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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for nfkb1_rela

Z-value: 1.62

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Transcription factors associated with nfkb1_rela

Gene Symbol Gene ID Gene Info
nfkb1
ENSDARG00000105261 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
rela
ENSDARG00000098696 v-rel avian reticuloendotheliosis viral oncogene homolog A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nfkb1dr11_v1_chr14_-_49859747_498598230.496.0e-07Click!
reladr11_v1_chr7_-_804515_8045150.303.0e-03Click!

Activity profile of nfkb1_rela motif

Sorted Z-values of nfkb1_rela motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_18716 21.53 ENSDART00000172454
ENSDART00000161190
nfkbiz
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr24_+_26006730 21.12 ENSDART00000140384
ENSDART00000139184
ccl20b
chemokine (C-C motif) ligand 20b
chr20_+_16881883 19.49 ENSDART00000130107
nfkbiaa
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a
chr20_-_51307815 19.06 ENSDART00000098833
nfkbie
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr2_+_42191592 17.31 ENSDART00000144716
cavin4a
caveolae associated protein 4a
chr7_+_12950507 16.77 ENSDART00000067629
ENSDART00000158004
saa
serum amyloid A
chr8_+_24281512 16.09 ENSDART00000062845
mmp9
matrix metallopeptidase 9
chr1_-_37377509 16.01 ENSDART00000113542
tnip2
TNFAIP3 interacting protein 2
chr1_-_52437056 13.78 ENSDART00000138337
si:ch211-217k17.12
si:ch211-217k17.12
chr7_-_34262080 13.65 ENSDART00000183246
si:ch211-98n17.5
si:ch211-98n17.5
chr5_+_22579975 13.44 ENSDART00000080877
tnfsf10l4
tumor necrosis factor (ligand) superfamily, member 10 like 4
chr1_-_52431220 13.29 ENSDART00000111256
zgc:194101
zgc:194101
chr12_+_20641471 13.10 ENSDART00000133654
calcoco2
calcium binding and coiled-coil domain 2
chr18_-_5527050 13.03 ENSDART00000145400
ENSDART00000132498
ENSDART00000146209
zgc:153317
zgc:153317
chr8_-_18667693 12.84 ENSDART00000100516
stap2b
signal transducing adaptor family member 2b
chr13_-_25819825 12.31 ENSDART00000077612
rel
v-rel avian reticuloendotheliosis viral oncogene homolog
chr23_+_31815423 12.27 ENSDART00000075730
ENSDART00000075726
myb
v-myb avian myeloblastosis viral oncogene homolog
chr3_-_21242460 12.21 ENSDART00000007293
tcap
titin-cap (telethonin)
chr15_+_32727848 12.14 ENSDART00000161361
postnb
periostin, osteoblast specific factor b
chr12_+_22576404 12.00 ENSDART00000172053
capgb
capping protein (actin filament), gelsolin-like b
chr24_-_33703504 11.40 ENSDART00000079292
cavin4b
caveolae associated protein 4b
chr12_+_20641102 11.23 ENSDART00000152964
calcoco2
calcium binding and coiled-coil domain 2
chr4_-_12795436 11.17 ENSDART00000131026
ENSDART00000075127
b2m
beta-2-microglobulin
chr17_+_12942634 10.33 ENSDART00000016597
nfkbiab
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b
chr21_+_19547806 10.26 ENSDART00000159707
ENSDART00000184869
ENSDART00000181321
ENSDART00000058487
ENSDART00000058485
rai14
retinoic acid induced 14
chr9_-_51563575 9.95 ENSDART00000167034
ENSDART00000148918
tank
TRAF family member-associated NFKB activator
chr8_-_12432604 9.73 ENSDART00000133350
ENSDART00000140699
ENSDART00000101174
traf1
TNF receptor-associated factor 1
chr23_+_19701587 9.72 ENSDART00000104425
dnase1l1
deoxyribonuclease I-like 1
chr16_+_23403602 9.52 ENSDART00000159848
s100w
S100 calcium binding protein W
chr16_-_29714540 9.36 ENSDART00000067854
tnfaip8l2b
tumor necrosis factor, alpha-induced protein 8-like 2b
chr14_+_3038473 9.33 ENSDART00000026021
ENSDART00000150000
cd74a
CD74 molecule, major histocompatibility complex, class II invariant chain a
chr19_+_7124337 9.33 ENSDART00000031380
tap2a
transporter associated with antigen processing, subunit type a
chr1_-_49225890 9.33 ENSDART00000111598
cxcl18b
chemokine (C-X-C motif) ligand 18b
chr6_+_54576520 9.28 ENSDART00000093199
ENSDART00000127519
ENSDART00000157142
tead3b
TEA domain family member 3 b
chr14_-_4121052 9.22 ENSDART00000167074
irf2
interferon regulatory factor 2
chr6_+_3334710 9.15 ENSDART00000132848
st3gal3a
ST3 beta-galactoside alpha-2,3-sialyltransferase 3a
chr19_-_7144548 9.09 ENSDART00000147177
ENSDART00000134850
psmb8a
psmb13a
proteasome subunit beta 8A
proteasome subunit beta 13a
chr24_+_22731228 8.78 ENSDART00000146733
si:dkey-225k4.1
si:dkey-225k4.1
chr6_-_436658 8.75 ENSDART00000191515
grap2b
GRB2-related adaptor protein 2b
chr14_-_4120636 8.68 ENSDART00000059230
irf2
interferon regulatory factor 2
chr9_+_41156287 8.68 ENSDART00000189195
ENSDART00000186270
stat4
signal transducer and activator of transcription 4
chr23_-_32162810 8.59 ENSDART00000155905
nr4a1
nuclear receptor subfamily 4, group A, member 1
chr5_-_42878178 8.54 ENSDART00000162981
CXCL11 (1 of many)
C-X-C motif chemokine ligand 11
chr9_-_98982 8.32 ENSDART00000147882
lims2
LIM and senescent cell antigen-like domains 2
chr24_+_25919809 8.07 ENSDART00000006615
map3k15
mitogen-activated protein kinase kinase kinase 15
chr14_-_1646360 8.01 ENSDART00000186528
LO018106.2

chr2_+_45191049 7.95 ENSDART00000165392
ccl20a.3
chemokine (C-C motif) ligand 20a, duplicate 3
chr20_+_23501535 7.94 ENSDART00000177922
ENSDART00000058532
palld
palladin, cytoskeletal associated protein
chr21_-_22693730 7.93 ENSDART00000158342
gig2d
grass carp reovirus (GCRV)-induced gene 2d
chr6_+_2030703 7.82 ENSDART00000109679
ENSDART00000187502
ENSDART00000191165
ENSDART00000187544
quo
quattro
chr18_-_11729 7.77 ENSDART00000159781
WHAMM
WAS protein homolog associated with actin, golgi membranes and microtubules
chr9_+_41156818 7.63 ENSDART00000105764
ENSDART00000147052
stat4
signal transducer and activator of transcription 4
chr22_-_651719 7.39 ENSDART00000148692
apobec2a
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2a
chr12_-_30760971 7.31 ENSDART00000066257
entpd1
ectonucleoside triphosphate diphosphohydrolase 1
chr21_+_30937690 7.13 ENSDART00000022562
rhogb
ras homolog family member Gb
chr21_-_435466 6.87 ENSDART00000110297
klf4
Kruppel-like factor 4
chr5_+_13373593 6.80 ENSDART00000051668
ENSDART00000183883
ccl19a.2
chemokine (C-C motif) ligand 19a, tandem duplicate 2
chr11_+_8129536 6.66 ENSDART00000158112
ENSDART00000011183
prkacba
protein kinase, cAMP-dependent, catalytic, beta a
chr23_-_12423778 6.56 ENSDART00000124091
wfdc2
WAP four-disulfide core domain 2
chr23_-_38054 6.50 ENSDART00000170393
CABZ01074076.1

chr23_+_42819221 6.36 ENSDART00000180495
myl9a
myosin, light chain 9a, regulatory
chr13_+_32148338 6.33 ENSDART00000188591
osr1
odd-skipped related transciption factor 1
chr2_-_51772438 6.27 ENSDART00000170241
BX908782.2
Danio rerio three-finger protein 5 (LOC100003647), mRNA.
chr8_-_13029297 6.24 ENSDART00000144305
dennd2da
DENN/MADD domain containing 2Da
chr24_+_80653 6.17 ENSDART00000158473
ENSDART00000129135
reck
reversion-inducing-cysteine-rich protein with kazal motifs
chr6_+_3334392 6.17 ENSDART00000133707
ENSDART00000130879
st3gal3a
ST3 beta-galactoside alpha-2,3-sialyltransferase 3a
chr1_-_52447364 6.03 ENSDART00000140740
si:ch211-217k17.10
si:ch211-217k17.10
chr8_+_25302172 5.99 ENSDART00000046182
ENSDART00000145316
gstm.3
glutathione S-transferase mu tandem duplicate 3
chr19_+_19767567 5.89 ENSDART00000169074
hoxa3a
homeobox A3a
chr19_+_7043634 5.88 ENSDART00000133954
mhc1uka
major histocompatibility complex class I UKA
chr16_-_25739331 5.84 ENSDART00000189455
bcl3
B cell CLL/lymphoma 3
chr5_+_24086227 5.83 ENSDART00000051549
ENSDART00000177458
ENSDART00000135934
tp53
tumor protein p53
chr4_-_149334 5.82 ENSDART00000163280
tbk1
TANK-binding kinase 1
chr1_-_52443379 5.78 ENSDART00000144676
si:ch211-217k17.11
si:ch211-217k17.11
chr7_+_29293452 5.76 ENSDART00000127358
si:ch211-112g6.4
si:ch211-112g6.4
chr13_+_22717366 5.75 ENSDART00000134122
nfkb2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr6_-_442163 5.70 ENSDART00000163564
ENSDART00000189134
ENSDART00000169789
grap2b
GRB2-related adaptor protein 2b
chr16_+_38394371 5.55 ENSDART00000137954
cd83
CD83 molecule
chr16_-_35975254 5.55 ENSDART00000167537
eva1ba
eva-1 homolog Ba (C. elegans)
chr5_+_9246018 5.44 ENSDART00000081769
ENSDART00000183189
susd1
sushi domain containing 1
chr23_+_10347851 5.25 ENSDART00000127667
krt18
keratin 18
chr11_+_6456146 5.23 ENSDART00000036939
gadd45ba
growth arrest and DNA-damage-inducible, beta a
chr25_-_13188214 5.17 ENSDART00000187298
si:ch211-147m6.1
si:ch211-147m6.1
chr3_-_32170850 5.11 ENSDART00000055307
ENSDART00000157366
tnnt1
troponin T type 1 (skeletal, slow)
chr4_+_70151160 5.04 ENSDART00000111816
si:dkey-3h2.4
si:dkey-3h2.4
chr17_-_29249258 5.04 ENSDART00000031458
traf3
TNF receptor-associated factor 3
chr17_+_51746830 4.96 ENSDART00000184230
odc1
ornithine decarboxylase 1
chr7_-_22632518 4.94 ENSDART00000161046
si:dkey-112a7.4
si:dkey-112a7.4
chr5_+_13385837 4.93 ENSDART00000191190
ccl19a.1
chemokine (C-C motif) ligand 19a, tandem duplicate 1
chr9_-_6380653 4.92 ENSDART00000078523
ecrg4a
esophageal cancer related gene 4a
chr7_-_22632690 4.87 ENSDART00000165245
si:dkey-112a7.4
si:dkey-112a7.4
chr14_+_36885524 4.85 ENSDART00000032547
lect2l
leukocyte cell-derived chemotaxin 2 like
chr2_-_2642476 4.80 ENSDART00000124032
serbp1b
SERPINE1 mRNA binding protein 1b
chr9_-_23894392 4.77 ENSDART00000133417
asb18
ankyrin repeat and SOCS box containing 18
chr14_+_36889893 4.77 ENSDART00000124159
si:ch211-132p1.3
si:ch211-132p1.3
chr13_-_51846224 4.74 ENSDART00000184663
LT631684.2

chr13_+_30692669 4.74 ENSDART00000187818
CR762483.1

chr6_+_18298444 4.67 ENSDART00000166018
card14
caspase recruitment domain family, member 14
chr25_-_6557854 4.64 ENSDART00000181740
cspg4
chondroitin sulfate proteoglycan 4
chr13_+_22717939 4.61 ENSDART00000188288
nfkb2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr17_-_7733037 4.59 ENSDART00000064657
stx11a
syntaxin 11a
chr7_+_57677120 4.55 ENSDART00000110623
arsj
arylsulfatase family, member J
chr11_-_25853212 4.43 ENSDART00000145655
tmem51b
transmembrane protein 51b
chr1_+_27690 4.38 ENSDART00000162928
eed
embryonic ectoderm development
chr1_+_33328857 4.27 ENSDART00000137151
mxra5a
matrix-remodelling associated 5a
chr3_+_57820913 4.26 ENSDART00000168101
CU571328.1

chr9_-_32604414 4.19 ENSDART00000088876
ENSDART00000166502
satb2
SATB homeobox 2
chr1_-_59232267 4.18 ENSDART00000169658
ENSDART00000163257
akap8l
A kinase (PRKA) anchor protein 8-like
chr13_-_39947335 4.18 ENSDART00000056996
sfrp5
secreted frizzled-related protein 5
chr19_+_46113828 4.16 ENSDART00000159331
ENSDART00000161826
rbm24a
RNA binding motif protein 24a
chr14_-_49859747 4.16 ENSDART00000169456
ENSDART00000164967
nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr15_-_4152582 4.16 ENSDART00000171942
si:dkey-83h2.5
si:dkey-83h2.5
chr2_+_36004381 4.12 ENSDART00000098706
lamc2
laminin, gamma 2
chr15_+_27364394 4.09 ENSDART00000122101
tbx2b
T-box 2b
chr2_+_21356242 4.03 ENSDART00000145670
ENSDART00000146600
ctdsplb
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like b
chr22_+_16497670 4.02 ENSDART00000014330
ier5
immediate early response 5
chr12_+_10631266 4.01 ENSDART00000161455
csf3a
colony stimulating factor 3 (granulocyte) a
chr7_+_19835569 3.98 ENSDART00000149812
ovol1a
ovo-like zinc finger 1a
chr7_-_59123066 3.92 ENSDART00000175438
dennd4c
DENN/MADD domain containing 4C
chr7_-_20241346 3.92 ENSDART00000173619
ENSDART00000127699
si:ch73-335l21.4
si:ch73-335l21.4
chr23_-_33738570 3.90 ENSDART00000131680
si:ch211-210c8.7
si:ch211-210c8.7
chr14_-_30967284 3.83 ENSDART00000149435
il2rgb
interleukin 2 receptor, gamma b
chr6_-_54815886 3.78 ENSDART00000180793
ENSDART00000007498
tnni1b
troponin I type 1b (skeletal, slow)
chr6_-_52675630 3.78 ENSDART00000083830
sdc4
syndecan 4
chr11_+_14333441 3.78 ENSDART00000171969
ptbp1b
polypyrimidine tract binding protein 1b
chr22_+_661711 3.65 ENSDART00000113795
elf3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr14_+_30773764 3.63 ENSDART00000186961
atl3
atlastin 3
chr12_+_48634927 3.62 ENSDART00000168441
zgc:165653
zgc:165653
chr19_-_10432134 3.58 ENSDART00000081440
il11b
interleukin 11b
chr8_+_22355909 3.54 ENSDART00000146457
ENSDART00000142883
zgc:153631
zgc:153631
chr6_+_49771626 3.53 ENSDART00000134207
ctsz
cathepsin Z
chr14_+_49376011 3.47 ENSDART00000020961
tnip1
TNFAIP3 interacting protein 1
chr7_-_8309505 3.44 ENSDART00000182530
f13a1b
coagulation factor XIII, A1 polypeptide b
chr6_+_19933763 3.40 ENSDART00000166192
pik3r5
phosphoinositide-3-kinase, regulatory subunit 5
chr22_-_31517300 3.38 ENSDART00000164799
slc6a6b
solute carrier family 6 (neurotransmitter transporter), member 6b
chr19_+_43119698 3.36 ENSDART00000167847
ENSDART00000186962
ENSDART00000187305
eef1a1l1
eukaryotic translation elongation factor 1 alpha 1, like 1
chr8_-_20230559 3.33 ENSDART00000193677
mllt1a
MLLT1, super elongation complex subunit a
chr3_+_22273123 3.32 ENSDART00000044157
scn4ab
sodium channel, voltage-gated, type IV, alpha, b
chr12_+_46740584 3.28 ENSDART00000171563
plaub
plasminogen activator, urokinase b
chr14_-_6987649 3.25 ENSDART00000060990
eif4ebp3l
eukaryotic translation initiation factor 4E binding protein 3, like
chr2_-_45191319 3.23 ENSDART00000192272
CR407590.2

chr23_-_437467 3.14 ENSDART00000192106
tspan2b
tetraspanin 2b
chr2_-_53592532 3.12 ENSDART00000184066
ccl25a
chemokine (C-C motif) ligand 25a
chr1_+_33322555 3.12 ENSDART00000113486
mxra5a
matrix-remodelling associated 5a
chr25_+_8955530 3.12 ENSDART00000156444
si:ch211-256a21.4
si:ch211-256a21.4
chr7_-_73843720 3.11 ENSDART00000111622
caap1
caspase activity and apoptosis inhibitor 1
chr17_+_8175998 3.09 ENSDART00000131200
myct1b
myc target 1b
chr16_+_35535375 3.05 ENSDART00000171675
cited4b
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4b
chr6_+_49771372 3.04 ENSDART00000063251
ctsz
cathepsin Z
chr10_+_8875195 3.04 ENSDART00000141045
itga2.3
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor), tandem duplicate 3
chr22_+_8536838 3.02 ENSDART00000132998
si:ch73-27e22.7
si:ch73-27e22.7
chr17_-_2685026 2.95 ENSDART00000191014
ENSDART00000179309
ptpn21
protein tyrosine phosphatase, non-receptor type 21
chr21_+_15866522 2.95 ENSDART00000110728
gcnt4b
glucosaminyl (N-acetyl) transferase 4, core 2, b
chr4_-_12914163 2.94 ENSDART00000140002
ENSDART00000145917
ENSDART00000141355
ENSDART00000067135
msrb3
methionine sulfoxide reductase B3
chr3_+_59899452 2.92 ENSDART00000064311
arhgdia
Rho GDP dissociation inhibitor (GDI) alpha
chr7_-_20338048 2.87 ENSDART00000125594
zgc:194312
zgc:194312
chr12_+_27462225 2.85 ENSDART00000105661
meox1
mesenchyme homeobox 1
chr7_-_22632938 2.84 ENSDART00000159867
ENSDART00000165706
si:dkey-112a7.4
si:dkey-112a7.4
chr18_-_18543358 2.83 ENSDART00000126460
il34
interleukin 34
chr7_-_51461649 2.82 ENSDART00000193947
ENSDART00000174328
arhgap36
Rho GTPase activating protein 36
chr14_+_16765992 2.77 ENSDART00000140061
sqstm1
sequestosome 1
chr16_+_34111919 2.76 ENSDART00000134037
ENSDART00000006061
ENSDART00000140552
tcea3
transcription elongation factor A (SII), 3
chr22_-_10354381 2.75 ENSDART00000092050
stab1
stabilin 1
chr10_+_20608676 2.70 ENSDART00000140141
si:dkey-81j8.6
si:dkey-81j8.6
chr7_-_804515 2.68 ENSDART00000159359
rela
v-rel avian reticuloendotheliosis viral oncogene homolog A
chr5_-_44496553 2.67 ENSDART00000178081
gas1a
growth arrest-specific 1a
chr16_-_27749172 2.64 ENSDART00000145198
steap4
STEAP family member 4
chr5_+_9246458 2.62 ENSDART00000081772
susd1
sushi domain containing 1
chr21_+_45626136 2.60 ENSDART00000158742
irf1b
interferon regulatory factor 1b
chr8_+_25629722 2.59 ENSDART00000026807
wasa
Wiskott-Aldrich syndrome (eczema-thrombocytopenia) a
chr7_-_28696556 2.57 ENSDART00000148822
adgrg1
adhesion G protein-coupled receptor G1
chr12_-_3903886 2.56 ENSDART00000184214
ENSDART00000041082
gdpd3b
glycerophosphodiester phosphodiesterase domain containing 3b
chr4_-_75681004 2.53 ENSDART00000186296
si:dkey-71l4.5
si:dkey-71l4.5
chr7_-_22941472 2.53 ENSDART00000190334
tnfsf10l
TNF superfamily member 10, like
chr10_+_31646020 2.53 ENSDART00000115251
esama
endothelial cell adhesion molecule a
chr4_+_76789395 2.51 ENSDART00000147574
si:ch73-56d11.3
si:ch73-56d11.3
chr25_+_16646113 2.50 ENSDART00000110426
cecr2
cat eye syndrome chromosome region, candidate 2
chr12_+_46745239 2.50 ENSDART00000057179
plaub
plasminogen activator, urokinase b
chr4_-_22311610 2.48 ENSDART00000137814
hcls1
hematopoietic cell-specific Lyn substrate 1
chr12_-_11349899 2.45 ENSDART00000079645
zgc:174164
zgc:174164
chr19_+_20713424 2.45 ENSDART00000129730
rab5aa
RAB5A, member RAS oncogene family, a
chr22_+_19425657 2.45 ENSDART00000187531
ENSDART00000078804
si:dkey-78l4.5
si:dkey-78l4.5
chr5_-_44496805 2.44 ENSDART00000110076
gas1a
growth arrest-specific 1a
chr4_+_68562464 2.43 ENSDART00000192954
BX548011.4

chr7_+_34786591 2.42 ENSDART00000173700
si:dkey-148a17.5
si:dkey-148a17.5
chr7_+_25053331 2.42 ENSDART00000173998
si:dkey-23i12.7
si:dkey-23i12.7
chr20_-_39367895 2.41 ENSDART00000136476
ENSDART00000021788
ENSDART00000180784
pbk
PDZ binding kinase
chr20_+_218886 2.41 ENSDART00000002661
lama4
laminin, alpha 4
chr15_+_17251191 2.40 ENSDART00000156587
si:ch73-223p23.2
si:ch73-223p23.2
chr5_+_51909740 2.37 ENSDART00000162541
thbs4a
thrombospondin 4a
chr1_+_17892944 2.37 ENSDART00000013021
tlr3
toll-like receptor 3
chr2_-_879800 2.34 ENSDART00000019733
irf4a
interferon regulatory factor 4a
chr11_+_35050253 2.32 ENSDART00000124800
fam212aa
family with sequence similarity 212, member Aa
chr14_-_40850481 2.32 ENSDART00000173236
elf1
E74-like ETS transcription factor 1
chr4_+_77681389 2.29 ENSDART00000099727
gbp4
guanylate binding protein 4
chr5_+_37785152 2.27 ENSDART00000053511
ENSDART00000189812
myo1ca
myosin Ic, paralog a
chr2_-_57227542 2.26 ENSDART00000182675
ENSDART00000159480
btbd2b
BTB (POZ) domain containing 2b
chr5_-_64168415 2.20 ENSDART00000048395
cmlc1
cardiac myosin light chain-1
chr24_+_41273252 2.19 ENSDART00000105526
nub1
negative regulator of ubiquitin-like proteins 1
chr23_-_29003864 2.19 ENSDART00000148257
casz1
castor zinc finger 1

Network of associatons between targets according to the STRING database.

First level regulatory network of nfkb1_rela

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.5 19.5 GO:1901533 negative regulation of hematopoietic progenitor cell differentiation(GO:1901533)
6.1 18.4 GO:0034138 toll-like receptor 3 signaling pathway(GO:0034138)
5.4 16.1 GO:0002631 granuloma formation(GO:0002432) chronic inflammatory response(GO:0002544) regulation of granuloma formation(GO:0002631) regulation of chronic inflammatory response(GO:0002676)
5.0 14.9 GO:0002468 dendritic cell antigen processing and presentation(GO:0002468)
3.3 20.0 GO:0051883 killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364) disruption of cells of other organism involved in symbiotic interaction(GO:0051818) killing of cells in other organism involved in symbiotic interaction(GO:0051883)
3.1 12.2 GO:0035994 response to muscle stretch(GO:0035994)
2.5 7.4 GO:0043388 positive regulation of DNA binding(GO:0043388)
2.1 6.3 GO:0048389 intermediate mesoderm development(GO:0048389)
2.1 6.2 GO:1905048 regulation of metallopeptidase activity(GO:1905048)
2.0 12.3 GO:0030852 regulation of granulocyte differentiation(GO:0030852) regulation of neutrophil differentiation(GO:0045658)
1.9 5.8 GO:0032197 regulation of transposition, RNA-mediated(GO:0010525) negative regulation of transposition, RNA-mediated(GO:0010526) transposition, RNA-mediated(GO:0032197) positive regulation of neuron apoptotic process(GO:0043525) positive regulation of neuron death(GO:1901216)
1.6 4.9 GO:0070314 G1 to G0 transition(GO:0070314)
1.6 11.4 GO:0033292 T-tubule organization(GO:0033292)
1.4 2.8 GO:0045649 regulation of macrophage differentiation(GO:0045649)
1.4 4.2 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
1.4 4.2 GO:0098528 skeletal muscle fiber differentiation(GO:0098528) regulation of skeletal muscle cell differentiation(GO:2001014)
1.4 4.1 GO:0072025 distal convoluted tubule development(GO:0072025) late distal convoluted tubule development(GO:0072068)
1.2 7.3 GO:0071405 response to methanol(GO:0033986) cellular response to methanol(GO:0071405)
1.0 8.3 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
1.0 3.1 GO:0072679 thymocyte migration(GO:0072679)
1.0 40.8 GO:0048247 lymphocyte chemotaxis(GO:0048247)
1.0 8.6 GO:0043435 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.9 3.8 GO:0036445 neuronal stem cell division(GO:0036445) somatic stem cell division(GO:0048103)
0.9 2.8 GO:0035973 aggrephagy(GO:0035973)
0.9 14.5 GO:0016203 muscle attachment(GO:0016203)
0.8 5.9 GO:0060017 parathyroid gland development(GO:0060017)
0.8 2.5 GO:0048169 regulation of long-term neuronal synaptic plasticity(GO:0048169)
0.8 3.2 GO:0014743 regulation of muscle hypertrophy(GO:0014743)
0.8 11.2 GO:0034122 regulation of toll-like receptor signaling pathway(GO:0034121) negative regulation of toll-like receptor signaling pathway(GO:0034122)
0.8 14.6 GO:0046686 response to cadmium ion(GO:0046686)
0.7 2.9 GO:0030091 protein repair(GO:0030091)
0.7 2.9 GO:0048939 anterior lateral line nerve glial cell differentiation(GO:0048913) myelination of anterior lateral line nerve axons(GO:0048914) anterior lateral line nerve glial cell development(GO:0048939) anterior lateral line nerve glial cell morphogenesis involved in differentiation(GO:0048940)
0.7 5.1 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.7 15.2 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.7 2.8 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
0.7 10.6 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.7 2.6 GO:0015677 copper ion import(GO:0015677)
0.6 13.9 GO:0038061 NIK/NF-kappaB signaling(GO:0038061)
0.6 2.3 GO:0002320 lymphoid progenitor cell differentiation(GO:0002320)
0.6 5.8 GO:0031639 plasminogen activation(GO:0031639)
0.6 9.7 GO:0000737 DNA catabolic process, endonucleolytic(GO:0000737)
0.6 4.0 GO:0070285 pigment cell development(GO:0070285)
0.6 5.0 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.5 2.2 GO:2000058 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787) regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.5 1.6 GO:0035971 peptidyl-histidine dephosphorylation(GO:0035971)
0.5 8.1 GO:0000186 activation of MAPKK activity(GO:0000186)
0.5 1.6 GO:0007567 parturition(GO:0007567) maternal process involved in parturition(GO:0060137)
0.5 2.6 GO:0070445 regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.5 1.5 GO:0003091 renal water homeostasis(GO:0003091) renal water transport(GO:0003097)
0.5 1.9 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway(GO:2001244)
0.4 1.3 GO:0060879 peripheral nervous system myelin formation(GO:0032290) semicircular canal fusion(GO:0060879)
0.4 4.2 GO:0061588 calcium activated phospholipid scrambling(GO:0061588)
0.4 2.9 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.4 2.0 GO:0033499 galactose catabolic process(GO:0019388) galactose catabolic process via UDP-galactose(GO:0033499)
0.4 1.6 GO:0090161 Golgi ribbon formation(GO:0090161)
0.4 1.6 GO:1903292 protein localization to Golgi membrane(GO:1903292)
0.4 12.0 GO:0051014 actin filament severing(GO:0051014)
0.4 2.2 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
0.3 10.7 GO:0055092 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.3 1.0 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.3 14.7 GO:0007259 JAK-STAT cascade(GO:0007259) STAT cascade(GO:0097696)
0.3 9.3 GO:0035329 hippo signaling(GO:0035329)
0.3 3.5 GO:2000406 positive regulation of lymphocyte migration(GO:2000403) positive regulation of T cell migration(GO:2000406)
0.3 2.8 GO:0061056 sclerotome development(GO:0061056)
0.3 9.1 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.3 1.7 GO:0097241 hematopoietic stem cell migration to bone marrow(GO:0097241)
0.3 7.7 GO:0072089 stem cell proliferation(GO:0072089)
0.3 3.9 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.3 2.5 GO:0070527 platelet aggregation(GO:0070527)
0.2 5.1 GO:0010737 protein kinase A signaling(GO:0010737)
0.2 1.9 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.2 2.6 GO:0050688 regulation of defense response to virus(GO:0050688)
0.2 3.4 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
0.2 1.1 GO:0010447 response to acidic pH(GO:0010447)
0.2 0.9 GO:0070255 regulation of mucus secretion(GO:0070255) positive regulation of mucus secretion(GO:0070257)
0.2 6.1 GO:0016601 Rac protein signal transduction(GO:0016601)
0.2 3.1 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.2 3.3 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.2 0.6 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) Schwann cell migration(GO:0036135) cardiac neuron differentiation(GO:0060945) cardiac neuron development(GO:0060959)
0.2 0.8 GO:0072003 kidney rudiment formation(GO:0072003) pronephros formation(GO:0072116)
0.2 18.3 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.2 2.6 GO:0051127 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.2 6.0 GO:0099500 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.2 0.6 GO:0060544 regulation of necrotic cell death(GO:0010939) regulation of necroptotic process(GO:0060544) negative regulation of necroptotic process(GO:0060546) negative regulation of necrotic cell death(GO:0060547)
0.2 13.1 GO:0007249 I-kappaB kinase/NF-kappaB signaling(GO:0007249)
0.2 1.7 GO:0002483 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.1 10.7 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.1 6.0 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 2.9 GO:0060324 face development(GO:0060324)
0.1 5.1 GO:0007050 cell cycle arrest(GO:0007050)
0.1 1.1 GO:0003303 BMP signaling pathway involved in determination of left/right symmetry(GO:0003154) BMP signaling pathway involved in heart jogging(GO:0003303) locus ceruleus development(GO:0021703)
0.1 2.6 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.1 7.4 GO:0048332 mesoderm morphogenesis(GO:0048332)
0.1 1.9 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.1 1.1 GO:0071379 cellular response to prostaglandin stimulus(GO:0071379)
0.1 0.5 GO:0090134 mesendoderm migration(GO:0090133) cell migration involved in mesendoderm migration(GO:0090134)
0.1 0.5 GO:0007412 axon target recognition(GO:0007412)
0.1 3.8 GO:0003009 skeletal muscle contraction(GO:0003009)
0.1 0.8 GO:0042214 carotene metabolic process(GO:0016119) carotene catabolic process(GO:0016121) terpene metabolic process(GO:0042214) terpene catabolic process(GO:0046247)
0.1 4.1 GO:0043113 receptor clustering(GO:0043113)
0.1 1.1 GO:0043171 peptide catabolic process(GO:0043171)
0.1 1.6 GO:0033627 cell adhesion mediated by integrin(GO:0033627)
0.1 1.2 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.1 1.7 GO:0071219 cellular response to molecule of bacterial origin(GO:0071219) cellular response to lipopolysaccharide(GO:0071222)
0.1 0.4 GO:0003139 secondary heart field specification(GO:0003139)
0.1 0.6 GO:0097345 mitochondrial outer membrane permeabilization(GO:0097345)
0.1 3.6 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.1 1.3 GO:0007032 endosome organization(GO:0007032)
0.1 15.9 GO:0045087 innate immune response(GO:0045087)
0.1 4.4 GO:0006342 chromatin silencing(GO:0006342)
0.1 2.8 GO:0043406 positive regulation of MAP kinase activity(GO:0043406)
0.1 0.3 GO:0035777 pronephric distal tubule development(GO:0035777)
0.1 4.2 GO:0055113 epiboly involved in gastrulation with mouth forming second(GO:0055113)
0.1 0.5 GO:0097178 ruffle assembly(GO:0097178)
0.1 1.0 GO:0045807 positive regulation of endocytosis(GO:0045807)
0.1 5.8 GO:0048545 response to steroid hormone(GO:0048545)
0.1 1.0 GO:0031397 negative regulation of protein ubiquitination(GO:0031397)
0.1 1.8 GO:0001649 osteoblast differentiation(GO:0001649)
0.1 3.0 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.1 2.8 GO:0001837 epithelial to mesenchymal transition(GO:0001837)
0.1 2.9 GO:0007266 Rho protein signal transduction(GO:0007266)
0.0 1.6 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.5 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.0 0.9 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 4.3 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.0 1.2 GO:0006884 cell volume homeostasis(GO:0006884)
0.0 0.4 GO:0030168 platelet activation(GO:0030168)
0.0 1.1 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.0 0.7 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 2.0 GO:0001816 cytokine production(GO:0001816)
0.0 1.9 GO:0099515 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.0 1.3 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.0 0.6 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.0 1.9 GO:0071482 cellular response to light stimulus(GO:0071482)
0.0 0.6 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.0 2.0 GO:0006954 inflammatory response(GO:0006954)
0.0 0.4 GO:0050919 negative chemotaxis(GO:0050919)
0.0 5.4 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 0.2 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.0 7.6 GO:0006955 immune response(GO:0006955)
0.0 0.9 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.0 GO:1990120 messenger ribonucleoprotein complex assembly(GO:1990120)
0.0 0.1 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.0 1.3 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 1.4 GO:0030838 positive regulation of actin filament polymerization(GO:0030838)
0.0 6.1 GO:0051603 cellular protein catabolic process(GO:0044257) proteolysis involved in cellular protein catabolic process(GO:0051603)
0.0 2.0 GO:0030833 regulation of actin filament polymerization(GO:0030833)
0.0 1.0 GO:0034620 cellular response to unfolded protein(GO:0034620)
0.0 6.0 GO:0006486 protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)
0.0 1.7 GO:0045765 regulation of angiogenesis(GO:0045765)
0.0 0.2 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.0 0.4 GO:0060319 primitive erythrocyte differentiation(GO:0060319)
0.0 1.6 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.3 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 1.4 GO:0007422 peripheral nervous system development(GO:0007422)
0.0 0.3 GO:0015671 oxygen transport(GO:0015671)
0.0 1.5 GO:0040008 regulation of growth(GO:0040008)
0.0 4.8 GO:0008283 cell proliferation(GO:0008283)
0.0 1.7 GO:0001755 neural crest cell migration(GO:0001755)
0.0 0.7 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.0 7.3 GO:0016567 protein ubiquitination(GO:0016567)
0.0 0.3 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage(GO:0008630)
0.0 0.2 GO:0021884 forebrain neuron development(GO:0021884)
0.0 0.3 GO:0050772 positive regulation of axonogenesis(GO:0050772)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 11.2 GO:0042612 MHC class I protein complex(GO:0042612)
1.5 6.2 GO:1990909 Wnt signalosome(GO:1990909)
1.2 9.3 GO:0042613 MHC class II protein complex(GO:0042613)
1.1 16.8 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.9 13.0 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.7 28.7 GO:0005901 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.6 2.5 GO:0098842 postsynaptic early endosome(GO:0098842)
0.6 2.3 GO:0060171 stereocilium membrane(GO:0060171)
0.5 3.8 GO:0016234 inclusion body(GO:0016234)
0.3 9.1 GO:0005839 proteasome core complex(GO:0005839)
0.3 4.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.3 4.8 GO:0000813 ESCRT I complex(GO:0000813)
0.2 6.0 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.2 3.4 GO:0097651 phosphatidylinositol 3-kinase complex, class IB(GO:0005944) phosphatidylinositol 3-kinase complex, class I(GO:0097651)
0.2 2.5 GO:0031010 ISWI-type complex(GO:0031010)
0.2 8.9 GO:0005861 troponin complex(GO:0005861)
0.2 0.9 GO:0030314 junctional membrane complex(GO:0030314)
0.2 0.7 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.2 1.3 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.1 2.9 GO:0009925 basal plasma membrane(GO:0009925)
0.1 8.9 GO:0001726 ruffle(GO:0001726)
0.1 12.2 GO:0030018 Z disc(GO:0030018)
0.1 13.7 GO:0005925 focal adhesion(GO:0005925)
0.1 0.4 GO:0043514 interleukin-12 complex(GO:0043514) interleukin-23 complex(GO:0070743)
0.1 18.7 GO:0031012 extracellular matrix(GO:0031012)
0.1 1.9 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 5.6 GO:0019814 immunoglobulin complex(GO:0019814)
0.1 13.9 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.1 0.3 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.1 5.1 GO:0005884 actin filament(GO:0005884)
0.1 12.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 6.2 GO:0016324 apical plasma membrane(GO:0016324)
0.0 15.8 GO:0000785 chromatin(GO:0000785)
0.0 7.8 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 1.5 GO:0016605 PML body(GO:0016605)
0.0 46.5 GO:0005615 extracellular space(GO:0005615)
0.0 1.9 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.4 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 3.8 GO:0005802 trans-Golgi network(GO:0005802)
0.0 1.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.3 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.3 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.3 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 2.6 GO:0010008 endosome membrane(GO:0010008)
0.0 4.4 GO:0005938 cell cortex(GO:0005938)
0.0 5.8 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.8 GO:0005643 nuclear pore(GO:0005643)
0.0 73.5 GO:0005634 nucleus(GO:0005634)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 13.2 GO:0051916 granulocyte colony-stimulating factor binding(GO:0051916)
2.2 15.3 GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity(GO:0008118)
2.1 12.6 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427) calcium-dependent protein kinase regulator activity(GO:0010858)
1.4 21.2 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
1.4 4.2 GO:1990825 sequence-specific mRNA binding(GO:1990825)
1.3 6.7 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
1.1 7.4 GO:0004126 cytidine deaminase activity(GO:0004126)
1.0 43.9 GO:0048020 CCR chemokine receptor binding(GO:0048020)
1.0 9.7 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.9 31.2 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.8 8.6 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.7 2.9 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.7 2.0 GO:0003978 UDP-glucose 4-epimerase activity(GO:0003978)
0.7 2.6 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.6 2.9 GO:0038131 neuregulin receptor activity(GO:0038131) neuregulin binding(GO:0038132)
0.6 2.3 GO:0015355 secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.6 5.0 GO:0004586 ornithine decarboxylase activity(GO:0004586)
0.5 1.6 GO:0004990 oxytocin receptor activity(GO:0004990)
0.5 12.8 GO:0035591 signaling adaptor activity(GO:0035591)
0.5 2.9 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.5 9.1 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.5 6.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.5 4.7 GO:0050700 CARD domain binding(GO:0050700)
0.5 13.0 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.5 3.2 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.4 4.0 GO:0008420 CTD phosphatase activity(GO:0008420)
0.4 12.2 GO:0008307 structural constituent of muscle(GO:0008307)
0.4 7.3 GO:0045134 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.4 9.3 GO:0042289 MHC class II protein binding(GO:0042289)
0.4 1.6 GO:0101006 protein histidine phosphatase activity(GO:0101006)
0.4 2.9 GO:0004984 olfactory receptor activity(GO:0004984) odorant binding(GO:0005549)
0.4 8.1 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.3 9.5 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.3 3.2 GO:0070700 BMP receptor binding(GO:0070700)
0.2 5.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.2 3.3 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.2 5.1 GO:0005523 tropomyosin binding(GO:0005523)
0.2 6.7 GO:0031593 polyubiquitin binding(GO:0031593)
0.2 1.5 GO:0015168 glycerol transmembrane transporter activity(GO:0015168)
0.2 0.5 GO:0031704 apelin receptor binding(GO:0031704)
0.2 3.4 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.2 7.9 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 4.6 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.1 1.2 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.1 1.2 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.1 1.3 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 4.2 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 18.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 2.4 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 3.9 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 0.3 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.1 0.4 GO:0019972 interleukin-12 binding(GO:0019972) interleukin-12 alpha subunit binding(GO:0042164)
0.1 3.4 GO:0005343 organic acid:sodium symporter activity(GO:0005343)
0.1 0.8 GO:0010436 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.1 4.4 GO:0031491 nucleosome binding(GO:0031491)
0.1 6.0 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 2.8 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 3.8 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1 1.8 GO:0005112 Notch binding(GO:0005112)
0.1 7.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 0.7 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 9.1 GO:0005125 cytokine activity(GO:0005125)
0.1 13.7 GO:0046982 protein heterodimerization activity(GO:0046982)
0.1 1.9 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 0.9 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.1 21.4 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.1 1.7 GO:0005518 collagen binding(GO:0005518)
0.1 0.6 GO:0043028 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.1 1.7 GO:0051020 GTPase binding(GO:0051020)
0.1 9.2 GO:0043492 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492)
0.1 11.5 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.1 0.9 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 0.6 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 16.5 GO:0051015 actin filament binding(GO:0051015)
0.0 6.6 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 1.1 GO:0030971 receptor tyrosine kinase binding(GO:0030971) protein tyrosine kinase binding(GO:1990782)
0.0 0.6 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.0 1.3 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 2.4 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 12.7 GO:0003779 actin binding(GO:0003779)
0.0 3.4 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.5 GO:0016408 C-acyltransferase activity(GO:0016408)
0.0 1.1 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.5 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 52.6 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 1.9 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 0.2 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 0.3 GO:0031720 haptoglobin binding(GO:0031720)
0.0 0.4 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.9 GO:0043130 ubiquitin binding(GO:0043130)
0.0 1.0 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.0 0.9 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.1 GO:0017020 myosin phosphatase regulator activity(GO:0017020)
0.0 0.3 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.5 GO:0004707 MAP kinase activity(GO:0004707)
0.0 1.3 GO:0005254 chloride channel activity(GO:0005254)
0.0 0.6 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 2.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 2.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.9 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 0.3 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 18.1 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
1.1 21.1 PID IL23 PATHWAY IL23-mediated signaling events
1.0 19.9 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.8 24.2 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.7 13.2 PID CD40 PATHWAY CD40/CD40L signaling
0.7 19.8 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.6 12.3 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.5 4.1 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.4 8.6 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.4 5.8 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.2 2.4 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.2 9.9 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.2 5.4 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.2 8.3 PID ILK PATHWAY Integrin-linked kinase signaling
0.2 0.8 PID ALK2 PATHWAY ALK2 signaling events
0.2 2.9 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.2 2.4 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 5.2 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 2.5 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 1.7 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.1 2.6 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.1 3.0 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 4.6 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.1 4.7 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 3.0 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 6.3 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 1.1 PID IL1 PATHWAY IL1-mediated signaling events
0.1 1.4 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 1.6 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 0.6 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 0.8 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 0.5 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 2.1 PID BMP PATHWAY BMP receptor signaling
0.0 6.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 5.8 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.9 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.4 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.4 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
5.0 5.0 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
2.3 16.1 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
2.2 11.2 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
1.9 33.7 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
1.8 10.7 REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
1.2 5.0 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.8 2.4 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.8 5.4 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.6 17.3 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.6 5.8 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.6 6.9 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.5 24.2 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.5 17.5 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.4 8.4 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.4 4.6 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.3 8.6 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.3 0.9 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.2 6.6 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.2 1.9 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.2 3.4 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.2 3.3 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 11.6 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 2.1 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.1 2.3 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.1 0.9 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.1 1.4 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 1.1 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.1 1.9 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 0.9 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 4.8 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.0 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 2.1 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 1.4 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.2 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.4 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 2.2 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.8 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0 0.9 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 0.6 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases