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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for noto+vax1

Z-value: 0.45

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Transcription factors associated with noto+vax1

Gene Symbol Gene ID Gene Info
noto
ENSDARG00000021201 notochord homeobox
vax1
ENSDARG00000021916 ventral anterior homeobox 1
vax1
ENSDARG00000114230 ventral anterior homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
notodr11_v1_chr13_+_14976108_149761080.171.1e-01Click!
vax1dr11_v1_chr17_-_21441464_21441464-0.112.9e-01Click!

Activity profile of noto+vax1 motif

Sorted Z-values of noto+vax1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_55982300 3.29 ENSDART00000183903
nmrk2
nicotinamide riboside kinase 2
chr19_+_2631565 2.88 ENSDART00000171487
fam126a
family with sequence similarity 126, member A
chr13_-_35808904 2.62 ENSDART00000171667
map3k4
mitogen-activated protein kinase kinase kinase 4
chr15_-_43284021 2.51 ENSDART00000041677
serpine2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr9_+_38372216 2.50 ENSDART00000141895
plcd4b
phospholipase C, delta 4b
chr4_+_73085993 2.45 ENSDART00000165749
si:ch73-170d6.2
si:ch73-170d6.2
chr21_-_35419486 2.35 ENSDART00000138529
si:dkeyp-23e4.3
si:dkeyp-23e4.3
chr8_+_22516728 2.27 ENSDART00000146013
si:ch211-261n11.3
si:ch211-261n11.3
chr14_+_51056605 2.25 ENSDART00000159639
CABZ01078593.1

chr3_+_59784632 2.24 ENSDART00000084729
pecam1
platelet/endothelial cell adhesion molecule 1
chr12_+_22580579 2.21 ENSDART00000171725
ENSDART00000192290
capgb
capping protein (actin filament), gelsolin-like b
chr17_+_16046314 2.14 ENSDART00000154554
ENSDART00000154338
ENSDART00000155336
si:ch73-204p21.2
si:ch73-204p21.2
chr3_+_27798094 1.97 ENSDART00000075100
ENSDART00000151437
carhsp1
calcium regulated heat stable protein 1
chr19_-_2861444 1.95 ENSDART00000169053
clec3bb
C-type lectin domain family 3, member Bb
chr24_+_19415124 1.89 ENSDART00000186931
sulf1
sulfatase 1
chr3_-_15734530 1.83 ENSDART00000141142
mvp
major vault protein
chr20_+_26966725 1.77 ENSDART00000029781
ahsa1a
AHA1, activator of heat shock protein ATPase homolog 1a
chr3_-_15734358 1.75 ENSDART00000137325
mvp
major vault protein
chr6_-_40581376 1.68 ENSDART00000185412
tspo
translocator protein
chr10_-_33621739 1.64 ENSDART00000142655
ENSDART00000128049
hunk
hormonally up-regulated Neu-associated kinase
chr9_+_30421489 1.63 ENSDART00000145025
ENSDART00000132058
zgc:113314
zgc:113314
chr22_-_30770751 1.52 ENSDART00000172115
AL831726.2

chr7_-_30174882 1.41 ENSDART00000110409
frmd5
FERM domain containing 5
chr19_-_7690975 1.34 ENSDART00000151384
si:dkey-204a24.10
si:dkey-204a24.10
chr18_-_46256560 1.30 ENSDART00000171375
si:dkey-244a7.1
si:dkey-244a7.1
chr20_-_37813863 1.27 ENSDART00000147529
batf3
basic leucine zipper transcription factor, ATF-like 3
chr6_+_6924637 1.27 ENSDART00000065551
ENSDART00000151393
zak
sterile alpha motif and leucine zipper containing kinase AZK
chr15_+_31701716 1.27 ENSDART00000113370
b3glcta
beta 3-glucosyltransferase a
chr15_+_31899312 1.24 ENSDART00000155315
frya
furry homolog a (Drosophila)
chr9_-_5263947 1.21 ENSDART00000088342
cytip
cytohesin 1 interacting protein
chr25_+_28825657 1.19 ENSDART00000153625
nfybb
nuclear transcription factor Y, beta b
chr16_+_13818743 1.18 ENSDART00000090191
flcn
folliculin
chr19_+_41464870 1.18 ENSDART00000102778
dlx6a
distal-less homeobox 6a
chr1_-_51719110 1.10 ENSDART00000190574
rnaseh2a
ribonuclease H2, subunit A
chr16_+_13818500 1.08 ENSDART00000135245
flcn
folliculin
chr1_+_513986 1.06 ENSDART00000109083
ENSDART00000081945
txnl4b
thioredoxin-like 4B
chr14_-_14640401 1.04 ENSDART00000168027
ENSDART00000167521
znf185
zinc finger protein 185 with LIM domain
chr21_-_26490186 1.00 ENSDART00000009889
zgc:110540
zgc:110540
chr4_+_21129752 0.93 ENSDART00000169764
syt1a
synaptotagmin Ia
chr20_-_14925281 0.93 ENSDART00000152641
dnm3a
dynamin 3a
chr18_-_2727764 0.92 ENSDART00000160841
ARHGEF17
si:ch211-248g20.5
chr22_+_19218733 0.86 ENSDART00000183212
ENSDART00000133595
si:dkey-21e2.7
si:dkey-21e2.7
chr6_-_19271210 0.82 ENSDART00000163628
ENSDART00000159124
zgc:174863
zgc:174863
chr15_+_5088210 0.81 ENSDART00000183423
mxf
myxovirus (influenza virus) resistance F
chr9_-_14683574 0.76 ENSDART00000144022
pard3bb
par-3 family cell polarity regulator beta b
chr6_-_30954268 0.74 ENSDART00000154523
pde4ba
phosphodiesterase 4B, cAMP-specific a
chr4_+_9011448 0.73 ENSDART00000192357
samm50l
sorting and assembly machinery component 50 homolog, like
chr3_-_32902138 0.66 ENSDART00000144026
ENSDART00000083874
ENSDART00000145443
ENSDART00000148239
ENSDART00000134917
kat7a
K(lysine) acetyltransferase 7a
chr1_-_513762 0.66 ENSDART00000148162
ENSDART00000144606
trmt10c
tRNA methyltransferase 10C, mitochondrial RNase P subunit
chr11_+_43043171 0.64 ENSDART00000180344
CABZ01092982.1

chr3_-_34084387 0.63 ENSDART00000155365
ighv4-3
immunoglobulin heavy variable 4-3
chr5_+_41477954 0.62 ENSDART00000185871
pias2
protein inhibitor of activated STAT, 2
chr7_-_46777876 0.61 ENSDART00000193954
tshz3b
teashirt zinc finger homeobox 3b
chr6_+_32382743 0.59 ENSDART00000190009
dock7
dedicator of cytokinesis 7
chr17_+_21902058 0.58 ENSDART00000142178
plekha1a
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1a
chr18_+_17827149 0.57 ENSDART00000190237
ENSDART00000189345
ZNF423
si:ch211-216l23.1
chr20_-_46362606 0.54 ENSDART00000153087
bmf2
BCL2 modifying factor 2
chr3_-_27601812 0.53 ENSDART00000077734
zgc:66160
zgc:66160
chr13_+_35339182 0.53 ENSDART00000019323
jag1b
jagged 1b
chr20_-_14924858 0.51 ENSDART00000047039
dnm3a
dynamin 3a
chr11_-_13107106 0.49 ENSDART00000184477
elovl1b
ELOVL fatty acid elongase 1b
chr8_+_25034544 0.47 ENSDART00000123300
ngrn
neugrin, neurite outgrowth associated
chr18_+_3332999 0.47 ENSDART00000160857
gdpd4a
glycerophosphodiester phosphodiesterase domain containing 4a
chr22_-_2959005 0.46 ENSDART00000040701
ing5a
inhibitor of growth family, member 5a
chr5_+_41477526 0.44 ENSDART00000153567
pias2
protein inhibitor of activated STAT, 2
chr12_+_20352400 0.43 ENSDART00000066383
hbae5
hemoglobin, alpha embryonic 5
chr2_-_2957970 0.41 ENSDART00000162505
si:ch1073-82l19.1
si:ch1073-82l19.1
chr14_+_30762131 0.40 ENSDART00000145039
si:ch211-145o7.3
si:ch211-145o7.3
chr2_-_26720854 0.40 ENSDART00000148110
si:dkey-181m9.8
si:dkey-181m9.8
chr12_+_30265802 0.37 ENSDART00000182412
afap1l2
actin filament associated protein 1-like 2
chr20_-_1635922 0.35 ENSDART00000181502
CR846082.1

chr14_-_4145594 0.35 ENSDART00000077348
casp3b
caspase 3, apoptosis-related cysteine peptidase b
chr13_+_35637048 0.31 ENSDART00000085037
thbs2a
thrombospondin 2a
chr15_+_1796313 0.31 ENSDART00000126253
fam124b
family with sequence similarity 124B
chr10_+_43039947 0.30 ENSDART00000193434
atg10
ATG10 autophagy related 10 homolog (S. cerevisiae)
chr20_+_29209615 0.29 ENSDART00000062350
katnbl1
katanin p80 subunit B-like 1
chr14_+_46313396 0.28 ENSDART00000047525
cryba1l1
crystallin, beta A1, like 1
chr3_-_27601544 0.28 ENSDART00000188201
zgc:66160
zgc:66160
chr20_+_11731039 0.26 ENSDART00000152215
ENSDART00000152585
si:ch211-155o21.3
si:ch211-155o21.3
chr4_-_45100253 0.25 ENSDART00000163870
si:dkey-51d8.3
si:dkey-51d8.3
chr17_+_24722646 0.24 ENSDART00000138356
mtfr1l
mitochondrial fission regulator 1-like
chr11_+_11303458 0.18 ENSDART00000162486
ENSDART00000160703
si:dkey-23f9.4
si:dkey-23f9.4
chr18_-_43884044 0.16 ENSDART00000087382
ddx6
DEAD (Asp-Glu-Ala-Asp) box helicase 6
chr14_+_46313135 0.14 ENSDART00000172902
cryba1l1
crystallin, beta A1, like 1
chr1_+_21731382 0.14 ENSDART00000054395
pax5
paired box 5
chr16_+_11834516 0.13 ENSDART00000146611
cxcr3.3
chemokine (C-X-C motif) receptor 3, tandem duplicate 3
chr5_+_48683447 0.11 ENSDART00000008043
adgrv1
adhesion G protein-coupled receptor V1
chr19_-_20430892 0.11 ENSDART00000111409
tbc1d5
TBC1 domain family, member 5
chr6_+_41191482 0.08 ENSDART00000000877
opn1mw3
opsin 1 (cone pigments), medium-wave-sensitive, 3
chr1_-_7970653 0.08 ENSDART00000188909
si:dkey-79f11.7
si:dkey-79f11.7
chr6_+_3280939 0.07 ENSDART00000151359
kdm4aa
lysine (K)-specific demethylase 4A, genome duplicate a
chr3_-_50443607 0.07 ENSDART00000074036
rcvrna
recoverin a
chr5_-_66397688 0.07 ENSDART00000161483
hip1rb
huntingtin interacting protein 1 related b
chr20_+_29209767 0.05 ENSDART00000141252
katnbl1
katanin p80 subunit B-like 1
chr8_-_52562672 0.04 ENSDART00000159333
ENSDART00000159974
si:ch73-199g24.2
si:ch73-199g24.2
chr5_-_15283509 0.02 ENSDART00000052712
gnb1l
guanine nucleotide binding protein (G protein), beta polypeptide 1-like
chr4_+_306036 0.02 ENSDART00000103659
msgn1
mesogenin 1
chr15_-_22074315 0.01 ENSDART00000149830
drd2a
dopamine receptor D2a

Network of associatons between targets according to the STRING database.

First level regulatory network of noto+vax1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.3 GO:1903846 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.2 0.7 GO:0045040 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.2 1.9 GO:0021910 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910) regulation of myotome development(GO:2000290)
0.2 0.8 GO:0051660 establishment of centrosome localization(GO:0051660)
0.2 1.1 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.2 1.8 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.1 0.7 GO:0090646 mitochondrial tRNA processing(GO:0090646)
0.1 0.4 GO:0032677 interleukin-8 production(GO:0032637) regulation of interleukin-8 production(GO:0032677) positive regulation of interleukin-8 production(GO:0032757)
0.1 2.2 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.1 2.2 GO:0051014 actin filament severing(GO:0051014)
0.1 3.6 GO:0031102 neuron projection regeneration(GO:0031102)
0.1 1.2 GO:0035141 medial fin morphogenesis(GO:0035141)
0.0 0.9 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 2.5 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.0 1.4 GO:0060319 primitive erythrocyte differentiation(GO:0060319)
0.0 2.0 GO:0030282 bone mineralization(GO:0030282)
0.0 0.7 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 2.9 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.1 GO:0097264 self proteolysis(GO:0097264)
0.0 1.1 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.5 GO:0060325 face morphogenesis(GO:0060325)
0.0 2.0 GO:0043488 regulation of mRNA stability(GO:0043488)
0.0 0.5 GO:0034626 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 2.4 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.5 GO:2001235 positive regulation of apoptotic signaling pathway(GO:2001235)
0.0 0.5 GO:0010507 negative regulation of autophagy(GO:0010507)
0.0 0.4 GO:0015671 oxygen transport(GO:0015671)
0.0 0.2 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.4 GO:0030216 keratinocyte differentiation(GO:0030216)
0.0 1.3 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 0.1 GO:0060005 reflex(GO:0060004) vestibular reflex(GO:0060005) vestibular receptor cell differentiation(GO:0060114) vestibular receptor cell development(GO:0060118)
0.0 0.8 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.0 0.2 GO:0000266 mitochondrial fission(GO:0000266)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.2 0.9 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 2.2 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.1 0.7 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.1 0.7 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 0.8 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 1.1 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.4 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.4 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.4 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.1 GO:0060171 stereocilium membrane(GO:0060171)
0.0 2.2 GO:0001726 ruffle(GO:0001726)
0.0 0.5 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 1.9 GO:0005795 Golgi stack(GO:0005795)
0.0 2.3 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 1.7 GO:0005741 mitochondrial outer membrane(GO:0005741)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.3 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262)
0.2 0.7 GO:0052905 tRNA (guanine(9)-N(1))-methyltransferase activity(GO:0052905)
0.2 1.1 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.1 1.0 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.1 1.8 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 1.9 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.3 GO:0019777 Atg12 transferase activity(GO:0019777)
0.1 1.1 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 2.5 GO:0004629 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.1 0.4 GO:0042169 SH2 domain binding(GO:0042169)
0.0 0.4 GO:0031720 haptoglobin binding(GO:0031720)
0.0 0.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.5 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.5 GO:0005112 Notch binding(GO:0005112)
0.0 0.6 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.9 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 2.0 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.4 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.0 1.3 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 0.1 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.7 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 4.7 GO:0005096 GTPase activator activity(GO:0005096)
0.0 1.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.6 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.1 1.3 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 3.6 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.1 1.3 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 1.1 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 2.2 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.9 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 2.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.6 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.2 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.9 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK