3 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.3 13.1 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.3 9.1 GO:0070593 dendrite self-avoidance(GO:0070593)
0.3 7.9 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.3 1.2 GO:0031446 regulation of twitch skeletal muscle contraction(GO:0014724) regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448) negative regulation of striated muscle contraction(GO:0045988) relaxation of skeletal muscle(GO:0090076)
0.3 1.2 GO:0070987 error-free translesion synthesis(GO:0070987)
0.3 6.1 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.3 2.9 GO:0055117 regulation of cardiac muscle contraction(GO:0055117)
0.3 5.9 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.2 2.7 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.2 6.0 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.2 4.7 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.2 15.1 GO:0032869 cellular response to insulin stimulus(GO:0032869)
0.2 15.7 GO:0030837 negative regulation of actin filament polymerization(GO:0030837) negative regulation of protein polymerization(GO:0032272)
0.2 3.7 GO:0006743 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.2 0.5 GO:1902571 regulation of serine-type peptidase activity(GO:1902571)
0.2 3.4 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.2 10.8 GO:0015914 phospholipid transport(GO:0015914)
0.2 3.7 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.2 4.9 GO:0033627 cell adhesion mediated by integrin(GO:0033627)
0.2 0.5 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.1 21.9 GO:0006936 muscle contraction(GO:0006936)
0.1 4.4 GO:0055064 chloride ion homeostasis(GO:0055064)
0.1 3.8 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 3.9 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.1 1.1 GO:2000785 regulation of autophagosome assembly(GO:2000785)
0.1 1.0 GO:0042572 retinol metabolic process(GO:0042572)
0.1 0.5 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.1 0.7 GO:0001992 regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.1 4.2 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.1 2.8 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 0.4 GO:0021634 optic nerve formation(GO:0021634)
0.1 1.4 GO:0046427 positive regulation of JAK-STAT cascade(GO:0046427) positive regulation of STAT cascade(GO:1904894)
0.1 3.1 GO:0010842 retina layer formation(GO:0010842)
0.0 13.3 GO:0006874 cellular calcium ion homeostasis(GO:0006874)
0.0 0.8 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.0 2.4 GO:0007338 single fertilization(GO:0007338)
0.0 1.2 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 0.6 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity(GO:0098962)
0.0 4.7 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 3.5 GO:0006979 response to oxidative stress(GO:0006979)
0.0 3.3 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 0.2 GO:0046549 retinal cone cell development(GO:0046549)
0.0 4.7 GO:0045087 innate immune response(GO:0045087)
0.0 3.0 GO:0007265 Ras protein signal transduction(GO:0007265)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 12.1 GO:0043034 costamere(GO:0043034)
2.1 20.7 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
2.0 14.3 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
2.0 11.7 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
1.7 32.8 GO:0031430 M band(GO:0031430)
1.5 12.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
1.0 4.2 GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex(GO:0008247)
0.5 9.9 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.4 3.3 GO:0072487 MSL complex(GO:0072487)
0.4 2.6 GO:0016012 sarcoglycan complex(GO:0016012)
0.3 8.0 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.3 12.6 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.3 3.9 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.3 26.9 GO:0048786 presynaptic active zone(GO:0048786)
0.3 1.2 GO:0031673 H zone(GO:0031673)
0.3 16.3 GO:0036379 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.2 3.4 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.2 17.4 GO:0030018 Z disc(GO:0030018)
0.2 4.7 GO:0031594 neuromuscular junction(GO:0031594)
0.2 13.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.2 7.6 GO:0044853 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.1 7.9 GO:0030426 growth cone(GO:0030426)
0.1 3.4 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 4.9 GO:0008305 integrin complex(GO:0008305)
0.1 3.8 GO:0042383 sarcolemma(GO:0042383)
0.1 5.7 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 6.8 GO:0014069 postsynaptic density(GO:0014069)
0.0 0.6 GO:0099572 postsynaptic specialization(GO:0099572)
0.0 4.2 GO:0005882 intermediate filament(GO:0005882)
0.0 8.6 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 6.1 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 8.1 GO:0030424 axon(GO:0030424)
0.0 11.8 GO:0043005 neuron projection(GO:0043005)
0.0 1.1 GO:0005776 autophagosome(GO:0005776)
0.0 4.9 GO:0031966 mitochondrial membrane(GO:0031966)
0.0 3.1 GO:0045202 synapse(GO:0045202)
0.0 0.8 GO:0030134 ER to Golgi transport vesicle(GO:0030134)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 15.1 GO:0004743 pyruvate kinase activity(GO:0004743)
1.9 7.6 GO:0071253 connexin binding(GO:0071253)
1.5 12.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
1.5 10.8 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
1.5 6.1 GO:0004419 hydroxymethylglutaryl-CoA lyase activity(GO:0004419)
1.5 4.4 GO:0031716 calcitonin receptor binding(GO:0031716)
1.4 20.7 GO:0051117 ATPase binding(GO:0051117)
1.4 6.8 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
1.3 12.0 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
1.3 10.3 GO:0008504 monoamine transmembrane transporter activity(GO:0008504)
1.1 11.5 GO:0051373 telethonin binding(GO:0031433) FATZ binding(GO:0051373)
1.1 45.1 GO:0017075 syntaxin-1 binding(GO:0017075)
1.1 3.4 GO:0071885 N-terminal protein N-methyltransferase activity(GO:0071885)
1.0 13.3 GO:0016775 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
1.0 8.6 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.7 7.9 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.7 7.2 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.6 13.5 GO:0005523 tropomyosin binding(GO:0005523)
0.5 6.5 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.5 7.3 GO:0051879 Hsp90 protein binding(GO:0051879)
0.5 2.3 GO:0034432 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.4 13.1 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.4 7.4 GO:0002039 p53 binding(GO:0002039)
0.4 3.7 GO:0048039 ubiquinone binding(GO:0048039)
0.4 6.5 GO:0048495 Roundabout binding(GO:0048495)
0.3 4.2 GO:0070840 dynein complex binding(GO:0070840)
0.3 7.9 GO:0017080 sodium channel regulator activity(GO:0017080)
0.3 4.2 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.3 9.1 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.3 3.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.2 18.6 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.2 0.7 GO:0004377 GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity(GO:0004377)
0.2 2.7 GO:0005163 nerve growth factor receptor binding(GO:0005163) neurotrophin receptor binding(GO:0005165)
0.2 12.2 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.2 1.0 GO:0070330 aromatase activity(GO:0070330)
0.2 3.7 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 3.9 GO:0016208 AMP binding(GO:0016208)
0.1 6.1 GO:0044325 ion channel binding(GO:0044325)
0.1 3.5 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 4.1 GO:0019003 GDP binding(GO:0019003)
0.1 2.9 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 4.9 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 14.6 GO:0005179 hormone activity(GO:0005179)
0.1 0.5 GO:0070412 R-SMAD binding(GO:0070412)
0.1 4.9 GO:0005178 integrin binding(GO:0005178)
0.1 1.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 7.7 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.1 0.7 GO:0005000 vasopressin receptor activity(GO:0005000)
0.1 0.8 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.1 13.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 53.2 GO:0005509 calcium ion binding(GO:0005509)
0.1 18.8 GO:0051015 actin filament binding(GO:0051015)
0.1 1.2 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 3.4 GO:0030276 clathrin binding(GO:0030276)
0.0 3.9 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.7 GO:0004629 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.0 7.2 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.7 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 6.0 GO:0003779 actin binding(GO:0003779)
0.0 4.6 GO:0005096 GTPase activator activity(GO:0005096)
0.0 2.4 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 13.0 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.4 7.6 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.3 7.2 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.2 2.3 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.1 9.2 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.1 5.7 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 4.4 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 4.4 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 2.3 PID P53 REGULATION PATHWAY p53 pathway
0.0 1.7 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 12.6 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
1.3 13.3 REACTOME PEPTIDE HORMONE BIOSYNTHESIS Genes involved in Peptide hormone biosynthesis
0.3 3.4 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.3 2.3 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.2 7.2 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.2 4.4 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 4.2 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.0 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.1 9.9 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.1 1.2 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.5 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 6.1 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.2 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis