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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for myog
Z-value: 1.31
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Transcription factors associated with myog
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| myog | dr11_v1_chr11_-_22599584_22599584 | 0.59 | 5.3e-10 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of myog
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 24.8 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 0.0 | 24.2 | GO:0016567 | protein ubiquitination(GO:0016567) |
| 0.2 | 22.4 | GO:0061515 | myeloid cell development(GO:0061515) |
| 7.2 | 21.7 | GO:0098528 | skeletal muscle fiber differentiation(GO:0098528) |
| 4.8 | 19.2 | GO:0014724 | regulation of twitch skeletal muscle contraction(GO:0014724) regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448) negative regulation of striated muscle contraction(GO:0045988) relaxation of skeletal muscle(GO:0090076) |
| 1.0 | 16.6 | GO:0048769 | sarcomerogenesis(GO:0048769) |
| 0.8 | 15.9 | GO:0006942 | regulation of striated muscle contraction(GO:0006942) |
| 3.5 | 14.1 | GO:0006740 | NADPH regeneration(GO:0006740) |
| 1.4 | 12.8 | GO:0046716 | muscle cell cellular homeostasis(GO:0046716) |
| 1.5 | 12.3 | GO:0032889 | regulation of vacuole fusion, non-autophagic(GO:0032889) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 36.9 | GO:0031672 | A band(GO:0031672) |
| 0.7 | 31.4 | GO:0005901 | caveola(GO:0005901) plasma membrane raft(GO:0044853) |
| 0.2 | 22.2 | GO:0005884 | actin filament(GO:0005884) |
| 0.1 | 21.8 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 4.8 | 19.2 | GO:0031673 | H zone(GO:0031673) |
| 0.2 | 15.8 | GO:0000786 | nucleosome(GO:0000786) |
| 0.7 | 15.7 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.3 | 13.7 | GO:0005861 | troponin complex(GO:0005861) |
| 1.5 | 12.3 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.1 | 12.1 | GO:0005925 | cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 22.9 | GO:0042803 | protein homodimerization activity(GO:0042803) |
| 1.1 | 19.2 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.1 | 17.3 | GO:0051015 | actin filament binding(GO:0051015) |
| 1.0 | 14.6 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 3.5 | 14.1 | GO:0008746 | NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652) |
| 1.2 | 13.7 | GO:0030172 | troponin C binding(GO:0030172) troponin I binding(GO:0031013) |
| 0.3 | 13.0 | GO:0042826 | histone deacetylase binding(GO:0042826) |
| 1.5 | 12.3 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.1 | 12.2 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.1 | 12.2 | GO:0008757 | S-adenosylmethionine-dependent methyltransferase activity(GO:0008757) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 10.1 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.2 | 9.3 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.2 | 7.5 | PID BMP PATHWAY | BMP receptor signaling |
| 0.2 | 6.1 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 5.4 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.2 | 4.8 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.2 | 4.4 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.1 | 4.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 2.2 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 19.2 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.1 | 8.5 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.2 | 6.8 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.3 | 6.6 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.6 | 6.1 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.2 | 3.9 | REACTOME PIP3 ACTIVATES AKT SIGNALING | Genes involved in PIP3 activates AKT signaling |
| 0.0 | 3.9 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.5 | 3.8 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.1 | 2.7 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.1 | 2.5 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |