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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for nr4a2a
Z-value: 1.36
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Transcription factors associated with nr4a2a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| nr4a2a | dr11_v1_chr9_-_5045378_5045378 | -0.22 | 3.5e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr18_-_48517040 Show fit | 15.72 |
ENSDART00000143645
|
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 3 |
|
| chr18_-_48492951 Show fit | 14.81 |
ENSDART00000146346
|
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 6 |
|
| chr18_-_48508585 Show fit | 13.04 |
ENSDART00000133364
|
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 4 |
|
| chr7_-_7810348 Show fit | 12.76 |
ENSDART00000171984
|
chemokine (C-X-C motif) ligand 19 |
|
| chr5_-_41831646 Show fit | 12.37 |
ENSDART00000134326
|
si:dkey-65b12.6 |
|
| chr8_-_36399884 Show fit | 11.59 |
ENSDART00000108538
|
si:zfos-2070c2.3 |
|
| chr22_+_19220459 Show fit | 9.66 |
ENSDART00000163070
|
si:dkey-21e2.7 |
|
| chr2_+_45191049 Show fit | 9.26 |
ENSDART00000165392
|
chemokine (C-C motif) ligand 20a, duplicate 3 |
|
| chr19_-_30404096 Show fit | 9.06 |
ENSDART00000103475
|
anterior gradient 2 |
|
| chr6_-_8480815 Show fit | 8.42 |
ENSDART00000162300
|
RAS protein activator like 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of nr4a2a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 38.5 | GO:1990573 | potassium ion import across plasma membrane(GO:1990573) |
| 0.4 | 22.0 | GO:0070098 | chemokine-mediated signaling pathway(GO:0070098) |
| 0.1 | 16.3 | GO:0043087 | regulation of GTPase activity(GO:0043087) |
| 1.6 | 15.6 | GO:0060575 | intestinal epithelial cell differentiation(GO:0060575) |
| 0.2 | 10.3 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.5 | 8.7 | GO:1902882 | regulation of response to oxidative stress(GO:1902882) |
| 0.5 | 8.3 | GO:0000737 | DNA catabolic process, endonucleolytic(GO:0000737) |
| 0.1 | 8.3 | GO:0019221 | cytokine-mediated signaling pathway(GO:0019221) |
| 0.1 | 7.7 | GO:0001946 | lymphangiogenesis(GO:0001946) |
| 2.3 | 7.0 | GO:0051973 | positive regulation of telomerase activity(GO:0051973) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 29.0 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.0 | 28.2 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 19.0 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.1 | 14.3 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 9.7 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 7.5 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.1 | 7.0 | GO:0005769 | early endosome(GO:0005769) |
| 0.5 | 6.8 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.1 | 6.2 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.2 | 5.8 | GO:0005839 | proteasome core complex(GO:0005839) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 49.2 | GO:0015272 | ATP-activated inward rectifier potassium channel activity(GO:0015272) |
| 0.0 | 18.6 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 14.5 | GO:0042803 | protein homodimerization activity(GO:0042803) |
| 0.3 | 14.0 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 1.2 | 12.8 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.1 | 12.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 2.1 | 10.3 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
| 0.1 | 10.1 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.8 | 8.3 | GO:0004530 | deoxyribonuclease I activity(GO:0004530) |
| 0.0 | 8.2 | GO:0003924 | GTPase activity(GO:0003924) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 5.8 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.2 | 5.3 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.1 | 4.4 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 4.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 4.1 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 3.5 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.4 | 3.3 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.1 | 3.0 | PID ATM PATHWAY | ATM pathway |
| 0.1 | 2.8 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.7 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.7 | 5.2 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.5 | 4.9 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.1 | 4.8 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.2 | 4.7 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 4.6 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.4 | 4.3 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.3 | 4.1 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.2 | 4.1 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.2 | 4.0 | REACTOME CD28 DEPENDENT PI3K AKT SIGNALING | Genes involved in CD28 dependent PI3K/Akt signaling |