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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for nr1h4

Z-value: 1.38

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Transcription factors associated with nr1h4

Gene Symbol Gene ID Gene Info
nr1h4
ENSDARG00000057741 nuclear receptor subfamily 1, group H, member 4
nr1h4
ENSDARG00000113600 nuclear receptor subfamily 1, group H, member 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nr1h4dr11_v1_chr18_+_15644559_156445590.665.0e-13Click!

Activity profile of nr1h4 motif

Sorted Z-values of nr1h4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_1769475 30.90 ENSDART00000079073
serpind1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr15_-_462783 23.79 ENSDART00000161049
CABZ01033205.1
Danio rerio uncharacterized LOC100002960 (LOC100002960), mRNA.
chr2_-_42234484 22.00 ENSDART00000132617
ENSDART00000136690
ENSDART00000141358
apom
apolipoprotein M
chr6_-_27139396 21.17 ENSDART00000055848
zgc:103559
zgc:103559
chr24_-_21689146 20.11 ENSDART00000105917
urad
ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase
chr5_+_28830388 18.93 ENSDART00000149150
serpina7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr21_+_40092301 18.88 ENSDART00000145150
serpinf2a
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2a
chr1_+_127250 17.33 ENSDART00000003463
f7i
coagulation factor VIIi
chr4_+_1530287 17.12 ENSDART00000067446
slc38a4
solute carrier family 38, member 4
chr6_-_609880 15.52 ENSDART00000149248
ENSDART00000148867
ENSDART00000149414
ENSDART00000148552
ENSDART00000148391
lgals2b
lectin, galactoside-binding, soluble, 2b
chr3_-_18030938 14.86 ENSDART00000013540
si:ch73-141c7.1
si:ch73-141c7.1
chr13_-_337318 14.65 ENSDART00000166175
zgc:171534
zgc:171534
chr3_+_4346854 14.48 ENSDART00000004273
si:dkey-73p2.3
si:dkey-73p2.3
chr23_-_44723102 13.97 ENSDART00000129138
mogat3a
monoacylglycerol O-acyltransferase 3a
chr17_-_36529016 12.68 ENSDART00000025019
colec11
collectin sub-family member 11
chr9_-_34269066 12.64 ENSDART00000059955
ildr1b
immunoglobulin-like domain containing receptor 1b
chr21_-_19918286 12.54 ENSDART00000180816
ppp1r3b
protein phosphatase 1, regulatory subunit 3B
chr10_+_28428222 12.27 ENSDART00000135003
si:ch211-222e20.4
si:ch211-222e20.4
chr15_+_45563656 12.22 ENSDART00000157501
cldn15lb
claudin 15-like b
chr17_-_36529449 11.73 ENSDART00000187252
colec11
collectin sub-family member 11
chr17_-_15149192 9.96 ENSDART00000180511
ENSDART00000103405
gch1
GTP cyclohydrolase 1
chr9_-_28616436 9.60 ENSDART00000136985
si:ch73-7i4.2
si:ch73-7i4.2
chr3_-_4303262 9.33 ENSDART00000112819
si:dkey-73p2.2
si:dkey-73p2.2
chr23_+_19790962 9.24 ENSDART00000142228
flna
filamin A, alpha (actin binding protein 280)
chr7_+_24523017 9.17 ENSDART00000077047
btr09
bloodthirsty-related gene family, member 9
chr24_+_28448387 9.16 ENSDART00000154077
ENSDART00000018037
arhgap29a
Rho GTPase activating protein 29a
chr15_+_6652396 8.54 ENSDART00000192813
ENSDART00000157678
nop53
NOP53 ribosome biogenesis factor
chr23_+_42810055 8.25 ENSDART00000186647
myl9a
myosin, light chain 9a, regulatory
chr19_-_32493866 7.73 ENSDART00000052090
fuca1.2
alpha-L-fucosidase 1, tandem duplicate 2
chr18_-_16791331 7.57 ENSDART00000148222
ampd3b
adenosine monophosphate deaminase 3b
chr25_-_24046870 7.47 ENSDART00000047569
igf2b
insulin-like growth factor 2b
chr13_-_23665580 7.27 ENSDART00000144282
map3k21
mitogen-activated protein kinase kinase kinase 21
chr18_+_46151505 7.26 ENSDART00000015034
ENSDART00000141287
blvrb
biliverdin reductase B
chr7_-_32980017 7.22 ENSDART00000113744
pkp3b
plakophilin 3b
chr20_-_19864131 7.11 ENSDART00000057819
ptk2bb
protein tyrosine kinase 2 beta, b
chr5_-_38777852 6.93 ENSDART00000131603
si:dkey-58f10.4
si:dkey-58f10.4
chr3_-_34027178 6.74 ENSDART00000170201
ENSDART00000151408
ighv1-4
ighv14-1
immunoglobulin heavy variable 1-4
immunoglobulin heavy variable 14-1
chr13_+_29238850 6.64 ENSDART00000026000
myofl
myoferlin like
chr21_-_20733615 6.44 ENSDART00000145544
si:ch211-22d5.2
si:ch211-22d5.2
chr21_+_29179887 6.42 ENSDART00000161941
si:ch211-57b15.1
si:ch211-57b15.1
chr21_-_5879897 6.42 ENSDART00000184034
rpl35
ribosomal protein L35
chr24_-_31332087 6.10 ENSDART00000161179
abcd3a
ATP-binding cassette, sub-family D (ALD), member 3a
chr8_+_10305400 6.05 ENSDART00000172400
pim1
Pim-1 proto-oncogene, serine/threonine kinase
chr17_+_20173882 6.00 ENSDART00000155379
si:ch211-248a14.8
si:ch211-248a14.8
chr3_-_49110710 5.78 ENSDART00000160404
trim35-12
tripartite motif containing 35-12
chr8_-_13013123 5.58 ENSDART00000147802
dennd2da
DENN/MADD domain containing 2Da
chr8_-_36469117 5.47 ENSDART00000111240
mhc2dab
major histocompatibility complex class II DAB gene
chr23_+_22597624 5.30 ENSDART00000054337
gpr157
G protein-coupled receptor 157
chr15_-_18091157 5.21 ENSDART00000153848
phldb1b
pleckstrin homology-like domain, family B, member 1b
chr9_+_48007081 5.06 ENSDART00000060593
ENSDART00000099835
zgc:92380
zgc:92380
chr15_+_24563504 4.97 ENSDART00000140658
ENSDART00000130589
ENSDART00000045549
dhrs13b
dehydrogenase/reductase (SDR family) member 13b
chr23_+_28809002 4.91 ENSDART00000134121
ENSDART00000183661
pex14
peroxisomal biogenesis factor 14
chr13_-_30713236 4.87 ENSDART00000112372
ENSDART00000142221
tmem72
transmembrane protein 72
chr17_+_30843881 4.80 ENSDART00000149600
ENSDART00000148547
tpp1
tripeptidyl peptidase I
chr2_-_37281748 4.76 ENSDART00000137598
nadkb
NAD kinase b
chr14_+_34514336 4.76 ENSDART00000024440
foxi3b
forkhead box I3b
chr15_+_20530649 4.76 ENSDART00000186312
tnfaip1
tumor necrosis factor, alpha-induced protein 1 (endothelial)
chr2_-_37862380 4.54 ENSDART00000186005
si:ch211-284o19.8
si:ch211-284o19.8
chr14_+_904850 4.47 ENSDART00000161847
si:ch73-208h1.1
si:ch73-208h1.1
chr13_-_11699530 4.35 ENSDART00000192161
slc39a8
solute carrier family 39 (zinc transporter), member 8
chr6_+_9398074 4.21 ENSDART00000151772
kalrnb
kalirin RhoGEF kinase b
chr17_+_15111319 4.17 ENSDART00000185099
CU464134.2

chr3_-_4253214 4.11 ENSDART00000155807
si:dkey-175d9.2
si:dkey-175d9.2
chr7_+_37359004 4.11 ENSDART00000192134
ENSDART00000189239
sall1a
spalt-like transcription factor 1a
chr9_+_38158570 4.00 ENSDART00000059549
ENSDART00000133060
nifk
nucleolar protein interacting with the FHA domain of MKI67
chr5_+_4366431 3.92 ENSDART00000168560
ENSDART00000149185
sat1a.2
spermidine/spermine N1-acetyltransferase 1a, duplicate 2
chr4_-_13518381 3.91 ENSDART00000067153
ifng1-1
interferon, gamma 1-1
chr24_+_28528000 3.88 ENSDART00000155924
arhgap29a
Rho GTPase activating protein 29a
chr5_-_69716501 3.88 ENSDART00000158956
mob1a
MOB kinase activator 1A
chr4_-_5597167 3.81 ENSDART00000132431
vegfab
vascular endothelial growth factor Ab
chr23_+_20431388 3.75 ENSDART00000132920
ENSDART00000102963
ENSDART00000109899
ENSDART00000140219
slc35c2
solute carrier family 35 (GDP-fucose transporter), member C2
chr5_-_19833310 3.71 ENSDART00000138186
trpv4
transient receptor potential cation channel, subfamily V, member 4
chr15_-_19705707 3.69 ENSDART00000047643
sytl2b
synaptotagmin-like 2b
chr1_-_9130136 3.60 ENSDART00000113013
palb2
partner and localizer of BRCA2
chr5_+_50913034 3.59 ENSDART00000149787
col4a3bpa
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein a
chr20_+_46311707 3.53 ENSDART00000184743
flvcr2b
feline leukemia virus subgroup C cellular receptor family, member 2b
chr22_-_36926342 3.52 ENSDART00000151804
si:dkey-37m8.11
si:dkey-37m8.11
chr5_+_50913357 3.45 ENSDART00000092938
col4a3bpa
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein a
chr18_-_21188768 3.41 ENSDART00000060166
got2a
glutamic-oxaloacetic transaminase 2a, mitochondrial
chr3_-_58582663 3.40 ENSDART00000180055
CABZ01038521.1

chr16_-_20312146 3.33 ENSDART00000134980
si:dkeyp-86h10.3
si:dkeyp-86h10.3
chr12_-_25201576 3.29 ENSDART00000077188
cox7a3
cytochrome c oxidase subunit VIIa polypeptide 3
chr1_-_58900851 3.23 ENSDART00000183085
ENSDART00000188855
ENSDART00000182567
CABZ01084501.3
Danio rerio microfibril-associated glycoprotein 4-like (LOC100334800), transcript variant 2, mRNA.
chr7_+_3597413 3.21 ENSDART00000064281
si:dkey-192d15.2
si:dkey-192d15.2
chr9_-_31090593 3.21 ENSDART00000089136
gpr18
G protein-coupled receptor 18
chr14_-_3174570 3.20 ENSDART00000163585
csf1ra
colony stimulating factor 1 receptor, a
chr1_-_39859626 3.12 ENSDART00000053763
dctd
dCMP deaminase
chr20_-_13625588 3.11 ENSDART00000078893
sytl3
synaptotagmin-like 3
chr9_-_27717006 3.10 ENSDART00000146860
gtf2e1
general transcription factor IIE, polypeptide 1, alpha
chr25_+_32473433 3.09 ENSDART00000152326
sqor
sulfide quinone oxidoreductase
chr5_+_35786141 3.08 ENSDART00000022043
ENSDART00000127383
stard8
StAR-related lipid transfer (START) domain containing 8
chr7_+_36539124 3.07 ENSDART00000173653
chd9
chromodomain helicase DNA binding protein 9
chr17_+_16192486 3.06 ENSDART00000156832
kif13ba
kinesin family member 13Ba
chr5_+_54400971 3.04 ENSDART00000169695
bspry
B-box and SPRY domain containing
chr7_+_29153018 3.02 ENSDART00000138065
tmppe
transmembrane protein with metallophosphoesterase domain
chr12_+_695619 2.98 ENSDART00000161691
abcc3
ATP-binding cassette, sub-family C (CFTR/MRP), member 3
chr6_+_11680726 2.90 ENSDART00000186732
calcrlb
calcitonin receptor-like b
chr21_-_22547496 2.80 ENSDART00000166835
ENSDART00000089030
myo5b
myosin VB
chr25_+_32473277 2.77 ENSDART00000146451
sqor
sulfide quinone oxidoreductase
chr16_-_11789108 2.74 ENSDART00000060142
tlr21
toll-like receptor 21
chr25_+_23591990 2.68 ENSDART00000151938
ENSDART00000089199
cpt1ab
carnitine palmitoyltransferase 1Ab (liver)
chr1_+_58323980 2.62 ENSDART00000145743
si:dkey-222h21.3
si:dkey-222h21.3
chr1_-_44940830 2.55 ENSDART00000097500
ENSDART00000134464
ENSDART00000137216
tmem176
transmembrane protein 176
chr3_+_4113551 2.52 ENSDART00000192309
LO018551.1

chr18_+_31056645 2.52 ENSDART00000159316
mvda
mevalonate (diphospho) decarboxylase a
chr4_+_60492313 2.47 ENSDART00000191043
ENSDART00000191631
si:dkey-211i20.2
si:dkey-211i20.2
chr20_-_28352352 2.41 ENSDART00000128806
ino80
INO80 complex subunit
chr9_+_15890558 2.39 ENSDART00000144032
si:dkey-14o1.20
si:dkey-14o1.20
chr25_+_245018 2.35 ENSDART00000155344
zgc:92481
zgc:92481
chr1_+_58303892 2.34 ENSDART00000147678
CR769768.1

chr25_+_5012791 2.33 ENSDART00000156970
si:ch73-265h17.5
si:ch73-265h17.5
chr17_-_25395395 2.30 ENSDART00000170233
fam167b
family with sequence similarity 167, member B
chr15_+_37954666 2.25 ENSDART00000126534
ENSDART00000155548
si:dkey-238d18.7
si:dkey-238d18.7
chr23_-_21515182 2.23 ENSDART00000142000
rnf207b
ring finger protein 207b
chr17_+_35431724 2.14 ENSDART00000190293
BX571665.1

chr15_+_37331585 2.11 ENSDART00000170715
zgc:171592
zgc:171592
chr4_-_77114795 2.10 ENSDART00000144849
CU467646.2

chr3_+_24595922 2.03 ENSDART00000169405
si:dkey-68o6.5
si:dkey-68o6.5
chr14_-_33308138 2.02 ENSDART00000136442
ENSDART00000139615
sept6
septin 6
chr10_-_26202766 2.01 ENSDART00000136393
fhdc3
FH2 domain containing 3
chr8_-_48675775 2.01 ENSDART00000060785
pimr183
Pim proto-oncogene, serine/threonine kinase, related 183
chr17_+_996509 1.99 ENSDART00000158830
cyp1c2
cytochrome P450, family 1, subfamily C, polypeptide 2
chr21_-_45186431 1.98 ENSDART00000193449
si:ch73-269m14.2
si:ch73-269m14.2
chr11_-_15090564 1.96 ENSDART00000162079
slc1a8a
solute carrier family 1 (glutamate transporter), member 8a
chr3_-_34060153 1.94 ENSDART00000151610
ighv1-1
immunoglobulin heavy variable 1-1
chr11_-_5563498 1.87 ENSDART00000160835
pex11g
peroxisomal biogenesis factor 11 gamma
chr15_+_37973197 1.85 ENSDART00000156661
si:dkey-238d18.9
si:dkey-238d18.9
chr8_-_48675411 1.84 ENSDART00000165081
pimr183
Pim proto-oncogene, serine/threonine kinase, related 183
chr22_+_10645088 1.84 ENSDART00000142265
rassf1
Ras association (RalGDS/AF-6) domain family 1
chr1_+_19708508 1.78 ENSDART00000054581
ENSDART00000131206
march1
membrane-associated ring finger (C3HC4) 1
chr22_+_21252790 1.76 ENSDART00000079046
cpamd8
C3 and PZP-like, alpha-2-macroglobulin domain containing 8
chr12_-_14143344 1.75 ENSDART00000152742
buc2l
bucky ball 2-like
chr7_+_22792132 1.70 ENSDART00000135207
ENSDART00000146801
rbm4.3
RNA binding motif protein 4.3
chr18_+_34181655 1.68 ENSDART00000130831
ENSDART00000109535
gmps
guanine monophosphate synthase
chr14_+_22297257 1.68 ENSDART00000113676
atp10b
ATPase phospholipid transporting 10B
chr16_-_17175731 1.63 ENSDART00000183057
opn9
opsin 9
chr15_-_31000275 1.61 ENSDART00000132493
ENSDART00000100183
lgals9l6
lgals9l5
lectin, galactoside-binding, soluble, 9 (galectin 9)-like 6
lectin, galactoside-binding, soluble, 9 (galectin 9)-like 5
chr1_+_58139102 1.60 ENSDART00000134826
si:ch211-15j1.4
si:ch211-15j1.4
chr21_+_261490 1.59 ENSDART00000177919
jak2a
Janus kinase 2a
chr16_+_54263921 1.58 ENSDART00000002856
drd2l
dopamine receptor D2 like
chr5_+_28260158 1.58 ENSDART00000181434
ncaph
non-SMC condensin I complex, subunit H
chr19_+_30990815 1.56 ENSDART00000134645
sync
syncoilin, intermediate filament protein
chr20_-_7547080 1.56 ENSDART00000146135
usp24
ubiquitin specific peptidase 24
chr4_+_70013627 1.49 ENSDART00000180432
si:dkey-190j3.4
si:dkey-190j3.4
chr4_-_16545085 1.48 ENSDART00000033188
btg1
B-cell translocation gene 1, anti-proliferative
chr11_+_21910752 1.47 ENSDART00000114288
foxp4
forkhead box P4
chr23_+_7471072 1.43 ENSDART00000135551
si:ch211-200e2.1
si:ch211-200e2.1
chr2_+_49799470 1.40 ENSDART00000146325
si:ch211-190k17.19
si:ch211-190k17.19
chr7_-_8014186 1.40 ENSDART00000190012
si:cabz01030277.1
si:cabz01030277.1
chr22_+_9294336 1.39 ENSDART00000193694
si:ch211-250k18.7
si:ch211-250k18.7
chr19_+_32166702 1.38 ENSDART00000021798
fabp11a
fatty acid binding protein 11a
chr22_+_34663328 1.33 ENSDART00000183912
si:ch73-304f21.1
si:ch73-304f21.1
chr4_-_3353595 1.29 ENSDART00000009076
pik3cg
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
chr2_-_40191603 1.29 ENSDART00000180691
si:ch211-122l24.6
si:ch211-122l24.6
chr2_+_371759 1.29 ENSDART00000153788
si:dkey-33c14.7
si:dkey-33c14.7
chr7_+_38667066 1.28 ENSDART00000013394
mtch2
mitochondrial carrier homolog 2
chr22_-_17474781 1.24 ENSDART00000186817
si:ch211-197g15.8
si:ch211-197g15.8
chr5_-_25072607 1.20 ENSDART00000145061
pnpla7b
patatin-like phospholipase domain containing 7b
chr6_+_38626684 1.20 ENSDART00000086533
atp10a
ATPase phospholipid transporting 10A
chr7_-_24838367 1.19 ENSDART00000139455
ENSDART00000012483
ENSDART00000131530
fam113
family with sequence similarity 113
chr3_+_32142382 1.18 ENSDART00000133035
syt5a
synaptotagmin Va
chr8_+_8735285 1.12 ENSDART00000165655
elk1
ELK1, member of ETS oncogene family
chr17_-_465285 1.10 ENSDART00000168718
chrm5a
cholinergic receptor, muscarinic 5a
chr2_+_49644803 1.07 ENSDART00000160342
si:ch211-209f23.7
si:ch211-209f23.7
chr12_-_30841679 1.06 ENSDART00000105594
crygmx
crystallin, gamma MX
chr15_-_17619306 1.04 ENSDART00000184011
adamts15b
ADAM metallopeptidase with thrombospondin type 1 motif, 15b
chr12_-_4370585 1.04 ENSDART00000129502
CA4 (1 of many)
si:ch211-173d10.4
chr9_-_135774 0.98 ENSDART00000160435
FQ377903.1

chr13_-_37108310 0.98 ENSDART00000163845
syne2b
spectrin repeat containing, nuclear envelope 2b
chr14_-_8787525 0.97 ENSDART00000160848
tgfb2l
transforming growth factor, beta 2, like
chr4_-_38281909 0.88 ENSDART00000162448
si:ch211-229l10.9
si:ch211-229l10.9
chr2_+_10127762 0.86 ENSDART00000100726
insl5b
insulin-like 5b
chr7_+_39399747 0.86 ENSDART00000147037
tnni2b.1
troponin I type 2b (skeletal, fast), tandem duplicate 1
chr3_+_46315016 0.85 ENSDART00000157199
mkl2b
MKL/myocardin-like 2b
chr11_+_24340166 0.85 ENSDART00000188719
rbm39a
RNA binding motif protein 39a
chr7_-_16237861 0.82 ENSDART00000173647
btr07
bloodthirsty-related gene family, member 7
chr15_-_37752236 0.79 ENSDART00000154263
si:dkey-42l23.5
si:dkey-42l23.5
chr22_-_17474583 0.79 ENSDART00000148027
si:ch211-197g15.8
si:ch211-197g15.8
chr15_+_37992275 0.77 ENSDART00000154928
si:dkey-238d18.7
si:dkey-238d18.7
chr16_-_4769877 0.70 ENSDART00000149421
ENSDART00000054078
rpa2
replication protein A2
chr1_-_44413629 0.69 ENSDART00000192747
CT583626.1

chr10_+_20070178 0.62 ENSDART00000027612
ENSDART00000145264
ENSDART00000172713
xpo7
exportin 7
chr23_-_22598002 0.60 ENSDART00000146966
si:ch211-28e16.5
si:ch211-28e16.5
chr5_+_9224051 0.56 ENSDART00000139265
si:ch211-12e13.12
si:ch211-12e13.12
chr2_+_10160484 0.56 ENSDART00000136018
nsun4
NOL1/NOP2/Sun domain family, member 4
chr11_-_41786522 0.50 ENSDART00000191066
CR847970.1

chr11_-_38510469 0.49 ENSDART00000162305
si:ch211-117k10.3
si:ch211-117k10.3
chr1_+_56768263 0.48 ENSDART00000158530
CABZ01049362.1

chr11_-_14924138 0.48 ENSDART00000168348
si:dkey-6d5.1
si:dkey-6d5.1
chr10_-_21542702 0.48 ENSDART00000146761
ENSDART00000134502
zgc:165539
zgc:165539
chr2_-_52020049 0.47 ENSDART00000128198
ENSDART00000135331
scn12aa
sodium channel, voltage gated, type XII, alpha a
chr11_+_12175162 0.47 ENSDART00000125446
si:ch211-156l18.7
si:ch211-156l18.7
chr4_-_31784872 0.39 ENSDART00000182911
si:dkey-19c16.12
si:dkey-19c16.12
chr10_+_3153973 0.39 ENSDART00000183223
hic2
hypermethylated in cancer 2
chr18_+_22302635 0.37 ENSDART00000141051
carmil2
capping protein regulator and myosin 1 linker 2
chr22_+_28888781 0.36 ENSDART00000145629
pimr98
Pim proto-oncogene, serine/threonine kinase, related 98
chr6_-_1514767 0.36 ENSDART00000067586
chchd6b
coiled-coil-helix-coiled-coil-helix domain containing 6b
chr15_+_5343186 0.35 ENSDART00000170086
CABZ01018874.1

chr10_-_18463934 0.32 ENSDART00000133116
ENSDART00000113422
si:dkey-28o19.1
si:dkey-28o19.1
chr5_+_65946222 0.31 ENSDART00000190969
ENSDART00000161578
mymk
myomaker, myoblast fusion factor

Network of associatons between targets according to the STRING database.

First level regulatory network of nr1h4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
10.3 41.3 GO:0000255 allantoin metabolic process(GO:0000255)
4.2 12.5 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
2.5 10.0 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
2.5 17.3 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
2.1 27.1 GO:0019730 antimicrobial humoral response(GO:0019730)
2.0 5.9 GO:0070221 sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221)
1.5 4.4 GO:0071421 manganese ion transmembrane transport(GO:0071421)
1.3 7.7 GO:0006004 fucose metabolic process(GO:0006004)
1.2 3.7 GO:0071470 cellular response to osmotic stress(GO:0071470) cellular response to fluid shear stress(GO:0071498)
1.2 4.8 GO:0009957 epidermal cell fate specification(GO:0009957)
1.0 3.1 GO:0009162 deoxyribonucleoside monophosphate metabolic process(GO:0009162)
1.0 3.1 GO:0001120 DNA-templated transcriptional open complex formation(GO:0001112) transcriptional open complex formation at RNA polymerase II promoter(GO:0001113) protein-DNA complex remodeling(GO:0001120)
1.0 6.1 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
1.0 3.9 GO:0009447 polyamine catabolic process(GO:0006598) putrescine catabolic process(GO:0009447)
0.9 3.5 GO:0097037 heme export(GO:0097037)
0.9 3.4 GO:0006531 aspartate metabolic process(GO:0006531)
0.8 3.2 GO:0071674 regulation of macrophage chemotaxis(GO:0010758) positive regulation of macrophage chemotaxis(GO:0010759) regulation of odontogenesis(GO:0042481) mononuclear cell migration(GO:0071674) regulation of mononuclear cell migration(GO:0071675)
0.8 14.9 GO:0006744 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.8 64.1 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.7 2.2 GO:1903779 regulation of cardiac conduction(GO:1903779)
0.7 12.6 GO:0048922 posterior lateral line neuromast deposition(GO:0048922)
0.7 2.8 GO:0003242 growth involved in heart morphogenesis(GO:0003241) cardiac chamber ballooning(GO:0003242) cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.7 4.8 GO:0006741 NADP biosynthetic process(GO:0006741)
0.6 2.5 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.6 10.4 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.5 7.1 GO:0007172 signal complex assembly(GO:0007172)
0.5 7.6 GO:0032264 IMP salvage(GO:0032264)
0.5 4.9 GO:0022615 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.5 2.4 GO:0042766 nucleosome mobilization(GO:0042766)
0.4 1.8 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.4 7.5 GO:0046626 regulation of insulin receptor signaling pathway(GO:0046626)
0.4 14.0 GO:0019432 triglyceride biosynthetic process(GO:0019432)
0.4 8.5 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.4 4.8 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.3 3.8 GO:0002690 mast cell chemotaxis(GO:0002551) positive regulation of leukocyte chemotaxis(GO:0002690) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.3 1.6 GO:2000561 negative regulation of interferon-gamma production(GO:0032689) CD4-positive, alpha-beta T cell proliferation(GO:0035739) regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000561) negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.3 1.9 GO:0016559 peroxisome fission(GO:0016559)
0.3 3.1 GO:0072386 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.3 17.1 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.3 7.0 GO:0007520 myoblast fusion(GO:0007520)
0.3 4.1 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.3 2.7 GO:0031998 regulation of fatty acid beta-oxidation(GO:0031998)
0.3 7.2 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.2 1.7 GO:0006177 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037)
0.2 6.1 GO:0007634 optokinetic behavior(GO:0007634)
0.2 4.8 GO:0007257 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.2 5.5 GO:0019882 antigen processing and presentation(GO:0019882)
0.2 6.4 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.2 8.7 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 1.3 GO:0045444 fat cell differentiation(GO:0045444)
0.1 1.6 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.1 1.6 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481) negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1 3.2 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.1 13.0 GO:0090630 activation of GTPase activity(GO:0090630)
0.1 1.1 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.1 15.5 GO:0002040 sprouting angiogenesis(GO:0002040)
0.1 2.9 GO:0045332 phospholipid translocation(GO:0045332)
0.1 2.0 GO:0071910 determination of digestive tract left/right asymmetry(GO:0071907) determination of liver left/right asymmetry(GO:0071910)
0.1 1.3 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.1 1.6 GO:0021551 central nervous system morphogenesis(GO:0021551)
0.1 0.2 GO:0042754 negative regulation of circadian rhythm(GO:0042754)
0.1 7.2 GO:0007043 cell-cell junction assembly(GO:0007043)
0.1 1.6 GO:0046427 positive regulation of JAK-STAT cascade(GO:0046427) positive regulation of STAT cascade(GO:1904894)
0.1 1.8 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.1 0.6 GO:0006611 protein export from nucleus(GO:0006611)
0.1 1.2 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 3.1 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 7.1 GO:0070507 regulation of microtubule cytoskeleton organization(GO:0070507)
0.0 0.8 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.0 4.6 GO:0000724 double-strand break repair via homologous recombination(GO:0000724)
0.0 0.5 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.0 0.6 GO:0031167 rRNA methylation(GO:0031167)
0.0 4.2 GO:0001756 somitogenesis(GO:0001756)
0.0 4.8 GO:0007626 locomotory behavior(GO:0007626)
0.0 0.4 GO:0030011 maintenance of cell polarity(GO:0030011)
0.0 1.6 GO:0007602 phototransduction(GO:0007602)
0.0 1.0 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.0 3.2 GO:0042157 lipoprotein metabolic process(GO:0042157)
0.0 0.9 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 1.5 GO:0045930 negative regulation of mitotic cell cycle(GO:0045930)
0.0 0.4 GO:0007007 inner mitochondrial membrane organization(GO:0007007)
0.0 0.3 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 8.3 GO:0016567 protein ubiquitination(GO:0016567)
0.0 4.0 GO:0007346 regulation of mitotic cell cycle(GO:0007346)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.9 GO:1990415 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)
0.7 12.5 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.7 5.5 GO:0042613 MHC class II protein complex(GO:0042613)
0.6 3.1 GO:0005673 transcription factor TFIIE complex(GO:0005673)
0.4 7.2 GO:0030057 desmosome(GO:0030057)
0.3 1.9 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.3 24.5 GO:0005581 collagen trimer(GO:0005581)
0.3 26.2 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.2 5.2 GO:0045180 basal cortex(GO:0045180)
0.2 1.6 GO:0000796 condensin complex(GO:0000796)
0.2 8.7 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.2 2.4 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.1 4.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 1.3 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 6.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 0.7 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 1.2 GO:0031045 dense core granule(GO:0031045)
0.1 11.3 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.1 95.7 GO:0005615 extracellular space(GO:0005615)
0.1 6.4 GO:0005882 intermediate filament(GO:0005882)
0.1 7.1 GO:0005925 focal adhesion(GO:0005925)
0.1 2.0 GO:0032156 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.1 12.3 GO:0005764 lysosome(GO:0005764)
0.0 0.3 GO:0030870 Mre11 complex(GO:0030870)
0.0 27.0 GO:0005576 extracellular region(GO:0005576)
0.0 1.6 GO:0098978 glutamatergic synapse(GO:0098978)
0.0 3.1 GO:0005871 kinesin complex(GO:0005871)
0.0 10.7 GO:0005730 nucleolus(GO:0005730)
0.0 0.4 GO:0061617 MICOS complex(GO:0061617)
0.0 9.7 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.9 GO:0005861 troponin complex(GO:0005861)
0.0 0.5 GO:0001518 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 1.7 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.6 GO:0005643 nuclear pore(GO:0005643)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
8.1 24.4 GO:0042806 fucose binding(GO:0042806)
5.3 21.2 GO:0050897 cobalt ion binding(GO:0050897)
2.6 7.7 GO:0004560 alpha-L-fucosidase activity(GO:0004560) fucosidase activity(GO:0015928)
2.0 5.9 GO:0070224 sulfide:quinone oxidoreductase activity(GO:0070224)
1.7 17.1 GO:0016936 galactoside binding(GO:0016936)
1.7 8.5 GO:0008097 5S rRNA binding(GO:0008097)
1.7 14.9 GO:0048039 ubiquinone binding(GO:0048039)
1.4 14.0 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
1.0 2.9 GO:0001605 adrenomedullin receptor activity(GO:0001605) calcitonin gene-related peptide receptor activity(GO:0001635)
1.0 3.8 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.9 7.5 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.9 3.4 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.8 12.5 GO:2001069 glycogen binding(GO:2001069)
0.8 7.3 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.7 7.6 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.7 2.0 GO:0050649 testosterone 6-beta-hydroxylase activity(GO:0050649)
0.6 70.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.6 3.9 GO:0019809 spermidine binding(GO:0019809)
0.5 22.6 GO:0016831 carboxy-lyase activity(GO:0016831)
0.4 3.5 GO:0015232 heme transporter activity(GO:0015232)
0.4 6.1 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.4 4.8 GO:0019238 cyclohydrolase activity(GO:0019238)
0.4 2.7 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.3 5.3 GO:0030552 cAMP binding(GO:0030552)
0.3 4.9 GO:0033691 sialic acid binding(GO:0033691)
0.3 6.8 GO:0042043 neurexin family protein binding(GO:0042043)
0.2 8.7 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.2 1.0 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.2 4.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 2.2 GO:0030544 Hsp70 protein binding(GO:0030544)
0.1 17.1 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.1 4.5 GO:0003951 NAD+ kinase activity(GO:0003951)
0.1 1.7 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.1 1.3 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.1 1.6 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.1 3.1 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.1 8.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 24.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 2.4 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.1 1.1 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.1 1.6 GO:0001671 ATPase activator activity(GO:0001671)
0.1 7.2 GO:0045296 cadherin binding(GO:0045296)
0.1 0.6 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.1 1.2 GO:0004622 lysophospholipase activity(GO:0004622)
0.1 1.8 GO:0042287 MHC protein binding(GO:0042287)
0.0 3.1 GO:0003678 DNA helicase activity(GO:0003678)
0.0 0.3 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 27.0 GO:0005525 GTP binding(GO:0005525)
0.0 0.8 GO:0004875 complement receptor activity(GO:0004875)
0.0 1.6 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 20.5 GO:0005198 structural molecule activity(GO:0005198)
0.0 0.5 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 1.2 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 3.2 GO:0019955 cytokine binding(GO:0019955)
0.0 3.1 GO:0003777 microtubule motor activity(GO:0003777)
0.0 15.3 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 8.8 GO:0005096 GTPase activator activity(GO:0005096)
0.0 3.7 GO:0005262 calcium channel activity(GO:0005262)
0.0 0.3 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 1.5 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.7 GO:0000146 microfilament motor activity(GO:0000146) actin-dependent ATPase activity(GO:0030898)
0.0 2.0 GO:0019904 protein domain specific binding(GO:0019904)
0.0 2.0 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 3.6 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 0.7 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 1.6 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 6.1 PID IL5 PATHWAY IL5-mediated signaling events
0.3 51.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 24.4 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3 9.2 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.1 1.3 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.1 4.6 PID FANCONI PATHWAY Fanconi anemia pathway
0.1 1.1 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.6 PID AURORA B PATHWAY Aurora B signaling
0.0 1.8 PID P53 REGULATION PATHWAY p53 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 10.0 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.7 17.1 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.5 7.3 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.5 3.0 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.3 4.4 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.3 1.3 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.2 3.9 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.2 3.6 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.1 3.1 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.1 1.7 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 4.8 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 2.8 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.1 3.1 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 0.7 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 6.4 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.1 2.9 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.1 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 3.2 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 3.1 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.3 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks