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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for nfat5a+nfat5b

Z-value: 0.77

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Transcription factors associated with nfat5a+nfat5b

Gene Symbol Gene ID Gene Info
nfat5a
ENSDARG00000020872 nuclear factor of activated T cells 5a
nfat5b
ENSDARG00000102556 nuclear factor of activated T cells 5b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nfat5adr11_v1_chr25_-_37121335_37121335-0.232.9e-02Click!
nfat5bdr11_v1_chr7_+_67381912_673819120.103.3e-01Click!

Activity profile of nfat5a+nfat5b motif

Sorted Z-values of nfat5a+nfat5b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_55982940 9.48 ENSDART00000097753
ENSDART00000097751
nmrk2
nicotinamide riboside kinase 2
chr2_+_55982300 8.34 ENSDART00000183903
nmrk2
nicotinamide riboside kinase 2
chr16_+_23397785 7.57 ENSDART00000148961
s100a10b
S100 calcium binding protein A10b
chr9_-_43082945 7.25 ENSDART00000142257
ccdc141
coiled-coil domain containing 141
chr11_-_30611814 7.23 ENSDART00000089803
slc8a1a
solute carrier family 8 (sodium/calcium exchanger), member 1a
chr16_+_23398369 6.90 ENSDART00000037694
s100a10b
S100 calcium binding protein A10b
chr3_-_32590164 6.51 ENSDART00000151151
tspan4b
tetraspanin 4b
chr11_-_30612166 6.21 ENSDART00000177984
slc8a1a
solute carrier family 8 (sodium/calcium exchanger), member 1a
chr6_+_49095646 5.37 ENSDART00000103385
slc25a55a
solute carrier family 25, member 55a
chr20_-_29787192 4.98 ENSDART00000125348
ENSDART00000048759
id2b
inhibitor of DNA binding 2b
chr2_-_20923864 4.84 ENSDART00000006870
ptgs2a
prostaglandin-endoperoxide synthase 2a
chr25_+_34013093 4.66 ENSDART00000011967
anxa2a
annexin A2a
chr3_-_2033105 4.02 ENSDART00000135249
si:dkey-88j15.3
si:dkey-88j15.3
chr6_+_2097690 3.99 ENSDART00000193770
tgm2b
transglutaminase 2b
chr20_-_23852174 3.82 ENSDART00000122414
si:dkey-15j16.6
si:dkey-15j16.6
chr13_-_42749916 3.70 ENSDART00000140019
capn2a
calpain 2, (m/II) large subunit a
chr20_-_487783 3.70 ENSDART00000162218
col10a1b
collagen, type X, alpha 1b
chr1_-_29658721 3.67 ENSDART00000132063
si:dkey-1h24.6
si:dkey-1h24.6
chr7_+_12950507 3.36 ENSDART00000067629
ENSDART00000158004
saa
serum amyloid A
chr21_-_17603182 3.20 ENSDART00000020048
ENSDART00000177270
gsna
gelsolin a
chr12_-_30549022 3.18 ENSDART00000102474
zgc:158404
zgc:158404
chr3_-_1906976 3.15 ENSDART00000180953
zgc:101806
zgc:101806
chr2_-_26499842 3.13 ENSDART00000186929
BX569796.1

chr6_-_50704689 3.06 ENSDART00000074100
osgn1
oxidative stress induced growth inhibitor 1
chr2_+_23790748 3.05 ENSDART00000041877
csrnp1a
cysteine-serine-rich nuclear protein 1a
chr9_+_33145522 3.04 ENSDART00000005879
atp5po
ATP synthase peripheral stalk subunit OSCP
chr8_+_31872992 2.97 ENSDART00000146933
c7a
complement component 7a
chr11_+_11751006 2.83 ENSDART00000180372
ENSDART00000081018
jupa
junction plakoglobin a
chr19_-_8748571 2.76 ENSDART00000031173
rps27.1
ribosomal protein S27, isoform 1
chr2_-_37862380 2.71 ENSDART00000186005
si:ch211-284o19.8
si:ch211-284o19.8
chr10_+_22782522 2.69 ENSDART00000079498
ENSDART00000145558
si:ch211-237l4.6
si:ch211-237l4.6
chr24_-_24060632 2.67 ENSDART00000090514
abcc13
ATP-binding cassette, sub-family C (CFTR/MRP), member 13
chr3_-_40529782 2.67 ENSDART00000055194
ENSDART00000141737
actb2
actin, beta 2
chr24_-_19719240 2.62 ENSDART00000135405
csrnp1b
cysteine-serine-rich nuclear protein 1b
chr7_+_29115890 2.62 ENSDART00000052345
tradd
tnfrsf1a-associated via death domain
chr2_+_31382590 2.49 ENSDART00000086863
colec12
collectin sub-family member 12
chr3_-_31019715 2.30 ENSDART00000156687
ENSDART00000156127
ENSDART00000153945
si:dkeyp-71f10.5
si:dkeyp-71f10.5
chr5_-_63109232 2.16 ENSDART00000115128
usp2b
ubiquitin specific peptidase 2b
chr19_-_25149034 2.02 ENSDART00000148432
ENSDART00000175266
ptp4a3
protein tyrosine phosphatase type IVA, member 3
chr17_+_33415319 2.02 ENSDART00000140805
ENSDART00000025501
ENSDART00000146447
snap23.1
synaptosomal-associated protein 23.1
chr15_+_33989181 1.99 ENSDART00000169487
vwde
von Willebrand factor D and EGF domains
chr12_-_10441661 1.96 ENSDART00000014379
uqcrc2b
ubiquinol-cytochrome c reductase core protein 2b
chr14_-_33218418 1.95 ENSDART00000163046
si:dkey-31j3.11
si:dkey-31j3.11
chr13_+_23623346 1.93 ENSDART00000057619
il22ra2
interleukin 22 receptor, alpha 2
chr9_+_30478768 1.92 ENSDART00000101097
acp6
acid phosphatase 6, lysophosphatidic
chr5_-_42904329 1.90 ENSDART00000112807
cxcl20
chemokine (C-X-C motif) ligand 20
chr16_+_34046733 1.90 ENSDART00000058424
fam46ba
family with sequence similarity 46, member Ba
chr2_+_36616830 1.88 ENSDART00000169547
ENSDART00000098417
pak2a
p21 protein (Cdc42/Rac)-activated kinase 2a
chr21_+_26657404 1.87 ENSDART00000129035
ENSDART00000186550
prdx5
peroxiredoxin 5
chr17_+_33415542 1.86 ENSDART00000183169
snap23.1
synaptosomal-associated protein 23.1
chr5_-_37900350 1.84 ENSDART00000084839
ENSDART00000084841
ENSDART00000133437
tmprss13b
transmembrane protease, serine 13b
chr23_-_45897900 1.73 ENSDART00000149263
ftr92
finTRIM family, member 92
chr6_+_58607488 1.73 ENSDART00000182648
helz2
helicase with zinc finger 2, transcriptional coactivator
chr6_-_36552844 1.68 ENSDART00000023613
her6
hairy-related 6
chr20_+_10498704 1.65 ENSDART00000192985
zgc:100997
zgc:100997
chr1_+_57041549 1.64 ENSDART00000152198
si:ch211-1f22.16
si:ch211-1f22.16
chr21_+_6291027 1.63 ENSDART00000180467
ENSDART00000184952
ENSDART00000184006
fnbp1b
formin binding protein 1b
chr2_-_24369087 1.61 ENSDART00000081237
plvapa
plasmalemma vesicle associated protein a
chr8_-_15292197 1.55 ENSDART00000140867
spata6
spermatogenesis associated 6
chr3_-_1938588 1.52 ENSDART00000013001
ENSDART00000186405
zgc:152753
zgc:152753
chr2_-_42492445 1.50 ENSDART00000139929
esyt2a
extended synaptotagmin-like protein 2a
chr15_+_37950556 1.47 ENSDART00000153947
si:dkey-238d18.12
si:dkey-238d18.12
chr10_+_1899595 1.45 ENSDART00000040271
CU861476.1

chr9_-_46415847 1.37 ENSDART00000009790
cx43.4
connexin 43.4
chr9_+_6255682 1.37 ENSDART00000149827
uxs1
UDP-glucuronate decarboxylase 1
chr10_+_4807913 1.36 ENSDART00000186099
palm2
paralemmin 2
chr6_+_51932563 1.36 ENSDART00000181778
angpt4
angiopoietin 4
chr8_+_20440297 1.34 ENSDART00000189486
mknk2b
MAP kinase interacting serine/threonine kinase 2b
chr4_+_47751483 1.34 ENSDART00000160043
si:ch211-196f19.1
si:ch211-196f19.1
chr4_+_57093908 1.25 ENSDART00000170198
si:ch211-238e22.5
si:ch211-238e22.5
chr13_+_33024547 1.22 ENSDART00000057377
arg2
arginase 2
chr22_-_32360464 1.22 ENSDART00000148886
pcbp4
poly(rC) binding protein 4
chr21_+_15865523 1.20 ENSDART00000155098
gcnt4b
glucosaminyl (N-acetyl) transferase 4, core 2, b
chr7_-_48667056 1.18 ENSDART00000006378
cdkn1ca
cyclin-dependent kinase inhibitor 1Ca
chr4_+_76722754 1.13 ENSDART00000153867
ms4a17a.3
membrane-spanning 4-domains, subfamily A, member 17A.3
chr21_+_5494561 1.13 ENSDART00000169728
ly6m3
lymphocyte antigen 6 family member M3
chr19_-_3781405 1.11 ENSDART00000170609
btr19
bloodthirsty-related gene family, member 19
chr3_-_26921475 1.09 ENSDART00000130281
ciita
class II, major histocompatibility complex, transactivator
chr21_-_2814709 1.03 ENSDART00000097664
SEMA4D
semaphorin 4D
chr25_-_35136267 1.03 ENSDART00000109751
zgc:173585
zgc:173585
chr2_-_42492201 1.02 ENSDART00000180762
ENSDART00000009093
esyt2a
extended synaptotagmin-like protein 2a
chr7_+_56098590 1.00 ENSDART00000098453
cdh15
cadherin 15, type 1, M-cadherin (myotubule)
chr2_-_29996036 1.00 ENSDART00000020792
cnpy1
canopy1
chr4_-_52504961 1.00 ENSDART00000163123
si:dkey-78o7.3
si:dkey-78o7.3
chr10_+_44955106 0.96 ENSDART00000185837
il1b
interleukin 1, beta
chr1_+_56972616 0.92 ENSDART00000152812
si:ch211-1f22.11
si:ch211-1f22.11
chr9_+_1352603 0.90 ENSDART00000146016
casp8l2
caspase 8, apoptosis-related cysteine peptidase, like 2
chr23_-_27875140 0.90 ENSDART00000143662
ankrd33aa
ankyrin repeat domain 33Aa
chr12_-_17024079 0.89 ENSDART00000129027
ifit11
interferon-induced protein with tetratricopeptide repeats 11
chr9_+_23003208 0.87 ENSDART00000021060
eaf2
ELL associated factor 2
chr20_+_10498986 0.87 ENSDART00000064114
zgc:100997
zgc:100997
chr1_+_19303241 0.86 ENSDART00000129970
si:dkeyp-118a3.2
si:dkeyp-118a3.2
chr15_-_18209672 0.86 ENSDART00000141508
ENSDART00000136280
btr16
bloodthirsty-related gene family, member 16
chr17_+_7513673 0.85 ENSDART00000156674
klhl10b.1
kelch-like family member 10b, tandem duplicate 1
chr10_+_44986419 0.80 ENSDART00000162566
h2afvb
H2A histone family, member Vb
chr17_-_33414781 0.79 ENSDART00000142203
ENSDART00000034638
ccdc28a
coiled-coil domain containing 28A
chr14_-_34633960 0.79 ENSDART00000128869
ENSDART00000179977
afap1l1a
actin filament associated protein 1-like 1a
chr9_+_53725128 0.78 ENSDART00000169062
cnmd
chondromodulin
chr9_+_310331 0.78 ENSDART00000172446
ENSDART00000187731
ENSDART00000193970
stac3
SH3 and cysteine rich domain 3
chr5_+_53479576 0.75 ENSDART00000099616
ENSDART00000169169
BX323994.1

chr13_+_1015749 0.75 ENSDART00000190982
prokr1b
prokineticin receptor 1b
chr10_+_13209580 0.73 ENSDART00000000887
ENSDART00000136932
rassf6
Ras association (RalGDS/AF-6) domain family 6
chr2_-_43151358 0.72 ENSDART00000061170
ENSDART00000056161
ftr15
finTRIM family, member 15
chr17_+_36627099 0.72 ENSDART00000154104
impg1b
interphotoreceptor matrix proteoglycan 1b
chr19_+_15440841 0.71 ENSDART00000182329
lin28a
lin-28 homolog A (C. elegans)
chr7_+_48667081 0.68 ENSDART00000083473
trpm5
transient receptor potential cation channel, subfamily M, member 5
chr16_-_14587332 0.67 ENSDART00000012479
dscc1
DNA replication and sister chromatid cohesion 1
chr9_+_53725294 0.66 ENSDART00000165991
cnmd
chondromodulin
chr16_+_33902006 0.65 ENSDART00000161807
ENSDART00000159474
gnl2
guanine nucleotide binding protein-like 2 (nucleolar)
chr13_-_24874950 0.63 ENSDART00000077775
kat6b
K(lysine) acetyltransferase 6B
chr16_-_28836523 0.63 ENSDART00000108596
ENSDART00000142920
plin6
perilipin 6
chr1_+_56502706 0.61 ENSDART00000188665
CABZ01059403.1

chr20_-_52631998 0.61 ENSDART00000145283
ENSDART00000139072
si:ch211-221n20.1
si:ch211-221n20.1
chr4_-_58883559 0.61 ENSDART00000164546
si:dkey-28i19.4
si:dkey-28i19.4
chr7_+_39444843 0.60 ENSDART00000143999
ENSDART00000173554
ENSDART00000173698
ENSDART00000173754
ENSDART00000144075
ENSDART00000138192
ENSDART00000145457
ENSDART00000141750
ENSDART00000103056
ENSDART00000142946
ENSDART00000173748
tnnt3b
troponin T type 3b (skeletal, fast)
chr20_-_52705325 0.60 ENSDART00000136807
ENSDART00000136126
si:ch211-221n20.7
si:ch211-221n20.7
chr23_+_36122058 0.60 ENSDART00000184448
hoxc3a
homeobox C3a
chr17_+_7524389 0.56 ENSDART00000067579
klhl10b.2
kelch-like family member 10b, tandem duplicate 2
chr6_+_40992883 0.55 ENSDART00000076061
tgfa
transforming growth factor, alpha
chr2_+_3881000 0.54 ENSDART00000081897
mpp7b
membrane protein, palmitoylated 7b (MAGUK p55 subfamily member 7)
chr23_-_26522760 0.53 ENSDART00000142417
ENSDART00000135606
ENSDART00000122668
si:dkey-205h13.1
si:dkey-205h13.1
chr2_-_37888429 0.52 ENSDART00000183277
mbl2
mannose binding lectin 2
chr2_+_6999369 0.51 ENSDART00000050597
xpr1b
xenotropic and polytropic retrovirus receptor 1b
chr5_-_49011912 0.51 ENSDART00000097450
si:dkey-172m14.2
si:dkey-172m14.2
chr20_-_51682095 0.50 ENSDART00000142430
si:ch211-14a11.1
si:ch211-14a11.1
chr16_+_31804590 0.50 ENSDART00000167321
wnt4b
wingless-type MMTV integration site family, member 4b
chr12_+_3301149 0.48 ENSDART00000010569
g6pc3
glucose 6 phosphatase, catalytic, 3
chr17_+_33311784 0.48 ENSDART00000156229
si:ch211-132f19.7
si:ch211-132f19.7
chr20_+_34326874 0.46 ENSDART00000061659
ivns1abpa
influenza virus NS1A binding protein a
chr25_+_30074947 0.46 ENSDART00000154849
si:ch211-147k10.5
si:ch211-147k10.5
chr18_-_14860435 0.45 ENSDART00000018502
mapk12a
mitogen-activated protein kinase 12a
chr17_+_43013171 0.45 ENSDART00000055541
gskip
gsk3b interacting protein
chr1_-_23595779 0.45 ENSDART00000134860
ENSDART00000138852
lcorl
ligand dependent nuclear receptor corepressor-like
chr20_-_51697437 0.44 ENSDART00000145391
si:ch211-14a11.2
si:ch211-14a11.2
chr21_+_44557006 0.43 ENSDART00000170159
cmc4
C-x(9)-C motif containing 4 homolog (S. cerevisiae)
chr22_-_9183042 0.42 ENSDART00000178327
si:ch211-213a13.5
si:ch211-213a13.5
chr1_+_44949909 0.41 ENSDART00000067621
vps37c
vacuolar protein sorting 37 homolog C (S. cerevisiae)
chr20_-_52616333 0.41 ENSDART00000138348
ENSDART00000132196
si:ch211-221n20.7
si:ch211-221n20.7
chr15_+_1796313 0.41 ENSDART00000126253
fam124b
family with sequence similarity 124B
chr20_-_52603094 0.41 ENSDART00000136945
ENSDART00000133798
si:dkey-235d18.6
si:dkey-235d18.6
chr1_-_493218 0.40 ENSDART00000031635
ercc5
excision repair cross-complementation group 5
chr21_-_14762944 0.38 ENSDART00000114096
arrdc1b
arrestin domain containing 1b
chr20_-_53624645 0.37 ENSDART00000083427
ENSDART00000152920
slc25a29
solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29
chr5_+_67971627 0.36 ENSDART00000144879
mtif3
mitochondrial translational initiation factor 3
chr20_-_52642504 0.35 ENSDART00000138982
ENSDART00000134999
si:ch211-221n20.2
si:ch211-221n20.2
chr7_+_55950229 0.35 ENSDART00000082780
ACSF3
acyl-CoA synthetase family member 3
chr5_-_49012569 0.34 ENSDART00000184690
si:dkey-172m14.2
si:dkey-172m14.2
chr7_-_2285499 0.32 ENSDART00000182211
si:dkey-187j14.6
si:dkey-187j14.6
chr16_+_12660477 0.32 ENSDART00000016834
aicda
activation-induced cytidine deaminase
chr24_-_24060460 0.32 ENSDART00000142813
abcc13
ATP-binding cassette, sub-family C (CFTR/MRP), member 13
chr4_+_31405646 0.30 ENSDART00000128732
si:rp71-5o12.3
si:rp71-5o12.3
chr4_-_52379723 0.30 ENSDART00000168272
si:dkeyp-107f9.4
si:dkeyp-107f9.4
chr13_-_50139916 0.30 ENSDART00000099475
nid1a
nidogen 1a
chr8_+_1843135 0.30 ENSDART00000141452
snap29
synaptosomal-associated protein 29
chr2_-_5502256 0.29 ENSDART00000193037
saga
S-antigen; retina and pineal gland (arrestin) a
chr16_+_20895904 0.25 ENSDART00000052662
hoxa13b
homeobox A13b
chr16_+_43077909 0.25 ENSDART00000014140
rundc3b
RUN domain containing 3b
chr17_-_33412868 0.23 ENSDART00000187521
BX323819.1

chr21_-_15282452 0.23 ENSDART00000143113
sfswap
splicing factor SWAP
chr9_+_6255973 0.20 ENSDART00000078525
uxs1
UDP-glucuronate decarboxylase 1
chr5_-_62940851 0.19 ENSDART00000137052
specc1
sperm antigen with calponin homology and coiled-coil domains 1
chr17_-_36529449 0.19 ENSDART00000187252
colec11
collectin sub-family member 11
chr21_+_31253048 0.17 ENSDART00000178521
ENSDART00000132317
ENSDART00000040190
asl
argininosuccinate lyase
chr12_-_17602958 0.15 ENSDART00000134690
ENSDART00000028090
eif2ak1
eukaryotic translation initiation factor 2-alpha kinase 1
chr8_-_4789034 0.15 ENSDART00000082256
ciao1
cytosolic iron-sulfur assembly component 1
chr8_-_43677762 0.15 ENSDART00000167762
ep400
E1A binding protein p400
chr10_+_2981090 0.14 ENSDART00000111830
zfyve16
zinc finger, FYVE domain containing 16
chr5_-_13353810 0.14 ENSDART00000146136
ENSDART00000099602
ENSDART00000004539
ube2l3b
ubiquitin-conjugating enzyme E2L 3b
chr20_-_52666150 0.13 ENSDART00000146716
ENSDART00000134155
si:ch211-221n20.4
si:ch211-221n20.4
chr1_+_54194801 0.12 ENSDART00000186802
CABZ01067150.1

chr4_+_10604110 0.10 ENSDART00000122636
ENSDART00000037140
ing3
inhibitor of growth family, member 3
chr15_-_25099233 0.09 ENSDART00000192617
rflnb
refilin B
chr7_+_29009161 0.08 ENSDART00000166458
CR376738.1

chr4_-_53047883 0.08 ENSDART00000157496
si:dkey-201g16.5
si:dkey-201g16.5
chr11_-_12051805 0.08 ENSDART00000110117
ENSDART00000182744
socs7
suppressor of cytokine signaling 7
chr14_-_30945515 0.07 ENSDART00000161540
si:zfos-80g12.1
si:zfos-80g12.1
chr15_-_25099679 0.05 ENSDART00000154628
rflnb
refilin B
chr1_+_2712956 0.03 ENSDART00000126093
gpc6a
glypican 6a

Network of associatons between targets according to the STRING database.

First level regulatory network of nfat5a+nfat5b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.8 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.8 3.0 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.7 13.4 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.6 2.8 GO:0002159 desmosome assembly(GO:0002159)
0.6 3.4 GO:0044364 killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364) disruption of cells of other organism involved in symbiotic interaction(GO:0051818) killing of cells in other organism involved in symbiotic interaction(GO:0051883)
0.5 5.4 GO:0015810 acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490)
0.3 3.8 GO:0031294 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.3 1.4 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.2 1.2 GO:0033119 negative regulation of RNA splicing(GO:0033119) negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.2 1.0 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659) negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.2 0.7 GO:0034088 maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088)
0.2 1.7 GO:0021794 thalamus development(GO:0021794)
0.2 4.0 GO:0018149 peptide cross-linking(GO:0018149)
0.2 0.2 GO:0006526 arginine biosynthetic process(GO:0006526)
0.2 1.2 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.2 0.7 GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000448)
0.2 7.2 GO:0019226 transmission of nerve impulse(GO:0019226)
0.2 1.2 GO:0019627 urea cycle(GO:0000050) urea metabolic process(GO:0019627)
0.1 1.9 GO:0042119 granulocyte activation(GO:0036230) neutrophil activation(GO:0042119)
0.1 0.4 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.1 4.2 GO:0016082 synaptic vesicle priming(GO:0016082)
0.1 0.8 GO:0014808 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880) release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0014808) sarcoplasmic reticulum calcium ion transport(GO:0070296) calcium ion transport from endoplasmic reticulum to cytosol(GO:1903514)
0.1 0.6 GO:0043476 pigment accumulation(GO:0043476)
0.1 2.7 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 5.0 GO:0032922 circadian regulation of gene expression(GO:0032922)
0.1 3.7 GO:0042129 regulation of T cell proliferation(GO:0042129)
0.1 3.2 GO:0051014 actin filament severing(GO:0051014)
0.1 1.5 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.1 2.5 GO:0019835 cytolysis(GO:0019835)
0.1 0.4 GO:0032790 ribosome disassembly(GO:0032790)
0.1 0.3 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 0.8 GO:0030431 sleep(GO:0030431)
0.1 1.9 GO:0097120 receptor localization to synapse(GO:0097120)
0.1 0.5 GO:0014004 microglia differentiation(GO:0014004) cellular anion homeostasis(GO:0030002) cellular monovalent inorganic anion homeostasis(GO:0030320) cellular phosphate ion homeostasis(GO:0030643) cellular divalent inorganic anion homeostasis(GO:0072501) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.1 0.7 GO:0050909 sensory perception of taste(GO:0050909)
0.1 0.6 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) positive regulation of receptor activity(GO:2000273)
0.1 1.9 GO:0052646 alditol phosphate metabolic process(GO:0052646)
0.0 0.1 GO:0061037 negative regulation of chondrocyte differentiation(GO:0032331) negative regulation of cartilage development(GO:0061037) negative regulation of chondrocyte development(GO:0061182) regulation of bone mineralization involved in bone maturation(GO:1900157) negative regulation of bone mineralization involved in bone maturation(GO:1900158) negative regulation of bone development(GO:1903011)
0.0 2.6 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.0 2.6 GO:0030901 midbrain development(GO:0030901)
0.0 0.5 GO:0038203 TORC2 signaling(GO:0038203)
0.0 0.2 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 2.5 GO:0001570 vasculogenesis(GO:0001570)
0.0 3.0 GO:0060215 primitive hemopoiesis(GO:0060215)
0.0 0.9 GO:0060029 convergent extension involved in organogenesis(GO:0060029)
0.0 0.6 GO:0006942 regulation of striated muscle contraction(GO:0006942)
0.0 0.3 GO:0022401 desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) G-protein coupled receptor internalization(GO:0002031) negative adaptation of signaling pathway(GO:0022401) adaptation of signaling pathway(GO:0023058)
0.0 3.1 GO:0010942 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.0 0.4 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.5 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.0 0.1 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 1.9 GO:0031101 fin regeneration(GO:0031101)
0.0 1.0 GO:0040036 regulation of fibroblast growth factor receptor signaling pathway(GO:0040036)
0.0 1.7 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.5 GO:0045839 negative regulation of mitotic nuclear division(GO:0045839)
0.0 2.0 GO:0021782 glial cell development(GO:0021782)
0.0 0.2 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.9 GO:0051607 defense response to virus(GO:0051607)
0.0 3.7 GO:0043062 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0 1.5 GO:0007283 spermatogenesis(GO:0007283)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.7 GO:0097433 dense body(GO:0097433)
0.4 3.0 GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.3 1.9 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.3 1.5 GO:0097224 sperm connecting piece(GO:0097224)
0.2 3.4 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.2 0.7 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.2 3.0 GO:0005579 membrane attack complex(GO:0005579)
0.1 2.8 GO:0030057 desmosome(GO:0030057)
0.1 0.7 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.1 12.7 GO:0042383 sarcolemma(GO:0042383)
0.1 0.9 GO:0032783 ELL-EAF complex(GO:0032783)
0.1 2.0 GO:0031594 neuromuscular junction(GO:0031594)
0.1 2.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 0.8 GO:0002102 podosome(GO:0002102)
0.1 5.0 GO:0005604 basement membrane(GO:0005604)
0.0 0.1 GO:0097361 CIA complex(GO:0097361)
0.0 4.2 GO:0031201 SNARE complex(GO:0031201)
0.0 3.0 GO:0005581 collagen trimer(GO:0005581)
0.0 7.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.5 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.4 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.5 GO:0031932 TORC2 complex(GO:0031932)
0.0 1.0 GO:0016342 catenin complex(GO:0016342)
0.0 2.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.7 GO:0000786 nucleosome(GO:0000786)
0.0 0.3 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.6 GO:0005861 troponin complex(GO:0005861)
0.0 14.4 GO:0005615 extracellular space(GO:0005615)
0.0 2.0 GO:0009986 cell surface(GO:0009986)
0.0 0.6 GO:0005811 lipid particle(GO:0005811)
0.0 0.4 GO:0031970 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 17.8 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262)
1.2 4.8 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
1.0 13.4 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.5 2.7 GO:0098973 structural constituent of postsynaptic actin cytoskeleton(GO:0098973)
0.5 14.5 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.5 1.5 GO:0032027 myosin light chain binding(GO:0032027)
0.5 2.5 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.5 1.9 GO:0005153 interleukin-8 receptor binding(GO:0005153)
0.4 5.4 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.4 2.6 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.4 4.7 GO:0055102 phospholipase inhibitor activity(GO:0004859) lipase inhibitor activity(GO:0055102)
0.3 2.8 GO:0045294 alpha-catenin binding(GO:0045294)
0.3 3.0 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.2 2.5 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.2 4.0 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.2 0.5 GO:0015562 inositol hexakisphosphate binding(GO:0000822) efflux transmembrane transporter activity(GO:0015562)
0.1 1.2 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 1.2 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 1.0 GO:0048019 receptor antagonist activity(GO:0048019)
0.1 3.7 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 1.6 GO:0070403 NAD+ binding(GO:0070403)
0.1 0.4 GO:1990756 protein binding, bridging involved in substrate recognition for ubiquitination(GO:1990756)
0.1 0.1 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 3.2 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1 0.7 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 4.2 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 0.6 GO:0031013 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.1 1.4 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.3 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.2 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.8 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 0.3 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.1 GO:0031005 filamin binding(GO:0031005)
0.0 1.3 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 1.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 3.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.6 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.5 GO:0050308 carbohydrate phosphatase activity(GO:0019203) sugar-phosphatase activity(GO:0050308)
0.0 0.7 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 0.5 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0 3.0 GO:0042626 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492)
0.0 0.9 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.5 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 1.9 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 0.5 GO:0051018 protein kinase A binding(GO:0051018)
0.0 9.0 GO:0005525 GTP binding(GO:0005525)
0.0 2.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.8 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.5 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.5 GO:0005109 frizzled binding(GO:0005109)
0.0 0.6 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 1.0 GO:0045296 cadherin binding(GO:0045296)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 2.3 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.1 2.0 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.1 4.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 0.6 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 1.4 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 2.0 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.6 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 1.0 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 1.4 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 1.0 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.1 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.4 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.4 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 0.5 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 0.1 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP