ISMARA results: mef2ca+mef2cb

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for mef2ca+mef2cb

Z-value: 2.80

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Transcription factors associated with mef2ca+mef2cb

Gene Symbol	Gene ID	Gene Info
mef2cb NCBI UniProt	ENSDARG00000009418	myocyte enhancer factor 2cb
mef2ca NCBI UniProt	ENSDARG00000029764	myocyte enhancer factor 2ca

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
mef2ca	dr11_v1_chr10_-_43568239_43568241	0.80	9.8e-22	Click!
mef2cb	dr11_v1_chr5_-_48307804_48307804	0.55	7.9e-09	Click!

Activity profile of mef2ca+mef2cb motif

Sorted Z-values of mef2ca+mef2cb motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_+_11201096 Show fit	74.60	ENSDART00000171916 ENSDART00000171521 ENSDART00000087105 ENSDART00000159603	myom2a NCBI UniProt Show fit	myomesin 2a
chr3_-_61205711 Show fit	57.34	ENSDART00000055062	pvalb1 NCBI UniProt Show fit	parvalbumin 1
chr5_+_51597677 Show fit	53.31	ENSDART00000048210 ENSDART00000184797	ckmt2b NCBI UniProt Show fit	creatine kinase, mitochondrial 2b (sarcomeric)
chr12_-_26064480 Show fit	51.06	ENSDART00000158215 ENSDART00000171206 ENSDART00000171212 ENSDART00000182956 ENSDART00000186779	ldb3b NCBI UniProt Show fit	LIM domain binding 3b
chr25_+_29160102 Show fit	49.82	ENSDART00000162854	pkmb NCBI UniProt Show fit	pyruvate kinase M1/2b
chr12_-_26064105 Show fit	49.54	ENSDART00000168825	ldb3b NCBI UniProt Show fit	LIM domain binding 3b
chr11_+_11200550 Show fit	48.48	ENSDART00000181339 ENSDART00000187116	myom2a NCBI UniProt Show fit	myomesin 2a
chr11_-_18253111 Show fit	47.62	ENSDART00000125984	mustn1b NCBI UniProt Show fit	musculoskeletal, embryonic nuclear protein 1b
chr15_-_23645810 Show fit	44.37	ENSDART00000168845	ckmb NCBI UniProt Show fit	creatine kinase, muscle b
chr9_-_42873700 Show fit	42.94	ENSDART00000125953	ttn.1 NCBI UniProt Show fit	titin, tandem duplicate 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of mef2ca+mef2cb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	205.6	GO:0006936	muscle contraction(GO:0006936)
0.4	121.7	GO:0061061	muscle structure development(GO:0061061)
0.2	108.6	GO:0016567	protein ubiquitination(GO:0016567)
7.5	97.7	GO:0006599	phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
2.7	75.4	GO:0032233	positive regulation of actin filament bundle assembly(GO:0032233)
2.0	68.4	GO:0050821	protein stabilization(GO:0050821)
0.4	56.9	GO:0006821	chloride transport(GO:0006821)
6.1	54.9	GO:0051694	pointed-end actin filament capping(GO:0051694)
3.4	54.8	GO:0035914	skeletal muscle cell differentiation(GO:0035914)
4.9	54.0	GO:0048769	sarcomerogenesis(GO:0048769)

Showing 1 to 10 of 130 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
14.4	302.1	GO:0031430	M band(GO:0031430)
3.0	139.7	GO:0031941	filamentous actin(GO:0031941)
1.8	121.8	GO:0030018	Z disc(GO:0030018)
1.6	93.8	GO:0036379	striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.6	76.1	GO:0016459	myosin complex(GO:0016459)
2.6	54.1	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
4.4	43.6	GO:0031672	A band(GO:0031672)
3.4	41.3	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.6	38.2	GO:0034707	chloride channel complex(GO:0034707)
0.9	28.3	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)

Showing 1 to 10 of 54 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	309.1	GO:0051015	actin filament binding(GO:0051015)
6.6	131.7	GO:0051393	muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.1	103.8	GO:0005509	calcium ion binding(GO:0005509)
7.5	97.7	GO:0004111	creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.2	80.0	GO:0061630	ubiquitin protein ligase activity(GO:0061630)
3.6	79.9	GO:0005523	tropomyosin binding(GO:0005523)
1.7	57.2	GO:0098632	protein binding involved in cell-cell adhesion(GO:0098632)
0.2	52.8	GO:0003779	actin binding(GO:0003779)
3.5	52.4	GO:0051879	Hsp90 protein binding(GO:0051879)
8.3	49.8	GO:0004743	pyruvate kinase activity(GO:0004743)

Showing 1 to 10 of 100 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	35.2	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.4	13.8	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.2	11.1	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.3	9.0	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.3	8.6	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.2	8.4	PID ILK PATHWAY	Integrin-linked kinase signaling
0.2	7.6	PID P53 REGULATION PATHWAY	p53 pathway
0.1	7.6	PID CMYB PATHWAY	C-MYB transcription factor network
0.1	5.6	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.1	3.8	PID CASPASE PATHWAY	Caspase cascade in apoptosis

Showing 1 to 10 of 14 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.6	34.0	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.4	14.9	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.7	12.5	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.7	12.5	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.8	11.5	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.8	9.2	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.2	9.0	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
1.1	8.8	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
1.0	8.2	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.6	7.8	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis

Showing 1 to 10 of 26 entries

Results for mef2ca+mef2cb

Z-value: 2.80

Motif logo

Transcription factors associated with mef2ca+mef2cb

Activity-expression correlation:

Activity profile of mef2ca+mef2cb motif

Sorted Z-values of mef2ca+mef2cb motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of mef2ca+mef2cb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: