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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for nr2f6a+nr2f6b

Z-value: 0.59

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Transcription factors associated with nr2f6a+nr2f6b

Gene Symbol Gene ID Gene Info
nr2f6b
ENSDARG00000003165 nuclear receptor subfamily 2, group F, member 6b
nr2f6a
ENSDARG00000003607 nuclear receptor subfamily 2, group F, member 6a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nr2f6adr11_v1_chr2_+_24376373_243763730.214.4e-02Click!
nr2f6bdr11_v1_chr11_+_6115621_6115677-0.161.3e-01Click!

Activity profile of nr2f6a+nr2f6b motif

Sorted Z-values of nr2f6a+nr2f6b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_39566999 11.12 ENSDART00000146867
aldoaa
aldolase a, fructose-bisphosphate, a
chr11_+_11201096 10.59 ENSDART00000171916
ENSDART00000171521
ENSDART00000087105
ENSDART00000159603
myom2a
myomesin 2a
chr7_+_31871830 9.65 ENSDART00000139899
mybpc3
myosin binding protein C, cardiac
chr3_+_30257582 9.40 ENSDART00000159497
ENSDART00000103457
ENSDART00000121883
mybpc2a
myosin binding protein C, fast type a
chr2_+_42191592 9.17 ENSDART00000144716
cavin4a
caveolae associated protein 4a
chr1_+_58353661 6.77 ENSDART00000140074
si:dkey-222h21.2
si:dkey-222h21.2
chr25_+_20119466 4.88 ENSDART00000104304
bpgm
2,3-bisphosphoglycerate mutase
chr16_-_24605969 4.47 ENSDART00000163305
ENSDART00000167121
fxyd6l
FXYD domain containing ion transport regulator 6 like
chr23_-_45504991 4.21 ENSDART00000148761
col24a1
collagen type XXIV alpha 1
chr19_+_2631565 4.18 ENSDART00000171487
fam126a
family with sequence similarity 126, member A
chr16_-_25233515 3.84 ENSDART00000058943
zgc:110182
zgc:110182
chr22_-_7050 3.64 ENSDART00000127829
atad3
ATPase family, AAA domain containing 3
chr9_+_54644626 3.53 ENSDART00000190609
egfl6
EGF-like-domain, multiple 6
chr10_+_20128267 3.53 ENSDART00000064615
dmtn
dematin actin binding protein
chr1_-_58868306 3.51 ENSDART00000166615
dnm2b
dynamin 2b
chr4_-_16451375 3.39 ENSDART00000192700
ENSDART00000128835
wu:fc23c09
wu:fc23c09
chr1_+_23783349 3.21 ENSDART00000007531
slit2
slit homolog 2 (Drosophila)
chr18_-_48550426 3.12 ENSDART00000145189
kcnj1a.1
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 1
chr12_+_46708920 3.00 ENSDART00000153089
exoc7
exocyst complex component 7
chr22_-_15587360 2.98 ENSDART00000142717
ENSDART00000138978
tpm4a
tropomyosin 4a
chr8_-_979735 2.87 ENSDART00000149612
znf366
zinc finger protein 366
chr3_-_34561624 2.79 ENSDART00000129313
sept9a
septin 9a
chr23_+_42810055 2.74 ENSDART00000186647
myl9a
myosin, light chain 9a, regulatory
chr10_+_45128375 2.60 ENSDART00000164805
camk2b2
calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 2
chr9_+_34380299 2.48 ENSDART00000131705
lamp1
lysosomal-associated membrane protein 1
chr14_+_30413758 2.46 ENSDART00000092953
cnot7
CCR4-NOT transcription complex, subunit 7
chr25_+_15647993 2.38 ENSDART00000186578
ENSDART00000031828
spon1b
spondin 1b
chr1_+_58182400 2.33 ENSDART00000144784
si:ch211-15j1.1
si:ch211-15j1.1
chr11_-_6974022 2.29 ENSDART00000172851
COMP
si:ch211-43f4.1
chr22_-_11833317 2.25 ENSDART00000125423
ENSDART00000000192
ptpn4b
protein tyrosine phosphatase, non-receptor type 4b
chr4_-_858434 2.18 ENSDART00000006961
sobpb
sine oculis binding protein homolog (Drosophila) b
chr24_+_81527 2.08 ENSDART00000192139
reck
reversion-inducing-cysteine-rich protein with kazal motifs
chr13_-_37254777 2.06 ENSDART00000139734
syne2b
spectrin repeat containing, nuclear envelope 2b
chr17_+_33418475 2.04 ENSDART00000169145
snap23.1
synaptosomal-associated protein 23.1
chr12_+_49125510 1.87 ENSDART00000185804
FO704607.1

chr1_+_58119117 1.85 ENSDART00000146788
si:ch211-15j1.5
si:ch211-15j1.5
chr6_-_49873020 1.72 ENSDART00000148511
gnas
GNAS complex locus
chr6_+_1787160 1.66 ENSDART00000113505
myl9b
myosin, light chain 9b, regulatory
chr18_-_12957451 1.65 ENSDART00000140403
srgap1a
SLIT-ROBO Rho GTPase activating protein 1a
chr6_+_40775800 1.62 ENSDART00000085090
si:ch211-157b11.8
si:ch211-157b11.8
chr1_-_51720633 1.54 ENSDART00000045894
rnaseh2a
ribonuclease H2, subunit A
chr22_-_3595439 1.48 ENSDART00000083308
ptprsa
protein tyrosine phosphatase, receptor type, s, a
chr1_+_58312187 1.42 ENSDART00000142285
si:dkey-222h21.10
si:dkey-222h21.10
chr23_+_27912079 1.30 ENSDART00000171859
BX539336.1

chr5_-_26330313 1.19 ENSDART00000148656
arvcfb
ARVCF, delta catenin family member b
chr13_+_45980163 1.17 ENSDART00000074547
ENSDART00000005195
bsdc1
BSD domain containing 1
chr24_-_1021318 1.17 ENSDART00000181403
ralaa
v-ral simian leukemia viral oncogene homolog Aa (ras related)
chr1_+_58303892 1.16 ENSDART00000147678
CR769768.1

chr1_+_57050899 1.15 ENSDART00000152601
si:ch211-1f22.14
si:ch211-1f22.14
chr2_-_56649883 1.13 ENSDART00000191786
gpx4b
glutathione peroxidase 4b
chr1_+_25848231 1.11 ENSDART00000027973
fabp2
fatty acid binding protein 2, intestinal
chr9_-_37613792 1.10 ENSDART00000138345
sema5ba
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5Ba
chr11_+_30729745 0.98 ENSDART00000103270
slc22a7a
solute carrier family 22 (organic anion transporter), member 7a
chr23_-_42810664 0.91 ENSDART00000102328
pfkfb2a
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2a
chr25_+_418932 0.86 ENSDART00000059193
prtgb
protogenin homolog b (Gallus gallus)
chr1_+_58260886 0.82 ENSDART00000110453
si:dkey-222h21.8
si:dkey-222h21.8
chr1_+_58312680 0.81 ENSDART00000138007
si:dkey-222h21.10
si:dkey-222h21.10
chr12_+_48681601 0.81 ENSDART00000187831
uros
uroporphyrinogen III synthase
chr18_+_31410652 0.80 ENSDART00000098504
def8
differentially expressed in FDCP 8 homolog (mouse)
chr6_+_40952031 0.78 ENSDART00000189219
patz1
POZ (BTB) and AT hook containing zinc finger 1
chr14_+_30413312 0.76 ENSDART00000186864
cnot7
CCR4-NOT transcription complex, subunit 7
chr7_+_25000060 0.75 ENSDART00000039265
ENSDART00000141814
naa40
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
chr23_-_21797517 0.73 ENSDART00000110041
lrrc38a
leucine rich repeat containing 38a
chr19_+_2275019 0.72 ENSDART00000136138
itgb8
integrin, beta 8
chr21_-_44512893 0.67 ENSDART00000166853
zgc:136410
zgc:136410
chr18_+_16330025 0.66 ENSDART00000142353
nts
neurotensin
chr15_+_47618221 0.63 ENSDART00000168722
paf1
PAF1 homolog, Paf1/RNA polymerase II complex component
chr1_+_58221372 0.61 ENSDART00000138467
si:dkey-222h21.10
si:dkey-222h21.10
chr23_-_46126444 0.55 ENSDART00000030004
CABZ01071903.1

chr18_-_1185772 0.54 ENSDART00000143245
nptnb
neuroplastin b
chr7_+_24520518 0.54 ENSDART00000173604
btr09
bloodthirsty-related gene family, member 9
chr22_-_16997246 0.51 ENSDART00000090242
nfia
nuclear factor I/A
chr3_+_1179601 0.48 ENSDART00000173378
triobpb
TRIO and F-actin binding protein b
chr21_-_1640547 0.46 ENSDART00000151041
zgc:152948
zgc:152948
chr9_-_15208129 0.45 ENSDART00000137043
ENSDART00000131512
pard3bb
par-3 family cell polarity regulator beta b
chr24_+_39034090 0.43 ENSDART00000185763
capn15
calpain 15
chr13_-_39159810 0.43 ENSDART00000131508
col9a1b
collagen, type IX, alpha 1b
chr1_+_58442694 0.42 ENSDART00000160897
zgc:194906
zgc:194906
chr4_-_75172216 0.37 ENSDART00000127522
naa40
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
chr18_-_18850302 0.33 ENSDART00000131965
ENSDART00000167624
tgm2l
transglutaminase 2, like
chr8_+_8699085 0.32 ENSDART00000021209
uxt
ubiquitously-expressed, prefoldin-like chaperone
chr8_+_36803415 0.31 ENSDART00000111680
iqsec2b
IQ motif and Sec7 domain 2b
chr25_-_19420949 0.28 ENSDART00000181338
map1ab
microtubule-associated protein 1Ab
chr7_-_36113098 0.20 ENSDART00000064913
fto
fat mass and obesity associated
chr22_-_16997475 0.14 ENSDART00000090237
nfia
nuclear factor I/A
chr23_+_30730121 0.14 ENSDART00000134141
asxl1
additional sex combs like transcriptional regulator 1
chr22_-_16997887 0.13 ENSDART00000138233
nfia
nuclear factor I/A
chr13_-_39160018 0.10 ENSDART00000168795
col9a1b
collagen, type IX, alpha 1b
chr6_+_27315173 0.04 ENSDART00000108831
espnla
espin like a
chr17_-_6954719 0.03 ENSDART00000188180
zbtb24
zinc finger and BTB domain containing 24
chr5_+_43870389 0.03 ENSDART00000141002
zgc:112966
zgc:112966
chr18_-_7400075 0.02 ENSDART00000101250
si:dkey-30c15.13
si:dkey-30c15.13
chr13_-_37127970 0.01 ENSDART00000135510
syne2b
spectrin repeat containing, nuclear envelope 2b

Network of associatons between targets according to the STRING database.

First level regulatory network of nr2f6a+nr2f6b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 9.7 GO:0003210 cardiac atrium formation(GO:0003210)
1.1 3.2 GO:0007414 axonal defasciculation(GO:0007414)
0.7 4.2 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065)
0.7 2.1 GO:1905048 regulation of metallopeptidase activity(GO:1905048)
0.5 11.1 GO:0001966 thigmotaxis(GO:0001966)
0.3 1.7 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.3 3.2 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.3 1.5 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.2 4.0 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.2 3.5 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.2 3.5 GO:0030032 lamellipodium assembly(GO:0030032)
0.1 0.4 GO:0051660 establishment of centrosome localization(GO:0051660)
0.1 1.1 GO:0050975 sensory perception of touch(GO:0050975)
0.1 1.5 GO:0099560 synaptic membrane adhesion(GO:0099560)
0.1 3.0 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.1 4.5 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.1 9.2 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 1.1 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.1 4.9 GO:0006096 glycolytic process(GO:0006096)
0.1 0.2 GO:0042245 RNA repair(GO:0042245)
0.1 2.6 GO:0035118 embryonic pectoral fin morphogenesis(GO:0035118)
0.1 2.0 GO:0016082 synaptic vesicle priming(GO:0016082)
0.1 0.9 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 10.1 GO:0006936 muscle contraction(GO:0006936)
0.1 4.2 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.1 0.8 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.0 3.1 GO:0010107 potassium ion import(GO:0010107) potassium ion import across plasma membrane(GO:1990573)
0.0 1.2 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.6 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0 2.8 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 1.7 GO:0030336 negative regulation of cell migration(GO:0030336)
0.0 0.7 GO:0033627 cell adhesion mediated by integrin(GO:0033627)
0.0 0.5 GO:0070593 dendrite self-avoidance(GO:0070593)
0.0 4.2 GO:0006887 exocytosis(GO:0006887)
0.0 0.3 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.3 GO:0031114 regulation of microtubule depolymerization(GO:0031114)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 GO:0005592 collagen type XI trimer(GO:0005592)
0.5 2.1 GO:1990909 Wnt signalosome(GO:1990909)
0.5 10.6 GO:0031430 M band(GO:0031430)
0.4 1.5 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.2 3.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.2 9.1 GO:0005901 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.2 3.5 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.2 0.6 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 3.0 GO:0000145 exocyst(GO:0000145)
0.1 2.8 GO:0031105 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 0.3 GO:0016272 prefoldin complex(GO:0016272)
0.0 1.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 3.0 GO:0005884 actin filament(GO:0005884)
0.0 2.0 GO:0031201 SNARE complex(GO:0031201)
0.0 0.1 GO:0035517 PR-DUB complex(GO:0035517)
0.0 1.7 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 0.7 GO:0008305 integrin complex(GO:0008305)
0.0 0.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 11.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
1.0 4.9 GO:0004619 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619)
0.9 9.7 GO:0032036 myosin heavy chain binding(GO:0032036)
0.3 1.7 GO:0050780 mu-type opioid receptor binding(GO:0031852) dopamine receptor binding(GO:0050780) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.3 1.1 GO:0043998 H2A histone acetyltransferase activity(GO:0043998)
0.2 1.1 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.2 3.1 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.2 1.5 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.2 3.2 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.2 3.2 GO:0048495 Roundabout binding(GO:0048495)
0.2 4.5 GO:0017080 sodium channel regulator activity(GO:0017080)
0.2 2.1 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 4.2 GO:0005178 integrin binding(GO:0005178)
0.1 0.9 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.1 2.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 0.2 GO:0035516 oxidative DNA demethylase activity(GO:0035516) DNA-N1-methyladenine dioxygenase activity(GO:0043734) RNA N6-methyladenosine dioxygenase activity(GO:1990931)
0.0 17.6 GO:0051015 actin filament binding(GO:0051015)
0.0 4.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.2 GO:0019003 GDP binding(GO:0019003)
0.0 2.0 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.6 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.1 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 1.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.3 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.7 GO:0044325 ion channel binding(GO:0044325)
0.0 2.8 GO:0060090 binding, bridging(GO:0060090)
0.0 0.5 GO:0098632 protein binding involved in cell adhesion(GO:0098631) protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.3 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 3.2 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 2.2 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 1.2 GO:0045296 cadherin binding(GO:0045296)
0.0 0.8 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 3.8 GO:0008017 microtubule binding(GO:0008017)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.2 PID GLYPICAN 1PATHWAY Glypican 1 network
0.1 4.2 NABA COLLAGENS Genes encoding collagen proteins
0.1 0.7 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 3.0 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 0.8 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 3.5 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.7 PID AP1 PATHWAY AP-1 transcription factor network
0.0 2.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.8 PID AR PATHWAY Coregulation of Androgen receptor activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.2 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.2 3.2 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 1.7 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.1 4.2 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 0.8 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.7 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions