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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for nr2f1b+nr2f5

Z-value: 0.75

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Transcription factors associated with nr2f1b+nr2f5

Gene Symbol Gene ID Gene Info
nr2f1b
ENSDARG00000017168 nuclear receptor subfamily 2, group F, member 1b
nr2f5
ENSDARG00000033172 nuclear receptor subfamily 2, group F, member 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nr2f1bdr11_v1_chr10_+_43797130_43797130-0.747.4e-18Click!
nr2f5dr11_v1_chr16_+_46294337_462943370.084.3e-01Click!

Activity profile of nr2f1b+nr2f5 motif

Sorted Z-values of nr2f1b+nr2f5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_56229674 10.21 ENSDART00000127714
c3a.2
complement component c3a, duplicate 2
chr20_+_25581627 9.74 ENSDART00000030229
cyp2p9
cytochrome P450, family 2, subfamily P, polypeptide 9
chr21_+_28445052 7.78 ENSDART00000077871
pygma
phosphorylase, glycogen, muscle A
chr18_+_8340886 7.25 ENSDART00000081132
cpt1b
carnitine palmitoyltransferase 1B (muscle)
chr19_+_8606883 6.32 ENSDART00000054469
ENSDART00000185264
s100a10a
S100 calcium binding protein A10a
chr24_+_42149453 6.22 ENSDART00000128766
serpinb1l3
serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 3
chr25_+_1549838 6.16 ENSDART00000115001
avpr1aa
arginine vasopressin receptor 1Aa
chr4_+_1530287 5.81 ENSDART00000067446
slc38a4
solute carrier family 38, member 4
chr18_-_49283058 5.69 ENSDART00000076554
si:zfos-464b6.2
si:zfos-464b6.2
chr9_-_9980704 5.51 ENSDART00000130243
ENSDART00000193475
ugt1ab
UDP glucuronosyltransferase 1 family a, b
chr11_+_6010177 5.23 ENSDART00000170047
ENSDART00000022526
ENSDART00000161001
ENSDART00000188999
gtpbp3
GTP binding protein 3, mitochondrial
chr3_-_19517462 5.10 ENSDART00000162027
CU571315.2

chr13_+_22249636 5.04 ENSDART00000108472
ENSDART00000173123
synpo2la
synaptopodin 2-like a
chr5_+_64856666 5.03 ENSDART00000050863
zgc:101858
zgc:101858
chr22_+_37888249 4.75 ENSDART00000076082
fetub
fetuin B
chr22_-_26834043 4.67 ENSDART00000087202
si:dkey-44g23.5
si:dkey-44g23.5
chr13_-_13754091 4.52 ENSDART00000131255
ky
kyphoscoliosis peptidase
chr24_+_42149296 4.49 ENSDART00000154231
serpinb1l3
serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 3
chr17_+_5351922 4.41 ENSDART00000105394
runx2a
runt-related transcription factor 2a
chr18_-_11729 4.28 ENSDART00000159781
WHAMM
WAS protein homolog associated with actin, golgi membranes and microtubules
chr20_+_53577502 4.24 ENSDART00000126983
myh6
myosin, heavy chain 6, cardiac muscle, alpha
chr14_+_2487672 4.23 ENSDART00000170629
ENSDART00000123063
fgf18a
fibroblast growth factor 18a
chr24_-_22015751 3.98 ENSDART00000147055
si:rp71-1f1.6
si:rp71-1f1.6
chr4_-_77120928 3.95 ENSDART00000174154
CU467646.1

chr10_-_76352 3.84 ENSDART00000186560
ENSDART00000144722
dyrk1aa
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, a
chr24_-_22003031 3.79 ENSDART00000133627
si:rp71-1f1.5
si:rp71-1f1.5
chr15_+_22394074 3.73 ENSDART00000109931
oafa
OAF homolog a (Drosophila)
chr24_+_42132962 3.53 ENSDART00000187739
wwp1
WW domain containing E3 ubiquitin protein ligase 1
chr14_-_5817039 3.45 ENSDART00000131820
kazald2
Kazal-type serine peptidase inhibitor domain 2
chr7_+_27251376 3.37 ENSDART00000173521
ENSDART00000173962
sox6
SRY (sex determining region Y)-box 6
chr7_+_4474880 3.34 ENSDART00000143528
si:dkey-83f18.14
si:dkey-83f18.14
chr19_+_26828502 3.30 ENSDART00000183654
ENSDART00000126006
ENSDART00000185341
FP085398.1

chr24_+_42127983 3.20 ENSDART00000190157
ENSDART00000176032
ENSDART00000175790
wwp1
WW domain containing E3 ubiquitin protein ligase 1
chr2_+_52847049 3.06 ENSDART00000121980
creb3l3b
cAMP responsive element binding protein 3-like 3b
chr1_+_144284 2.96 ENSDART00000064061
prozb
protein Z, vitamin K-dependent plasma glycoprotein b
chr24_+_42117231 2.79 ENSDART00000067734
snx16
sorting nexin 16
chr15_+_34933552 2.76 ENSDART00000155368
zgc:66024
zgc:66024
chr19_+_7938121 2.66 ENSDART00000140053
ENSDART00000146649
si:dkey-266f7.5
si:dkey-266f7.5
chr20_-_16906623 2.47 ENSDART00000012859
ENSDART00000171628
psma6b
proteasome subunit alpha 6b
chr8_-_13419049 2.35 ENSDART00000133656
pimr101
Pim proto-oncogene, serine/threonine kinase, related 101
chr4_-_837768 2.34 ENSDART00000185280
ENSDART00000135618
sobpb
sine oculis binding protein homolog (Drosophila) b
chr21_+_5882300 2.31 ENSDART00000165065
uqcr10
ubiquinol-cytochrome c reductase, complex III subunit X
chr15_-_41756454 2.28 ENSDART00000139498
ENSDART00000099302
ftr72
finTRIM family, member 72
chr8_-_13428740 2.26 ENSDART00000131826
CR354547.3

chr4_-_13613148 2.23 ENSDART00000067164
ENSDART00000111247
irf5
interferon regulatory factor 5
chr8_-_13471916 2.23 ENSDART00000146558
pimr105
Pim proto-oncogene, serine/threonine kinase, related 105
chr22_+_344763 2.17 ENSDART00000181934
CU914780.1

chr1_-_55785722 2.17 ENSDART00000142069
ENSDART00000043933
ndufb7
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7
chr17_-_53282539 2.12 ENSDART00000164953
FO704905.1

chr13_-_50546634 2.05 ENSDART00000192127
CU570781.2

chr8_-_13454281 2.02 ENSDART00000141959
CR354547.2

chr20_+_43925266 1.96 ENSDART00000037379
clic5b
chloride intracellular channel 5b
chr1_-_20824411 1.96 ENSDART00000182810
tll1
tolloid-like 1
chr22_+_18316144 1.94 ENSDART00000137985
gatad2ab
GATA zinc finger domain containing 2Ab
chr1_-_18772241 1.89 ENSDART00000147645
ENSDART00000133194
ENSDART00000147525
ENSDART00000191493
tbc1d1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr24_-_21991770 1.87 ENSDART00000147296
si:rp71-1f1.4
si:rp71-1f1.4
chr8_+_23711842 1.84 ENSDART00000128783
ppardb
peroxisome proliferator-activated receptor delta b
chr18_+_7073130 1.83 ENSDART00000101216
ENSDART00000148947
si:dkey-88e18.2
si:dkey-88e18.2
chr5_-_25084318 1.83 ENSDART00000089339
dph7
diphthamide biosynthesis 7
chr5_+_54400971 1.82 ENSDART00000169695
bspry
B-box and SPRY domain containing
chr4_+_73215536 1.79 ENSDART00000174290
LO018260.2
Danio rerio protein NLRC3-like (LOC101883187), mRNA.
chr14_+_34558480 1.74 ENSDART00000075170
pttg1
pituitary tumor-transforming 1
chr8_-_13486258 1.68 ENSDART00000137459
pimr104
Pim proto-oncogene, serine/threonine kinase, related 104
chr8_-_13442871 1.63 ENSDART00000144887
pimr106
Pim proto-oncogene, serine/threonine kinase, related 106
chr2_-_5502256 1.56 ENSDART00000193037
saga
S-antigen; retina and pineal gland (arrestin) a
chr15_+_27364394 1.44 ENSDART00000122101
tbx2b
T-box 2b
chr18_-_6975175 1.42 ENSDART00000134194
si:dkey-266m15.6
si:dkey-266m15.6
chr5_-_8910703 1.36 ENSDART00000097221
adamts12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr17_+_389218 1.32 ENSDART00000162898
si:rp71-62i8.1
si:rp71-62i8.1
chr13_+_50778187 1.28 ENSDART00000159597
dntt
deoxynucleotidyltransferase, terminal
chr16_+_20895904 1.15 ENSDART00000052662
hoxa13b
homeobox A13b
chr6_+_103361 1.11 ENSDART00000151899
ldlrb
low density lipoprotein receptor b
chr5_-_40292299 1.07 ENSDART00000097525
snx18a
sorting nexin 18a
chr2_+_33382648 0.92 ENSDART00000137207
ENSDART00000098831
slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr15_+_1199407 0.89 ENSDART00000163827
mfsd1
major facilitator superfamily domain containing 1
chr15_+_47582207 0.82 ENSDART00000159388
CABZ01087566.1

chr2_+_2904080 0.76 ENSDART00000110416
eif2b5
eukaryotic translation initiation factor 2B, subunit 5 epsilon
chr14_+_46118834 0.67 ENSDART00000124417
ENSDART00000017785
naa15a
N(alpha)-acetyltransferase 15, NatA auxiliary subunit a
chr4_+_9011448 0.66 ENSDART00000192357
samm50l
sorting and assembly machinery component 50 homolog, like
chr2_-_16449504 0.61 ENSDART00000144801
atr
ATR serine/threonine kinase
chr15_-_34933560 0.58 ENSDART00000006288
dhx16
DEAH (Asp-Glu-Ala-His) box polypeptide 16
chr1_-_26544268 0.55 ENSDART00000152117
si:ch211-202n12.2
si:ch211-202n12.2
chr23_+_25822742 0.52 ENSDART00000184436
r3hdml
R3H domain containing-like
chr7_-_2039060 0.48 ENSDART00000173879
si:cabz01007794.1
si:cabz01007794.1
chr16_+_53710416 0.42 ENSDART00000155929
nod1
nucleotide-binding oligomerization domain containing 1
chr9_+_500052 0.35 ENSDART00000166707
CU984600.1

chr7_-_26446726 0.34 ENSDART00000173607
zgc:172079
zgc:172079
chr24_+_37700259 0.33 ENSDART00000066556
zmp:0000000624
zmp:0000000624
chr4_+_9011825 0.28 ENSDART00000058007
samm50l
sorting and assembly machinery component 50 homolog, like
chr2_-_1468258 0.23 ENSDART00000114431
gpaa1
glycosylphosphatidylinositol anchor attachment 1
chr19_-_48039400 0.20 ENSDART00000166748
ENSDART00000165921
csf3b
colony stimulating factor 3 (granulocyte) b
chr14_+_41518257 0.20 ENSDART00000050037
chrnb3b
cholinergic receptor, nicotinic, beta 3b (neuronal)
chr3_-_12970418 0.10 ENSDART00000158747
pdgfab
platelet-derived growth factor alpha polypeptide b
chr18_+_910992 0.09 ENSDART00000161206
ENSDART00000167229
pkma
pyruvate kinase M1/2a
chr8_-_41273768 0.04 ENSDART00000108518
rnf10
ring finger protein 10
chr22_-_31788170 0.01 ENSDART00000170925
pimr207
Pim proto-oncogene, serine/threonine kinase, related 207

Network of associatons between targets according to the STRING database.

First level regulatory network of nr2f1b+nr2f5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 7.8 GO:0052576 carbohydrate localization(GO:0052575) carbohydrate storage(GO:0052576)
0.7 4.2 GO:0055014 atrial cardiac muscle cell development(GO:0055014)
0.6 6.2 GO:0001992 regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.5 2.0 GO:0035124 embryonic caudal fin morphogenesis(GO:0035124)
0.5 1.4 GO:0072068 distal convoluted tubule development(GO:0072025) late distal convoluted tubule development(GO:0072068)
0.4 7.3 GO:0009437 carnitine metabolic process(GO:0009437)
0.3 3.4 GO:0060612 adipose tissue development(GO:0060612)
0.3 0.9 GO:0045040 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.3 2.8 GO:0006622 protein targeting to lysosome(GO:0006622)
0.2 0.9 GO:0060092 regulation of synaptic transmission, glycinergic(GO:0060092)
0.2 2.3 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.2 5.2 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.2 1.8 GO:0010887 negative regulation of cholesterol storage(GO:0010887)
0.2 10.2 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.2 9.7 GO:0017144 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.2 5.0 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.2 15.5 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.1 1.6 GO:0002031 G-protein coupled receptor internalization(GO:0002031)
0.1 0.6 GO:1901207 regulation of heart looping(GO:1901207)
0.1 5.8 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.1 0.7 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.1 2.5 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 4.4 GO:0002062 chondrocyte differentiation(GO:0002062)
0.1 1.7 GO:0033048 negative regulation of sister chromatid segregation(GO:0033046) negative regulation of mitotic sister chromatid segregation(GO:0033048) negative regulation of mitotic sister chromatid separation(GO:2000816)
0.1 3.1 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.1 6.7 GO:0045732 positive regulation of protein catabolic process(GO:0045732)
0.1 3.8 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.1 0.4 GO:0035188 hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.0 4.2 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.0 3.0 GO:0007596 blood coagulation(GO:0007596)
0.0 0.2 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.9 GO:0061462 protein localization to lysosome(GO:0061462)
0.0 2.2 GO:0051607 defense response to virus(GO:0051607)
0.0 8.6 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 1.3 GO:0006304 DNA modification(GO:0006304)
0.0 3.4 GO:0001558 regulation of cell growth(GO:0001558)
0.0 2.0 GO:0007605 sensory perception of sound(GO:0007605)
0.0 1.3 GO:0045010 actin nucleation(GO:0045010)
0.0 0.6 GO:0035987 endodermal cell differentiation(GO:0035987)
0.0 1.9 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.2 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.0 3.1 GO:0000122 negative regulation of transcription from RNA polymerase II promoter(GO:0000122)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.8 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.4 3.4 GO:0005614 interstitial matrix(GO:0005614)
0.2 2.3 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.2 2.5 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.2 0.8 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.1 0.7 GO:0031415 NatA complex(GO:0031415)
0.1 4.7 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 0.9 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.1 1.9 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 1.6 GO:0001917 photoreceptor inner segment(GO:0001917)
0.1 7.3 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 2.2 GO:0031970 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0 5.0 GO:0030018 Z disc(GO:0030018)
0.0 0.2 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 4.2 GO:0016459 myosin complex(GO:0016459)
0.0 2.0 GO:0034707 chloride channel complex(GO:0034707)
0.0 33.0 GO:0005615 extracellular space(GO:0005615)
0.0 1.3 GO:0005884 actin filament(GO:0005884)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 9.6 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
1.6 7.8 GO:0008184 phosphorylase activity(GO:0004645) glycogen phosphorylase activity(GO:0008184)
1.0 7.3 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.6 6.2 GO:0005000 vasopressin receptor activity(GO:0005000)
0.5 4.2 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.2 6.3 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.2 3.1 GO:0035497 cAMP response element binding(GO:0035497)
0.1 9.7 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.1 25.7 GO:0004866 endopeptidase inhibitor activity(GO:0004866)
0.1 3.4 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 2.2 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 5.5 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 3.8 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 1.8 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 0.4 GO:1900750 oligopeptide binding(GO:1900750)
0.1 0.9 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 5.8 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.1 1.3 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 0.7 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.8 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 3.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 2.0 GO:0005254 chloride channel activity(GO:0005254)
0.0 4.2 GO:0003774 motor activity(GO:0003774)
0.0 3.9 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 0.1 GO:0004743 pyruvate kinase activity(GO:0004743)
0.0 5.4 GO:0016757 transferase activity, transferring glycosyl groups(GO:0016757)
0.0 3.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 5.2 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 2.5 GO:0004175 endopeptidase activity(GO:0004175)
0.0 5.2 GO:0003924 GTPase activity(GO:0003924)
0.0 0.1 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 7.3 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 6.7 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 1.3 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 7.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.6 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 2.2 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 7.3 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.2 5.8 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.2 4.2 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 0.9 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 2.2 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 0.6 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.1 6.7 REACTOME SIGNALING BY ERBB4 Genes involved in Signaling by ERBB4
0.0 2.0 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 2.2 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 1.7 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0 0.4 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation