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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for mycn
Z-value: 1.16
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Transcription factors associated with mycn
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| mycn | dr11_v1_chr20_+_33294428_33294428 | -0.33 | 1.4e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of mycn
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 15.0 | GO:0009749 | response to glucose(GO:0009749) |
| 0.7 | 14.8 | GO:0050829 | defense response to Gram-negative bacterium(GO:0050829) |
| 0.4 | 13.3 | GO:0006383 | transcription from RNA polymerase III promoter(GO:0006383) |
| 1.1 | 11.2 | GO:0006189 | 'de novo' IMP biosynthetic process(GO:0006189) |
| 2.0 | 9.9 | GO:0010872 | regulation of cholesterol esterification(GO:0010872) positive regulation of cholesterol esterification(GO:0010873) |
| 0.3 | 9.8 | GO:0030488 | tRNA methylation(GO:0030488) |
| 2.3 | 9.2 | GO:0046900 | tetrahydrofolylpolyglutamate metabolic process(GO:0046900) |
| 1.5 | 8.8 | GO:0044209 | AMP salvage(GO:0044209) |
| 0.1 | 8.4 | GO:0051091 | positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091) |
| 0.1 | 8.3 | GO:0006364 | rRNA processing(GO:0006364) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 33.4 | GO:0005730 | nucleolus(GO:0005730) |
| 0.0 | 25.4 | GO:0005829 | cytosol(GO:0005829) |
| 0.3 | 14.6 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.6 | 13.3 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.2 | 12.6 | GO:0005902 | microvillus(GO:0005902) |
| 0.8 | 9.9 | GO:0042627 | chylomicron(GO:0042627) |
| 1.4 | 7.0 | GO:0031515 | tRNA (m1A) methyltransferase complex(GO:0031515) |
| 0.1 | 5.5 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 5.4 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 5.1 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 17.1 | GO:0004540 | ribonuclease activity(GO:0004540) |
| 3.6 | 14.6 | GO:0004373 | glycogen (starch) synthase activity(GO:0004373) |
| 0.0 | 10.9 | GO:0003723 | RNA binding(GO:0003723) |
| 2.0 | 9.9 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 0.4 | 9.2 | GO:0016881 | acid-amino acid ligase activity(GO:0016881) |
| 0.2 | 8.4 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.9 | 8.1 | GO:0004731 | purine-nucleoside phosphorylase activity(GO:0004731) |
| 0.0 | 8.1 | GO:0022834 | ligand-gated ion channel activity(GO:0015276) ligand-gated channel activity(GO:0022834) |
| 1.1 | 7.8 | GO:0015189 | L-lysine transmembrane transporter activity(GO:0015189) |
| 0.3 | 7.6 | GO:0008483 | transaminase activity(GO:0008483) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.2 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.2 | 3.9 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.1 | 3.9 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.0 | 3.0 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 2.8 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.3 | 2.0 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.1 | 1.8 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.0 | 1.5 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.2 | 1.4 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 1.0 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 17.6 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |
| 0.2 | 13.1 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.8 | 11.2 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.4 | 11.0 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.5 | 10.7 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 1.0 | 7.1 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.0 | 6.2 | REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | Genes involved in Class A/1 (Rhodopsin-like receptors) |
| 0.3 | 5.9 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.1 | 5.3 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.4 | 5.1 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |