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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for msx1b+msx3

Z-value: 0.98

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Transcription factors associated with msx1b+msx3

Gene Symbol Gene ID Gene Info
msx1b
ENSDARG00000008886 muscle segment homeobox 1b
msx3
ENSDARG00000015674 muscle segment homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
msx3dr11_v1_chr13_+_24662238_24662238-0.804.8e-22Click!
msx1bdr11_v1_chr1_+_49352900_49352900-0.356.0e-04Click!

Activity profile of msx1b+msx3 motif

Sorted Z-values of msx1b+msx3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr25_+_29160102 15.54 ENSDART00000162854
pkmb
pyruvate kinase M1/2b
chr15_-_5815006 11.00 ENSDART00000102459
rbp2a
retinol binding protein 2a, cellular
chr24_+_38306010 10.75 ENSDART00000143184
mybpc2b
myosin binding protein C, fast type b
chr13_+_22476742 10.45 ENSDART00000078759
ENSDART00000130101
ENSDART00000137220
ENSDART00000133065
ENSDART00000147348
ldb3a
LIM domain binding 3a
chr9_-_22821901 8.30 ENSDART00000101711
neb
nebulin
chr18_-_16801033 8.00 ENSDART00000100100
admb
adrenomedullin b
chr18_+_9171778 7.65 ENSDART00000101192
sema3d
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr5_+_56023186 7.44 ENSDART00000156230
fzd9a
frizzled class receptor 9a
chr1_-_25966068 7.27 ENSDART00000137869
ENSDART00000134192
synpo2b
synaptopodin 2b
chr20_+_46040666 7.09 ENSDART00000060744
si:dkey-7c18.24
si:dkey-7c18.24
chr12_+_28749189 6.96 ENSDART00000013980
tbx21
T-box 21
chr24_+_20373605 6.96 ENSDART00000112349
plcd1a
phospholipase C, delta 1a
chr5_-_29534748 6.86 ENSDART00000159587
AL831768.1

chr11_-_40457325 6.30 ENSDART00000128442
tnfrsf1b
tumor necrosis factor receptor superfamily, member 1B
chr6_+_50451337 6.11 ENSDART00000155051
mych
myelocytomatosis oncogene homolog
chr17_+_24851951 5.82 ENSDART00000180746
cx35.4
connexin 35.4
chr5_+_29794058 5.76 ENSDART00000045410
thy1
Thy-1 cell surface antigen
chr15_+_46344655 5.75 ENSDART00000155893
si:ch1073-340i21.2
si:ch1073-340i21.2
chr10_+_36178713 5.71 ENSDART00000140816
or108-3
odorant receptor, family D, subfamily 108, member 3
chr3_+_23692462 5.59 ENSDART00000145934
hoxb7a
homeobox B7a
chr6_-_19042294 5.50 ENSDART00000159461
si:rp71-81e14.2
si:rp71-81e14.2
chr17_-_6514962 5.47 ENSDART00000163514
dnajc5gb
DnaJ (Hsp40) homolog, subfamily C, member 5 gamma b
chr12_+_3078221 5.45 ENSDART00000148835
ENSDART00000149427
sgca
sarcoglycan, alpha
chr18_+_48423973 5.43 ENSDART00000184233
ENSDART00000147074
fli1a
Fli-1 proto-oncogene, ETS transcription factor a
chr11_-_2478374 5.19 ENSDART00000173205
si:ch73-267c23.10
si:ch73-267c23.10
chr10_-_44560165 5.11 ENSDART00000181217
ENSDART00000076084
npm2b
nucleophosmin/nucleoplasmin, 2b
chr15_-_37733238 5.10 ENSDART00000115178
si:dkey-42l23.7
si:dkey-42l23.7
chr20_-_40755614 5.08 ENSDART00000061247
cx32.3
connexin 32.3
chr12_-_33357655 5.07 ENSDART00000066233
ENSDART00000148165
slc16a3
solute carrier family 16 (monocarboxylate transporter), member 3
chr19_-_8768564 5.04 ENSDART00000170416
si:ch73-350k19.1
si:ch73-350k19.1
chr15_-_37767901 4.93 ENSDART00000154763
si:dkey-42l23.4
si:dkey-42l23.4
chr3_+_2719243 4.90 ENSDART00000189256
CR388047.3

chr1_-_19402802 4.87 ENSDART00000135552
rbm47
RNA binding motif protein 47
chr24_-_9979342 4.78 ENSDART00000138576
ENSDART00000191206
zgc:171977
zgc:171977
chr9_+_21277846 4.76 ENSDART00000139620
ENSDART00000110996
ENSDART00000111899
lats2
large tumor suppressor kinase 2
chr11_+_37251825 4.75 ENSDART00000169804
il17rc
interleukin 17 receptor C
chr4_+_77943184 4.59 ENSDART00000159094
pacsin2
protein kinase C and casein kinase substrate in neurons 2
chr19_-_19871211 4.58 ENSDART00000170980
evx1
even-skipped homeobox 1
chr16_+_33144306 4.31 ENSDART00000101953
rhbdl2
rhomboid, veinlet-like 2 (Drosophila)
chr1_+_40801696 4.30 ENSDART00000147497
cpz
carboxypeptidase Z
chr15_+_7057050 4.28 ENSDART00000061828
foxl2a
forkhead box L2a
chr5_+_27897504 4.26 ENSDART00000130936
adam28
ADAM metallopeptidase domain 28
chr15_-_25518084 4.26 ENSDART00000158594
hif1al
hypoxia-inducible factor 1, alpha subunit, like
chr16_-_41714988 4.16 ENSDART00000138798
cep85
centrosomal protein 85
chr16_+_33144112 4.09 ENSDART00000183149
rhbdl2
rhomboid, veinlet-like 2 (Drosophila)
chr11_+_31864921 4.06 ENSDART00000180252
diaph3
diaphanous-related formin 3
chr24_-_25144441 4.03 ENSDART00000152104
phldb2b
pleckstrin homology-like domain, family B, member 2b
chr22_+_12770877 4.01 ENSDART00000044683
ftcd
formimidoyltransferase cyclodeaminase
chr16_-_35975254 3.97 ENSDART00000167537
eva1ba
eva-1 homolog Ba (C. elegans)
chr1_+_54626491 3.95 ENSDART00000136063
si:ch211-202h22.9
si:ch211-202h22.9
chr10_+_39212898 3.84 ENSDART00000159501
stt3a
STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
chr10_-_13343831 3.83 ENSDART00000135941
il11ra
interleukin 11 receptor, alpha
chr4_-_9891874 3.80 ENSDART00000067193
adm2a
adrenomedullin 2a
chr15_-_37709072 3.77 ENSDART00000157115
si:dkey-117a8.2
si:dkey-117a8.2
chr15_-_37683768 3.76 ENSDART00000059609
si:dkey-117a8.3
si:dkey-117a8.3
chr5_+_7564644 3.69 ENSDART00000192173
CABZ01039096.1

chr7_+_8324506 3.66 ENSDART00000168110
si:dkey-185m8.2
si:dkey-185m8.2
chr15_-_37620167 3.65 ENSDART00000059582
si:ch211-137j23.8
si:ch211-137j23.8
chr9_-_35633827 3.64 ENSDART00000077745
zp2l1
zona pellucida glycoprotein 2, like 1
chr15_-_37719015 3.62 ENSDART00000154875
si:dkey-117a8.1
si:dkey-117a8.1
chr23_+_16889352 3.62 ENSDART00000145275
si:dkey-147f3.8
si:dkey-147f3.8
chr17_+_26352372 3.54 ENSDART00000155177
grid1a
glutamate receptor, ionotropic, delta 1a
chr11_-_25538341 3.53 ENSDART00000171560
si:dkey-245f22.3
si:dkey-245f22.3
chr22_+_5532003 3.48 ENSDART00000106174
si:ch73-256j6.2
si:ch73-256j6.2
chr19_-_18127808 3.41 ENSDART00000108627
snx10a
sorting nexin 10a
chr15_-_37673733 3.39 ENSDART00000154513
si:dkey-117a8.4
si:dkey-117a8.4
chr1_+_55730205 3.37 ENSDART00000148075
adgre10
adhesion G protein-coupled receptor E10
chr25_+_6471401 3.36 ENSDART00000132927
snx33
sorting nexin 33
chr8_-_27656765 3.34 ENSDART00000078491
mov10b.2
Moloney leukemia virus 10b, tandem duplicate 2
chr5_-_47727819 3.33 ENSDART00000165249
cox7c
cytochrome c oxidase, subunit VIIc
chr10_+_36194527 3.10 ENSDART00000076810
or108-1
odorant receptor, family D, subfamily 108, member 1
chr23_-_5729484 3.06 ENSDART00000000488
tnni1a
troponin I type 1a (skeletal, slow)
chr19_-_18127629 3.05 ENSDART00000187722
snx10a
sorting nexin 10a
chr16_+_35595312 3.00 ENSDART00000170438
si:ch211-1i11.3
si:ch211-1i11.3
chr3_+_32663865 2.99 ENSDART00000190240
si:dkey-16l2.16
si:dkey-16l2.16
chr17_-_50071748 2.99 ENSDART00000075188
zgc:113886
zgc:113886
chr11_+_24716837 2.98 ENSDART00000145217
zgc:153953
zgc:153953
chr1_+_29068654 2.97 ENSDART00000053932
cbsa
cystathionine-beta-synthase a
chr13_+_27328098 2.92 ENSDART00000037585
mb21d1
Mab-21 domain containing 1
chr16_+_41171949 2.90 ENSDART00000135294
nek11
NIMA-related kinase 11
chr13_+_15701596 2.66 ENSDART00000130832
trmt61a
tRNA methyltransferase 61A
chr8_-_53680653 2.59 ENSDART00000164739
wnt5a
wingless-type MMTV integration site family, member 5a
chr20_-_9095105 2.53 ENSDART00000140792
oma1
OMA1 zinc metallopeptidase
chr21_-_8085635 2.47 ENSDART00000082790
si:dkey-163m14.2
si:dkey-163m14.2
chr10_-_40416054 2.45 ENSDART00000137947
ENSDART00000143606
taar20j
trace amine associated receptor 20j
chr21_-_22647695 2.41 ENSDART00000187553
gig2l
grass carp reovirus (GCRV)-induced gene 2l
chr8_-_15129573 2.39 ENSDART00000142358
bcar3
BCAR3, NSP family adaptor protein
chr25_+_10947743 2.38 ENSDART00000073381
mhc1lfa
major histocompatibility complex class I LFA
chr4_-_12997348 2.37 ENSDART00000171451
si:dkey-6a5.3
si:dkey-6a5.3
chr14_+_34490445 2.36 ENSDART00000132193
ENSDART00000148044
wnt8a
wingless-type MMTV integration site family, member 8a
chr10_+_39212601 2.32 ENSDART00000168778
stt3a
STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
chr20_+_46897504 2.31 ENSDART00000158124
si:ch73-21k16.1
si:ch73-21k16.1
chr2_+_31804582 2.29 ENSDART00000086646
rnf182
ring finger protein 182
chr13_+_9468535 2.23 ENSDART00000135088
ENSDART00000164270
ENSDART00000099619
ENSDART00000164656
HTRA2 (1 of many)
si:dkey-265c15.6
chr4_+_62576422 2.23 ENSDART00000180679
si:ch211-79g12.2
si:ch211-79g12.2
chr4_-_42408339 2.21 ENSDART00000172612
si:ch211-59d8.3
si:ch211-59d8.3
chr25_-_13558172 2.18 ENSDART00000139970
ENSDART00000133789
ENSDART00000144426
ano10b
anoctamin 10b
chr4_-_14162327 2.15 ENSDART00000138656
si:dkey-234l24.1
si:dkey-234l24.1
chr6_-_9695294 2.15 ENSDART00000162728
nop58
NOP58 ribonucleoprotein homolog (yeast)
chr16_+_9713850 2.13 ENSDART00000164103
ecm1b
extracellular matrix protein 1b
chr17_+_7513673 2.11 ENSDART00000156674
klhl10b.1
kelch-like family member 10b, tandem duplicate 1
chr4_-_75681004 2.11 ENSDART00000186296
si:dkey-71l4.5
si:dkey-71l4.5
chr2_+_30369116 2.10 ENSDART00000142137
pi15b
peptidase inhibitor 15b
chr4_-_20292821 2.08 ENSDART00000136069
ENSDART00000192504
cacna2d4a
calcium channel, voltage-dependent, alpha 2/delta subunit 4a
chr16_-_26855936 2.01 ENSDART00000167320
ENSDART00000078119
ino80c
INO80 complex subunit C
chr17_+_15041647 2.00 ENSDART00000108999
samd4a
sterile alpha motif domain containing 4A
chr16_-_7379328 1.99 ENSDART00000060447
med18
mediator of RNA polymerase II transcription, subunit 18 homolog (yeast)
chr21_+_15592426 1.88 ENSDART00000138207
smarcb1b
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1b
chr4_-_14173138 1.87 ENSDART00000142487
si:dkey-234l24.7
si:dkey-234l24.7
chr14_-_1543834 1.86 ENSDART00000185876
CABZ01109480.1

chr1_-_7975755 1.86 ENSDART00000141765
si:dkey-79f11.7
si:dkey-79f11.7
chr21_-_22648007 1.85 ENSDART00000121788
gig2l
grass carp reovirus (GCRV)-induced gene 2l
chr18_+_50461981 1.81 ENSDART00000158761
CU896640.1

chr14_+_36521005 1.77 ENSDART00000192286
TENM3
si:dkey-237h12.3
chr5_-_67629263 1.74 ENSDART00000133753
zbtb20
zinc finger and BTB domain containing 20
chr9_+_18829360 1.73 ENSDART00000006514
gtf2f2b
general transcription factor IIF, polypeptide 2b
chr6_+_39370587 1.73 ENSDART00000157165
ENSDART00000155079
si:dkey-195m11.8
si:dkey-195m11.8
chr2_+_30032303 1.68 ENSDART00000151841
rbm33b
RNA binding motif protein 33b
chr19_+_9212031 1.63 ENSDART00000052930
ndufv1
NADH dehydrogenase (ubiquinone) flavoprotein 1
chr17_-_6618574 1.62 ENSDART00000184486
si:ch211-189e2.3
si:ch211-189e2.3
chr5_+_4806851 1.57 ENSDART00000067599
angptl2a
angiopoietin-like 2a
chr24_-_7957581 1.53 ENSDART00000145815
txndc5
thioredoxin domain containing 5
chr17_-_41081806 1.45 ENSDART00000030622
rbks
ribokinase
chr2_+_6253246 1.45 ENSDART00000058256
ENSDART00000076700
zp3b
zona pellucida glycoprotein 3b
chr13_+_31402067 1.37 ENSDART00000019202
tdrd9
tudor domain containing 9
chr17_+_24821627 1.28 ENSDART00000112389
wdr43
WD repeat domain 43
chr2_+_30368800 1.28 ENSDART00000179564
pi15b
peptidase inhibitor 15b
chr23_-_35483163 1.27 ENSDART00000138660
ENSDART00000113643
ENSDART00000189269
fbxo25
F-box protein 25
chr15_+_27384798 1.25 ENSDART00000164887
tbx4
T-box 4
chr10_+_21867307 1.24 ENSDART00000126629
cbln17
cerebellin 17
chr5_+_9224051 1.18 ENSDART00000139265
si:ch211-12e13.12
si:ch211-12e13.12
chr18_-_46380471 1.16 ENSDART00000144444
ENSDART00000086772
slc19a3b
solute carrier family 19 (thiamine transporter), member 3b
chr13_-_9045879 1.15 ENSDART00000155463
ENSDART00000140041
ENSDART00000137454
si:dkey-112g5.11
si:dkey-112g5.11
chr14_+_20918701 1.14 ENSDART00000144736
ENSDART00000148204
zgc:66433
zgc:66433
chr4_+_54519511 1.12 ENSDART00000161653
znf974
zinc finger protein 974
chr22_+_9114416 1.06 ENSDART00000190169
nlrp15
NACHT, LRR and PYD domains-containing protein 15
chr7_-_69647988 1.06 ENSDART00000169943
LO018231.1

chr20_+_25568694 0.97 ENSDART00000063107
ENSDART00000063128
cyp2p7
cytochrome P450, family 2, subfamily P, polypeptide 7
chr13_+_35955562 0.91 ENSDART00000137377
si:ch211-67f13.7
si:ch211-67f13.7
chr5_-_68093169 0.86 ENSDART00000051849
slc25a11
solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
chr25_-_25550938 0.86 ENSDART00000150412
ENSDART00000103622
irf7
interferon regulatory factor 7
chr1_+_40801448 0.81 ENSDART00000187394
cpz
carboxypeptidase Z
chr23_+_22658700 0.79 ENSDART00000192248
eno1a
enolase 1a, (alpha)
chr13_-_9159852 0.78 ENSDART00000170185
ENSDART00000158697
ENSDART00000143393
ENSDART00000164973
ENSDART00000159910
HTRA2 (1 of many)
si:dkey-112g5.16
chr5_+_19933356 0.77 ENSDART00000088819
ankrd13a
ankyrin repeat domain 13A
chr17_-_2834764 0.76 ENSDART00000024027
bdkrb1
bradykinin receptor B1
chr11_-_1935883 0.72 ENSDART00000172885
faim2b
Fas apoptotic inhibitory molecule 2b
chr11_+_2855430 0.65 ENSDART00000172837
kif21b
kinesin family member 21B
chr22_+_1615691 0.60 ENSDART00000171555
si:ch211-255f4.13
si:ch211-255f4.13
chr2_-_20788698 0.58 ENSDART00000181823
CABZ01020455.1

chr5_+_872299 0.56 ENSDART00000130042
fubp3
far upstream element (FUSE) binding protein 3
chr18_+_43891051 0.55 ENSDART00000024213
cxcr5
chemokine (C-X-C motif) receptor 5
chr24_-_4782052 0.54 ENSDART00000149911
agtr1b
angiotensin II receptor, type 1b
chr4_-_62714083 0.54 ENSDART00000188299
si:dkey-28k24.2
si:dkey-28k24.2
chr13_+_9521629 0.53 ENSDART00000149870
ENSDART00000137666
si:dkey-19p15.4
si:dkey-19p15.4
chr25_+_19666621 0.51 ENSDART00000112746
zgc:171459
zgc:171459
chr15_+_31303355 0.50 ENSDART00000143423
or116-2
odorant receptor, family F, subfamily 116, member 2
chr18_+_34225520 0.47 ENSDART00000126115
v2rl1
vomeronasal 2 receptor, l1
chr23_-_16485190 0.41 ENSDART00000155038
si:dkeyp-100a5.4
si:dkeyp-100a5.4
chr24_+_22485710 0.39 ENSDART00000146058
si:dkey-40h20.1
si:dkey-40h20.1
chr4_-_67969695 0.38 ENSDART00000190016
si:ch211-223k15.1
si:ch211-223k15.1
chr14_+_6535426 0.35 ENSDART00000055961
thg1l
tRNA-histidine guanylyltransferase 1-like
chr3_-_31079186 0.35 ENSDART00000145636
ENSDART00000140569
ELOB (1 of many)
elob
elongin B
elongin B
chr13_-_9213207 0.33 ENSDART00000139861
ENSDART00000140524
HTRA2 (1 of many)
si:dkey-33c12.11
chr4_+_19700308 0.31 ENSDART00000027919
pax4
paired box 4
chr17_+_41081977 0.29 ENSDART00000137091
ENSDART00000143714
babam2
BRISC and BRCA1 A complex member 2
chr4_-_14185225 0.24 ENSDART00000147061
si:dkey-234l24.8
si:dkey-234l24.8
chr15_+_5360407 0.22 ENSDART00000110420
or112-1
odorant receptor, family A, subfamily 112, member 1
chr15_-_14212777 0.03 ENSDART00000165572
CR925813.1

chr24_+_17345521 0.01 ENSDART00000024722
ENSDART00000154250
ezh2
enhancer of zeste 2 polycomb repressive complex 2 subunit
chr21_-_13661631 0.01 ENSDART00000184408
pnpla7a
patatin-like phospholipase domain containing 7a

Network of associatons between targets according to the STRING database.

First level regulatory network of msx1b+msx3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 7.7 GO:0002164 larval development(GO:0002164) larval heart development(GO:0007508)
1.4 7.2 GO:2000742 regulation of anterior head development(GO:2000742)
1.4 4.3 GO:0048496 maintenance of organ identity(GO:0048496)
1.4 28.2 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
1.4 8.3 GO:0071691 cardiac muscle thin filament assembly(GO:0071691)
1.3 4.0 GO:0043606 formate metabolic process(GO:0015942) histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
1.3 6.5 GO:0070986 left/right axis specification(GO:0070986)
0.7 3.3 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.6 3.0 GO:0070814 cysteine biosynthetic process from serine(GO:0006535) hydrogen sulfide biosynthetic process(GO:0070814)
0.5 4.6 GO:0072498 embryonic skeletal joint development(GO:0072498)
0.5 1.5 GO:0019323 pentose catabolic process(GO:0019323)
0.5 4.6 GO:0070836 membrane raft assembly(GO:0001765) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.4 0.9 GO:1901533 negative regulation of hematopoietic progenitor cell differentiation(GO:1901533)
0.4 4.8 GO:0046620 secondary heart field specification(GO:0003139) regulation of organ growth(GO:0046620)
0.4 6.3 GO:1901534 positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.4 2.5 GO:1900048 positive regulation of blood coagulation(GO:0030194) positive regulation of coagulation(GO:0050820) positive regulation of hemostasis(GO:1900048)
0.3 6.2 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279) post-translational protein modification(GO:0043687)
0.3 5.1 GO:0045740 positive regulation of DNA replication(GO:0045740)
0.3 2.5 GO:1990845 adaptive thermogenesis(GO:1990845)
0.3 2.0 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.3 5.2 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.3 7.3 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.3 3.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.3 16.3 GO:0006096 glycolytic process(GO:0006096)
0.2 1.2 GO:0030326 embryonic limb morphogenesis(GO:0030326)
0.2 2.9 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
0.2 4.3 GO:0014823 response to activity(GO:0014823)
0.2 3.0 GO:0000186 activation of MAPKK activity(GO:0000186)
0.2 1.4 GO:0007141 male meiosis I(GO:0007141)
0.2 0.9 GO:0071422 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) succinate transport(GO:0015744) succinate transmembrane transport(GO:0071422) malate transmembrane transport(GO:0071423)
0.2 3.6 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.1 2.4 GO:0007339 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.1 2.1 GO:0046549 retinal cone cell development(GO:0046549)
0.1 7.4 GO:0035567 non-canonical Wnt signaling pathway(GO:0035567)
0.1 2.4 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.1 2.4 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.1 7.0 GO:0072676 lymphocyte migration(GO:0072676)
0.1 1.6 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 7.0 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.1 2.1 GO:0070167 regulation of bone mineralization(GO:0030500) regulation of biomineral tissue development(GO:0070167)
0.1 2.3 GO:0019432 triglyceride biosynthetic process(GO:0019432)
0.1 3.0 GO:0032456 endocytic recycling(GO:0032456)
0.1 3.4 GO:0000281 mitotic cytokinesis(GO:0000281)
0.1 10.4 GO:0007626 locomotory behavior(GO:0007626)
0.1 3.1 GO:0003009 skeletal muscle contraction(GO:0003009)
0.1 2.0 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.1 9.9 GO:0008284 positive regulation of cell proliferation(GO:0008284)
0.1 4.4 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 5.5 GO:0002250 adaptive immune response(GO:0002250)
0.0 1.2 GO:0051180 vitamin transport(GO:0051180)
0.0 1.4 GO:0030488 tRNA methylation(GO:0030488)
0.0 1.7 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 3.5 GO:0035249 synaptic transmission, glutamatergic(GO:0035249)
0.0 9.0 GO:0060537 muscle tissue development(GO:0060537)
0.0 4.0 GO:0070507 regulation of microtubule cytoskeleton organization(GO:0070507)
0.0 2.2 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.0 1.3 GO:0001570 vasculogenesis(GO:0001570)
0.0 2.6 GO:0045165 cell fate commitment(GO:0045165)
0.0 1.0 GO:0042738 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.0 0.3 GO:1990798 pancreas regeneration(GO:1990798)
0.0 5.6 GO:0009952 anterior/posterior pattern specification(GO:0009952)
0.0 3.4 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.0 2.0 GO:0006338 chromatin remodeling(GO:0006338)
0.0 0.1 GO:0072401 signal transduction involved in DNA integrity checkpoint(GO:0072401) signal transduction involved in DNA damage checkpoint(GO:0072422) signal transduction involved in G2 DNA damage checkpoint(GO:0072425)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0097189 apoptotic body(GO:0097189)
0.8 5.5 GO:0016012 sarcoglycan complex(GO:0016012)
0.5 2.7 GO:0031515 tRNA (m1A) methyltransferase complex(GO:0031515)
0.4 2.1 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.3 2.0 GO:0070847 core mediator complex(GO:0070847)
0.3 26.0 GO:0030018 Z disc(GO:0030018)
0.2 1.7 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.2 1.9 GO:0035060 brahma complex(GO:0035060)
0.2 4.3 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.2 4.0 GO:0045180 basal cortex(GO:0045180)
0.1 4.7 GO:0043186 P granule(GO:0043186)
0.1 2.0 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.1 4.6 GO:0032587 ruffle membrane(GO:0032587)
0.1 0.8 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 3.1 GO:0005861 troponin complex(GO:0005861)
0.1 0.4 GO:0030891 VCB complex(GO:0030891)
0.1 13.5 GO:0005813 centrosome(GO:0005813)
0.1 4.8 GO:0000922 spindle pole(GO:0000922)
0.0 3.6 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.6 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 4.0 GO:0005765 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 2.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 1.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 2.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 6.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.1 GO:0070552 BRISC complex(GO:0070552)
0.0 2.3 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 5.9 GO:0005743 mitochondrial inner membrane(GO:0005743)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 15.5 GO:0004743 pyruvate kinase activity(GO:0004743)
1.5 6.2 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
1.3 28.2 GO:0004875 complement receptor activity(GO:0004875)
1.1 3.3 GO:0032574 5'-3' RNA helicase activity(GO:0032574)
1.0 4.0 GO:0016841 ammonia-lyase activity(GO:0016841)
0.6 3.0 GO:0004122 cystathionine beta-synthase activity(GO:0004122)
0.5 2.7 GO:0016429 tRNA (adenine-N1-)-methyltransferase activity(GO:0016429)
0.5 10.4 GO:0051393 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.5 7.7 GO:0038191 neuropilin binding(GO:0038191)
0.5 7.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.4 5.1 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.4 4.7 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.3 2.5 GO:0015057 thrombin receptor activity(GO:0015057)
0.2 7.0 GO:0004629 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.2 5.1 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.2 0.9 GO:0015140 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) malate transmembrane transporter activity(GO:0015140)
0.1 2.4 GO:0032190 acrosin binding(GO:0032190)
0.1 0.5 GO:0004945 angiotensin type I receptor activity(GO:0001596) angiotensin type II receptor activity(GO:0004945)
0.1 3.0 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 4.9 GO:0005109 frizzled binding(GO:0005109)
0.1 3.3 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 1.5 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 2.1 GO:0030515 snoRNA binding(GO:0030515)
0.1 3.5 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 2.4 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.1 0.8 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 5.8 GO:0005178 integrin binding(GO:0005178)
0.1 1.2 GO:0090482 vitamin transmembrane transporter activity(GO:0090482)
0.1 2.0 GO:0030371 translation repressor activity(GO:0030371)
0.1 4.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 4.3 GO:0008013 beta-catenin binding(GO:0008013)
0.1 1.6 GO:0010181 NADH dehydrogenase (ubiquinone) activity(GO:0008137) FMN binding(GO:0010181) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 2.3 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.4 GO:0070568 guanylyltransferase activity(GO:0070568)
0.0 4.4 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 1.5 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 7.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 21.7 GO:0008289 lipid binding(GO:0008289)
0.0 2.1 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 7.5 GO:0051015 actin filament binding(GO:0051015)
0.0 1.7 GO:0003678 DNA helicase activity(GO:0003678)
0.0 1.4 GO:0003724 RNA helicase activity(GO:0003724)
0.0 1.0 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 3.0 GO:0042393 histone binding(GO:0042393)
0.0 22.8 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 6.3 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.5 7.0 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.3 5.8 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.2 4.3 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 2.6 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 7.7 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.4 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 4.8 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 4.1 PID CDC42 PATHWAY CDC42 signaling events
0.0 2.4 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.9 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.1 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.3 8.3 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.2 4.8 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 0.5 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 5.0 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 0.9 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.1 6.2 REACTOME ASPARAGINE N LINKED GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.1 1.5 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 2.6 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.9 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 2.0 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 4.0 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 2.3 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.8 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors