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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for nr6a1a
Z-value: 2.08
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Transcription factors associated with nr6a1a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| nr6a1a | dr11_v1_chr8_-_52909850_52909850 | -0.10 | 3.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_-_12660318 Show fit | 60.25 |
ENSDART00000008498
|
alcohol dehydrogenase 8a |
|
| chr20_+_10539293 Show fit | 49.90 |
ENSDART00000182265
|
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, like |
|
| chr4_-_17409533 Show fit | 34.01 |
ENSDART00000011943
|
phenylalanine hydroxylase |
|
| chr20_+_10545514 Show fit | 31.49 |
ENSDART00000153667
|
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 |
|
| chr16_-_45235947 Show fit | 31.47 |
ENSDART00000164436
|
si:dkey-33i11.4 |
|
| chr3_+_21189766 Show fit | 28.29 |
ENSDART00000078807
|
zgc:123295 |
|
| chr3_+_39540014 Show fit | 26.36 |
ENSDART00000074848
|
zgc:165423 |
|
| chr3_+_19299309 Show fit | 23.44 |
ENSDART00000046297
ENSDART00000146955 |
low density lipoprotein receptor a |
|
| chr5_-_37103487 Show fit | 21.63 |
ENSDART00000149211
|
interleukin 13 receptor, alpha 2 |
|
| chr7_+_52122224 Show fit | 20.74 |
ENSDART00000174268
|
cytochrome P450, family 2, subfamily X, polypeptide 12 |
Network of associatons between targets according to the STRING database.
First level regulatory network of nr6a1a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 125.9 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
| 8.6 | 60.3 | GO:0046294 | formaldehyde metabolic process(GO:0046292) formaldehyde catabolic process(GO:0046294) |
| 0.0 | 60.1 | GO:0035556 | intracellular signal transduction(GO:0035556) |
| 0.4 | 57.5 | GO:0042742 | defense response to bacterium(GO:0042742) |
| 16.1 | 48.3 | GO:0071831 | chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830) intermediate-density lipoprotein particle clearance(GO:0071831) |
| 0.8 | 40.0 | GO:0042737 | drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) |
| 2.0 | 38.1 | GO:0042574 | retinal metabolic process(GO:0042574) |
| 11.3 | 34.0 | GO:0009595 | detection of biotic stimulus(GO:0009595) detection of bacterium(GO:0016045) detection of other organism(GO:0098543) detection of external biotic stimulus(GO:0098581) |
| 2.8 | 34.0 | GO:1902222 | L-phenylalanine metabolic process(GO:0006558) L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222) |
| 3.9 | 23.2 | GO:0032367 | intracellular cholesterol transport(GO:0032367) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 196.7 | GO:0005615 | extracellular space(GO:0005615) |
| 12.1 | 48.3 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.0 | 41.2 | GO:0005829 | cytosol(GO:0005829) |
| 0.2 | 30.4 | GO:0031227 | intrinsic component of endoplasmic reticulum membrane(GO:0031227) |
| 0.1 | 23.9 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.8 | 20.1 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 0.3 | 19.2 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.3 | 17.8 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 14.5 | GO:0000139 | Golgi membrane(GO:0000139) |
| 2.0 | 13.8 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 123.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 12.1 | 60.3 | GO:0051903 | alcohol dehydrogenase activity, zinc-dependent(GO:0004024) S-(hydroxymethyl)glutathione dehydrogenase activity(GO:0051903) |
| 0.2 | 55.4 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 16.1 | 48.3 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.6 | 40.0 | GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712) |
| 4.6 | 36.7 | GO:0004745 | retinol dehydrogenase activity(GO:0004745) |
| 0.6 | 36.2 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.3 | 35.6 | GO:0019955 | cytokine binding(GO:0019955) |
| 11.3 | 34.0 | GO:0016019 | peptidoglycan receptor activity(GO:0016019) |
| 3.8 | 34.0 | GO:0016714 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 31.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.9 | 31.5 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 2.7 | 21.6 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.3 | 19.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.3 | 14.3 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.3 | 11.9 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.4 | 11.5 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.4 | 7.6 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.2 | 6.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.2 | 5.5 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 33.8 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 23.8 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.8 | 17.4 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 16.3 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.8 | 10.5 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 1.7 | 8.6 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.3 | 7.3 | REACTOME SEMA4D IN SEMAPHORIN SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.7 | 6.7 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.4 | 6.7 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.2 | 5.9 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |