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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for mef2d

Z-value: 3.17

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Transcription factors associated with mef2d

Gene Symbol Gene ID Gene Info
mef2d
ENSDARG00000040237 myocyte enhancer factor 2d

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
mef2ddr11_v1_chr16_-_29146624_291466530.242.2e-02Click!

Activity profile of mef2d motif

Sorted Z-values of mef2d motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_11201096 92.87 ENSDART00000171916
ENSDART00000171521
ENSDART00000087105
ENSDART00000159603
myom2a
myomesin 2a
chr1_+_7546259 80.74 ENSDART00000015732
mylz3
myosin, light polypeptide 3, skeletal muscle
chr3_-_61205711 72.47 ENSDART00000055062
pvalb1
parvalbumin 1
chr12_-_17707449 65.02 ENSDART00000142427
ENSDART00000034914
pvalb3
parvalbumin 3
chr15_-_23645810 61.04 ENSDART00000168845
ckmb
creatine kinase, muscle b
chr12_-_26064105 60.30 ENSDART00000168825
ldb3b
LIM domain binding 3b
chr18_+_26719787 59.13 ENSDART00000141672
alpk3a
alpha-kinase 3a
chr12_-_17712393 57.85 ENSDART00000143534
ENSDART00000010144
pvalb2
parvalbumin 2
chr25_+_29160102 56.61 ENSDART00000162854
pkmb
pyruvate kinase M1/2b
chr23_+_20110086 55.35 ENSDART00000054664
tnnc1b
troponin C type 1b (slow)
chr11_+_11200550 53.60 ENSDART00000181339
ENSDART00000187116
myom2a
myomesin 2a
chr25_+_31264155 51.52 ENSDART00000012256
tnni2a.3
troponin I type 2a (skeletal, fast), tandem duplicate 3
chr5_-_72125551 51.43 ENSDART00000149412
smyd1a
SET and MYND domain containing 1a
chr7_+_31879649 50.93 ENSDART00000099789
mybpc3
myosin binding protein C, cardiac
chr11_-_18253111 46.11 ENSDART00000125984
mustn1b
musculoskeletal, embryonic nuclear protein 1b
chr21_+_28445052 45.97 ENSDART00000077871
pygma
phosphorylase, glycogen, muscle A
chr16_+_29663809 45.51 ENSDART00000191336
tmod4
tropomodulin 4 (muscle)
chr8_-_11112058 44.99 ENSDART00000042755
ampd1
adenosine monophosphate deaminase 1 (isoform M)
chr7_+_31879986 44.66 ENSDART00000138491
mybpc3
myosin binding protein C, cardiac
chr5_+_51597677 43.53 ENSDART00000048210
ENSDART00000184797
ckmt2b
creatine kinase, mitochondrial 2b (sarcomeric)
chr16_-_43356018 41.39 ENSDART00000181683
FO704821.1

chr22_-_31059670 40.16 ENSDART00000022445
cand2
cullin-associated and neddylation-dissociated 2 (putative)
chr23_-_21515182 39.19 ENSDART00000142000
rnf207b
ring finger protein 207b
chr6_+_29410986 38.68 ENSDART00000065293
usp13
ubiquitin specific peptidase 13
chr13_+_22249636 38.57 ENSDART00000108472
ENSDART00000173123
synpo2la
synaptopodin 2-like a
chr6_-_18199062 37.26 ENSDART00000167513
ppp1r27b
protein phosphatase 1, regulatory subunit 27b
chr16_-_31919568 37.16 ENSDART00000027364
rbfox1l
RNA binding fox-1 homolog 1, like
chr6_-_42003780 36.66 ENSDART00000032527
cav3
caveolin 3
chr20_-_26001288 36.42 ENSDART00000136518
ENSDART00000063177
capn3b
calpain 3b
chr11_+_29671661 35.92 ENSDART00000024318
ENSDART00000165024
rnf207a
ring finger protein 207a
chr6_+_14301214 35.56 ENSDART00000129491
tmem182b
transmembrane protein 182b
chr12_+_6002715 35.44 ENSDART00000114961
si:ch211-131k2.3
si:ch211-131k2.3
chr9_-_41784799 35.28 ENSDART00000144573
ENSDART00000112542
ENSDART00000190486
obsl1b
obscurin-like 1b
chr16_+_25245857 34.26 ENSDART00000155220
klhl38b
kelch-like family member 38b
chr24_+_34089977 33.92 ENSDART00000157466
asb10
ankyrin repeat and SOCS box containing 10
chr24_+_25471196 33.84 ENSDART00000066625
smpx
small muscle protein, X-linked
chr14_-_7128980 33.78 ENSDART00000171311
si:ch73-43g23.1
si:ch73-43g23.1
chr19_-_31035155 33.28 ENSDART00000161882
bzw2
basic leucine zipper and W2 domains 2
chr12_-_26430507 33.24 ENSDART00000153214
synpo2lb
synaptopodin 2-like b
chr16_-_17200120 33.06 ENSDART00000147739
gapdh
glyceraldehyde-3-phosphate dehydrogenase
chr21_-_22730832 32.04 ENSDART00000101797
fbxo40.1
F-box protein 40, tandem duplicate 1
chr19_-_31035325 31.16 ENSDART00000147504
bzw2
basic leucine zipper and W2 domains 2
chr21_-_22737228 30.39 ENSDART00000151366
fbxo40.2
F-box protein 40, tandem duplicate 2
chr2_-_23768818 30.34 ENSDART00000148685
ENSDART00000191167
xirp1
xin actin binding repeat containing 1
chr7_+_6969909 29.76 ENSDART00000189886
actn3b
actinin alpha 3b
chr6_+_3680651 29.73 ENSDART00000013588
klhl41b
kelch-like family member 41b
chr1_-_25936677 29.72 ENSDART00000146488
ENSDART00000136321
myoz2b
myozenin 2b
chr7_-_23745984 29.05 ENSDART00000048050
ITGB1BP2
zgc:92429
chr23_+_22658700 28.98 ENSDART00000192248
eno1a
enolase 1a, (alpha)
chr3_+_28953274 27.96 ENSDART00000133528
ENSDART00000103602
lgals2a
lectin, galactoside-binding, soluble, 2a
chr24_-_24038800 27.91 ENSDART00000080549
lyz
lysozyme
chr5_+_64368770 27.49 ENSDART00000162246
plpp7
phospholipid phosphatase 7 (inactive)
chr20_-_36617313 27.02 ENSDART00000172395
ENSDART00000152856
enah
enabled homolog (Drosophila)
chr4_-_9592402 26.32 ENSDART00000114060
cdnf
cerebral dopamine neurotrophic factor
chr8_-_26388090 26.32 ENSDART00000147912
si:dkey-20d21.12
si:dkey-20d21.12
chr23_-_32157865 25.25 ENSDART00000000876
nr4a1
nuclear receptor subfamily 4, group A, member 1
chr9_+_17438765 25.21 ENSDART00000138953
rgcc
regulator of cell cycle
chr9_-_43142636 25.20 ENSDART00000134349
ENSDART00000181835
ccdc141
coiled-coil domain containing 141
chr9_-_34191627 24.94 ENSDART00000142664
dcaf6
ddb1 and cul4 associated factor 6
chr24_+_34085940 24.83 ENSDART00000171189
asb10
ankyrin repeat and SOCS box containing 10
chr9_-_33107237 24.24 ENSDART00000013918
casq2
calsequestrin 2
chr25_-_21795930 24.10 ENSDART00000127033
ppp1r3ab
protein phosphatase 1, regulatory subunit 3Ab
chr7_+_69841017 24.03 ENSDART00000169107
FO818704.1

chr23_+_6077503 23.45 ENSDART00000081714
ENSDART00000139834
mybpha
myosin binding protein Ha
chr4_+_6572364 23.44 ENSDART00000122574
ppp1r3aa
protein phosphatase 1, regulatory subunit 3Aa
chr1_-_38815361 23.43 ENSDART00000148790
ENSDART00000148572
ENSDART00000149080
asb5b
ankyrin repeat and SOCS box containing 5b
chr6_-_40722480 22.45 ENSDART00000188187
kbtbd12
kelch repeat and BTB (POZ) domain containing 12
chr17_-_10025234 21.98 ENSDART00000008355
cfl2
cofilin 2 (muscle)
chr24_+_38301080 21.52 ENSDART00000105672
mybpc2b
myosin binding protein C, fast type b
chr19_+_40983221 21.36 ENSDART00000144544
col1a2
collagen, type I, alpha 2
chr24_+_20575259 21.32 ENSDART00000010488
klhl40b
kelch-like family member 40b
chr23_+_24931999 21.21 ENSDART00000136162
ENSDART00000140335
klhl21
kelch-like family member 21
chr24_+_9298198 21.06 ENSDART00000165780
otud1
OTU deubiquitinase 1
chr21_-_131236 21.01 ENSDART00000160005
si:ch1073-398f15.1
si:ch1073-398f15.1
chr2_+_9552456 20.09 ENSDART00000056896
dnajb4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr17_-_14671098 19.97 ENSDART00000037371
ppp1r13ba
protein phosphatase 1, regulatory subunit 13Ba
chr8_-_32497815 19.21 ENSDART00000122359
si:dkey-164f24.2
si:dkey-164f24.2
chr9_-_48281941 19.01 ENSDART00000099787
klhl41a
kelch-like family member 41a
chr9_-_23891102 18.87 ENSDART00000186799
asb18
ankyrin repeat and SOCS box containing 18
chr6_-_40697585 18.76 ENSDART00000113196
si:ch211-157b11.14
si:ch211-157b11.14
chr9_-_23894392 17.54 ENSDART00000133417
asb18
ankyrin repeat and SOCS box containing 18
chr22_-_29204960 17.46 ENSDART00000131386
pvalb7
parvalbumin 7
chr23_+_18722715 17.38 ENSDART00000137438
myh7bb
myosin, heavy chain 7B, cardiac muscle, beta b
chr12_+_30563550 17.11 ENSDART00000126064
si:ch211-28p3.4
si:ch211-28p3.4
chr23_+_18722915 16.87 ENSDART00000025057
myh7bb
myosin, heavy chain 7B, cardiac muscle, beta b
chr5_-_48268049 15.77 ENSDART00000187454
mef2cb
myocyte enhancer factor 2cb
chr8_-_32497581 15.64 ENSDART00000176298
ENSDART00000183340
si:dkey-164f24.2
si:dkey-164f24.2
chr17_-_15611744 15.33 ENSDART00000010496
fhl5
four and a half LIM domains 5
chr16_-_32975951 15.17 ENSDART00000101969
ENSDART00000175149
me1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr2_-_6182098 15.14 ENSDART00000156167
si:ch73-182a11.2
si:ch73-182a11.2
chr3_+_24207243 15.11 ENSDART00000023454
ENSDART00000136400
adsl
adenylosuccinate lyase
chr14_-_30366196 14.58 ENSDART00000007022
pdgfrl
platelet-derived growth factor receptor-like
chr24_+_26276805 14.53 ENSDART00000089749
adipoqa
adiponectin, C1Q and collagen domain containing, a
chr3_-_50046004 14.38 ENSDART00000109544
si:ch1073-100f3.2
si:ch1073-100f3.2
chr14_+_29780113 14.35 ENSDART00000173195
zgc:153146
zgc:153146
chr9_+_32178374 14.32 ENSDART00000078576
coq10b
coenzyme Q10B
chr4_-_2350371 14.02 ENSDART00000166274
phlda1
pleckstrin homology-like domain, family A, member 1
chr21_+_34929598 13.96 ENSDART00000135806
si:dkey-71d15.2
si:dkey-71d15.2
chr6_-_15101477 13.86 ENSDART00000187713
ENSDART00000124132
fhl2b
four and a half LIM domains 2b
chr4_-_20521441 13.80 ENSDART00000066895
rassf8b
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8b
chr7_-_4315859 13.73 ENSDART00000172762
si:ch211-63p21.8
si:ch211-63p21.8
chr14_+_30285613 13.64 ENSDART00000173090
mtus1a
microtubule associated tumor suppressor 1a
chr9_+_32178050 13.62 ENSDART00000169526
coq10b
coenzyme Q10B
chr9_+_31795343 13.30 ENSDART00000139584
itgbl1
integrin, beta-like 1
chr19_-_38611814 13.12 ENSDART00000151958
col16a1
collagen, type XVI, alpha 1
chr1_-_38813679 13.10 ENSDART00000148917
asb5b
ankyrin repeat and SOCS box containing 5b
chr17_+_38566717 13.06 ENSDART00000145147
sptb
spectrin, beta, erythrocytic
chr8_-_17980317 13.04 ENSDART00000129148
tnni3k
TNNI3 interacting kinase
chr14_-_21064199 12.73 ENSDART00000172099
si:dkey-74k8.3
si:dkey-74k8.3
chr21_-_22951604 12.69 ENSDART00000083449
ENSDART00000180129
dub
duboraya
chr16_-_22713152 12.69 ENSDART00000140953
ENSDART00000143836
si:ch211-105c13.3
si:ch211-105c13.3
chr10_-_39153959 12.65 ENSDART00000150193
ENSDART00000111362
slc37a4b
solute carrier family 37 (glucose-6-phosphate transporter), member 4b
chr18_-_16791331 12.34 ENSDART00000148222
ampd3b
adenosine monophosphate deaminase 3b
chr25_+_5039050 12.33 ENSDART00000154700
parvb
parvin, beta
chr18_+_23218980 12.29 ENSDART00000185014
mef2aa
myocyte enhancer factor 2aa
chr23_+_24926407 12.11 ENSDART00000137486
klhl21
kelch-like family member 21
chr7_+_46004893 11.85 ENSDART00000183798
si:ch211-260e23.9
si:ch211-260e23.9
chr23_+_17417539 11.79 ENSDART00000182605
BX649300.2

chr11_+_13207898 11.76 ENSDART00000060310
atp5f1b
ATP synthase F1 subunit beta
chr9_+_24065855 11.72 ENSDART00000161468
ENSDART00000171577
ENSDART00000172743
ENSDART00000159324
ENSDART00000079689
ENSDART00000023196
ENSDART00000101577
lrrfip1a
leucine rich repeat (in FLII) interacting protein 1a
chr23_-_39849155 11.58 ENSDART00000115330
ppp1r14c
protein phosphatase 1, regulatory (inhibitor) subunit 14C
chr13_-_11536951 11.49 ENSDART00000018155
adss
adenylosuccinate synthase
chr2_-_31791633 11.39 ENSDART00000180662
retreg1
reticulophagy regulator 1
chr9_+_6578580 10.85 ENSDART00000061577
fhl2a
four and a half LIM domains 2a
chr21_+_40589770 10.82 ENSDART00000164650
ENSDART00000161584
ENSDART00000161108
pdk3b
pyruvate dehydrogenase kinase, isozyme 3b
chr2_+_6181383 10.80 ENSDART00000153307
si:ch73-344o19.1
si:ch73-344o19.1
chr5_+_51227147 10.76 ENSDART00000083340
ubac1
UBA domain containing 1
chr1_-_11075403 10.69 ENSDART00000102903
ENSDART00000170290
dmd
dystrophin
chr14_-_21063977 10.44 ENSDART00000164373
si:dkey-74k8.3
si:dkey-74k8.3
chr15_-_34458495 10.39 ENSDART00000059954
meox2a
mesenchyme homeobox 2a
chr10_-_39154594 10.28 ENSDART00000148825
slc37a4b
solute carrier family 37 (glucose-6-phosphate transporter), member 4b
chr2_+_54641644 10.27 ENSDART00000027313
ndufv2
NADH dehydrogenase (ubiquinone) flavoprotein 2
chr19_+_44039849 10.07 ENSDART00000086040
lrrc14b
leucine rich repeat containing 14B
chr1_+_18965750 9.47 ENSDART00000132379
limch1a
LIM and calponin homology domains 1a
chr25_+_16945348 9.20 ENSDART00000016591
fgf6a
fibroblast growth factor 6a
chr11_-_22303678 9.19 ENSDART00000159527
ENSDART00000159681
tfeb
transcription factor EB
chr9_-_23990416 8.99 ENSDART00000113176
col6a3
collagen, type VI, alpha 3
chr14_+_23520986 8.46 ENSDART00000170473
ENSDART00000175970
si:ch211-221f10.2
si:ch211-221f10.2
chr2_-_44199722 8.09 ENSDART00000140633
ENSDART00000145728
sdhc
succinate dehydrogenase complex, subunit C, integral membrane protein
chr5_-_51819027 7.79 ENSDART00000164267
homer1b
homer scaffolding protein 1b
chr20_+_6756247 7.73 ENSDART00000167344
igfbp3
insulin-like growth factor binding protein 3
chr17_-_20118145 7.53 ENSDART00000149737
ENSDART00000165606
ryr2b
ryanodine receptor 2b (cardiac)
chr22_-_22164338 7.51 ENSDART00000183840
cdc34a
cell division cycle 34 homolog (S. cerevisiae) a
chr14_+_24215046 7.43 ENSDART00000079215
stc2a
stanniocalcin 2a
chr7_-_48263516 7.32 ENSDART00000006619
ENSDART00000142370
ENSDART00000148273
ENSDART00000147968
rbpms2b
RNA binding protein with multiple splicing 2b
chr22_+_336256 7.15 ENSDART00000019155
btg2
B-cell translocation gene 2
chr20_+_23173710 7.00 ENSDART00000074172
sgcb
sarcoglycan, beta (dystrophin-associated glycoprotein)
chr7_-_21905851 6.93 ENSDART00000111066
ENSDART00000020288
epoa
erythropoietin a
chr23_-_35545554 6.80 ENSDART00000147915
alkal2a
ALK and LTK ligand 2a
chr3_+_18398876 6.75 ENSDART00000141100
ENSDART00000138107
rps2
ribosomal protein S2
chr7_+_8367929 6.68 ENSDART00000173303
zgc:172143
zgc:172143
chr16_+_34523515 6.64 ENSDART00000041007
stmn1b
stathmin 1b
chr9_+_41690153 6.60 ENSDART00000100226
ctdsp1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr20_-_39271844 6.57 ENSDART00000192708
clu
clusterin
chr23_-_29878643 6.42 ENSDART00000058407
slc25a33
solute carrier family 25 (pyrimidine nucleotide carrier), member 33
chr20_-_42534504 6.40 ENSDART00000132310
rfx6
regulatory factor X, 6
chr22_+_16497670 6.21 ENSDART00000014330
ier5
immediate early response 5
chr16_+_16968682 6.21 ENSDART00000111074
si:ch211-120k19.1
si:ch211-120k19.1
chr8_+_4337312 6.20 ENSDART00000182228
myl2b
myosin, light chain 2b, regulatory, cardiac, slow
chr6_-_46768040 6.17 ENSDART00000154071
igfn1.2
immunoglobulin-like and fibronectin type III domain containing 1, tandem duplicate 2
chr3_+_18399315 6.16 ENSDART00000110842
rps2
ribosomal protein S2
chr23_-_27479558 5.98 ENSDART00000013563
atf7a
activating transcription factor 7a
chr22_+_15898221 5.96 ENSDART00000062587
klf2a
Kruppel-like factor 2a
chr14_-_30704075 5.96 ENSDART00000134098
efemp2a
EGF containing fibulin extracellular matrix protein 2a
chr24_+_8736497 5.85 ENSDART00000181904
tmem14ca
transmembrane protein 14Ca
chr21_-_25685739 5.83 ENSDART00000129619
ENSDART00000101205
phkg1b
phosphorylase kinase, gamma 1b (muscle)
chr7_-_35708450 5.70 ENSDART00000193886
irx5a
iroquois homeobox 5a
chr7_+_38811800 5.58 ENSDART00000052322
zgc:110699
zgc:110699
chr6_-_25201810 5.34 ENSDART00000168683
lrrc8c
leucine rich repeat containing 8 VRAC subunit C
chr16_+_5259886 5.29 ENSDART00000186668
plecb
plectin b
chr19_-_42566527 5.24 ENSDART00000147818
ENSDART00000142135
si:dkey-228a15.1
si:dkey-228a15.1
chr13_-_30149973 5.22 ENSDART00000041515
sar1ab
secretion associated, Ras related GTPase 1Ab
chr22_-_8509215 5.18 ENSDART00000140146
si:ch73-27e22.3
si:ch73-27e22.3
chr20_+_19066858 5.05 ENSDART00000192086
sox7
SRY (sex determining region Y)-box 7
chr7_-_30143092 5.04 ENSDART00000173636
frmd5
FERM domain containing 5
chr13_-_42673978 4.95 ENSDART00000133848
ENSDART00000099738
ENSDART00000099729
ENSDART00000169083
lrrfip2
leucine rich repeat (in FLII) interacting protein 2
chr15_-_31406093 4.90 ENSDART00000123444
or111-8
odorant receptor, family D, subfamily 111, member 8
chr25_-_16554757 4.74 ENSDART00000154480
si:ch211-266k8.6
si:ch211-266k8.6
chr21_-_22828593 4.70 ENSDART00000150993
angptl5
angiopoietin-like 5
chr2_+_35880600 4.69 ENSDART00000004277
lamc1
laminin, gamma 1
chr16_+_31542645 4.68 ENSDART00000163724
SLA (1 of many)
Src like adaptor
chr1_-_49250490 4.61 ENSDART00000150386
si:ch73-6k14.2
si:ch73-6k14.2
chr16_+_16969060 4.57 ENSDART00000182819
ENSDART00000191876
si:ch211-120k19.1
rpl18
si:ch211-120k19.1
ribosomal protein L18
chr14_-_15699528 4.53 ENSDART00000161123
neurl1b
neuralized E3 ubiquitin protein ligase 1B
chr10_-_17501528 4.47 ENSDART00000144847
slc2a11l
solute carrier family 2 (facilitated glucose transporter), member 11-like
chr16_-_17541890 4.37 ENSDART00000131328
clcn1b
chloride channel, voltage-sensitive 1b
chr5_+_51248784 4.30 ENSDART00000159571
ENSDART00000189513
ENSDART00000092285
msh3
mutS homolog 3 (E. coli)
chr15_-_14552101 4.28 ENSDART00000171169
numbl
numb homolog (Drosophila)-like
chr13_-_28674422 4.26 ENSDART00000122754
ENSDART00000057574
nt5c2a
5'-nucleotidase, cytosolic IIa
chr11_+_40148181 4.15 ENSDART00000125119
si:dkey-264d12.5
si:dkey-264d12.5
chr1_+_19332837 4.15 ENSDART00000078594
tyrp1b
tyrosinase-related protein 1b
chr23_+_23022790 4.04 ENSDART00000189843
samd11
sterile alpha motif domain containing 11
chr17_-_24439672 4.02 ENSDART00000155020
wdpcp
WD repeat containing planar cell polarity effector
chr15_+_31886284 4.02 ENSDART00000156706
frya
furry homolog a (Drosophila)
chr14_-_16151055 3.90 ENSDART00000162431
ptcd3
pentatricopeptide repeat domain 3
chr13_+_18520738 3.89 ENSDART00000113952
tlr4al
toll-like receptor 4a, like
chr21_-_20381481 3.78 ENSDART00000115236
atp5mea
ATP synthase membrane subunit ea
chr12_+_41697664 3.78 ENSDART00000162302
bnip3
BCL2 interacting protein 3
chr25_-_13381854 3.73 ENSDART00000164621
ENSDART00000169129
ndrg4
NDRG family member 4
chr19_-_48371092 3.68 ENSDART00000169464
rpl14
ribosomal protein L14

Network of associatons between targets according to the STRING database.

First level regulatory network of mef2d

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
19.1 95.6 GO:0003210 cardiac atrium formation(GO:0003210)
15.3 46.0 GO:0052575 carbohydrate localization(GO:0052575) carbohydrate storage(GO:0052576)
13.4 40.2 GO:0010265 SCF complex assembly(GO:0010265)
13.1 39.2 GO:1903779 regulation of cardiac conduction(GO:1903779)
12.1 36.4 GO:0097264 self proteolysis(GO:0097264)
9.2 46.1 GO:0035988 chondrocyte proliferation(GO:0035988)
9.0 27.0 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
8.0 104.6 GO:0046314 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
7.3 22.0 GO:0030043 actin filament fragmentation(GO:0030043)
7.1 21.3 GO:0098528 skeletal muscle fiber differentiation(GO:0098528)
6.1 24.2 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
5.7 51.4 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
5.7 45.5 GO:0051694 pointed-end actin filament capping(GO:0051694)
5.3 37.2 GO:0048739 cardiac muscle fiber development(GO:0048739)
4.6 23.2 GO:0071480 response to gamma radiation(GO:0010332) cellular response to gamma radiation(GO:0071480)
4.2 12.7 GO:0061341 non-canonical Wnt signaling pathway involved in heart development(GO:0061341)
4.2 58.7 GO:0032264 IMP salvage(GO:0032264)
4.1 36.7 GO:0046716 muscle cell cellular homeostasis(GO:0046716)
3.0 48.7 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
2.9 11.8 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
2.9 23.5 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
2.9 81.3 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
2.9 14.4 GO:0015709 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) succinate transport(GO:0015744) succinate transmembrane transport(GO:0071422) malate transmembrane transport(GO:0071423)
2.8 25.2 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
2.4 35.4 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
2.3 108.1 GO:0003009 skeletal muscle contraction(GO:0003009)
2.2 71.7 GO:0050821 protein stabilization(GO:0050821)
2.2 47.5 GO:0005979 regulation of glycogen biosynthetic process(GO:0005979) regulation of glucan biosynthetic process(GO:0010962)
2.1 6.4 GO:1990519 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
2.1 6.4 GO:0035773 insulin secretion involved in cellular response to glucose stimulus(GO:0035773) regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
2.1 35.0 GO:0034629 cellular protein complex localization(GO:0034629)
2.0 28.0 GO:0090303 positive regulation of wound healing(GO:0090303)
2.0 6.0 GO:0003223 ventricular compact myocardium morphogenesis(GO:0003223)
1.7 13.8 GO:0034334 adherens junction maintenance(GO:0034334)
1.6 8.1 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
1.6 25.7 GO:0014823 response to activity(GO:0014823)
1.5 96.8 GO:0010842 retina layer formation(GO:0010842)
1.5 15.2 GO:0006108 malate metabolic process(GO:0006108)
1.5 15.1 GO:0006188 IMP biosynthetic process(GO:0006188)
1.5 7.3 GO:0051145 smooth muscle cell differentiation(GO:0051145) negative regulation of muscle cell differentiation(GO:0051148)
1.4 4.3 GO:0051096 regulation of helicase activity(GO:0051095) positive regulation of helicase activity(GO:0051096)
1.4 27.9 GO:0006743 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
1.3 5.2 GO:0003400 regulation of COPII vesicle coating(GO:0003400) regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis(GO:0090113)
1.1 11.4 GO:0061709 reticulophagy(GO:0061709)
1.1 6.8 GO:0070376 ERK5 cascade(GO:0070375) regulation of ERK5 cascade(GO:0070376) positive regulation of ERK5 cascade(GO:0070378)
1.1 7.8 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
1.1 138.9 GO:0006936 muscle contraction(GO:0006936)
1.0 56.6 GO:0006096 glycolytic process(GO:0006096)
0.9 20.7 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.9 4.5 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.8 4.2 GO:0097066 response to thyroid hormone(GO:0097066)
0.8 21.1 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.7 15.7 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.7 7.7 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.6 5.7 GO:0072498 embryonic skeletal joint development(GO:0072498)
0.6 1.8 GO:0002155 regulation of thyroid hormone mediated signaling pathway(GO:0002155)
0.6 10.3 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.6 25.2 GO:0019226 transmission of nerve impulse(GO:0019226)
0.6 2.8 GO:0021731 trigeminal motor nucleus development(GO:0021731)
0.5 12.3 GO:0030032 lamellipodium assembly(GO:0030032)
0.5 3.0 GO:0032367 intracellular cholesterol transport(GO:0032367)
0.5 10.8 GO:0010675 regulation of cellular carbohydrate metabolic process(GO:0010675) regulation of glucose metabolic process(GO:0010906)
0.5 1.9 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.5 9.2 GO:0022010 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.4 2.2 GO:1904036 negative regulation of epithelial cell apoptotic process(GO:1904036)
0.4 3.8 GO:0097345 mitochondrial outer membrane permeabilization(GO:0097345)
0.4 13.3 GO:0033627 cell adhesion mediated by integrin(GO:0033627)
0.4 4.7 GO:0050962 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.4 1.9 GO:0003321 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996) positive regulation of blood pressure by epinephrine-norepinephrine(GO:0003321) positive regulation of heart rate(GO:0010460)
0.4 1.9 GO:0018197 peptidyl-aspartic acid modification(GO:0018197) peptidyl-aspartic acid hydroxylation(GO:0042264)
0.4 34.5 GO:0045732 positive regulation of protein catabolic process(GO:0045732)
0.4 1.8 GO:0060231 mesenchymal to epithelial transition(GO:0060231)
0.4 11.9 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.4 2.1 GO:0007603 phototransduction, visible light(GO:0007603)
0.3 15.8 GO:0055013 cardiac muscle cell development(GO:0055013)
0.3 1.0 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.3 2.6 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.3 7.5 GO:0051209 sequestering of calcium ion(GO:0051208) release of sequestered calcium ion into cytosol(GO:0051209) regulation of sequestering of calcium ion(GO:0051282) negative regulation of sequestering of calcium ion(GO:0051283)
0.3 15.2 GO:0051693 actin filament capping(GO:0051693)
0.3 5.3 GO:0031581 hemidesmosome assembly(GO:0031581)
0.3 22.3 GO:0009612 response to mechanical stimulus(GO:0009612)
0.3 6.0 GO:0048251 elastic fiber assembly(GO:0048251)
0.3 3.3 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.2 28.7 GO:0021782 glial cell development(GO:0021782)
0.2 0.7 GO:0003209 cardiac atrium morphogenesis(GO:0003209)
0.2 5.8 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.2 3.7 GO:0060038 cardiac muscle cell proliferation(GO:0060038)
0.2 4.0 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.2 5.8 GO:0006783 heme biosynthetic process(GO:0006783)
0.2 2.5 GO:0060416 growth hormone receptor signaling pathway(GO:0060396) response to growth hormone(GO:0060416) cellular response to growth hormone stimulus(GO:0071378)
0.2 12.8 GO:0030239 myofibril assembly(GO:0030239)
0.2 28.6 GO:0061061 muscle structure development(GO:0061061)
0.2 3.8 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.2 2.6 GO:0036065 fucosylation(GO:0036065)
0.2 1.7 GO:0001992 regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.2 11.9 GO:1905037 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.1 2.5 GO:0097553 calcium ion transmembrane import into cytosol(GO:0097553) calcium ion import into cytosol(GO:1902656)
0.1 2.6 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.1 1.8 GO:0099639 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887) endosome to plasma membrane protein transport(GO:0099638) neurotransmitter receptor transport, endosome to plasma membrane(GO:0099639)
0.1 21.5 GO:0060537 muscle tissue development(GO:0060537)
0.1 4.3 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 19.5 GO:0008284 positive regulation of cell proliferation(GO:0008284)
0.1 2.0 GO:0021551 central nervous system morphogenesis(GO:0021551)
0.1 3.9 GO:0032543 mitochondrial translation(GO:0032543)
0.1 6.6 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.1 70.9 GO:0016567 protein ubiquitination(GO:0016567)
0.1 1.9 GO:0007622 rhythmic behavior(GO:0007622) circadian behavior(GO:0048512)
0.1 1.7 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity(GO:0098962)
0.1 5.1 GO:0001570 vasculogenesis(GO:0001570)
0.1 11.6 GO:0043068 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.1 3.2 GO:0019432 triglyceride biosynthetic process(GO:0019432)
0.1 6.1 GO:0008045 motor neuron axon guidance(GO:0008045)
0.1 10.4 GO:0061053 somite development(GO:0061053)
0.1 5.0 GO:0031032 actomyosin structure organization(GO:0031032)
0.1 0.7 GO:0035306 positive regulation of dephosphorylation(GO:0035306) positive regulation of protein dephosphorylation(GO:0035307)
0.1 5.4 GO:0048469 cell maturation(GO:0048469)
0.1 1.2 GO:0043486 histone exchange(GO:0043486)
0.0 1.0 GO:0048263 determination of dorsal identity(GO:0048263)
0.0 0.7 GO:0005977 glycogen metabolic process(GO:0005977) cellular glucan metabolic process(GO:0006073) glucan metabolic process(GO:0044042)
0.0 1.5 GO:2000027 regulation of organ morphogenesis(GO:2000027)
0.0 1.8 GO:0002224 toll-like receptor signaling pathway(GO:0002224)
0.0 6.9 GO:0006874 cellular calcium ion homeostasis(GO:0006874)
0.0 1.6 GO:0034968 histone lysine methylation(GO:0034968)
0.0 6.6 GO:0030198 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0 1.1 GO:0006368 transcription elongation from RNA polymerase II promoter(GO:0006368)
0.0 2.7 GO:0044782 cilium organization(GO:0044782)
0.0 0.1 GO:0006567 threonine metabolic process(GO:0006566) threonine catabolic process(GO:0006567)
0.0 0.6 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 0.9 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.4 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.6 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
11.0 231.7 GO:0031430 M band(GO:0031430)
3.5 24.2 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
3.0 48.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
2.9 23.5 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
2.8 47.5 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
2.7 21.4 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
2.6 153.6 GO:0036379 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
2.6 13.1 GO:0008091 spectrin(GO:0008091)
2.4 9.5 GO:0016460 myosin II complex(GO:0016460)
2.3 243.1 GO:0031674 I band(GO:0031674)
1.7 11.8 GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
1.6 8.1 GO:0045281 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
1.3 4.0 GO:0097541 axonemal basal plate(GO:0097541)
1.1 33.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.9 26.7 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.9 36.7 GO:0044853 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.8 17.7 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.7 6.6 GO:0042583 chromaffin granule(GO:0042583)
0.5 6.5 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.4 4.3 GO:0032300 mismatch repair complex(GO:0032300)
0.4 5.3 GO:0030056 hemidesmosome(GO:0030056)
0.3 4.2 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.3 11.9 GO:0016605 PML body(GO:0016605)
0.3 5.7 GO:0030127 COPII vesicle coat(GO:0030127)
0.3 3.6 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.3 12.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.3 3.8 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.2 11.6 GO:0008305 integrin complex(GO:0008305)
0.2 10.3 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.2 1.1 GO:0030891 VCB complex(GO:0030891)
0.2 2.3 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.2 18.8 GO:0016459 myosin complex(GO:0016459)
0.2 4.6 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 12.0 GO:0030055 cell-substrate junction(GO:0030055)
0.1 35.2 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 1.2 GO:0000812 Swr1 complex(GO:0000812)
0.1 3.0 GO:0005758 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.1 9.0 GO:0005581 collagen trimer(GO:0005581)
0.1 3.9 GO:0005840 ribosome(GO:0005840)
0.1 2.6 GO:0000795 synaptonemal complex(GO:0000795)
0.1 24.1 GO:0015629 actin cytoskeleton(GO:0015629)
0.1 3.6 GO:0005811 lipid particle(GO:0005811)
0.1 1.0 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 3.7 GO:0022626 cytosolic ribosome(GO:0022626)
0.1 1.7 GO:0000145 exocyst(GO:0000145)
0.1 2.5 GO:0042383 sarcolemma(GO:0042383)
0.0 2.7 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 2.6 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 60.6 GO:0005829 cytosol(GO:0005829)
0.0 6.6 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.9 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.6 GO:0016363 nuclear matrix(GO:0016363)
0.0 5.1 GO:0031966 mitochondrial membrane(GO:0031966)
0.0 0.3 GO:0038037 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor heterodimeric complex(GO:0038039) G-protein coupled receptor complex(GO:0097648)
0.0 34.5 GO:0005615 extracellular space(GO:0005615)
0.0 0.4 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.0 1.6 GO:0000775 chromosome, centromeric region(GO:0000775)
0.0 1.9 GO:0016324 apical plasma membrane(GO:0016324)
0.0 7.4 GO:0030054 cell junction(GO:0030054)
0.0 13.6 GO:0045202 synapse(GO:0045202)
0.0 82.8 GO:0005737 cytoplasm(GO:0005737)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
9.6 105.1 GO:0032036 myosin heavy chain binding(GO:0032036)
9.4 56.6 GO:0004743 pyruvate kinase activity(GO:0004743)
9.2 46.0 GO:0004645 phosphorylase activity(GO:0004645) glycogen phosphorylase activity(GO:0008184)
9.2 36.7 GO:0071253 connexin binding(GO:0071253)
8.3 33.1 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
8.0 104.6 GO:0004111 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
7.0 27.9 GO:0003796 lysozyme activity(GO:0003796)
5.3 58.7 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
5.0 75.1 GO:0030544 Hsp70 protein binding(GO:0030544)
4.0 8.1 GO:0000104 succinate dehydrogenase activity(GO:0000104)
3.8 15.2 GO:0004470 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
3.8 15.1 GO:0016842 amidine-lyase activity(GO:0016842)
3.2 47.5 GO:2001069 glycogen binding(GO:2001069)
3.1 27.9 GO:0048039 ubiquinone binding(GO:0048039)
3.1 12.2 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
3.0 60.3 GO:0051393 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
3.0 29.7 GO:0051373 telethonin binding(GO:0031433) FATZ binding(GO:0051373)
3.0 35.4 GO:0051879 Hsp90 protein binding(GO:0051879)
2.9 23.5 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
2.9 14.4 GO:0015140 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) malate transmembrane transporter activity(GO:0015140)
2.8 28.0 GO:0016936 galactoside binding(GO:0016936)
2.7 27.0 GO:0005522 profilin binding(GO:0005522)
2.4 68.0 GO:0048306 calcium-dependent protein binding(GO:0048306)
2.3 6.9 GO:0005128 erythropoietin receptor binding(GO:0005128)
2.3 25.2 GO:0035259 glucocorticoid receptor binding(GO:0035259)
2.1 6.4 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
2.1 45.5 GO:0005523 tropomyosin binding(GO:0005523)
1.6 7.8 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
1.5 7.5 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
1.4 10.8 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
1.3 11.6 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
1.2 5.8 GO:0004689 phosphorylase kinase activity(GO:0004689)
1.1 6.8 GO:0030298 receptor signaling protein tyrosine kinase activator activity(GO:0030298)
1.1 20.0 GO:0002039 p53 binding(GO:0002039)
1.1 9.8 GO:0008420 CTD phosphatase activity(GO:0008420)
1.1 4.3 GO:0032135 DNA insertion or deletion binding(GO:0032135)
1.1 11.8 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
1.0 3.9 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.8 26.2 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.8 2.5 GO:0070186 growth hormone receptor binding(GO:0005131) growth hormone activity(GO:0070186)
0.8 3.3 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
0.7 20.1 GO:0051087 chaperone binding(GO:0051087)
0.7 49.2 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.7 7.7 GO:0031995 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.6 1.8 GO:0004377 GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity(GO:0004377)
0.6 28.1 GO:0042826 histone deacetylase binding(GO:0042826)
0.5 33.6 GO:0019902 phosphatase binding(GO:0019902)
0.5 188.8 GO:0051015 actin filament binding(GO:0051015)
0.5 1.9 GO:0004419 hydroxymethylglutaryl-CoA lyase activity(GO:0004419)
0.5 1.9 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.5 61.8 GO:0036459 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.4 1.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.4 2.1 GO:0050254 rhodopsin kinase activity(GO:0050254)
0.4 1.6 GO:0031708 endothelin B receptor binding(GO:0031708)
0.4 108.6 GO:0003779 actin binding(GO:0003779)
0.3 1.7 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.3 9.8 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.3 6.0 GO:0035497 cAMP response element binding(GO:0035497)
0.3 42.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.3 3.9 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.3 10.3 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.3 13.3 GO:0005178 integrin binding(GO:0005178)
0.2 1.9 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.2 233.3 GO:0005509 calcium ion binding(GO:0005509)
0.2 2.6 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.2 4.0 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.2 2.5 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.2 1.2 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262)
0.2 6.0 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.2 14.0 GO:1901981 phosphatidylinositol phosphate binding(GO:1901981)
0.2 1.7 GO:0005000 vasopressin receptor activity(GO:0005000)
0.2 2.0 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 54.5 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 3.6 GO:0016208 AMP binding(GO:0016208)
0.1 1.7 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 21.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 1.0 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.1 17.5 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 4.4 GO:0015485 cholesterol binding(GO:0015485)
0.1 1.5 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.1 16.0 GO:0015293 symporter activity(GO:0015293)
0.1 0.5 GO:0030548 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.1 10.8 GO:0008083 growth factor activity(GO:0008083)
0.1 7.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 1.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.1 2.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 7.9 GO:0005179 hormone activity(GO:0005179)
0.1 0.6 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 5.6 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 3.4 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.4 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 3.7 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.5 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.0 2.2 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.3 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 3.8 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616)
0.0 6.4 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 6.2 GO:0008017 microtubule binding(GO:0008017)
0.0 0.4 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.9 GO:0015631 tubulin binding(GO:0015631)
0.0 1.3 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 36.7 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
1.2 25.2 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
1.1 43.5 NABA COLLAGENS Genes encoding collagen proteins
0.7 27.0 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.5 33.1 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.5 11.0 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.4 6.6 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.4 4.7 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.4 12.2 PID ILK PATHWAY Integrin-linked kinase signaling
0.3 17.4 PID CMYB PATHWAY C-MYB transcription factor network
0.2 2.2 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.2 7.0 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 3.7 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 2.6 PID SHP2 PATHWAY SHP2 signaling
0.1 2.8 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 2.0 PID BMP PATHWAY BMP receptor signaling
0.1 4.6 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 45.0 REACTOME PURINE SALVAGE Genes involved in Purine salvage
2.7 21.4 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
1.9 26.6 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
1.3 16.1 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
1.3 27.6 REACTOME GLYCOLYSIS Genes involved in Glycolysis
1.0 25.8 REACTOME AMYLOIDS Genes involved in Amyloids
1.0 7.7 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.9 12.3 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.8 13.1 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.8 24.1 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.5 22.1 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.4 8.1 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.4 10.7 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.2 2.0 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.2 1.7 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.2 12.9 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2 3.2 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.2 3.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.2 10.3 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.2 2.0 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 1.9 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 8.2 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.1 1.7 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.1 0.8 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 2.7 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.1 0.7 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 3.0 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.5 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 1.0 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.9 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.0 0.4 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling