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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for msx1a

Z-value: 0.96

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Transcription factors associated with msx1a

Gene Symbol Gene ID Gene Info
msx1a
ENSDARG00000116118 muscle segment homeobox 1a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
msx1adr11_v1_chr14_-_12822_12847-0.534.1e-08Click!

Activity profile of msx1a motif

Sorted Z-values of msx1a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_-_29437373 11.79 ENSDART00000148405
si:ch211-113g11.6
si:ch211-113g11.6
chr17_-_12389259 10.37 ENSDART00000185724
snap25b
synaptosomal-associated protein, 25b
chr12_+_24342303 10.00 ENSDART00000111239
nrxn1a
neurexin 1a
chr16_+_39159752 9.74 ENSDART00000122081
sybu
syntabulin (syntaxin-interacting)
chr4_+_12615836 9.37 ENSDART00000003583
lmo3
LIM domain only 3
chr13_-_36911118 9.27 ENSDART00000048739
trim9
tripartite motif containing 9
chr7_+_32722227 8.77 ENSDART00000126565
si:ch211-150g13.3
si:ch211-150g13.3
chr6_+_3828560 8.17 ENSDART00000185273
ENSDART00000179091
gad1b
glutamate decarboxylase 1b
chr1_-_18811517 7.69 ENSDART00000142026
si:dkey-167i21.2
si:dkey-167i21.2
chr7_+_30787903 7.65 ENSDART00000174000
apba2b
amyloid beta (A4) precursor protein-binding, family A, member 2b
chr22_-_23253481 7.63 ENSDART00000054807
lhx9
LIM homeobox 9
chr4_-_15420452 7.60 ENSDART00000016230
plxna4
plexin A4
chr20_-_28800999 7.54 ENSDART00000049462
rab15
RAB15, member RAS oncogene family
chr21_+_6751760 7.50 ENSDART00000135914
olfm1b
olfactomedin 1b
chr24_-_24849091 7.37 ENSDART00000133649
ENSDART00000038290
crhb
corticotropin releasing hormone b
chr5_-_23280098 7.34 ENSDART00000126540
ENSDART00000051533
plp1b
proteolipid protein 1b
chr16_-_27628994 7.22 ENSDART00000157407
nacad
NAC alpha domain containing
chr20_-_32110882 7.15 ENSDART00000030324
grm1a
glutamate receptor, metabotropic 1a
chr16_+_5774977 6.94 ENSDART00000134202
ccka
cholecystokinin a
chr1_-_50859053 6.90 ENSDART00000132779
ENSDART00000137648
si:dkeyp-123h10.2
si:dkeyp-123h10.2
chr21_+_6751405 6.77 ENSDART00000037265
ENSDART00000146371
olfm1b
olfactomedin 1b
chr13_-_20381485 6.63 ENSDART00000131351
si:ch211-270n8.1
si:ch211-270n8.1
chr10_+_21867307 6.36 ENSDART00000126629
cbln17
cerebellin 17
chr23_+_40460333 6.30 ENSDART00000184658
soga3b
SOGA family member 3b
chr2_+_50626476 6.12 ENSDART00000018150
neurod6b
neuronal differentiation 6b
chr15_-_21877726 6.08 ENSDART00000127819
ENSDART00000145646
ENSDART00000100897
ENSDART00000144739
zgc:162608
zgc:162608
chr25_-_32869794 5.61 ENSDART00000162784
tmem266
transmembrane protein 266
chr11_-_6452444 5.58 ENSDART00000137879
ENSDART00000134957
ENSDART00000004483
larp6b
La ribonucleoprotein domain family, member 6b
chr2_+_50608099 5.40 ENSDART00000185805
ENSDART00000111135
neurod6b
neuronal differentiation 6b
chr13_+_38430466 5.33 ENSDART00000132691
adgrb3
adhesion G protein-coupled receptor B3
chr10_+_42690374 5.31 ENSDART00000123496
rhobtb2b
Rho-related BTB domain containing 2b
chr18_-_40708537 5.08 ENSDART00000077577
si:ch211-132b12.8
si:ch211-132b12.8
chr11_-_44801968 5.07 ENSDART00000161846
map1lc3c
microtubule-associated protein 1 light chain 3 gamma
chr20_+_30490682 4.99 ENSDART00000184871
myt1la
myelin transcription factor 1-like, a
chr15_-_6247775 4.85 ENSDART00000148350
dscamb
Down syndrome cell adhesion molecule b
chr6_-_6487876 4.81 ENSDART00000137642
cep170ab
centrosomal protein 170Ab
chr8_+_22582146 4.80 ENSDART00000157655
ENSDART00000189892
CT583651.2

chr17_-_44247707 4.74 ENSDART00000126097
otx2b
orthodenticle homeobox 2b
chr7_-_23996133 4.69 ENSDART00000173761
si:dkey-183c6.8
si:dkey-183c6.8
chr6_+_21001264 4.62 ENSDART00000044519
ENSDART00000151278
cx44.2
connexin 44.2
chr20_+_19238382 4.39 ENSDART00000136757
fndc4a
fibronectin type III domain containing 4a
chr2_+_6253246 4.34 ENSDART00000058256
ENSDART00000076700
zp3b
zona pellucida glycoprotein 3b
chr14_-_2364761 4.22 ENSDART00000167322
PCDHGC3 (1 of many)
si:ch73-233f7.3
chr10_-_34915886 4.11 ENSDART00000141201
ENSDART00000002166
ccna1
cyclin A1
chr9_-_35633827 4.07 ENSDART00000077745
zp2l1
zona pellucida glycoprotein 2, like 1
chr12_+_21298317 3.95 ENSDART00000178562
ca10a
carbonic anhydrase Xa
chr3_+_28860283 3.76 ENSDART00000077235
alg1
ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase
chr21_+_25777425 3.74 ENSDART00000021620
cldnd
claudin d
chr19_-_8604429 3.57 ENSDART00000151165
trim46b
tripartite motif containing 46b
chr4_+_11384891 3.57 ENSDART00000092381
ENSDART00000186577
ENSDART00000191054
ENSDART00000191584
pcloa
piccolo presynaptic cytomatrix protein a
chr1_+_18811679 3.53 ENSDART00000078610
slc25a51a
solute carrier family 25, member 51a
chr23_+_28582865 3.51 ENSDART00000020296
l1cama
L1 cell adhesion molecule, paralog a
chr18_-_2433011 3.39 ENSDART00000181922
ENSDART00000193276
CR769778.1

chr9_-_20372977 3.29 ENSDART00000113418
igsf3
immunoglobulin superfamily, member 3
chr6_+_39232245 3.24 ENSDART00000187351
b4galnt1b
beta-1,4-N-acetyl-galactosaminyl transferase 1b
chr15_-_20024205 3.18 ENSDART00000161379
auts2b
autism susceptibility candidate 2b
chr20_-_40755614 3.17 ENSDART00000061247
cx32.3
connexin 32.3
chr7_-_28148310 3.16 ENSDART00000044208
lmo1
LIM domain only 1
chr18_+_24921587 3.09 ENSDART00000191345
rgma
repulsive guidance molecule family member a
chr10_-_34002185 3.08 ENSDART00000046599
zar1l
zygote arrest 1-like
chr14_-_34044369 2.98 ENSDART00000149396
ENSDART00000123607
ENSDART00000190746
cyfip2
cytoplasmic FMR1 interacting protein 2
chr10_-_25217347 2.97 ENSDART00000036906
kpna7
karyopherin alpha 7 (importin alpha 8)
chr11_-_29563437 2.92 ENSDART00000163958
arhgef10la
Rho guanine nucleotide exchange factor (GEF) 10-like a
chr18_+_10884996 2.88 ENSDART00000147613
mical3a
microtubule associated monooxygenase, calponin and LIM domain containing 3a
chr19_-_20403507 2.86 ENSDART00000052603
ENSDART00000137590
dazl
deleted in azoospermia-like
chr10_-_34916208 2.83 ENSDART00000187371
ccna1
cyclin A1
chr2_-_21167652 2.81 ENSDART00000185792
bmi1b
bmi1 polycomb ring finger oncogene 1b
chr22_-_7129631 2.77 ENSDART00000171359
asic1b
acid-sensing (proton-gated) ion channel 1b
chr2_-_33645411 2.76 ENSDART00000114663
b4galt2
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
chr20_-_23426339 2.73 ENSDART00000004625
zar1
zygote arrest 1
chr3_+_32365811 2.70 ENSDART00000155967
ap2a1
adaptor-related protein complex 2, alpha 1 subunit
chr5_+_37032038 2.70 ENSDART00000045036
nfkbib
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr19_-_19556778 2.58 ENSDART00000164060
tax1bp1a
Tax1 (human T-cell leukemia virus type I) binding protein 1a
chr12_+_31744217 2.54 ENSDART00000190361
RNF157
si:dkey-49c17.3
chr19_+_46237665 2.53 ENSDART00000159391
vps28
vacuolar protein sorting 28 (yeast)
chr11_+_18183220 2.51 ENSDART00000113468
LO018315.10

chr24_-_31846366 2.49 ENSDART00000155295
steap2
STEAP family member 2, metalloreductase
chr3_+_56366395 2.48 ENSDART00000154367
cacng5b
calcium channel, voltage-dependent, gamma subunit 5b
chr6_-_40352215 2.45 ENSDART00000103992
ttll3
tubulin tyrosine ligase-like family, member 3
chr11_+_30244356 2.41 ENSDART00000036050
ENSDART00000150080
rs1a
retinoschisin 1a
chr20_-_19511016 2.41 ENSDART00000168521
snx17
sorting nexin 17
chr18_+_15644559 2.38 ENSDART00000061794
nr1h4
nuclear receptor subfamily 1, group H, member 4
chr5_-_12219572 2.36 ENSDART00000167834
nos1
nitric oxide synthase 1 (neuronal)
chr23_-_28141419 2.35 ENSDART00000133039
tac3a
tachykinin 3a
chr12_-_33579873 2.33 ENSDART00000184661
tdrkh
tudor and KH domain containing
chr20_-_46362606 2.30 ENSDART00000153087
bmf2
BCL2 modifying factor 2
chr15_-_22074315 2.29 ENSDART00000149830
drd2a
dopamine receptor D2a
chr22_+_5176255 2.29 ENSDART00000092647
cers1
ceramide synthase 1
chr1_-_47071979 2.14 ENSDART00000160817
itsn1
intersectin 1 (SH3 domain protein)
chr2_-_55298075 2.12 ENSDART00000186404
ENSDART00000149062
rab8a
RAB8A, member RAS oncogene family
chr1_+_34696503 2.09 ENSDART00000186106
CR339054.2

chr11_-_42554290 2.09 ENSDART00000130573
atp6ap1la
ATPase H+ transporting accessory protein 1 like a
chr11_+_7264457 2.04 ENSDART00000154182
reep6
receptor accessory protein 6
chr10_-_21362071 2.03 ENSDART00000125167
avd
avidin
chr5_+_60590796 2.00 ENSDART00000159859
tmem132e
transmembrane protein 132E
chr11_-_30158191 2.00 ENSDART00000155278
ENSDART00000156121
scml2
Scm polycomb group protein like 2
chr20_+_41021054 1.95 ENSDART00000146052
man1a1
mannosidase, alpha, class 1A, member 1
chr19_-_42391383 1.93 ENSDART00000110075
ENSDART00000087002
plekho1a
pleckstrin homology domain containing, family O member 1a
chr24_+_12835935 1.91 ENSDART00000114762
nanog
nanog homeobox
chr13_+_25449681 1.83 ENSDART00000101328
atoh7
atonal bHLH transcription factor 7
chr7_-_31940590 1.80 ENSDART00000131009
bdnf
brain-derived neurotrophic factor
chr8_+_45334255 1.78 ENSDART00000126848
ENSDART00000134161
ENSDART00000142322
ENSDART00000145011
ENSDART00000183560
pabpc1l
poly(A) binding protein, cytoplasmic 1-like
chr3_-_32898626 1.70 ENSDART00000103201
kat7a
K(lysine) acetyltransferase 7a
chr12_+_2446837 1.70 ENSDART00000112032
ARHGAP22
si:dkey-191m6.4
chr3_+_18807006 1.69 ENSDART00000180091
tnpo2
transportin 2 (importin 3, karyopherin beta 2b)
chr1_-_55248496 1.68 ENSDART00000098615
nanos3
nanos homolog 3
chr16_+_35661771 1.64 ENSDART00000161393
map7d1a
MAP7 domain containing 1a
chr24_+_40860320 1.61 ENSDART00000161351
gorasp1b
golgi reassembly stacking protein 1b
chr6_-_44711942 1.60 ENSDART00000055035
cntn3b
contactin 3b
chr3_+_45365098 1.59 ENSDART00000052746
ENSDART00000156555
ube2ia
ubiquitin-conjugating enzyme E2Ia
chr4_+_16885854 1.56 ENSDART00000017726
etnk1
ethanolamine kinase 1
chr21_+_34088110 1.54 ENSDART00000145123
ENSDART00000029599
ENSDART00000147519
mtmr1b
myotubularin related protein 1b
chr15_-_8665662 1.53 ENSDART00000090675
arhgap35a
Rho GTPase activating protein 35a
chr23_+_33963619 1.52 ENSDART00000140666
ENSDART00000084792
plpbp
pyridoxal phosphate binding protein
chr2_-_23004286 1.50 ENSDART00000134664
ENSDART00000110373
ENSDART00000185833
ENSDART00000187235
znf414
mllt1b
zinc finger protein 414
MLLT1, super elongation complex subunit b
chr11_+_18130300 1.50 ENSDART00000169146
zgc:175135
zgc:175135
chr10_+_6884627 1.49 ENSDART00000125262
ENSDART00000121729
ENSDART00000105384
ddx4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chr2_-_57076687 1.49 ENSDART00000161523
slc25a42
solute carrier family 25, member 42
chr14_-_30587814 1.46 ENSDART00000144912
ENSDART00000149714
tmem265
transmembrane protein 265
chr9_-_52962521 1.43 ENSDART00000170419
CU855885.1

chr11_+_18157260 1.41 ENSDART00000144659
zgc:173545
zgc:173545
chr8_-_38477817 1.38 ENSDART00000075989
inpp5l
inositol polyphosphate-5-phosphatase L
chr7_+_42460302 1.30 ENSDART00000004120
adamts18
ADAM metallopeptidase with thrombospondin type 1 motif, 18
chr4_-_27099224 1.16 ENSDART00000048383
creld2
cysteine-rich with EGF-like domains 2
chr18_-_25568994 1.15 ENSDART00000133029
si:ch211-13k12.2
si:ch211-13k12.2
chr17_+_25856671 1.11 ENSDART00000064817
wapla
WAPL cohesin release factor a
chr25_-_18913336 1.11 ENSDART00000171010
parietopsin
parietopsin
chr3_-_26806032 1.08 ENSDART00000143710
pigq
phosphatidylinositol glycan anchor biosynthesis, class Q
chr22_+_5176693 1.07 ENSDART00000160927
cers1
ceramide synthase 1
chr14_+_34490445 1.07 ENSDART00000132193
ENSDART00000148044
wnt8a
wingless-type MMTV integration site family, member 8a
chr15_-_16177603 1.06 ENSDART00000156352
si:ch211-259g3.4
si:ch211-259g3.4
chr5_+_60928576 1.04 ENSDART00000131041
doc2b
double C2-like domains, beta
chr17_-_31659670 1.00 ENSDART00000030448
vsx2
visual system homeobox 2
chr20_-_11178022 0.97 ENSDART00000152246
flrt2
fibronectin leucine rich transmembrane protein 2
chr14_-_32631013 0.96 ENSDART00000176815
atp11c
ATPase phospholipid transporting 11C
chr7_-_36096582 0.94 ENSDART00000188507
CR848715.1

chr20_-_29864390 0.91 ENSDART00000161834
ENSDART00000132278
rnf144ab
ring finger protein 144ab
chr16_-_16120941 0.89 ENSDART00000131227
ankib1b
ankyrin repeat and IBR domain containing 1b
chr4_-_72638972 0.88 ENSDART00000193312
CABZ01054394.1

chr16_+_33163858 0.83 ENSDART00000101943
rragca
Ras-related GTP binding Ca
chr24_-_30843250 0.82 ENSDART00000162920
ptbp2a
polypyrimidine tract binding protein 2a
chr21_-_36396334 0.80 ENSDART00000183627
mrpl22
mitochondrial ribosomal protein L22
chr8_-_10961991 0.80 ENSDART00000139603
trim33
tripartite motif containing 33
chr15_-_5172170 0.76 ENSDART00000062830
or126-5
odorant receptor, family E, subfamily 126, member 5
chr10_-_21362320 0.75 ENSDART00000189789
avd
avidin
chr17_+_24821627 0.71 ENSDART00000112389
wdr43
WD repeat domain 43
chr16_+_31827653 0.70 ENSDART00000187261
mlf2
myeloid leukemia factor 2
chr19_-_8768564 0.70 ENSDART00000170416
si:ch73-350k19.1
si:ch73-350k19.1
chr14_-_2933185 0.69 ENSDART00000161677
ENSDART00000162446
ENSDART00000109378
si:dkey-201i24.6
si:dkey-201i24.6
chr13_-_44630111 0.69 ENSDART00000110092
mdga1
MAM domain containing glycosylphosphatidylinositol anchor 1
chr10_+_43039947 0.67 ENSDART00000193434
atg10
ATG10 autophagy related 10 homolog (S. cerevisiae)
chr3_-_26805455 0.60 ENSDART00000180648
pigq
phosphatidylinositol glycan anchor biosynthesis, class Q
chr19_-_20403845 0.55 ENSDART00000151265
ENSDART00000147911
ENSDART00000151356
dazl
deleted in azoospermia-like
chr15_-_26931541 0.54 ENSDART00000027563
ccdc9
coiled-coil domain containing 9
chr8_+_26125218 0.54 ENSDART00000145095
celsr3
cadherin, EGF LAG seven-pass G-type receptor 3
chr8_-_46894362 0.52 ENSDART00000111124
acot7
acyl-CoA thioesterase 7
chr8_-_25034411 0.41 ENSDART00000135973
nfyal
nuclear transcription factor Y, alpha, like
chr4_+_12612145 0.40 ENSDART00000181201
lmo3
LIM domain only 3
chrM_+_11009 0.39 ENSDART00000093617
mt-nd4l
NADH dehydrogenase 4L, mitochondrial
chr23_-_31913231 0.36 ENSDART00000146852
ENSDART00000085054
mtfr2
mitochondrial fission regulator 2
chr18_-_33979693 0.35 ENSDART00000021215
si:ch211-203b20.7
si:ch211-203b20.7
chr15_+_5360407 0.34 ENSDART00000110420
or112-1
odorant receptor, family A, subfamily 112, member 1
chr10_+_17714866 0.33 ENSDART00000039969
slc20a1b
solute carrier family 20 (phosphate transporter), member 1b
chr16_+_42471455 0.32 ENSDART00000166640
si:ch211-215k15.5
si:ch211-215k15.5
chr13_+_38990939 0.30 ENSDART00000145979
col19a1
collagen, type XIX, alpha 1
chr4_+_14727018 0.28 ENSDART00000124189
cmasa
cytidine monophosphate N-acetylneuraminic acid synthetase a
chr21_-_3853204 0.27 ENSDART00000188829
st6galnac4
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
chr17_+_21295132 0.27 ENSDART00000103845
eno4
enolase family member 4
chr15_+_30323491 0.26 ENSDART00000048847
nos2b
nitric oxide synthase 2b, inducible
chr9_-_21460164 0.25 ENSDART00000133469
zmym2
zinc finger, MYM-type 2
chr2_+_31804582 0.25 ENSDART00000086646
rnf182
ring finger protein 182
chr13_-_36184476 0.24 ENSDART00000057185
map3k9
mitogen-activated protein kinase kinase kinase 9
chr16_+_31827502 0.23 ENSDART00000045210
mlf2
myeloid leukemia factor 2
chr23_-_1348933 0.22 ENSDART00000168981
CABZ01078120.1

chr4_+_12612723 0.21 ENSDART00000133767
lmo3
LIM domain only 3
chr11_+_33312601 0.20 ENSDART00000188024
cntnap5l
contactin associated protein-like 5 like
chr10_-_28513861 0.19 ENSDART00000177781
bbx
bobby sox homolog (Drosophila)
chr18_-_29896367 0.17 ENSDART00000191303
cmc2
C-x(9)-C motif containing 2
chr13_+_30903816 0.16 ENSDART00000191727
ercc6
excision repair cross-complementation group 6
chr24_-_40860603 0.13 ENSDART00000188032
CU633479.7

chr15_+_23911655 0.13 ENSDART00000156304
si:ch1073-145m9.1
si:ch1073-145m9.1
chr7_-_12464412 0.13 ENSDART00000178723
adamtsl3
ADAMTS-like 3
chr4_+_72723304 0.11 ENSDART00000186791
ENSDART00000158902
ENSDART00000191925
rab3ip
RAB3A interacting protein (rabin3)
chr18_+_9362455 0.10 ENSDART00000187025
sema3ab
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Ab
chr4_-_43388943 0.10 ENSDART00000150796
si:dkey-29j8.2
si:dkey-29j8.2
chr19_-_15855427 0.09 ENSDART00000133059
cited4a
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4a
chr21_+_28478663 0.07 ENSDART00000077887
ENSDART00000134150
slc22a6l
solute carrier family 22 (organic anion transporter), member 6, like
chr20_-_45060241 0.07 ENSDART00000185227
klhl29
kelch-like family member 29
chr20_+_28803977 0.04 ENSDART00000153351
ENSDART00000038149
fntb
farnesyltransferase, CAAX box, beta
chr1_+_30100257 0.03 ENSDART00000134311
vps8
vacuolar protein sorting 8 homolog (S. cerevisiae)
chr12_-_18872927 0.02 ENSDART00000187717
shisa8b
shisa family member 8b
chr7_-_31941330 0.00 ENSDART00000144682
bdnf
brain-derived neurotrophic factor

Network of associatons between targets according to the STRING database.

First level regulatory network of msx1a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 8.2 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
2.5 7.6 GO:0097377 interneuron axon guidance(GO:0097376) spinal cord interneuron axon guidance(GO:0097377) dorsal spinal cord interneuron axon guidance(GO:0097378)
2.5 7.6 GO:0007414 axonal defasciculation(GO:0007414)
2.5 7.4 GO:0035902 response to immobilization stress(GO:0035902)
2.4 9.7 GO:0060074 synapse maturation(GO:0060074)
1.2 6.1 GO:0010873 regulation of cholesterol esterification(GO:0010872) positive regulation of cholesterol esterification(GO:0010873)
1.1 5.3 GO:0016322 neuron remodeling(GO:0016322)
0.8 2.4 GO:0098924 retrograde trans-synaptic signaling by soluble gas(GO:0098923) retrograde trans-synaptic signaling by nitric oxide(GO:0098924)
0.7 3.7 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.7 10.4 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.6 2.5 GO:0015677 copper ion import(GO:0015677)
0.6 3.1 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.6 3.4 GO:0060965 negative regulation of posttranscriptional gene silencing(GO:0060149) negative regulation of gene silencing by miRNA(GO:0060965) negative regulation of gene silencing by RNA(GO:0060967)
0.5 2.1 GO:0048210 Golgi vesicle fusion to target membrane(GO:0048210)
0.5 2.3 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.4 1.7 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.4 1.6 GO:0036306 embryonic heart tube elongation(GO:0036306)
0.4 2.8 GO:0070207 protein homotrimerization(GO:0070207)
0.4 1.1 GO:0060623 regulation of chromosome condensation(GO:0060623)
0.4 7.3 GO:0022010 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.4 3.6 GO:1904071 presynaptic active zone assembly(GO:1904071)
0.4 1.1 GO:0039015 spinal cord anterior/posterior patterning(GO:0021512) cell proliferation involved in pronephros development(GO:0039015) cell proliferation involved in kidney development(GO:0072111)
0.3 2.5 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.3 4.7 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.3 3.5 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.3 5.1 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.3 4.3 GO:0035803 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.2 3.0 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.2 7.5 GO:0032482 Rab protein signal transduction(GO:0032482)
0.2 2.9 GO:0006991 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.2 7.2 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.2 2.8 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.2 3.0 GO:0001964 startle response(GO:0001964)
0.2 2.0 GO:0035677 posterior lateral line neuromast hair cell development(GO:0035677)
0.2 4.8 GO:0070593 dendrite self-avoidance(GO:0070593)
0.2 6.9 GO:0007586 digestion(GO:0007586)
0.2 3.5 GO:0045773 positive regulation of axon extension(GO:0045773)
0.2 5.3 GO:0043652 engulfment of apoptotic cell(GO:0043652)
0.2 1.8 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 2.4 GO:0050728 negative regulation of inflammatory response(GO:0050728)
0.1 2.5 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.1 6.9 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.1 5.8 GO:0036269 swimming behavior(GO:0036269)
0.1 0.8 GO:0048569 post-embryonic organ development(GO:0048569)
0.1 1.6 GO:0051967 negative regulation of cytosolic calcium ion concentration(GO:0051481) negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1 1.0 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.1 2.4 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.1 2.3 GO:0010507 negative regulation of autophagy(GO:0010507)
0.1 0.3 GO:0030823 regulation of cGMP metabolic process(GO:0030823) positive regulation of cGMP metabolic process(GO:0030825) regulation of cGMP biosynthetic process(GO:0030826) positive regulation of cGMP biosynthetic process(GO:0030828) regulation of guanylate cyclase activity(GO:0031282) positive regulation of guanylate cyclase activity(GO:0031284)
0.1 7.2 GO:0006612 protein targeting to membrane(GO:0006612)
0.1 1.4 GO:0048016 inositol phosphate-mediated signaling(GO:0048016)
0.1 2.0 GO:0006491 N-glycan processing(GO:0006491)
0.1 1.5 GO:0051445 regulation of meiotic cell cycle(GO:0051445)
0.1 6.9 GO:0010506 regulation of autophagy(GO:0010506)
0.1 2.7 GO:0009950 dorsal/ventral axis specification(GO:0009950)
0.1 3.4 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.1 1.0 GO:0061074 regulation of neural retina development(GO:0061074)
0.1 1.7 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.1 2.0 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.1 3.2 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.0 8.3 GO:0002040 sprouting angiogenesis(GO:0002040)
0.0 1.9 GO:0060968 regulation of gene silencing(GO:0060968)
0.0 1.5 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 1.8 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.0 0.3 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
0.0 1.5 GO:0007006 mitochondrial membrane organization(GO:0007006)
0.0 11.2 GO:0009100 glycoprotein metabolic process(GO:0009100)
0.0 1.7 GO:1902593 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593)
0.0 2.7 GO:0017148 negative regulation of translation(GO:0017148) negative regulation of cellular amide metabolic process(GO:0034249)
0.0 1.0 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.2 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.0 2.5 GO:0003341 cilium movement(GO:0003341)
0.0 1.4 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.0 0.5 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.0 1.1 GO:0006368 transcription elongation from RNA polymerase II promoter(GO:0006368)
0.0 1.6 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.0 1.6 GO:0007030 Golgi organization(GO:0007030)
0.0 0.7 GO:0006497 protein lipidation(GO:0006497)
0.0 1.7 GO:0016573 histone acetylation(GO:0016573)
0.0 3.0 GO:0006887 exocytosis(GO:0006887)
0.0 8.8 GO:0007268 chemical synaptic transmission(GO:0007268) anterograde trans-synaptic signaling(GO:0098916) trans-synaptic signaling(GO:0099537)
0.0 0.7 GO:0001570 vasculogenesis(GO:0001570)
0.0 0.8 GO:0042255 ribosome assembly(GO:0042255)
0.0 1.5 GO:0048545 response to steroid hormone(GO:0048545)
0.0 0.3 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 0.3 GO:0048846 axon extension involved in axon guidance(GO:0048846) neuron projection extension involved in neuron projection guidance(GO:1902284)
0.0 2.1 GO:0016197 endosomal transport(GO:0016197)
0.0 0.2 GO:0007257 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 6.9 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
1.7 10.4 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
1.2 7.2 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.9 5.3 GO:0043083 synaptic cleft(GO:0043083)
0.8 7.5 GO:0032593 insulin-responsive compartment(GO:0032593)
0.5 6.1 GO:0042627 chylomicron(GO:0042627)
0.4 7.3 GO:0043209 myelin sheath(GO:0043209)
0.4 7.6 GO:0002116 semaphorin receptor complex(GO:0002116)
0.4 3.6 GO:0098982 GABA-ergic synapse(GO:0098982)
0.4 1.1 GO:0097189 apoptotic body(GO:0097189)
0.3 2.1 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.3 3.5 GO:0044295 axonal growth cone(GO:0044295)
0.3 1.7 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.3 2.7 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.3 9.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.2 3.0 GO:0031209 SCAR complex(GO:0031209)
0.2 9.6 GO:0099634 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.2 0.8 GO:0034448 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.1 2.5 GO:0000813 ESCRT I complex(GO:0000813)
0.1 5.1 GO:0000421 autophagosome membrane(GO:0000421)
0.1 3.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 2.8 GO:0035102 PRC1 complex(GO:0035102)
0.1 12.1 GO:0043197 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.1 3.2 GO:0043186 P granule(GO:0043186)
0.1 13.6 GO:0030424 axon(GO:0030424)
0.1 2.0 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.0 1.6 GO:0098978 glutamatergic synapse(GO:0098978)
0.0 2.8 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 3.2 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 0.4 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 2.5 GO:0005930 axoneme(GO:0005930)
0.0 1.0 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 1.2 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.1 GO:0070319 Golgi to plasma membrane transport vesicle(GO:0070319)
0.0 2.5 GO:0010008 endosome membrane(GO:0010008)
0.0 12.4 GO:0045202 synapse(GO:0045202)
0.0 2.3 GO:0016459 myosin complex(GO:0016459)
0.0 1.0 GO:0055037 recycling endosome(GO:0055037)
0.0 0.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.7 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.4 GO:0005769 early endosome(GO:0005769)
0.0 1.1 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.0 GO:0030897 HOPS complex(GO:0030897)
0.0 1.1 GO:0030425 dendrite(GO:0030425)
0.0 1.4 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 8.2 GO:0004351 glutamate decarboxylase activity(GO:0004351)
1.2 6.1 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
1.0 7.2 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.8 2.5 GO:0070735 protein-glycine ligase activity(GO:0070735) tubulin-glycine ligase activity(GO:0070738)
0.7 3.5 GO:0008046 axon guidance receptor activity(GO:0008046)
0.6 2.5 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.6 2.8 GO:0009374 biotin binding(GO:0009374)
0.6 2.8 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.5 4.7 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.5 20.1 GO:0017075 syntaxin-1 binding(GO:0017075)
0.5 1.5 GO:0071077 coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.5 7.3 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.4 1.6 GO:0061656 SUMO conjugating enzyme activity(GO:0061656)
0.4 2.4 GO:0032052 bile acid binding(GO:0032052)
0.4 4.3 GO:0035804 structural constituent of egg coat(GO:0035804)
0.4 3.4 GO:0008494 translation activator activity(GO:0008494)
0.4 2.6 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.3 7.6 GO:0001540 beta-amyloid binding(GO:0001540)
0.3 4.7 GO:0061608 nuclear import signal receptor activity(GO:0061608)
0.2 7.6 GO:0017154 semaphorin receptor activity(GO:0017154)
0.2 1.7 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.2 3.4 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.2 0.7 GO:0019777 Atg12 transferase activity(GO:0019777)
0.2 3.6 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.2 2.0 GO:0015924 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.2 3.0 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.2 6.9 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.2 3.1 GO:0015026 coreceptor activity(GO:0015026)
0.2 1.4 GO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.2 1.5 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 4.8 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.1 3.9 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 1.8 GO:0005165 nerve growth factor receptor binding(GO:0005163) neurotrophin receptor binding(GO:0005165)
0.1 1.8 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 3.8 GO:0000030 mannosyltransferase activity(GO:0000030)
0.1 2.7 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 2.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 1.6 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.1 6.9 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 2.8 GO:0008378 galactosyltransferase activity(GO:0008378)
0.1 1.4 GO:0031726 CCR1 chemokine receptor binding(GO:0031726) CCR4 chemokine receptor binding(GO:0031729)
0.1 7.2 GO:0051082 unfolded protein binding(GO:0051082)
0.1 0.5 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.1 3.2 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.1 5.1 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.1 2.9 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 3.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 1.8 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 17.3 GO:0003924 GTPase activity(GO:0003924)
0.0 0.3 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 1.7 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 1.7 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 2.5 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.2 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 5.6 GO:0022832 voltage-gated channel activity(GO:0022832)
0.0 0.3 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 1.5 GO:0003724 RNA helicase activity(GO:0003724)
0.0 1.1 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.0 0.8 GO:0005109 frizzled binding(GO:0005109)
0.0 5.8 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 2.1 GO:0060090 binding, bridging(GO:0060090)
0.0 3.6 GO:0042802 identical protein binding(GO:0042802)
0.0 16.2 GO:0008270 zinc ion binding(GO:0008270)
0.0 5.8 GO:0046983 protein dimerization activity(GO:0046983)
0.0 1.0 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 6.9 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 2.7 PID ARF 3PATHWAY Arf1 pathway
0.1 2.4 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 3.0 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 3.1 PID BMP PATHWAY BMP receptor signaling
0.1 2.7 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.1 2.1 PID EPHB FWD PATHWAY EPHB forward signaling
0.1 1.8 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 6.9 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.3 2.7 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.2 2.5 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.1 2.7 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 2.4 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1 1.6 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.1 3.8 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.1 2.8 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.1 1.7 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 0.3 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 3.1 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.1 2.0 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 2.1 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.8 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 7.3 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 1.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.3 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants