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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for nkx2.4a+nkx2.4b

Z-value: 0.46

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Transcription factors associated with nkx2.4a+nkx2.4b

Gene Symbol Gene ID Gene Info
nkx2.4a
ENSDARG00000075107 NK2 homeobox 4a
nkx2.4b
ENSDARG00000104107 NK2 homeobox 4b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nkx2.4adr11_v1_chr17_-_42097267_420972670.132.2e-01Click!
nkx2.4bdr11_v1_chr20_+_48803248_488032480.112.9e-01Click!

Activity profile of nkx2.4a+nkx2.4b motif

Sorted Z-values of nkx2.4a+nkx2.4b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_-_22139566 3.11 ENSDART00000149017
scn3b
sodium channel, voltage-gated, type III, beta
chr1_-_38816685 2.74 ENSDART00000075230
asb5b
ankyrin repeat and SOCS box containing 5b
chr7_-_35708450 2.63 ENSDART00000193886
irx5a
iroquois homeobox 5a
chr13_-_51846224 2.43 ENSDART00000184663
LT631684.2

chr5_-_28915130 2.39 ENSDART00000078592
npdc1b
neural proliferation, differentiation and control, 1b
chr1_-_14234076 1.92 ENSDART00000040049
camk2d2
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 2
chr17_+_27456804 1.88 ENSDART00000017756
ENSDART00000181461
ENSDART00000180178
ctsl.1
cathepsin L.1
chr23_-_35347714 1.71 ENSDART00000161770
ENSDART00000165615
cpne9
copine family member IX
chr8_-_30316436 1.59 ENSDART00000111358
ENSDART00000167065
zgc:162939
zgc:162939
chr2_-_898899 1.56 ENSDART00000058289
dusp22b
dual specificity phosphatase 22b
chr12_-_20362041 1.55 ENSDART00000184145
ENSDART00000105952
aqp8a.2
aquaporin 8a, tandem duplicate 2
chr24_-_28259127 1.49 ENSDART00000149589
prkag2a
protein kinase, AMP-activated, gamma 2 non-catalytic subunit a
chr9_-_23033818 1.46 ENSDART00000022392
rnd3b
Rho family GTPase 3b
chr17_-_31044803 1.43 ENSDART00000185941
ENSDART00000152016
eml1
echinoderm microtubule associated protein like 1
chr12_+_27243059 1.36 ENSDART00000066269
arl4d
ADP-ribosylation factor-like 4D
chr1_-_14233815 1.34 ENSDART00000044896
camk2d2
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 2
chr24_+_19210001 1.33 ENSDART00000179373
ENSDART00000139299
zgc:162928
zgc:162928
chr11_+_24046179 1.32 ENSDART00000006703
maf1
MAF1 homolog, negative regulator of RNA polymerase III
chr5_+_34981584 1.32 ENSDART00000134795
ankra2
ankyrin repeat, family A (RFXANK-like), 2
chr19_-_27776649 1.22 ENSDART00000135348
adcy2b
adenylate cyclase 2b (brain)
chr21_+_27189490 1.20 ENSDART00000125349
bada
BCL2 associated agonist of cell death a
chr1_-_38171648 1.11 ENSDART00000137451
ENSDART00000047159
hmgb2a
high mobility group box 2a
chr7_+_25323742 1.11 ENSDART00000110347
cyp26b1
cytochrome P450, family 26, subfamily b, polypeptide 1
chr8_-_49345388 1.08 ENSDART00000053203
plp2
proteolipid protein 2
chr10_+_21807497 1.05 ENSDART00000164634
pcdh1g32
protocadherin 1 gamma 32
chr5_-_33460959 1.04 ENSDART00000085636
si:ch211-182d3.1
si:ch211-182d3.1
chr19_+_23982466 0.98 ENSDART00000080673
syt11a
synaptotagmin XIa
chr4_+_22365061 0.97 ENSDART00000039277
lhfpl3
LHFPL tetraspan subfamily member 3
chr17_+_8184649 0.97 ENSDART00000091818
tulp4b
tubby like protein 4b
chr12_+_5977777 0.96 ENSDART00000152302
si:ch211-131k2.2
si:ch211-131k2.2
chr22_+_39096911 0.93 ENSDART00000157127
ENSDART00000153841
lmcd1
LIM and cysteine-rich domains 1
chr10_-_10863936 0.91 ENSDART00000180568
nrarpa
NOTCH regulated ankyrin repeat protein a
chr4_+_65649267 0.89 ENSDART00000184068
si:dkey-205i10.1
si:dkey-205i10.1
chr7_-_35126374 0.88 ENSDART00000141211
hsd11b2
hydroxysteroid (11-beta) dehydrogenase 2
chr6_+_374875 0.87 ENSDART00000171698
si:zfos-169g10.3
si:zfos-169g10.3
chr10_+_5268054 0.87 ENSDART00000114491
ror2
receptor tyrosine kinase-like orphan receptor 2
chr17_+_43032529 0.85 ENSDART00000055611
ENSDART00000154863
isca2
iron-sulfur cluster assembly 2
chr10_-_10864331 0.84 ENSDART00000122657
nrarpa
NOTCH regulated ankyrin repeat protein a
chr12_-_28848015 0.84 ENSDART00000153200
si:ch211-194k22.8
si:ch211-194k22.8
chr6_-_13114821 0.82 ENSDART00000164579
ENSDART00000165375
zgc:194469
zgc:194469
chr12_+_49100365 0.82 ENSDART00000171905
CABZ01075125.1

chr8_+_23485079 0.81 ENSDART00000026316
sema3gb
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Gb
chr14_+_23158021 0.81 ENSDART00000084664
enox2
ecto-NOX disulfide-thiol exchanger 2
chr22_+_8753092 0.80 ENSDART00000140720
si:dkey-182g1.2
si:dkey-182g1.2
chr16_-_11766265 0.77 ENSDART00000141547
zgc:158701
zgc:158701
chr8_-_17516448 0.74 ENSDART00000100667
skia
v-ski avian sarcoma viral oncogene homolog a
chr8_+_36803415 0.73 ENSDART00000111680
iqsec2b
IQ motif and Sec7 domain 2b
chr11_-_30352333 0.72 ENSDART00000030794
tmem169a
transmembrane protein 169a
chr23_+_6795709 0.71 ENSDART00000149136
si:ch211-117c9.5
si:ch211-117c9.5
chr22_+_3223489 0.71 ENSDART00000082011
lim2.2
lens intrinsic membrane protein 2.2
chr14_+_14225048 0.70 ENSDART00000168749
nlgn3a
neuroligin 3a
chr7_+_60551133 0.70 ENSDART00000148038
lrfn4b
leucine rich repeat and fibronectin type III domain containing 4b
chr23_+_39346930 0.70 ENSDART00000102843
src
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr8_+_39607466 0.69 ENSDART00000097427
msi1
musashi RNA-binding protein 1
chr15_-_47937204 0.68 ENSDART00000154705
si:ch1073-111c8.3
si:ch1073-111c8.3
chr22_-_7457247 0.67 ENSDART00000106081
BX511034.2

chr19_-_25113660 0.65 ENSDART00000035538
ptp4a3
protein tyrosine phosphatase type IVA, member 3
chr14_-_8816933 0.63 ENSDART00000163383
si:dkeyp-115e12.7
si:dkeyp-115e12.7
chr11_+_39120306 0.61 ENSDART00000155746
ENSDART00000154158
cdc42
cell division cycle 42
chr7_+_39416336 0.61 ENSDART00000171783
CT030188.1

chr14_+_23709134 0.61 ENSDART00000191162
ENSDART00000179754
ENSDART00000054266
gnpda1
glucosamine-6-phosphate deaminase 1
chr25_+_19485198 0.60 ENSDART00000156730
glsl
glutaminase like
chr15_-_12011390 0.59 ENSDART00000187403
si:dkey-202l22.6
si:dkey-202l22.6
chr14_+_23709543 0.58 ENSDART00000136909
gnpda1
glucosamine-6-phosphate deaminase 1
chr1_+_45671687 0.58 ENSDART00000146101
mcoln1a
mucolipin 1a
chr10_+_8481660 0.57 ENSDART00000109559
BX682234.1

chr5_+_53824959 0.57 ENSDART00000169565
sat2b
spermidine/spermine N1-acetyltransferase family member 2b
chr10_-_15048781 0.56 ENSDART00000038401
ENSDART00000155674
si:ch211-95j8.2
si:ch211-95j8.2
chr21_+_30084823 0.55 ENSDART00000154573
prob1
proline-rich basic protein 1
chr22_-_28373698 0.55 ENSDART00000157592
si:ch211-213c4.5
si:ch211-213c4.5
chr12_-_11768889 0.54 ENSDART00000057866
atoh1c
atonal bHLH transcription factor 1c
chr2_+_24203229 0.54 ENSDART00000138088
map4l
microtubule associated protein 4 like
chr15_+_17441734 0.54 ENSDART00000153729
snx19b
sorting nexin 19b
chr6_-_42073367 0.53 ENSDART00000154304
grm2a
glutamate receptor, metabotropic 2a
chr4_-_60312069 0.52 ENSDART00000167207
si:dkey-248e17.4
si:dkey-248e17.4
chr7_-_26049282 0.52 ENSDART00000136389
ENSDART00000101124
rnaseka
ribonuclease, RNase K a
chr3_+_33340939 0.52 ENSDART00000128786
pyya
peptide YYa
chr17_-_42213285 0.52 ENSDART00000140549
nkx2.2a
NK2 homeobox 2a
chr20_+_27020201 0.51 ENSDART00000126919
ENSDART00000016014
chga
chromogranin A
chr10_+_9346383 0.51 ENSDART00000064975
ENSDART00000141869
rbm18
RNA binding motif protein 18
chr6_+_58832155 0.51 ENSDART00000144842
dctn2
dynactin 2 (p50)
chr17_-_7496341 0.50 ENSDART00000186907
si:ch211-278p9.3
si:ch211-278p9.3
chr13_-_2112008 0.48 ENSDART00000110814
fam83b
family with sequence similarity 83, member B
chr8_-_22558773 0.48 ENSDART00000074309
porcnl
porcupine O-acyltransferase like
chr14_-_30876708 0.45 ENSDART00000147597
ubl3b
ubiquitin-like 3b
chr7_-_5039562 0.45 ENSDART00000154438
ltb4r
leukotriene B4 receptor
chr16_+_11151699 0.45 ENSDART00000140674
cicb
capicua transcriptional repressor b
chr9_+_18716485 0.44 ENSDART00000135125
serp2
stress-associated endoplasmic reticulum protein family member 2
chr7_+_26049818 0.42 ENSDART00000173611
si:dkey-6n21.12
si:dkey-6n21.12
chr5_-_54554583 0.42 ENSDART00000158865
ENSDART00000158069
ssna1
Sjogren syndrome nuclear autoantigen 1
chr21_+_17110598 0.40 ENSDART00000101282
ENSDART00000191864
bcr
breakpoint cluster region
chr11_+_36158134 0.40 ENSDART00000189827
ENSDART00000163330
grm2b
glutamate receptor, metabotropic 2b
chr23_-_18982499 0.39 ENSDART00000012507
bcl2l1
bcl2-like 1
chr15_+_850829 0.39 ENSDART00000157374
si:dkey-77f5.11
si:dkey-77f5.11
chr15_-_23485752 0.38 ENSDART00000152706
nlrx1
NLR family member X1
chr13_-_48388726 0.37 ENSDART00000169473
fbxo11a
F-box protein 11a
chr1_+_22654875 0.37 ENSDART00000019698
ENSDART00000161874
anxa5b
annexin A5b
chr2_-_22575851 0.37 ENSDART00000182932
FQ377628.2

chr8_-_39859688 0.36 ENSDART00000019907
unc119.1
unc-119 homolog 1
chr8_+_53120278 0.36 ENSDART00000125232
nr2c2
nuclear receptor subfamily 2, group C, member 2
chr1_-_59232267 0.35 ENSDART00000169658
ENSDART00000163257
akap8l
A kinase (PRKA) anchor protein 8-like
chr3_+_24134418 0.34 ENSDART00000156204
si:ch211-246i5.5
si:ch211-246i5.5
chr14_+_8343498 0.34 ENSDART00000164551
nrg2b
neuregulin 2b
chr15_+_22722684 0.34 ENSDART00000156760
grik4
glutamate receptor, ionotropic, kainate 4
chr23_+_39346774 0.34 ENSDART00000190985
src
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr19_-_3261019 0.34 ENSDART00000134407
si:ch211-133n4.12
si:ch211-133n4.12
chr4_+_23126558 0.33 ENSDART00000162859
mdm2
MDM2 oncogene, E3 ubiquitin protein ligase
chr4_-_43731342 0.33 ENSDART00000146627
si:ch211-226o13.3
si:ch211-226o13.3
chr15_-_8517555 0.32 ENSDART00000140213
npas1
neuronal PAS domain protein 1
chr25_-_1079417 0.31 ENSDART00000163134
FO907089.1

chr6_-_13114406 0.31 ENSDART00000188015
zgc:194469
zgc:194469
chr6_-_30210378 0.31 ENSDART00000157359
ENSDART00000113924
lrrc7
leucine rich repeat containing 7
chr19_-_17303500 0.30 ENSDART00000162355
sf3a3
splicing factor 3a, subunit 3
chr5_-_32882162 0.30 ENSDART00000085769
lrsam1
leucine rich repeat and sterile alpha motif containing 1
chr2_+_23731194 0.29 ENSDART00000155747
slc22a13a
solute carrier family 22 member 13a
chr14_+_14224730 0.29 ENSDART00000180112
ENSDART00000184891
ENSDART00000174760
nlgn3a
neuroligin 3a
chr20_+_23742574 0.27 ENSDART00000050559
sh3rf1
SH3 domain containing ring finger 1
chr9_+_25832329 0.26 ENSDART00000130059
zeb2a
zinc finger E-box binding homeobox 2a
chr10_-_17179415 0.26 ENSDART00000131751
depdc5
DEP domain containing 5
chr21_-_41147818 0.25 ENSDART00000167339
ENSDART00000192730
msx2b
muscle segment homeobox 2b
chr7_+_39664055 0.25 ENSDART00000146171
zgc:158564
zgc:158564
chr5_+_36870737 0.25 ENSDART00000145182
slc8a2a
solute carrier family 8 (sodium/calcium exchanger), member 2a
chr4_+_50410452 0.25 ENSDART00000146006
si:dkey-156k2.8
si:dkey-156k2.8
chr10_-_9346360 0.24 ENSDART00000039536
mrrf
mitochondrial ribosome recycling factor
chr4_+_23127104 0.24 ENSDART00000139543
mdm2
MDM2 oncogene, E3 ubiquitin protein ligase
chr18_-_7481036 0.24 ENSDART00000101292
si:dkey-238c7.16
si:dkey-238c7.16
chr16_+_25259313 0.23 ENSDART00000058938
fbxo32
F-box protein 32
chr14_-_9982603 0.23 ENSDART00000054687
il1rapl2
interleukin 1 receptor accessory protein-like 2
chr23_-_26532696 0.23 ENSDART00000124811
ENSDART00000180274
si:dkey-205h13.2
si:dkey-205h13.2
chr19_+_7938121 0.22 ENSDART00000140053
ENSDART00000146649
si:dkey-266f7.5
si:dkey-266f7.5
chr2_-_51507540 0.22 ENSDART00000166605
ENSDART00000161093
pigrl2.3
polymeric immunoglobulin receptor-like 2.3
chr8_-_25120231 0.21 ENSDART00000147308
amigo1
adhesion molecule with Ig-like domain 1
chr1_-_7603734 0.21 ENSDART00000009315
mxb
myxovirus (influenza) resistance B
chr1_+_29862074 0.20 ENSDART00000133905
ENSDART00000136786
ENSDART00000135252
pcca
propionyl CoA carboxylase, alpha polypeptide
chr5_+_56119975 0.20 ENSDART00000083137
mrm1
mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
chr17_-_8673278 0.20 ENSDART00000171850
ENSDART00000017337
ENSDART00000148504
ENSDART00000148808
ctbp2a
C-terminal binding protein 2a
chr7_+_42206847 0.19 ENSDART00000149250
phkb
phosphorylase kinase, beta
chr17_-_42213822 0.19 ENSDART00000187904
ENSDART00000180029
nkx2.2a
NK2 homeobox 2a
chr11_-_34628789 0.19 ENSDART00000192433
mapkapk3
mitogen-activated protein kinase-activated protein kinase 3
chr2_-_6292510 0.18 ENSDART00000092182
ppm1la
protein phosphatase, Mg2+/Mn2+ dependent, 1La
chr16_-_34258931 0.18 ENSDART00000145485
phactr4b
phosphatase and actin regulator 4b
chr16_+_24971717 0.18 ENSDART00000156958
fpr1
formyl peptide receptor 1
chr1_-_31657854 0.18 ENSDART00000085309
dpcd
deleted in primary ciliary dyskinesia homolog (mouse)
chr13_+_25761279 0.18 ENSDART00000177818
ENSDART00000002863
neurog3
neurogenin 3
chr4_+_44454270 0.17 ENSDART00000150482
si:dkeyp-100h4.4
si:dkeyp-100h4.4
chr3_+_58354852 0.16 ENSDART00000155715
vwa3a
von Willebrand factor A domain containing 3A
chr5_-_39171302 0.16 ENSDART00000020808
paqr3a
progestin and adipoQ receptor family member IIIa
chr20_+_27464721 0.16 ENSDART00000189552
kif26aa
kinesin family member 26Aa
chr5_+_36611128 0.15 ENSDART00000097684
nova1
neuro-oncological ventral antigen 1
chr17_-_8673567 0.15 ENSDART00000192714
ENSDART00000012546
ctbp2a
C-terminal binding protein 2a
chr2_-_32668668 0.15 ENSDART00000190450
puf60a
poly-U binding splicing factor a
chr17_-_22552678 0.15 ENSDART00000079401
si:ch211-125o16.4
si:ch211-125o16.4
chr17_-_28097760 0.15 ENSDART00000149861
kdm1a
lysine (K)-specific demethylase 1a
chr20_+_35484070 0.14 ENSDART00000026234
ENSDART00000141675
mep1a.2
meprin A, alpha (PABA peptide hydrolase), tandem duplicate 2
chr1_-_21599219 0.13 ENSDART00000148327
adamtsl7
ADAMTS-like 7
chr23_+_7505943 0.13 ENSDART00000135787
hck
HCK proto-oncogene, Src family tyrosine kinase
chr1_+_31658011 0.12 ENSDART00000192203
poll
polymerase (DNA directed), lambda
chr10_+_2742499 0.12 ENSDART00000122847
grk5
G protein-coupled receptor kinase 5
chr7_-_18601206 0.12 ENSDART00000111636
DTX4
si:ch211-119e14.2
chr23_+_34321237 0.12 ENSDART00000173272
plxna1a
plexin A1a
chr8_-_23776399 0.12 ENSDART00000114800
INAVA
si:ch211-163l21.4
chr2_-_36604589 0.12 ENSDART00000167352
tradv41.0
T-cell receptor alpha/delta variable 41.0
chr2_+_47754419 0.11 ENSDART00000188221
mbnl1
muscleblind-like splicing regulator 1
chr19_-_23470709 0.11 ENSDART00000138884
pimr80
Pim proto-oncogene, serine/threonine kinase, related 80
chr11_-_438294 0.10 ENSDART00000040812
nuf2
NUF2, NDC80 kinetochore complex component, homolog
chr4_-_965267 0.10 ENSDART00000093289
atp23
ATP23 metallopeptidase and ATP synthase assembly factor homolog
chr14_-_32486757 0.09 ENSDART00000148830
mcf2a
MCF.2 cell line derived transforming sequence a
chr3_-_11008532 0.09 ENSDART00000165086
CR382337.3

chr14_-_17622080 0.09 ENSDART00000112149
si:ch211-159i8.4
si:ch211-159i8.4
chr15_-_1590858 0.09 ENSDART00000081875
nnr
nanor
chr12_+_32199651 0.08 ENSDART00000153027
si:ch211-277e21.1
si:ch211-277e21.1
chr3_-_39305291 0.08 ENSDART00000102674
plcd3a
phospholipase C, delta 3a
chr5_+_36896933 0.08 ENSDART00000151984
srsf7a
serine/arginine-rich splicing factor 7a
chr9_+_20869166 0.08 ENSDART00000147892
wdr3
WD repeat domain 3
chr1_+_31657842 0.08 ENSDART00000057880
poll
polymerase (DNA directed), lambda
chr14_+_16083818 0.07 ENSDART00000168462
rnf103
ring finger protein 103
chr12_-_1361517 0.07 ENSDART00000188297
LO018020.2

chr18_+_23397010 0.06 ENSDART00000193765
mctp2a
multiple C2 domains, transmembrane 2a
chr4_-_17838179 0.05 ENSDART00000146931
avpr2l
arginine vasopressin receptor 2, like
chr15_-_28569786 0.05 ENSDART00000127845
ssh2a
slingshot protein phosphatase 2a
chr20_-_43079478 0.04 ENSDART00000060982
snx9b
sorting nexin 9b
chr4_-_65747476 0.04 ENSDART00000142421
si:dkey-28k24.2
si:dkey-28k24.2
chr19_-_23452345 0.04 ENSDART00000136875
pimr82
Pim proto-oncogene, serine/threonine kinase, related 82
chr3_+_32571929 0.04 ENSDART00000151025
si:ch73-248e21.1
si:ch73-248e21.1
chr17_+_43659940 0.03 ENSDART00000145738
ENSDART00000075619
adob
2-aminoethanethiol (cysteamine) dioxygenase b
chr20_+_48782068 0.03 ENSDART00000159275
nkx2.2b
NK2 homeobox 2b
chr9_+_159720 0.02 ENSDART00000166215
cldn10l2
claudin 10-like 2
chr19_+_26424734 0.02 ENSDART00000187402
npr1a
natriuretic peptide receptor 1a
chr15_-_12011202 0.02 ENSDART00000160427
ENSDART00000168715
si:dkey-202l22.6
si:dkey-202l22.6
chr2_+_36608387 0.02 ENSDART00000159541
pak2a
p21 protein (Cdc42/Rac)-activated kinase 2a
chr12_-_19279103 0.01 ENSDART00000186669
si:ch211-141o9.10
si:ch211-141o9.10
chr9_-_35155089 0.01 ENSDART00000077901
appb
amyloid beta (A4) precursor protein b
chr4_+_17843717 0.01 ENSDART00000113507
apaf1
apoptotic peptidase activating factor 1
chr10_-_9086716 0.01 ENSDART00000140095
arl15b
ADP-ribosylation factor-like 15b
chr22_+_19111444 0.01 ENSDART00000109655
fgf22
fibroblast growth factor 22
chr4_-_17680493 0.00 ENSDART00000180131
BX890572.2

chr7_+_20966434 0.00 ENSDART00000185570
efnb3b
ephrin-B3b

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx2.4a+nkx2.4b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.1 GO:0086005 ventricular cardiac muscle cell action potential(GO:0086005)
0.4 1.2 GO:0006043 glucosamine metabolic process(GO:0006041) glucosamine catabolic process(GO:0006043)
0.4 1.1 GO:0035992 tendon formation(GO:0035992)
0.3 1.0 GO:0050847 progesterone receptor signaling pathway(GO:0050847)
0.3 2.6 GO:0072498 embryonic skeletal joint development(GO:0072498)
0.2 0.7 GO:0021530 spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.2 1.0 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.2 0.5 GO:0002792 negative regulation of peptide secretion(GO:0002792) negative regulation of peptide hormone secretion(GO:0090278)
0.2 0.8 GO:0007624 ultradian rhythm(GO:0007624)
0.2 0.5 GO:0061355 Wnt protein secretion(GO:0061355)
0.1 1.8 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.1 1.4 GO:0036368 cone photoresponse recovery(GO:0036368)
0.1 0.9 GO:0034650 cortisol metabolic process(GO:0034650)
0.1 0.8 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.1 0.6 GO:1904036 negative regulation of epithelial cell apoptotic process(GO:1904036)
0.1 1.0 GO:0097105 presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
0.1 0.6 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.1 0.6 GO:0006537 glutamate biosynthetic process(GO:0006537) glutamine catabolic process(GO:0006543)
0.1 0.4 GO:0035332 positive regulation of hippo signaling(GO:0035332)
0.1 0.6 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.1 0.3 GO:0098908 regulation of neuronal action potential(GO:0098908)
0.1 0.6 GO:0061337 cardiac conduction(GO:0061337)
0.1 0.3 GO:0036037 CD8-positive, alpha-beta T cell activation(GO:0036037)
0.1 0.4 GO:0070073 clustering of voltage-gated calcium channels(GO:0070073)
0.0 0.5 GO:0021707 cerebellar granular layer development(GO:0021681) cerebellar granular layer morphogenesis(GO:0021683) cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0 0.5 GO:0030719 P granule organization(GO:0030719)
0.0 1.5 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.3 GO:0090243 fibroblast growth factor receptor signaling pathway involved in somitogenesis(GO:0090243)
0.0 2.2 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 1.2 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 0.9 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling(GO:0014068)
0.0 1.6 GO:0046330 positive regulation of JNK cascade(GO:0046330)
0.0 0.1 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.0 0.2 GO:0002283 neutrophil activation involved in immune response(GO:0002283)
0.0 0.9 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 0.2 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.0 0.4 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0 0.2 GO:0046716 muscle cell cellular homeostasis(GO:0046716)
0.0 0.6 GO:0035675 neuromast hair cell development(GO:0035675)
0.0 0.3 GO:0032088 negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.0 1.2 GO:0006171 cAMP biosynthetic process(GO:0006171)
0.0 0.1 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.0 1.9 GO:0045732 positive regulation of protein catabolic process(GO:0045732)
0.0 0.4 GO:0042953 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.0 0.7 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.4 GO:0040019 positive regulation of embryonic development(GO:0040019)
0.0 0.5 GO:0007631 feeding behavior(GO:0007631)
0.0 0.4 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.5 GO:0060319 primitive erythrocyte differentiation(GO:0060319)
0.0 1.5 GO:0030865 cortical cytoskeleton organization(GO:0030865)
0.0 0.8 GO:1902668 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.0 0.2 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.0 0.9 GO:0010038 response to metal ion(GO:0010038)
0.0 0.2 GO:0007413 axonal fasciculation(GO:0007413)
0.0 0.2 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.0 0.5 GO:0038127 epidermal growth factor receptor signaling pathway(GO:0007173) ERBB signaling pathway(GO:0038127)
0.0 0.4 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 2.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 0.3 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.1 0.5 GO:0042583 chromaffin granule(GO:0042583)
0.0 0.3 GO:1990130 Iml1 complex(GO:1990130)
0.0 0.5 GO:0005869 dynactin complex(GO:0005869)
0.0 0.2 GO:0043034 costamere(GO:0043034)
0.0 1.3 GO:0072686 mitotic spindle(GO:0072686)
0.0 0.2 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.6 GO:0030496 midbody(GO:0030496)
0.0 0.2 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.0 0.1 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.4 1.1 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.4 2.9 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.3 1.0 GO:0031834 neurokinin receptor binding(GO:0031834) substance P receptor binding(GO:0031835)
0.2 1.6 GO:0015250 water channel activity(GO:0015250)
0.1 0.9 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.1 0.5 GO:0031843 neuropeptide Y receptor binding(GO:0031841) type 2 neuropeptide Y receptor binding(GO:0031843)
0.1 0.6 GO:0019809 spermidine binding(GO:0019809)
0.1 0.6 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.1 3.4 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 0.6 GO:0004359 glutaminase activity(GO:0004359)
0.1 0.5 GO:0004974 leukotriene receptor activity(GO:0004974)
0.1 0.3 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 1.1 GO:0008301 DNA binding, bending(GO:0008301)
0.1 1.5 GO:0016208 AMP binding(GO:0016208)
0.0 0.2 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.0 1.2 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 1.4 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.2 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.9 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0033764)
0.0 1.0 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.4 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.0 0.7 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.3 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 2.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.8 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.2 GO:0016421 CoA carboxylase activity(GO:0016421)
0.0 0.1 GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0 1.6 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.2 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 1.2 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.9 GO:0005507 copper ion binding(GO:0005507)
0.0 0.8 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 1.8 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.2 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0 1.9 GO:0019901 protein kinase binding(GO:0019901)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 ST STAT3 PATHWAY STAT3 Pathway
0.1 0.6 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 0.6 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 0.4 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.3 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.9 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.6 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 2.5 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.2 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.4 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.3 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 0.4 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.3 PID HES HEY PATHWAY Notch-mediated HES/HEY network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.1 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 1.6 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.1 0.4 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 1.1 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.5 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.6 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.2 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 0.4 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.9 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.3 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.2 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.2 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.4 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling