ISMARA results: nr2f1a

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for nr2f1a

Z-value: 1.92

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Transcription factors associated with nr2f1a

Gene Symbol	Gene ID	Gene Info
nr2f1a NCBI UniProt	ENSDARG00000052695	nuclear receptor subfamily 2, group F, member 1a

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
nr2f1a	dr11_v1_chr5_+_49744713_49744713	-0.09	4.0e-01	Click!

Activity profile of nr2f1a motif

Sorted Z-values of nr2f1a motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr16_+_23913943 Show fit	38.28	ENSDART00000175404 ENSDART00000129525	apoa4b.1 NCBI UniProt Show fit	apolipoprotein A-IV b, tandem duplicate 1
chr23_+_42454292 Show fit	37.24	ENSDART00000171459	cyp2aa2 NCBI UniProt Show fit	y cytochrome P450, family 2, subfamily AA, polypeptide 2
chr15_-_16884912 Show fit	33.96	ENSDART00000062135	zgc:103681 NCBI UniProt Show fit	zgc:103681
chr7_+_52122224 Show fit	32.84	ENSDART00000174268	cyp2x12 NCBI UniProt Show fit	cytochrome P450, family 2, subfamily X, polypeptide 12
chr17_-_30702411 Show fit	31.30	ENSDART00000114358	zgc:194392 NCBI UniProt Show fit	zgc:194392
chr15_-_21239416 Show fit	30.85	ENSDART00000155787	A2ML1 (1 of many) NCBI UniProt Show fit	si:dkey-105h12.2
chr16_-_45917322 Show fit	30.50	ENSDART00000060822	afp4 NCBI UniProt Show fit	antifreeze protein type IV
chr15_+_28202170 Show fit	30.23	ENSDART00000077736	vtna NCBI UniProt Show fit	vitronectin a
chr2_-_42234484 Show fit	29.13	ENSDART00000132617 ENSDART00000136690 ENSDART00000141358	apom NCBI UniProt Show fit	apolipoprotein M
chr24_-_2843107 Show fit	28.49	ENSDART00000165290	cyb5a NCBI UniProt Show fit	cytochrome b5 type A (microsomal)

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of nr2f1a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.5	122.3	GO:0042738	drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
9.7	48.7	GO:0006642	triglyceride mobilization(GO:0006642)
15.6	46.7	GO:0046415	urate catabolic process(GO:0019628) urate metabolic process(GO:0046415)
0.1	34.9	GO:0043066	negative regulation of apoptotic process(GO:0043066)
3.4	33.7	GO:0045444	fat cell differentiation(GO:0045444)
0.2	33.6	GO:0042157	lipoprotein metabolic process(GO:0042157)
1.0	33.1	GO:0060030	dorsal convergence(GO:0060030)
0.6	28.5	GO:0071466	cellular response to xenobiotic stimulus(GO:0071466)
1.8	27.7	GO:0016486	peptide hormone processing(GO:0016486)
9.0	27.1	GO:0043385	mycotoxin metabolic process(GO:0043385) aflatoxin metabolic process(GO:0046222) organic heteropentacyclic compound metabolic process(GO:1901376)

Showing 1 to 10 of 217 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	137.2	GO:0005576	extracellular region(GO:0005576)
0.7	75.6	GO:0005777	peroxisome(GO:0005777) microbody(GO:0042579)
0.1	70.7	GO:0005739	mitochondrion(GO:0005739)
9.7	48.7	GO:0034359	mature chylomicron(GO:0034359)
0.1	39.4	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.9	38.1	GO:0005637	nuclear inner membrane(GO:0005637)
1.3	29.2	GO:0030667	secretory granule membrane(GO:0030667)
0.5	24.9	GO:0005811	lipid particle(GO:0005811)
0.3	23.0	GO:0030173	integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.3	21.4	GO:0034707	chloride channel complex(GO:0034707)

Showing 1 to 10 of 69 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.4	157.7	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.3	70.0	GO:0004252	serine-type endopeptidase activity(GO:0004252)
5.4	48.7	GO:0050750	low-density lipoprotein particle receptor binding(GO:0050750) lipoprotein particle receptor binding(GO:0070325)
0.8	46.5	GO:0015020	glucuronosyltransferase activity(GO:0015020)
2.7	32.0	GO:0019238	cyclohydrolase activity(GO:0019238)
0.4	31.0	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.5	29.5	GO:0009055	electron carrier activity(GO:0009055)
0.2	27.4	GO:0004879	RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
3.4	27.2	GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.1	25.9	GO:0061630	ubiquitin protein ligase activity(GO:0061630)

Showing 1 to 10 of 179 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	40.1	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.5	18.0	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.2	8.4	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.1	8.3	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.2	6.1	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.1	4.9	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.3	3.5	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.1	3.4	PID ALK1 PATHWAY	ALK1 signaling events
0.0	2.0	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0	1.9	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms

Showing 1 to 10 of 17 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	43.4	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
1.3	23.8	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
2.8	22.5	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
2.9	20.0	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
2.4	19.5	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
4.7	18.9	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.8	18.7	REACTOME TRIGLYCERIDE BIOSYNTHESIS	Genes involved in Triglyceride Biosynthesis
1.5	17.5	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.2	17.4	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression
1.3	17.1	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism

Showing 1 to 10 of 60 entries

Results for nr2f1a

Z-value: 1.92

Motif logo

Transcription factors associated with nr2f1a

Activity-expression correlation:

Activity profile of nr2f1a motif

Sorted Z-values of nr2f1a motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of nr2f1a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: