ISMARA results: nr3c1

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for nr3c1_ar

Z-value: 1.53

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Transcription factors associated with nr3c1_ar

Gene Symbol	Gene ID	Gene Info
nr3c1 NCBI UniProt	ENSDARG00000025032	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
nr3c1 NCBI UniProt	ENSDARG00000112480	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
nr3c1 NCBI UniProt	ENSDARG00000116957	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
ar NCBI UniProt	ENSDARG00000067976	androgen receptor
ar NCBI UniProt	ENSDARG00000114287	androgen receptor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
nr3c1	dr11_v1_chr14_-_23801389_23801389	0.10	3.4e-01	Click!
ar	dr11_v1_chr5_+_35561607_35561607	-0.08	4.2e-01	Click!

Activity profile of nr3c1_ar motif

Sorted Z-values of nr3c1_ar motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr6_+_41096058 Show fit	48.68	ENSDART00000028373	fkbp5 NCBI UniProt Show fit	FK506 binding protein 5
chr6_+_41099787 Show fit	41.28	ENSDART00000186884	fkbp5 NCBI UniProt Show fit	FK506 binding protein 5
chr16_+_50089417 Show fit	18.63	ENSDART00000153675	nr1d2a NCBI UniProt Show fit	nuclear receptor subfamily 1, group D, member 2a
chr7_+_48288762 Show fit	12.36	ENSDART00000083569	oaz2b NCBI UniProt Show fit	ornithine decarboxylase antizyme 2b
chr16_+_10776688 Show fit	11.10	ENSDART00000161969 ENSDART00000172657	atp1a3b NCBI UniProt Show fit	ATPase Na+/K+ transporting subunit alpha 3b
chr16_+_10777116 Show fit	9.12	ENSDART00000190902	atp1a3b NCBI UniProt Show fit	ATPase Na+/K+ transporting subunit alpha 3b
chr20_+_28266892 Show fit	7.88	ENSDART00000103330	chac1 NCBI UniProt Show fit	ChaC, cation transport regulator homolog 1 (E. coli)
chr3_-_5067585 Show fit	7.63	ENSDART00000169609	tefb NCBI UniProt Show fit	thyrotrophic embryonic factor b
chr12_-_46959990 Show fit	6.93	ENSDART00000084557	lhpp NCBI UniProt Show fit	phospholysine phosphohistidine inorganic pyrophosphate phosphatase
chr15_+_40188076 Show fit	6.78	ENSDART00000063779	efhd1 NCBI UniProt Show fit	EF-hand domain family, member D1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of nr3c1_ar

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.9	90.0	GO:0000413	protein peptidyl-prolyl isomerization(GO:0000413)
1.3	24.2	GO:0030007	cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.5	22.8	GO:0032922	circadian regulation of gene expression(GO:0032922)
0.6	13.7	GO:0006595	polyamine metabolic process(GO:0006595)
0.0	9.4	GO:0006470	protein dephosphorylation(GO:0006470)
0.8	8.9	GO:0010955	negative regulation of protein processing(GO:0010955) negative regulation of protein maturation(GO:1903318)
1.4	8.4	GO:0035313	wound healing, spreading of epidermal cells(GO:0035313) negative regulation of ruffle assembly(GO:1900028)
0.0	7.4	GO:0018105	peptidyl-serine phosphorylation(GO:0018105)
0.0	7.1	GO:0070588	calcium ion transmembrane transport(GO:0070588)
0.4	7.0	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)

Showing 1 to 10 of 159 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	100.6	GO:0005737	cytoplasm(GO:0005737)
0.0	22.1	GO:0005829	cytosol(GO:0005829)
0.1	10.2	GO:0005925	focal adhesion(GO:0005925)
0.7	8.7	GO:0005964	phosphorylase kinase complex(GO:0005964)
0.1	7.3	GO:0005802	trans-Golgi network(GO:0005802)
0.4	6.1	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.1	5.0	GO:0044309	dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.1	4.5	GO:0005844	polysome(GO:0005844)
0.0	4.5	GO:0030054	cell junction(GO:0030054)
0.2	4.1	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)

Showing 1 to 10 of 77 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
22.5	90.0	GO:0005527	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
2.0	20.2	GO:0005391	sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0	19.3	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1	18.4	GO:0004879	RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
3.1	12.4	GO:0008073	ornithine decarboxylase inhibitor activity(GO:0008073)
0.0	11.5	GO:0003779	actin binding(GO:0003779)
2.0	7.9	GO:0003839	gamma-glutamylcyclotransferase activity(GO:0003839)
0.5	7.0	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
1.7	6.9	GO:0101006	inorganic diphosphatase activity(GO:0004427) protein histidine phosphatase activity(GO:0101006)
0.1	6.9	GO:0008201	heparin binding(GO:0008201)

Showing 1 to 10 of 129 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	92.6	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
0.2	7.5	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.4	4.9	PID S1P S1P2 PATHWAY	S1P2 pathway
0.1	3.5	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.1	3.4	PID ILK PATHWAY	Integrin-linked kinase signaling
0.1	2.7	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.0	2.1	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0	2.1	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.1	1.8	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.1	1.5	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III

Showing 1 to 10 of 16 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	5.3	REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER	Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.3	3.9	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
0.2	3.2	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.3	3.1	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.1	2.3	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.4	1.8	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.1	1.7	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.1	1.7	REACTOME RNA POL I TRANSCRIPTION INITIATION	Genes involved in RNA Polymerase I Transcription Initiation
0.2	1.5	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.0	1.5	REACTOME CIRCADIAN CLOCK	Genes involved in Circadian Clock

Showing 1 to 10 of 29 entries

Results for nr3c1_ar

Z-value: 1.53

Motif logo

Transcription factors associated with nr3c1_ar

Activity-expression correlation:

Activity profile of nr3c1_ar motif

Sorted Z-values of nr3c1_ar motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of nr3c1_ar

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: