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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for mtf1

Z-value: 1.09

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Transcription factors associated with mtf1

Gene Symbol Gene ID Gene Info
mtf1
ENSDARG00000102898 metal-regulatory transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
mtf1dr11_v1_chr16_+_4138331_4138379-0.462.8e-06Click!

Activity profile of mtf1 motif

Sorted Z-values of mtf1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_497680 20.14 ENSDART00000154888
cnbpb
CCHC-type zinc finger, nucleic acid binding protein b
chr17_-_125091 19.77 ENSDART00000158825
actc1b
actin, alpha, cardiac muscle 1b
chr23_-_18057553 9.11 ENSDART00000173102
ENSDART00000058742
zgc:92287
zgc:92287
chr4_-_68564988 8.94 ENSDART00000191212
BX548011.3

chr12_-_49165751 7.55 ENSDART00000148491
ENSDART00000112479
acadsb
acyl-CoA dehydrogenase short/branched chain
chr3_+_23221047 6.48 ENSDART00000009393
col1a1a
collagen, type I, alpha 1a
chr7_+_74150839 5.50 ENSDART00000160195
ppp1cbl
protein phosphatase 1, catalytic subunit, beta isoform, like
chr19_+_31183495 5.29 ENSDART00000088618
meox2b
mesenchyme homeobox 2b
chr23_-_18057270 5.10 ENSDART00000173385
zgc:92287
zgc:92287
chr3_-_50124413 4.92 ENSDART00000189920
cldnk
claudin k
chr22_-_38607504 4.88 ENSDART00000164609
si:ch211-126j24.1
si:ch211-126j24.1
chr2_+_33457310 4.31 ENSDART00000056657
zgc:113531
zgc:113531
chr12_+_22745618 4.24 ENSDART00000181024
ENSDART00000183993
ENSDART00000077548
ablim2
actin binding LIM protein family, member 2
chr16_-_29452039 4.12 ENSDART00000148960
si:ch211-113g11.6
si:ch211-113g11.6
chr1_+_50085440 3.96 ENSDART00000018469
ENSDART00000134988
npnt
nephronectin
chr2_+_54641644 3.90 ENSDART00000027313
ndufv2
NADH dehydrogenase (ubiquinone) flavoprotein 2
chr6_-_20875111 3.76 ENSDART00000115118
ENSDART00000159916
tns1a
tensin 1a
chr1_+_50085640 3.55 ENSDART00000158988
ENSDART00000165973
npnt
nephronectin
chr11_-_497854 3.44 ENSDART00000104520
cnbpb
CCHC-type zinc finger, nucleic acid binding protein b
chr13_-_23756700 3.41 ENSDART00000057612
rgs17
regulator of G protein signaling 17
chr20_+_27298783 3.35 ENSDART00000013861
ppp4r4
protein phosphatase 4, regulatory subunit 4
chr10_+_24445698 3.35 ENSDART00000146370
slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr2_-_7666021 3.30 ENSDART00000180007
CABZ01021592.1

chr1_-_12278522 3.29 ENSDART00000142122
ENSDART00000003825
cplx2l
complexin 2, like
chr4_+_23223881 3.11 ENSDART00000133056
ENSDART00000089126
trhde.1
thyrotropin releasing hormone degrading enzyme, tandem duplicate 1
chr1_-_12278056 3.08 ENSDART00000139336
ENSDART00000137463
cplx2l
complexin 2, like
chr11_-_575786 3.06 ENSDART00000019997
mkrn2
makorin, ring finger protein, 2
chr20_+_39250673 3.01 ENSDART00000153003
reps1
RALBP1 associated Eps domain containing 1
chr17_-_12385308 3.01 ENSDART00000080927
snap25b
synaptosomal-associated protein, 25b
chr20_-_54259780 2.97 ENSDART00000172631
fkbp3
FK506 binding protein 3
chr16_-_42152145 2.90 ENSDART00000038748
dyrk1b
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
chr13_-_27621246 2.86 ENSDART00000102232
kcnq5a
potassium voltage-gated channel, KQT-like subfamily, member 5a
chr23_-_3681026 2.84 ENSDART00000192128
ENSDART00000040086
pacsin1a
protein kinase C and casein kinase substrate in neurons 1a
chr16_-_7692568 2.80 ENSDART00000148980
pimr209
Pim proto-oncogene, serine/threonine kinase, related 209
chr24_-_38384432 2.71 ENSDART00000140739
lrrc4bb
leucine rich repeat containing 4Bb
chr13_-_27620815 2.62 ENSDART00000139904
kcnq5a
potassium voltage-gated channel, KQT-like subfamily, member 5a
chr9_-_48397702 2.59 ENSDART00000147169
zgc:172182
zgc:172182
chr23_-_28239750 2.54 ENSDART00000003548
znf385a
zinc finger protein 385A
chr20_-_1314355 2.52 ENSDART00000152436
pcmt
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr21_+_3093419 2.51 ENSDART00000162520
SHC3
SHC adaptor protein 3
chr6_+_31684 2.43 ENSDART00000188853
ENSDART00000184553
CZQB01141835.2

chr10_+_21789954 2.42 ENSDART00000157769
ENSDART00000171703
pcdh1gc5
protocadherin 1 gamma c 5
chr1_-_53750522 2.42 ENSDART00000190755
akt3b
v-akt murine thymoma viral oncogene homolog 3b
chr8_+_26329482 2.38 ENSDART00000048676
prkar2aa
protein kinase, cAMP-dependent, regulatory, type II, alpha A
chr15_+_3219134 2.34 ENSDART00000113532
LO017656.1

chr17_+_48831579 2.34 ENSDART00000154824
ENSDART00000178697
ENSDART00000192703
ENSDART00000180378
daam2
dishevelled associated activator of morphogenesis 2
chr14_+_5117072 2.32 ENSDART00000189628
nanos1
nanos homolog 1
chr9_-_135774 2.27 ENSDART00000160435
FQ377903.1

chr6_+_10450000 2.17 ENSDART00000151288
ENSDART00000187431
ENSDART00000192474
ENSDART00000188214
ENSDART00000184766
ENSDART00000190082
kcnh7
potassium channel, voltage gated eag related subfamily H, member 7
chr4_+_38981587 2.13 ENSDART00000142713
si:dkey-66k12.3
si:dkey-66k12.3
chr3_+_53052769 2.02 ENSDART00000156935
pbx4
pre-B-cell leukemia transcription factor 4
chr5_+_36614196 2.00 ENSDART00000150574
nova1
neuro-oncological ventral antigen 1
chr14_-_41075262 1.95 ENSDART00000180518
drp2
dystrophin related protein 2
chr5_-_45651548 1.94 ENSDART00000097645
NPFFR2
neuropeptide FF receptor 2a
chr4_+_8376362 1.94 ENSDART00000138653
ENSDART00000132647
erc1b
ELKS/RAB6-interacting/CAST family member 1b
chr3_+_3469600 1.86 ENSDART00000113616
zgc:171426
zgc:171426
chr11_-_18017287 1.86 ENSDART00000155443
qrich1
glutamine-rich 1
chr19_+_37701450 1.86 ENSDART00000087694
thsd7aa
thrombospondin, type I, domain containing 7Aa
chr17_-_36988455 1.83 ENSDART00000187180
ENSDART00000126823
dnmt3ab
DNA (cytosine-5-)-methyltransferase 3 alpha b
chr14_-_45394704 1.81 ENSDART00000173078
ENSDART00000125970
si:ch211-168f7.5
si:ch211-168f7.5
chr14_+_44588353 1.80 ENSDART00000173421
lingo2a
leucine rich repeat and Ig domain containing 2a
chr19_-_19556778 1.74 ENSDART00000164060
tax1bp1a
Tax1 (human T-cell leukemia virus type I) binding protein 1a
chr3_-_56933578 1.72 ENSDART00000192185
hid1a
HID1 domain containing a
chr20_+_700616 1.72 ENSDART00000168166
senp6a
SUMO1/sentrin specific peptidase 6a
chr2_+_33796207 1.71 ENSDART00000124647
kiss1ra
KISS1 receptor a
chr17_+_37215820 1.70 ENSDART00000104009
slc30a1b
solute carrier family 30 (zinc transporter), member 1b
chr2_+_49246099 1.65 ENSDART00000179089
sema6ba
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Ba
chr21_+_25777425 1.64 ENSDART00000021620
cldnd
claudin d
chr11_+_575665 1.63 ENSDART00000122133
mkrn2os.1
MKRN2 opposite strand, tandem duplicate 1
chr15_-_18429550 1.60 ENSDART00000136208
ncam1b
neural cell adhesion molecule 1b
chr5_-_24270989 1.59 ENSDART00000146251
si:ch211-137i24.12
si:ch211-137i24.12
chr20_-_1314537 1.56 ENSDART00000144288
pcmt
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr22_-_14247276 1.53 ENSDART00000033332
si:ch211-246m6.5
si:ch211-246m6.5
chr15_-_30816370 1.51 ENSDART00000142982
ENSDART00000050649
ENSDART00000136901
ENSDART00000100194
msi2b
musashi RNA-binding protein 2b
chr2_+_29257942 1.47 ENSDART00000184362
ENSDART00000025562
cdh18a
cadherin 18, type 2a
chr4_-_23643272 1.43 ENSDART00000112301
ENSDART00000133184
trhde.2
thyrotropin releasing hormone degrading enzyme, tandem duplicate 2
chr17_+_51499789 1.40 ENSDART00000187701
CABZ01067581.1

chr12_-_44070043 1.40 ENSDART00000180059
si:ch73-329n5.3
si:ch73-329n5.3
chr10_+_5954787 1.40 ENSDART00000161887
ENSDART00000160345
ENSDART00000190046
map3k1
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
chr3_+_1211242 1.38 ENSDART00000171287
ENSDART00000165769
poldip3
polymerase (DNA-directed), delta interacting protein 3
chr24_-_37877554 1.37 ENSDART00000132219
tmem204
transmembrane protein 204
chr12_+_48851381 1.37 ENSDART00000187241
ENSDART00000187796
dlg5b.1
discs, large homolog 5b (Drosophila), tandem duplicate 1
chr15_-_43284021 1.36 ENSDART00000041677
serpine2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr23_+_45611649 1.35 ENSDART00000169521
dclk2b
doublecortin-like kinase 2b
chr2_-_16216568 1.31 ENSDART00000173758
arhgef4
Rho guanine nucleotide exchange factor (GEF) 4
chr23_+_32101361 1.30 ENSDART00000138849
zgc:56699
zgc:56699
chr18_+_18000887 1.30 ENSDART00000147797
si:ch211-212o1.2
si:ch211-212o1.2
chr18_-_7454422 1.24 ENSDART00000124709
pdp2
putative pyruvate dehydrogenase phosphatase isoenzyme 2
chr10_-_28477023 1.19 ENSDART00000137008
bbx
bobby sox homolog (Drosophila)
chr23_+_32101202 1.18 ENSDART00000000992
zgc:56699
zgc:56699
chr7_-_50604626 1.14 ENSDART00000073903
ENSDART00000174031
crtc3
CREB regulated transcription coactivator 3
chr11_-_3334248 1.10 ENSDART00000154314
ENSDART00000121861
prph
peripherin
chr6_+_54498220 1.08 ENSDART00000103282
si:ch211-233f11.5
si:ch211-233f11.5
chr3_+_30501135 1.05 ENSDART00000165869
si:dkey-13n23.3
si:dkey-13n23.3
chr19_+_43017931 1.04 ENSDART00000132213
nkain1
sodium/potassium transporting ATPase interacting 1
chr22_+_26703026 1.01 ENSDART00000158756
crebbpa
CREB binding protein a
chr22_+_29067388 1.00 ENSDART00000133673
pimr100
Pim proto-oncogene, serine/threonine kinase, related 100
chr10_-_26997344 1.00 ENSDART00000146595
zgc:193742
zgc:193742
chr23_+_20931030 0.99 ENSDART00000167014
pax7b
paired box 7b
chr22_+_28888781 0.95 ENSDART00000145629
pimr98
Pim proto-oncogene, serine/threonine kinase, related 98
chr14_+_3071110 0.90 ENSDART00000162445
hmgxb3
HMG box domain containing 3
chr23_+_39413163 0.87 ENSDART00000184254
src
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr1_-_54971968 0.86 ENSDART00000140016
khsrp
KH-type splicing regulatory protein
chr5_-_14211487 0.86 ENSDART00000135731
npffr1l2
neuropeptide FF receptor 1 like 2
chr22_-_37349967 0.85 ENSDART00000104493
sox2
SRY (sex determining region Y)-box 2
chr4_+_53268458 0.84 ENSDART00000165335
si:dkey-250k10.1
si:dkey-250k10.1
chr20_-_48470599 0.82 ENSDART00000166857
CABZ01059120.1

chr12_+_20149707 0.81 ENSDART00000181942
foxj1b
forkhead box J1b
chr22_+_28995391 0.79 ENSDART00000164486
pimr99
Pim proto-oncogene, serine/threonine kinase, related 99
chr13_+_52006253 0.78 ENSDART00000181259
CABZ01080135.1

chr7_-_74090168 0.75 ENSDART00000050528
tyrp1a
tyrosinase-related protein 1a
chr20_-_3403033 0.75 ENSDART00000092264
rev3l
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr1_-_16394814 0.74 ENSDART00000013024
fgf20a
fibroblast growth factor 20a
chr22_+_29027037 0.73 ENSDART00000170071
pimr97
Pim proto-oncogene, serine/threonine kinase, related 97
chr9_+_156142 0.73 ENSDART00000171501
cldn10b
claudin 10b
chr7_+_25323742 0.71 ENSDART00000110347
cyp26b1
cytochrome P450, family 26, subfamily b, polypeptide 1
chr19_+_1005933 0.71 ENSDART00000191953
zdhhc3b
zinc finger, DHHC-type containing 3b
chr22_+_29009541 0.69 ENSDART00000169449
pimr97
Pim proto-oncogene, serine/threonine kinase, related 97
chr1_-_59251874 0.69 ENSDART00000168919
olfm2b
olfactomedin 2b
chr9_-_128036 0.66 ENSDART00000165960
FQ377903.2

chr23_-_45682136 0.61 ENSDART00000164646
fam160a1b
family with sequence similarity 160, member A1b
chr12_-_48312647 0.60 ENSDART00000114415
ascc1
activating signal cointegrator 1 complex subunit 1
chr20_-_36408836 0.56 ENSDART00000076419
lbr
lamin B receptor
chr22_+_569565 0.52 ENSDART00000037069
usp49
ubiquitin specific peptidase 49
chr18_-_50947868 0.51 ENSDART00000174276
st7
suppression of tumorigenicity 7
chr14_-_3070613 0.50 ENSDART00000193729
ENSDART00000090196
slc35a4
solute carrier family 35, member A4
chr3_+_30500968 0.50 ENSDART00000103447
si:dkey-13n23.3
si:dkey-13n23.3
chr15_+_2559875 0.48 ENSDART00000178505
SH2B2
SH2B adaptor protein 2
chr3_+_23029934 0.46 ENSDART00000110343
nags
N-acetylglutamate synthase
chr24_+_10397865 0.45 ENSDART00000155557
si:ch211-69l10.4
si:ch211-69l10.4
chr10_-_28519505 0.39 ENSDART00000137964
bbx
bobby sox homolog (Drosophila)
chr8_-_39977026 0.38 ENSDART00000141707
asphd2
aspartate beta-hydroxylase domain containing 2
chr1_-_54972170 0.38 ENSDART00000150548
ENSDART00000038330
khsrp
KH-type splicing regulatory protein
chr7_-_38861741 0.36 ENSDART00000173629
ENSDART00000037361
ENSDART00000173953
phf21aa
PHD finger protein 21Aa
chr3_-_47038481 0.36 ENSDART00000193260
CR392045.1

chr14_-_31619408 0.34 ENSDART00000173277
mmgt1
membrane magnesium transporter 1
chr12_+_41510492 0.33 ENSDART00000170976
ENSDART00000176164
kif5bb
kinesin family member 5B, b
chr8_-_53926228 0.33 ENSDART00000015554
ubiad1
UbiA prenyltransferase domain containing 1
chr11_-_27827442 0.29 ENSDART00000121847
ENSDART00000132018
ENSDART00000145744
ENSDART00000134677
ENSDART00000130800
cstf1
cleavage stimulation factor, 3' pre-RNA, subunit 1
chr4_-_72513569 0.28 ENSDART00000174130
CR788316.4

chr13_-_36184476 0.24 ENSDART00000057185
map3k9
mitogen-activated protein kinase kinase kinase 9
chr16_-_19026414 0.23 ENSDART00000141208
pimr98
Pim proto-oncogene, serine/threonine kinase, related 98
chr24_-_37877743 0.22 ENSDART00000105658
tmem204
transmembrane protein 204
chr12_+_41991635 0.22 ENSDART00000186161
ENSDART00000192510
TCERG1L
transcription elongation regulator 1 like
chr6_+_42918933 0.20 ENSDART00000064896
gnat1
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
chr8_+_38417461 0.17 ENSDART00000132718
nkx6.3
NK6 homeobox 3
chr2_-_43739740 0.17 ENSDART00000113849
kif5ba
kinesin family member 5B, a
chr17_+_10094063 0.17 ENSDART00000168055
sec23a
Sec23 homolog A, COPII coat complex component
chr23_+_36178104 0.11 ENSDART00000103131
hoxc1a
homeobox C1a
chr16_+_35395597 0.11 ENSDART00000158143
si:dkey-34d22.5
si:dkey-34d22.5
chr10_-_28519309 0.11 ENSDART00000142476
bbx
bobby sox homolog (Drosophila)
chr2_-_51095743 0.09 ENSDART00000184646
THEM6
si:ch73-52e5.2
chr12_-_45875946 0.09 ENSDART00000149970
pax2b
paired box 2b
chr1_+_56779495 0.06 ENSDART00000192871
FO680692.1

chr20_+_560805 0.06 ENSDART00000152149
si:dkey-121j17.6
si:dkey-121j17.6
chr8_-_51524446 0.06 ENSDART00000167394
ENSDART00000147742
fgfr1a
fibroblast growth factor receptor 1a

Network of associatons between targets according to the STRING database.

First level regulatory network of mtf1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.7 23.6 GO:2000767 positive regulation of cytoplasmic translation(GO:2000767)
1.6 6.5 GO:0035630 bone mineralization involved in bone maturation(GO:0035630)
0.8 2.3 GO:0014014 negative regulation of gliogenesis(GO:0014014)
0.4 1.7 GO:0090230 regulation of centromere complex assembly(GO:0090230) regulation of kinetochore assembly(GO:0090234)
0.4 3.4 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.3 2.0 GO:0003232 bulbus arteriosus development(GO:0003232)
0.3 1.6 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.3 1.2 GO:1904184 regulation of pyruvate dehydrogenase activity(GO:1904182) positive regulation of pyruvate dehydrogenase activity(GO:1904184)
0.3 1.8 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
0.3 0.9 GO:0050847 progesterone receptor signaling pathway(GO:0050847)
0.2 0.7 GO:0035992 tendon formation(GO:0035992)
0.2 1.9 GO:0021628 olfactory nerve development(GO:0021553) olfactory nerve morphogenesis(GO:0021627) olfactory nerve formation(GO:0021628)
0.2 3.9 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.2 3.0 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.2 1.0 GO:0050938 regulation of xanthophore differentiation(GO:0050938)
0.2 4.2 GO:0030032 lamellipodium assembly(GO:0030032)
0.2 1.9 GO:0048790 maintenance of presynaptic active zone structure(GO:0048790) maintenance of synapse structure(GO:0099558)
0.2 1.1 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.1 2.4 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 2.8 GO:0097320 membrane tubulation(GO:0097320)
0.1 6.4 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.1 5.6 GO:0043297 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.1 5.5 GO:0042752 regulation of circadian rhythm(GO:0042752)
0.1 0.8 GO:0021982 pineal gland development(GO:0021982)
0.1 2.3 GO:0008354 germ cell migration(GO:0008354)
0.1 0.5 GO:0006526 arginine biosynthetic process(GO:0006526)
0.1 0.3 GO:0071498 vitamin K metabolic process(GO:0042373) cellular response to fluid shear stress(GO:0071498)
0.1 1.5 GO:0021988 olfactory bulb development(GO:0021772) olfactory lobe development(GO:0021988)
0.1 5.8 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.1 0.8 GO:0006582 melanin metabolic process(GO:0006582) melanin biosynthetic process(GO:0042438)
0.1 0.8 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.1 4.3 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.1 0.7 GO:0046850 regulation of bone remodeling(GO:0046850)
0.1 1.8 GO:0006306 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.1 2.9 GO:0001706 endoderm formation(GO:0001706)
0.1 0.8 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.1 1.9 GO:0072015 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0 1.4 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.3 GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence(GO:0045050)
0.0 1.6 GO:0002377 immunoglobulin production(GO:0002377)
0.0 1.5 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.6 GO:0061055 myotome development(GO:0061055)
0.0 0.5 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.0 7.6 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 4.9 GO:0072659 protein localization to plasma membrane(GO:0072659) protein localization to cell periphery(GO:1990778)
0.0 5.3 GO:0061053 somite development(GO:0061053)
0.0 1.0 GO:0002028 regulation of sodium ion transport(GO:0002028)
0.0 1.1 GO:0045103 intermediate filament-based process(GO:0045103) intermediate filament cytoskeleton organization(GO:0045104)
0.0 0.2 GO:0098971 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.0 2.5 GO:0007283 spermatogenesis(GO:0007283)
0.0 7.2 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 0.7 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 3.0 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.0 0.2 GO:0035587 adenosine receptor signaling pathway(GO:0001973) purinergic receptor signaling pathway(GO:0035587) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0 0.6 GO:1902653 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.0 1.7 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 4.1 GO:0032259 methylation(GO:0032259)
0.0 0.2 GO:0043507 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.0 1.1 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 2.1 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 0.3 GO:0060349 bone morphogenesis(GO:0060349)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 19.8 GO:0005869 dynactin complex(GO:0005869)
0.5 3.0 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.3 1.7 GO:0005797 Golgi medial cisterna(GO:0005797)
0.3 2.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.3 6.4 GO:0043195 terminal bouton(GO:0043195)
0.1 4.9 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 4.3 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 5.5 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.1 6.5 GO:0005581 collagen trimer(GO:0005581)
0.1 2.3 GO:0060293 germ plasm(GO:0060293)
0.1 1.9 GO:0048788 cytoskeleton of presynaptic active zone(GO:0048788) presynaptic active zone cytoplasmic component(GO:0098831)
0.1 0.8 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 0.8 GO:0042575 DNA polymerase complex(GO:0042575)
0.1 7.3 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 1.5 GO:0005844 polysome(GO:0005844)
0.0 0.3 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 1.5 GO:0016342 catenin complex(GO:0016342)
0.0 1.6 GO:1903293 protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.0 0.6 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.3 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.0 0.8 GO:0030173 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 1.1 GO:0005882 intermediate filament(GO:0005882)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.1 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.6 25.9 GO:0045182 translation regulator activity(GO:0045182)
0.5 7.5 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.3 2.4 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.3 1.2 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.2 0.7 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.2 9.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.2 1.7 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.2 1.1 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.2 0.5 GO:0034618 arginine binding(GO:0034618)
0.1 1.8 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1 1.2 GO:0017091 AU-rich element binding(GO:0017091) mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 5.5 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 3.9 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.1 1.9 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.1 5.8 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 4.9 GO:0044325 ion channel binding(GO:0044325)
0.1 1.8 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 2.9 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 5.5 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.3 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 1.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 2.6 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 0.3 GO:0032977 membrane insertase activity(GO:0032977)
0.0 0.8 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.2 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 1.6 GO:0070851 growth factor receptor binding(GO:0070851)
0.0 0.5 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 2.2 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 0.6 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 1.0 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 1.0 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 1.6 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.7 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 1.5 GO:0045296 cadherin binding(GO:0045296)
0.0 9.8 GO:0005198 structural molecule activity(GO:0005198)
0.0 9.3 GO:0004674 protein serine/threonine kinase activity(GO:0004674)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 7.2 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 0.9 ST STAT3 PATHWAY STAT3 Pathway
0.0 3.0 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 2.5 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 1.4 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 1.3 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 0.5 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 2.5 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.3 PID BARD1 PATHWAY BARD1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 7.5 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.2 2.5 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.1 1.2 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 0.9 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 0.5 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.1 3.4 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.1 1.2 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.1 3.9 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 2.2 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.4 REACTOME TRAF6 MEDIATED NFKB ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.0 0.2 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 1.3 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 1.9 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.3 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs