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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for nr4a2a

Z-value: 1.36

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Transcription factors associated with nr4a2a

Gene Symbol Gene ID Gene Info
nr4a2a
ENSDARG00000017007 nuclear receptor subfamily 4, group A, member 2a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nr4a2adr11_v1_chr9_-_5045378_5045378-0.223.5e-02Click!

Activity profile of nr4a2a motif

Sorted Z-values of nr4a2a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_-_48517040 15.72 ENSDART00000143645
kcnj1a.3
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 3
chr18_-_48492951 14.81 ENSDART00000146346
kcnj1a.6
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 6
chr18_-_48508585 13.04 ENSDART00000133364
kcnj1a.4
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 4
chr7_-_7810348 12.76 ENSDART00000171984
cxcl19
chemokine (C-X-C motif) ligand 19
chr5_-_41831646 12.37 ENSDART00000134326
si:dkey-65b12.6
si:dkey-65b12.6
chr8_-_36399884 11.59 ENSDART00000108538
si:zfos-2070c2.3
si:zfos-2070c2.3
chr22_+_19220459 9.66 ENSDART00000163070
si:dkey-21e2.7
si:dkey-21e2.7
chr2_+_45191049 9.26 ENSDART00000165392
ccl20a.3
chemokine (C-C motif) ligand 20a, duplicate 3
chr19_-_30404096 9.06 ENSDART00000103475
agr2
anterior gradient 2
chr6_-_8480815 8.42 ENSDART00000162300
rasal3
RAS protein activator like 3
chr20_+_36806398 8.31 ENSDART00000153317
abracl
ABRA C-terminal like
chr20_+_2589414 8.31 ENSDART00000043626
il20ra
interleukin 20 receptor, alpha
chr23_+_19701587 8.27 ENSDART00000104425
dnase1l1
deoxyribonuclease I-like 1
chr23_-_24488696 7.99 ENSDART00000155593
tmem82
transmembrane protein 82
chr2_+_7106837 7.74 ENSDART00000138691
vcam1a
vascular cell adhesion molecule 1a
chr8_+_16758304 7.71 ENSDART00000133514
elovl7a
ELOVL fatty acid elongase 7a
chr3_+_57820913 7.62 ENSDART00000168101
CU571328.1

chr10_+_15064433 7.00 ENSDART00000179978
parm1
prostate androgen-regulated mucin-like protein 1
chr1_+_58353661 7.00 ENSDART00000140074
si:dkey-222h21.2
si:dkey-222h21.2
chr21_-_7940043 6.92 ENSDART00000099733
ENSDART00000136671
f2rl1.1
coagulation factor II (thrombin) receptor-like 1, tandem duplicate 1
chr7_+_12950507 6.77 ENSDART00000067629
ENSDART00000158004
saa
serum amyloid A
chr19_-_30403922 6.52 ENSDART00000181841
agr2
anterior gradient 2
chr12_+_46634736 6.50 ENSDART00000008009
trim16
tripartite motif containing 16
chr15_-_28618502 6.45 ENSDART00000086902
slc6a4a
solute carrier family 6 (neurotransmitter transporter), member 4a
chr5_-_41838354 6.34 ENSDART00000146793
si:dkey-65b12.6
si:dkey-65b12.6
chr7_+_20344222 6.30 ENSDART00000141186
ENSDART00000139274
ponzr1
plac8 onzin related protein 1
chr3_+_42923275 6.17 ENSDART00000168228
tmem184a
transmembrane protein 184a
chr20_-_10288156 6.04 ENSDART00000064110
si:dkey-63b1.1
si:dkey-63b1.1
chr19_+_11214007 5.94 ENSDART00000127362
si:ch73-109i22.2
si:ch73-109i22.2
chr5_-_41841892 5.93 ENSDART00000167089
si:dkey-65b12.6
si:dkey-65b12.6
chr15_+_11840311 5.88 ENSDART00000167671
prkd2
protein kinase D2
chr25_+_13191615 5.86 ENSDART00000168849
si:ch211-147m6.2
si:ch211-147m6.2
chr19_-_7144548 5.84 ENSDART00000147177
ENSDART00000134850
psmb8a
psmb13a
proteasome subunit beta 8A
proteasome subunit beta 13a
chr11_-_30634286 5.81 ENSDART00000191019
zgc:153665
zgc:153665
chr19_+_7043634 5.75 ENSDART00000133954
mhc1uka
major histocompatibility complex class I UKA
chr23_+_26142807 5.71 ENSDART00000158878
ptpn22
protein tyrosine phosphatase, non-receptor type 22
chr17_+_15213496 5.70 ENSDART00000058351
ENSDART00000131663
gnpnat1
glucosamine-phosphate N-acetyltransferase 1
chr3_-_8130491 5.66 ENSDART00000162309
si:ch211-51i16.1
si:ch211-51i16.1
chr18_-_48550426 5.66 ENSDART00000145189
kcnj1a.1
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 1
chr14_+_35428152 5.51 ENSDART00000172597
sytl4
synaptotagmin-like 4
chr4_-_67799941 5.43 ENSDART00000185830
si:ch211-66c13.1
si:ch211-66c13.1
chr4_+_30785713 5.24 ENSDART00000165945
si:dkey-178j11.5
si:dkey-178j11.5
chr22_-_23000815 5.16 ENSDART00000137111
ptprc
protein tyrosine phosphatase, receptor type, C
chr5_+_4564233 5.10 ENSDART00000193435
CABZ01058647.1

chr17_-_53353653 4.93 ENSDART00000180744
ENSDART00000026879
unm_sa911
un-named sa911
chr3_+_46764022 4.89 ENSDART00000023814
prkcsh
protein kinase C substrate 80K-H
chr3_-_49925313 4.81 ENSDART00000164361
gcgra
glucagon receptor a
chr2_-_53592532 4.78 ENSDART00000184066
ccl25a
chemokine (C-C motif) ligand 25a
chr20_-_39735952 4.75 ENSDART00000101049
ENSDART00000137485
ENSDART00000062402
tpd52l1
tumor protein D52-like 1
chr14_-_14659023 4.66 ENSDART00000170355
ENSDART00000159888
ENSDART00000172241
nsdhl
NAD(P) dependent steroid dehydrogenase-like
chr23_+_26142613 4.56 ENSDART00000165046
ptpn22
protein tyrosine phosphatase, non-receptor type 22
chr23_-_36313431 4.51 ENSDART00000125860
nfe2
nuclear factor, erythroid 2
chr24_-_30263301 4.51 ENSDART00000162328
snx7
sorting nexin 7
chr17_+_53424415 4.47 ENSDART00000157022
slc9a1b
solute carrier family 9 member A1b
chr21_-_22724980 4.32 ENSDART00000035469
c1qa
complement component 1, q subcomponent, A chain
chr24_-_36723116 4.31 ENSDART00000088204
si:ch73-334d15.1
si:ch73-334d15.1
chr6_+_7250824 4.23 ENSDART00000177226
dzip1
DAZ interacting zinc finger protein 1
chr12_-_44122412 4.20 ENSDART00000169094
si:ch73-329n5.3
si:ch73-329n5.3
chr5_-_38197080 4.18 ENSDART00000140708
si:ch211-284e13.9
si:ch211-284e13.9
chr21_-_43428040 4.15 ENSDART00000148325
stk26
serine/threonine protein kinase 26
chr14_+_31788733 4.14 ENSDART00000109063
cd40lg
CD40 ligand
chr7_-_28413224 4.09 ENSDART00000076502
rerglb
RERG/RAS-like b
chr1_+_58312187 4.08 ENSDART00000142285
si:dkey-222h21.10
si:dkey-222h21.10
chr20_+_6535438 4.06 ENSDART00000145763
si:ch211-191a24.4
si:ch211-191a24.4
chr7_+_73801377 3.99 ENSDART00000184051
si:ch73-252p3.1
si:ch73-252p3.1
chr22_+_29113796 3.92 ENSDART00000150264
pla2g6
phospholipase A2, group VI (cytosolic, calcium-independent)
chr1_+_58260886 3.91 ENSDART00000110453
si:dkey-222h21.8
si:dkey-222h21.8
chr2_-_55298075 3.91 ENSDART00000186404
ENSDART00000149062
rab8a
RAB8A, member RAS oncogene family
chr7_+_34297271 3.90 ENSDART00000180342
bbox1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr21_+_11105007 3.87 ENSDART00000128859
ENSDART00000193105
prlra
prolactin receptor a
chr15_-_37875601 3.84 ENSDART00000122439
si:dkey-238d18.4
si:dkey-238d18.4
chr23_+_5631381 3.80 ENSDART00000149143
pkp1a
plakophilin 1a
chr22_-_15593824 3.79 ENSDART00000123125
tpm4a
tropomyosin 4a
chr21_-_5879897 3.79 ENSDART00000184034
rpl35
ribosomal protein L35
chr9_-_4075620 3.75 ENSDART00000046903
mylka
myosin, light chain kinase a
chr9_-_9419704 3.72 ENSDART00000138996
si:ch211-214p13.9
si:ch211-214p13.9
chr1_+_58303892 3.70 ENSDART00000147678
CR769768.1

chr3_-_4591643 3.70 ENSDART00000138144
ftr50
finTRIM family, member 50
chr4_+_9536860 3.63 ENSDART00000130083
lsm8
LSM8 homolog, U6 small nuclear RNA associated
chr15_+_19324697 3.59 ENSDART00000022015
vps26b
VPS26 retromer complex component B
chr18_-_37241080 3.58 ENSDART00000126421
ENSDART00000078064
six9
SIX homeobox 9
chr1_+_58067815 3.57 ENSDART00000156678
si:ch211-114l13.4
si:ch211-114l13.4
chr15_+_3766101 3.56 ENSDART00000042580
ENSDART00000112698
ENSDART00000187035
ENSDART00000165571
ENSDART00000121752
RNF14 (1 of many)
zmp:0000000524
chr13_+_7241170 3.55 ENSDART00000109434
aifm2
apoptosis-inducing factor, mitochondrion-associated, 2
chr2_+_2168547 3.51 ENSDART00000029347
higd1a
HIG1 hypoxia inducible domain family, member 1A
chr25_+_21829777 3.46 ENSDART00000027393
ckmt1
creatine kinase, mitochondrial 1
chr15_-_33834577 3.46 ENSDART00000163354
mmp13b
matrix metallopeptidase 13b
chr5_-_14509137 3.44 ENSDART00000180742
si:ch211-244o22.2
si:ch211-244o22.2
chr17_+_17764979 3.44 ENSDART00000105013
alkbh1
alkB homolog 1, histone H2A dioxygenase
chr2_-_3045861 3.40 ENSDART00000105818
ENSDART00000187575
guk1a
guanylate kinase 1a
chr22_+_19247255 3.38 ENSDART00000144053
si:dkey-21e2.10
si:dkey-21e2.10
chr12_-_23658888 3.31 ENSDART00000088319
map3k8
mitogen-activated protein kinase kinase kinase 8
chr3_+_50201240 3.29 ENSDART00000156347
epn3a
epsin 3a
chr1_-_48933 3.22 ENSDART00000171162
ildr1a
immunoglobulin-like domain containing receptor 1a
chr13_+_25412307 3.21 ENSDART00000175339
calhm1
calcium homeostasis modulator 1
chr11_-_41966854 3.21 ENSDART00000055709
her2
hairy-related 2
chr5_+_20693724 3.15 ENSDART00000141368
si:ch211-240b21.2
si:ch211-240b21.2
chr4_-_14470071 3.13 ENSDART00000143773
plxnb2a
plexin b2a
chr5_+_36896933 3.07 ENSDART00000151984
srsf7a
serine/arginine-rich splicing factor 7a
chr15_-_41762530 3.07 ENSDART00000187125
ENSDART00000154971
ftr91
finTRIM family, member 91
chr19_-_47571456 3.03 ENSDART00000158071
ENSDART00000165841
rrm2
ribonucleotide reductase M2 polypeptide
chr18_-_2222128 2.97 ENSDART00000171402
pigb
phosphatidylinositol glycan anchor biosynthesis, class B
chr10_+_10788811 2.95 ENSDART00000101077
ENSDART00000139143
ptgdsa
prostaglandin D2 synthase a
chr13_-_12581388 2.93 ENSDART00000079655
enpep
glutamyl aminopeptidase
chr23_+_22597624 2.88 ENSDART00000054337
gpr157
G protein-coupled receptor 157
chr14_+_7898372 2.84 ENSDART00000159593
ube2d2
ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)
chr7_+_34296789 2.83 ENSDART00000052471
ENSDART00000173798
ENSDART00000173778
bbox1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr7_-_33351485 2.83 ENSDART00000146420
anp32a
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr5_-_10082244 2.82 ENSDART00000036421
chek2
checkpoint kinase 2
chr17_+_6217704 2.80 ENSDART00000129100
BX000363.1

chr22_-_11137268 2.80 ENSDART00000178882
atp6ap2
ATPase H+ transporting accessory protein 2
chr24_-_28419444 2.80 ENSDART00000105749
nrros
negative regulator of reactive oxygen species
chr19_-_7043355 2.77 ENSDART00000104845
tapbp.1
TAP binding protein (tapasin), tandem duplicate 1
chr3_+_31680592 2.77 ENSDART00000172456
mylk5
myosin, light chain kinase 5
chr21_-_35534401 2.76 ENSDART00000112308
si:dkeyp-23e4.3
si:dkeyp-23e4.3
chr10_+_41199660 2.72 ENSDART00000125314
adrb3b
adrenoceptor beta 3b
chr13_-_31397987 2.66 ENSDART00000008287
pgam1a
phosphoglycerate mutase 1a
chr7_-_26601307 2.64 ENSDART00000188934
plscr3b
phospholipid scramblase 3b
chr22_-_11136625 2.54 ENSDART00000016873
ENSDART00000125561
atp6ap2
ATPase H+ transporting accessory protein 2
chr1_-_39859626 2.52 ENSDART00000053763
dctd
dCMP deaminase
chr10_-_33251876 2.41 ENSDART00000184565
bcl7ba
BCL tumor suppressor 7Ba
chr18_+_44769211 2.37 ENSDART00000177181
ilvbl
ilvB (bacterial acetolactate synthase)-like
chr1_+_39859782 2.35 ENSDART00000149984
irf2a
interferon regulatory factor 2a
chr20_-_40729364 2.33 ENSDART00000101014
cx32.2
connexin 32.2
chr20_-_40717900 2.32 ENSDART00000181663
cx43
connexin 43
chr5_+_63288599 2.28 ENSDART00000140065
si:ch73-37h15.2
si:ch73-37h15.2
chr20_+_49119633 2.27 ENSDART00000151435
cd109
CD109 molecule
chr12_-_5120339 2.27 ENSDART00000168759
rbp4
retinol binding protein 4, plasma
chr17_-_25303486 2.25 ENSDART00000162235
ppie
peptidylprolyl isomerase E (cyclophilin E)
chr18_+_13182528 2.24 ENSDART00000166298
zgc:56622
zgc:56622
chr2_+_30787128 2.22 ENSDART00000189233
atp6v1h
ATPase H+ transporting V1 subunit H
chr11_-_44194132 2.22 ENSDART00000182954
ENSDART00000111271
CABZ01080074.1

chr18_-_13360106 2.19 ENSDART00000091512
cmip
c-Maf inducing protein
chr7_+_11459235 2.19 ENSDART00000159611
il16
interleukin 16
chr4_-_42242844 2.16 ENSDART00000163476
si:ch211-129p6.2
si:ch211-129p6.2
chr7_+_58736889 2.15 ENSDART00000175932
plag1
pleiomorphic adenoma gene 1
chr17_+_48314724 2.12 ENSDART00000125617
smoc1
SPARC related modular calcium binding 1
chr22_+_21252790 2.11 ENSDART00000079046
cpamd8
C3 and PZP-like, alpha-2-macroglobulin domain containing 8
chr12_-_28983584 2.08 ENSDART00000112374
zgc:171713
zgc:171713
chr6_-_1587291 2.08 ENSDART00000067592
ENSDART00000178877
zgc:123305
zgc:123305
chr13_+_31321297 2.07 ENSDART00000143308
antxr1d
anthrax toxin receptor 1d
chr22_+_17399124 2.00 ENSDART00000145769
rabgap1l
RAB GTPase activating protein 1-like
chr16_-_41787421 1.97 ENSDART00000147210
si:dkey-199f5.8
si:dkey-199f5.8
chr24_+_39518774 1.95 ENSDART00000132939
dcun1d3
defective in cullin neddylation 1 domain containing 3
chr6_-_11523987 1.94 ENSDART00000189363
gulp1b
GULP, engulfment adaptor PTB domain containing 1b
chr2_-_56385373 1.94 ENSDART00000169101
cers4b
ceramide synthase 4b
chr22_+_9764731 1.92 ENSDART00000161441
BX664625.4

chr17_-_15189397 1.90 ENSDART00000133710
ENSDART00000110507
wdhd1
WD repeat and HMG-box DNA binding protein 1
chr21_-_25250594 1.89 ENSDART00000163862
nfrkb
nuclear factor related to kappaB binding protein
chr11_-_11458208 1.87 ENSDART00000005485
krt93
keratin 93
chr16_+_21242491 1.87 ENSDART00000145886
osbpl3b
oxysterol binding protein-like 3b
chr3_+_36646054 1.86 ENSDART00000170013
ENSDART00000159948
gspt1l
G1 to S phase transition 1, like
chr17_-_51224159 1.85 ENSDART00000185749
psen1
presenilin 1
chr23_+_5736226 1.85 ENSDART00000134527
ENSDART00000112220
ftr57
finTRIM family, member 57
chr25_+_3326885 1.84 ENSDART00000104866
ldhbb
lactate dehydrogenase Bb
chr17_+_5976683 1.84 ENSDART00000110276
zgc:194275
zgc:194275
chr5_+_23201370 1.82 ENSDART00000138123
tpcn1
two pore segment channel 1
chr11_+_7432533 1.81 ENSDART00000180977
adgrl2a
adhesion G protein-coupled receptor L2a
chr12_-_5120175 1.80 ENSDART00000160729
rbp4
retinol binding protein 4, plasma
chr23_-_9855627 1.80 ENSDART00000180159
prkcbp1l
protein kinase C binding protein 1, like
chr20_+_49081967 1.78 ENSDART00000112689
crnkl1
crooked neck pre-mRNA splicing factor 1
chr16_+_8716800 1.77 ENSDART00000124693
ENSDART00000181961
cabz01093075.1
cabz01093075.1
chr2_+_2967255 1.77 ENSDART00000167649
ENSDART00000166449
pik3r3a
phosphoinositide-3-kinase, regulatory subunit 3a (gamma)
chr5_+_22677786 1.76 ENSDART00000142112
vma21
VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
chr9_+_32872690 1.75 ENSDART00000020798
si:dkey-145p14.5
si:dkey-145p14.5
chr2_+_37836821 1.75 ENSDART00000143203
parp2
poly (ADP-ribose) polymerase 2
chr3_+_58984463 1.74 ENSDART00000162097
CABZ01044156.1

chr2_+_28672152 1.71 ENSDART00000157410
ENSDART00000169614
nadsyn1
NAD synthetase 1
chr17_+_21546993 1.69 ENSDART00000182387
chst15
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
chr7_+_39679944 1.69 ENSDART00000133420
tbc1d14
TBC1 domain family, member 14
chr8_+_22477922 1.68 ENSDART00000189766
ENSDART00000179717
si:ch211-261n11.7
si:ch211-261n11.7
chr22_+_19486711 1.68 ENSDART00000144389
ENSDART00000139256
ENSDART00000160855
si:dkey-78l4.10
si:dkey-78l4.10
chr8_+_10823069 1.68 ENSDART00000081341
mapk13
mitogen-activated protein kinase 13
chr13_-_25581303 1.67 ENSDART00000087533
csgalnact2
chondroitin sulfate N-acetylgalactosaminyltransferase 2
chr19_+_1465004 1.64 ENSDART00000159157
CABZ01073736.1

chr5_-_41841675 1.60 ENSDART00000141683
si:dkey-65b12.6
si:dkey-65b12.6
chr10_+_29199172 1.58 ENSDART00000148828
picalma
phosphatidylinositol binding clathrin assembly protein a
chr8_-_17184482 1.57 ENSDART00000025803
pola2
polymerase (DNA directed), alpha 2
chr5_-_17601759 1.53 ENSDART00000138387
si:ch211-130h14.6
si:ch211-130h14.6
chr19_-_6631900 1.52 ENSDART00000144571
pvrl2l
poliovirus receptor-related 2 like
chr6_-_40429411 1.50 ENSDART00000156005
ENSDART00000156357
si:dkey-28n18.9
si:dkey-28n18.9
chr8_+_25893071 1.49 ENSDART00000078161
tmem115
transmembrane protein 115
chr22_-_37834312 1.49 ENSDART00000076128
ppp1r2
protein phosphatase 1, regulatory (inhibitor) subunit 2
chr21_-_22317920 1.49 ENSDART00000191083
ENSDART00000108701
gdpd4b
glycerophosphodiester phosphodiesterase domain containing 4b
chr1_-_57629639 1.46 ENSDART00000158984
zmp:0000001289
zmp:0000001289
chr15_+_25439106 1.45 ENSDART00000156252
aifm4
apoptosis-inducing factor, mitochondrion-associated, 4
chr23_-_22598002 1.44 ENSDART00000146966
si:ch211-28e16.5
si:ch211-28e16.5
chr12_-_31726748 1.44 ENSDART00000153174
srsf2a
serine/arginine-rich splicing factor 2a
chr11_-_39118882 1.43 ENSDART00000113185
ENSDART00000156526
ap5b1
adaptor-related protein complex 5, beta 1 subunit
chr7_-_41338923 1.39 ENSDART00000099138
ncf2
neutrophil cytosolic factor 2
chr11_-_44999858 1.38 ENSDART00000167759
ENSDART00000126845
ldb1b
LIM-domain binding 1b
chr25_+_3327071 1.37 ENSDART00000136131
ENSDART00000133243
ldhbb
lactate dehydrogenase Bb
chr4_+_77971104 1.36 ENSDART00000188609
zgc:113921
zgc:113921
chr13_+_2394264 1.35 ENSDART00000168595
elovl5
ELOVL fatty acid elongase 5
chr23_+_2714949 1.34 ENSDART00000105284
ncoa6
nuclear receptor coactivator 6
chr9_-_40846447 1.33 ENSDART00000143384
si:dkey-95p16.1
si:dkey-95p16.1
chr15_-_21165237 1.31 ENSDART00000157069
A2ML1 (1 of many)
si:ch211-212c13.8
chr13_-_37127970 1.29 ENSDART00000135510
syne2b
spectrin repeat containing, nuclear envelope 2b
chr5_-_28016805 1.29 ENSDART00000078642
vps37b
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr10_-_22918214 1.25 ENSDART00000163908
rnasekb
ribonuclease, RNase K b

Network of associatons between targets according to the STRING database.

First level regulatory network of nr4a2a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 7.0 GO:0051973 positive regulation of telomerase activity(GO:0051973)
1.6 6.5 GO:0051610 serotonin transport(GO:0006837) serotonin uptake(GO:0051610)
1.6 4.8 GO:0072679 thymocyte migration(GO:0072679)
1.6 15.6 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
1.1 6.8 GO:0031640 killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364) disruption of cells of other organism involved in symbiotic interaction(GO:0051818) killing of cells in other organism involved in symbiotic interaction(GO:0051883)
1.0 4.1 GO:0002637 regulation of immunoglobulin production(GO:0002637) positive regulation of immunoglobulin production(GO:0002639)
1.0 5.9 GO:0089700 endocardial cushion formation(GO:0003272) protein kinase D signaling(GO:0089700)
1.0 3.9 GO:0048210 Golgi vesicle fusion to target membrane(GO:0048210)
1.0 3.9 GO:0038161 prolactin signaling pathway(GO:0038161)
1.0 6.7 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.9 2.8 GO:0036363 transforming growth factor beta activation(GO:0036363)
0.9 6.9 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.8 2.5 GO:0009162 deoxyribonucleoside monophosphate metabolic process(GO:0009162)
0.7 3.4 GO:0035513 oxidative RNA demethylation(GO:0035513)
0.6 2.4 GO:0009097 isoleucine metabolic process(GO:0006549) isoleucine biosynthetic process(GO:0009097)
0.6 1.8 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.6 3.5 GO:0097250 mitochondrial respiratory chain supercomplex assembly(GO:0097250)
0.6 4.1 GO:0046865 retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865)
0.6 6.3 GO:0061333 renal tubule morphogenesis(GO:0061333) nephron tubule morphogenesis(GO:0072078) nephron epithelium morphogenesis(GO:0072088)
0.5 2.7 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.5 3.8 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.5 3.2 GO:0007405 neuroblast proliferation(GO:0007405)
0.5 0.5 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211) pyrimidine deoxyribonucleotide metabolic process(GO:0009219)
0.5 5.7 GO:0018120 peptidyl-arginine ADP-ribosylation(GO:0018120)
0.5 8.3 GO:0000737 DNA catabolic process, endonucleolytic(GO:0000737)
0.5 38.5 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.5 1.8 GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis(GO:0051563)
0.5 4.1 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.5 8.7 GO:1902882 regulation of response to oxidative stress(GO:1902882)
0.4 5.7 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.4 4.5 GO:0098719 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.4 0.8 GO:0044068 modification by symbiont of host morphology or physiology(GO:0044003) modulation by symbiont of host cellular process(GO:0044068)
0.4 22.0 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.4 1.9 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.4 4.2 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.3 1.4 GO:0045730 respiratory burst(GO:0045730)
0.3 2.2 GO:0048069 eye pigmentation(GO:0048069)
0.3 0.9 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.3 6.0 GO:0034625 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.3 3.4 GO:0035306 positive regulation of dephosphorylation(GO:0035306) positive regulation of protein dephosphorylation(GO:0035307)
0.3 3.5 GO:0006603 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.3 1.3 GO:0098529 neuromuscular junction development, skeletal muscle fiber(GO:0098529)
0.3 1.0 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.3 2.8 GO:0019883 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.2 0.7 GO:0009258 10-formyltetrahydrofolate metabolic process(GO:0009256) 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.2 2.1 GO:1901998 toxin transport(GO:1901998)
0.2 10.3 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.2 4.8 GO:2001235 positive regulation of apoptotic signaling pathway(GO:2001235)
0.2 1.1 GO:0019240 citrulline biosynthetic process(GO:0019240)
0.2 1.1 GO:2000319 regulation of T-helper 17 type immune response(GO:2000316) negative regulation of T-helper 17 type immune response(GO:2000317) regulation of T-helper 17 cell differentiation(GO:2000319) negative regulation of T-helper 17 cell differentiation(GO:2000320) regulation of T-helper 17 cell lineage commitment(GO:2000328) negative regulation of T-helper 17 cell lineage commitment(GO:2000329)
0.2 4.9 GO:0006491 N-glycan processing(GO:0006491)
0.2 3.8 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.2 0.6 GO:0051660 establishment of centrosome localization(GO:0051660)
0.2 5.8 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.2 2.3 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.2 3.7 GO:0030183 B cell differentiation(GO:0030183)
0.2 0.9 GO:0098773 skin epidermis development(GO:0098773)
0.2 0.8 GO:0010828 positive regulation of glucose transport(GO:0010828)
0.2 6.0 GO:0006939 smooth muscle contraction(GO:0006939)
0.1 2.2 GO:0050927 regulation of positive chemotaxis(GO:0050926) positive regulation of positive chemotaxis(GO:0050927) induction of positive chemotaxis(GO:0050930)
0.1 1.7 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.1 3.5 GO:0008637 apoptotic mitochondrial changes(GO:0008637)
0.1 1.8 GO:0043551 regulation of lipid kinase activity(GO:0043550) regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.1 1.7 GO:0009435 NAD biosynthetic process(GO:0009435)
0.1 7.7 GO:0001946 lymphangiogenesis(GO:0001946)
0.1 1.9 GO:0045116 protein neddylation(GO:0045116)
0.1 4.7 GO:0001878 response to yeast(GO:0001878)
0.1 0.4 GO:0000066 mitochondrial ornithine transport(GO:0000066) mitochondrial L-ornithine transmembrane transport(GO:1990575)
0.1 1.2 GO:0031268 pseudopodium organization(GO:0031268) pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.1 0.9 GO:0061298 retina vasculature development in camera-type eye(GO:0061298)
0.1 2.9 GO:0043171 peptide catabolic process(GO:0043171)
0.1 4.8 GO:0010906 regulation of glucose metabolic process(GO:0010906)
0.1 0.4 GO:0051012 microtubule sliding(GO:0051012)
0.1 1.7 GO:2000785 regulation of autophagosome assembly(GO:2000785)
0.1 3.5 GO:0044243 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.1 1.7 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.1 3.1 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.1 2.8 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.1 0.8 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 2.8 GO:0045879 negative regulation of smoothened signaling pathway(GO:0045879)
0.1 5.2 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation(GO:0050731)
0.1 2.8 GO:0044773 mitotic DNA damage checkpoint(GO:0044773)
0.1 0.5 GO:0097198 histone H3-K36 trimethylation(GO:0097198)
0.1 0.7 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.1 0.5 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.1 1.0 GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902253) negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902254)
0.1 2.6 GO:0017121 phospholipid scrambling(GO:0017121)
0.1 2.1 GO:0046463 triglyceride biosynthetic process(GO:0019432) neutral lipid biosynthetic process(GO:0046460) acylglycerol biosynthetic process(GO:0046463)
0.1 1.7 GO:0019319 hexose biosynthetic process(GO:0019319)
0.1 3.6 GO:0030217 T cell differentiation(GO:0030217)
0.1 2.2 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 4.2 GO:0010842 retina layer formation(GO:0010842)
0.1 0.3 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.1 1.5 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.1 0.4 GO:0006552 leucine catabolic process(GO:0006552)
0.1 8.3 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.1 16.3 GO:0043087 regulation of GTPase activity(GO:0043087)
0.1 3.6 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.1 3.8 GO:0060048 cardiac muscle contraction(GO:0060048)
0.1 2.1 GO:0002072 optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.1 1.6 GO:0006270 DNA replication initiation(GO:0006270)
0.1 0.9 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 2.7 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 2.7 GO:0006096 glycolytic process(GO:0006096)
0.0 3.1 GO:0006958 humoral immune response mediated by circulating immunoglobulin(GO:0002455) complement activation, classical pathway(GO:0006958)
0.0 0.9 GO:0006743 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 0.6 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 1.5 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.4 GO:0072576 liver morphogenesis(GO:0072576)
0.0 1.2 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.0 0.2 GO:0060017 parathyroid gland development(GO:0060017)
0.0 0.2 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 0.9 GO:0040001 establishment of mitotic spindle localization(GO:0040001)
0.0 2.8 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 4.5 GO:0001889 liver development(GO:0001889)
0.0 0.1 GO:0060546 regulation of necrotic cell death(GO:0010939) regulation of necroptotic process(GO:0060544) negative regulation of necroptotic process(GO:0060546) negative regulation of necrotic cell death(GO:0060547)
0.0 1.9 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 0.6 GO:0035336 long-chain fatty-acyl-CoA metabolic process(GO:0035336)
0.0 1.9 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.0 2.8 GO:0051169 nucleocytoplasmic transport(GO:0006913) nuclear transport(GO:0051169)
0.0 1.0 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.7 GO:0043491 protein kinase B signaling(GO:0043491)
0.0 1.4 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 1.8 GO:0060326 cell chemotaxis(GO:0060326)
0.0 0.9 GO:0031638 zymogen activation(GO:0031638)
0.0 0.9 GO:0016575 histone deacetylation(GO:0016575)
0.0 1.2 GO:0090305 nucleic acid phosphodiester bond hydrolysis(GO:0090305)
0.0 3.1 GO:0000375 RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 1.1 GO:0035383 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 0.8 GO:0006414 translational elongation(GO:0006414)
0.0 5.7 GO:0006955 immune response(GO:0006955)
0.0 1.0 GO:0030178 negative regulation of Wnt signaling pathway(GO:0030178)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.9 GO:0017177 glucosidase II complex(GO:0017177)
0.9 3.7 GO:0019815 B cell receptor complex(GO:0019815)
0.8 2.4 GO:0005948 acetolactate synthase complex(GO:0005948)
0.5 6.8 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.4 1.9 GO:0018444 translation release factor complex(GO:0018444)
0.4 1.8 GO:0043198 dendritic shaft(GO:0043198)
0.4 3.6 GO:0005688 U6 snRNP(GO:0005688)
0.3 5.3 GO:0032591 dendritic spine membrane(GO:0032591)
0.3 3.6 GO:0030904 retromer complex(GO:0030904)
0.3 2.2 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.3 1.6 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.3 0.9 GO:0005828 kinetochore microtubule(GO:0005828)
0.2 5.8 GO:0005839 proteasome core complex(GO:0005839)
0.2 3.8 GO:0030057 desmosome(GO:0030057)
0.2 1.8 GO:0000974 Prp19 complex(GO:0000974)
0.2 2.9 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.2 1.1 GO:0016589 NURF complex(GO:0016589)
0.2 1.4 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 3.9 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.1 3.3 GO:0030125 clathrin vesicle coat(GO:0030125)
0.1 1.5 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 1.9 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.1 7.5 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 0.9 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.1 0.4 GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex(GO:0008247)
0.1 0.7 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 6.2 GO:0031901 early endosome membrane(GO:0031901)
0.1 1.2 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.1 1.4 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.1 29.0 GO:0031012 extracellular matrix(GO:0031012)
0.1 7.0 GO:0005769 early endosome(GO:0005769)
0.1 2.1 GO:0043596 nuclear replication fork(GO:0043596)
0.1 3.6 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 3.8 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 0.2 GO:0097134 cyclin E1-CDK2 complex(GO:0097134)
0.1 14.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 1.0 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.1 1.1 GO:0070822 Sin3-type complex(GO:0070822)
0.0 4.2 GO:0036064 ciliary basal body(GO:0036064)
0.0 5.4 GO:0016607 nuclear speck(GO:0016607)
0.0 5.2 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.6 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 3.8 GO:0005884 actin filament(GO:0005884)
0.0 9.7 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.7 GO:0005776 autophagosome(GO:0005776)
0.0 1.8 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 28.2 GO:0005615 extracellular space(GO:0005615)
0.0 1.1 GO:0042641 actomyosin(GO:0042641)
0.0 0.4 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 19.0 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 0.6 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 3.4 GO:0000785 chromatin(GO:0000785)
0.0 4.0 GO:0005730 nucleolus(GO:0005730)
0.0 0.3 GO:0000118 histone deacetylase complex(GO:0000118)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 49.2 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
2.2 6.7 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
2.2 6.5 GO:0005335 serotonin:sodium symporter activity(GO:0005335) serotonin transmembrane transporter activity(GO:0015222)
2.1 10.3 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
1.2 12.8 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
1.0 3.9 GO:0004925 prolactin receptor activity(GO:0004925)
1.0 4.8 GO:0016519 gastric inhibitory peptide receptor activity(GO:0016519)
0.9 2.8 GO:0016649 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.9 6.9 GO:0015057 thrombin receptor activity(GO:0015057)
0.9 3.4 GO:0035516 oxidative DNA demethylase activity(GO:0035516)
0.8 8.3 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.8 2.4 GO:0003984 acetolactate synthase activity(GO:0003984)
0.7 3.4 GO:0004385 guanylate kinase activity(GO:0004385)
0.7 2.7 GO:0051380 norepinephrine binding(GO:0051380)
0.6 3.0 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.6 4.1 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.6 4.1 GO:0034632 retinol transporter activity(GO:0034632)
0.5 2.7 GO:0004619 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619)
0.5 4.7 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.5 5.7 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.5 6.5 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.5 3.2 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.4 2.2 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.4 2.2 GO:0042609 CD4 receptor binding(GO:0042609)
0.4 4.5 GO:0015385 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.3 14.0 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.3 5.8 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.3 6.0 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.3 3.5 GO:0016775 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.2 0.7 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.2 1.2 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.2 1.2 GO:0034046 poly(G) binding(GO:0034046)
0.2 1.8 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.2 1.8 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.2 2.6 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.2 4.5 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.2 5.5 GO:0042043 neurexin family protein binding(GO:0042043)
0.2 1.4 GO:0030274 LIM domain binding(GO:0030274)
0.2 1.7 GO:0004359 glutaminase activity(GO:0004359)
0.2 1.9 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.2 1.7 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.2 4.7 GO:0004698 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.2 2.9 GO:0030552 cAMP binding(GO:0030552)
0.2 6.1 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.2 1.1 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.2 1.4 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 0.4 GO:0004485 methylcrotonoyl-CoA carboxylase activity(GO:0004485)
0.1 1.7 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.1 3.3 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 2.2 GO:0016018 cyclosporin A binding(GO:0016018)
0.1 1.9 GO:0002020 protease binding(GO:0002020)
0.1 1.9 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 1.1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 4.1 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 0.9 GO:0001032 polymerase III regulatory region sequence-specific DNA binding(GO:0000992) RNA polymerase III type 3 promoter sequence-specific DNA binding(GO:0001006) RNA polymerase III regulatory region DNA binding(GO:0001016) RNA polymerase III type 3 promoter DNA binding(GO:0001032)
0.1 14.5 GO:0042803 protein homodimerization activity(GO:0042803)
0.1 3.2 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.1 1.0 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.1 0.9 GO:0043515 kinetochore binding(GO:0043515)
0.1 5.7 GO:0048029 monosaccharide binding(GO:0048029)
0.1 2.9 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 0.5 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.1 0.6 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.1 10.1 GO:0004896 cytokine receptor activity(GO:0004896)
0.1 2.2 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 4.3 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 2.0 GO:0008378 galactosyltransferase activity(GO:0008378)
0.1 1.9 GO:0015248 sterol transporter activity(GO:0015248)
0.1 2.6 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 1.1 GO:0001968 fibronectin binding(GO:0001968)
0.1 1.2 GO:0035497 cAMP response element binding(GO:0035497)
0.1 0.3 GO:0031852 mu-type opioid receptor binding(GO:0031852) dopamine receptor binding(GO:0050780) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 0.9 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.1 0.3 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 2.8 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 12.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 1.8 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 2.3 GO:0019239 deaminase activity(GO:0019239)
0.1 1.0 GO:0016251 obsolete general RNA polymerase II transcription factor activity(GO:0016251)
0.0 18.6 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.8 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.0 1.7 GO:0004707 MAP kinase activity(GO:0004707)
0.0 1.4 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 1.8 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.4 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 3.8 GO:0045296 cadherin binding(GO:0045296)
0.0 3.2 GO:0019838 growth factor binding(GO:0019838)
0.0 1.3 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.5 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.9 GO:0004659 prenyltransferase activity(GO:0004659)
0.0 1.5 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.7 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 4.9 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 1.2 GO:0019003 GDP binding(GO:0019003)
0.0 6.0 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.1 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.0 0.2 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 8.2 GO:0003924 GTPase activity(GO:0003924)
0.0 2.1 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 1.2 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 1.7 GO:0008146 sulfotransferase activity(GO:0008146)
0.0 3.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 2.7 GO:0004866 endopeptidase inhibitor activity(GO:0004866)
0.0 2.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0003917 DNA topoisomerase type I activity(GO:0003917)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.3 4.1 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.2 5.3 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 5.8 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.1 1.7 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 9.7 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.8 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 3.0 PID ATM PATHWAY ATM pathway
0.1 2.8 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.1 4.4 PID E2F PATHWAY E2F transcription factor network
0.0 2.2 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 0.9 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 1.7 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 1.1 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 2.5 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 3.5 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 1.0 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 1.0 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 4.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.6 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 2.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 5.2 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.5 4.9 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.4 4.3 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.4 3.9 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.3 5.7 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.3 4.1 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2 3.4 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.2 1.7 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.2 2.8 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 2.8 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.2 2.2 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.2 4.1 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.2 4.7 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.2 4.0 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.2 1.8 REACTOME SIGNALING BY NOTCH4 Genes involved in Signaling by NOTCH4
0.2 3.1 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.2 1.4 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1 1.4 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.1 1.3 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.1 1.6 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.1 2.5 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.1 4.8 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 1.3 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 4.6 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 2.8 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.0 0.7 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.6 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.9 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 3.8 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.9 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 1.0 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.2 REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE Genes involved in p53-Dependent G1 DNA Damage Response
0.0 1.0 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 0.7 REACTOME TRANSLATION Genes involved in Translation