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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for nr6a1a

Z-value: 2.08

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Transcription factors associated with nr6a1a

Gene Symbol Gene ID Gene Info
nr6a1a
ENSDARG00000101508 nuclear receptor subfamily 6, group A, member 1a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nr6a1adr11_v1_chr8_-_52909850_52909850-0.103.3e-01Click!

Activity profile of nr6a1a motif

Sorted Z-values of nr6a1a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr13_-_12660318 60.25 ENSDART00000008498
adh8a
alcohol dehydrogenase 8a
chr20_+_10539293 49.90 ENSDART00000182265
serpina1l
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, like
chr4_-_17409533 34.01 ENSDART00000011943
pah
phenylalanine hydroxylase
chr20_+_10545514 31.49 ENSDART00000153667
serpina1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr16_-_45235947 31.47 ENSDART00000164436
si:dkey-33i11.4
si:dkey-33i11.4
chr3_+_21189766 28.29 ENSDART00000078807
zgc:123295
zgc:123295
chr3_+_39540014 26.36 ENSDART00000074848
zgc:165423
zgc:165423
chr3_+_19299309 23.44 ENSDART00000046297
ENSDART00000146955
ldlra
low density lipoprotein receptor a
chr5_-_37103487 21.63 ENSDART00000149211
il13ra2
interleukin 13 receptor, alpha 2
chr7_+_52122224 20.74 ENSDART00000174268
cyp2x12
cytochrome P450, family 2, subfamily X, polypeptide 12
chr15_-_26549693 20.62 ENSDART00000186432
serpinf2b
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2b
chr20_+_25581627 19.97 ENSDART00000030229
cyp2p9
cytochrome P450, family 2, subfamily P, polypeptide 9
chr8_+_1769475 19.78 ENSDART00000079073
serpind1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr16_+_23960933 19.70 ENSDART00000146077
apoeb
apolipoprotein Eb
chr15_+_14854666 19.26 ENSDART00000163066
diabloa
diablo, IAP-binding mitochondrial protein a
chr3_+_13469704 18.83 ENSDART00000166806
zgc:77748
zgc:77748
chr6_-_8498908 18.69 ENSDART00000149222
pglyrp2
peptidoglycan recognition protein 2
chr12_-_4346085 18.16 ENSDART00000112433
ca15c
carbonic anhydrase XV c
chr21_-_30658509 18.02 ENSDART00000139764
si:dkey-22f5.9
si:dkey-22f5.9
chr16_-_17197546 17.44 ENSDART00000139939
ENSDART00000135146
ENSDART00000063800
ENSDART00000163606
gapdh
glyceraldehyde-3-phosphate dehydrogenase
chr22_-_24858042 17.19 ENSDART00000137998
ENSDART00000078216
ENSDART00000138378
vtg7
vitellogenin 7
chr25_-_13188678 17.02 ENSDART00000125754
si:ch211-147m6.1
si:ch211-147m6.1
chr25_+_23280220 16.62 ENSDART00000153940
ptprjb.1
protein tyrosine phosphatase, receptor type, Jb, tandem duplicate 1
chr15_+_28410664 16.45 ENSDART00000132028
ENSDART00000057697
ENSDART00000057257
pitpnaa
phosphatidylinositol transfer protein, alpha a
chr5_-_41531629 16.10 ENSDART00000051082
akr1a1a
aldo-keto reductase family 1, member A1a (aldehyde reductase)
chr20_-_30370884 15.85 ENSDART00000062429
allc
allantoicase
chr3_+_1749793 15.45 ENSDART00000149308
si:dkeyp-52c3.7
si:dkeyp-52c3.7
chr6_-_8498676 15.30 ENSDART00000148627
pglyrp2
peptidoglycan recognition protein 2
chr8_+_19514294 15.25 ENSDART00000170622
si:ch73-281k2.5
si:ch73-281k2.5
chr16_+_23961276 15.09 ENSDART00000192754
apoeb
apolipoprotein Eb
chr11_+_14333441 14.58 ENSDART00000171969
ptbp1b
polypyrimidine tract binding protein 1b
chr13_+_8306399 14.26 ENSDART00000080339
galm
galactose mutarotase
chr22_-_23781083 14.01 ENSDART00000166563
ENSDART00000170458
ENSDART00000166158
ENSDART00000171246
cfhl3
complement factor H like 3
chr2_+_51028269 13.80 ENSDART00000161254
eef1da
eukaryotic translation elongation factor 1 delta a (guanine nucleotide exchange protein)
chr25_-_35963158 13.68 ENSDART00000153612
snx20
sorting nexin 20
chr17_-_8862424 13.51 ENSDART00000064633
nkl.4
NK-lysin tandem duplicate 4
chr16_+_23960744 13.49 ENSDART00000058965
apoeb
apolipoprotein Eb
chr8_+_19356072 13.38 ENSDART00000063272
mpeg1.2
macrophage expressed 1, tandem duplicate 2
chr5_+_22579975 13.27 ENSDART00000080877
tnfsf10l4
tumor necrosis factor (ligand) superfamily, member 10 like 4
chr21_+_15713097 13.16 ENSDART00000015841
gstt1b
glutathione S-transferase theta 1b
chr25_+_10830269 13.13 ENSDART00000175736
si:ch211-147g22.5
si:ch211-147g22.5
chr3_-_1970820 13.13 ENSDART00000136467
si:ch211-254c8.3
si:ch211-254c8.3
chr7_+_19482084 13.07 ENSDART00000173873
si:ch211-212k18.7
si:ch211-212k18.7
chr5_-_38064065 12.63 ENSDART00000137181
si:dkey-111e8.5
si:dkey-111e8.5
chr21_-_17956739 12.39 ENSDART00000148154
stx2a
syntaxin 2a
chr25_-_29415369 12.30 ENSDART00000110774
ENSDART00000019183
ugt5a2
ugt5a1
UDP glucuronosyltransferase 5 family, polypeptide A2
UDP glucuronosyltransferase 5 family, polypeptide A1
chr16_+_29509133 12.27 ENSDART00000112116
ctss2.1
cathepsin S, ortholog2, tandem duplicate 1
chr25_+_22107643 12.24 ENSDART00000089680
sigirr
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr7_-_24181159 11.98 ENSDART00000181206
zgc:153151
zgc:153151
chr9_-_48700806 11.79 ENSDART00000026210
rdh1
retinol dehydrogenase 1
chr22_+_25086942 11.29 ENSDART00000061117
rrbp1b
ribosome binding protein 1b
chr14_+_34514336 11.27 ENSDART00000024440
foxi3b
forkhead box I3b
chr10_-_36793412 11.24 ENSDART00000185966
dhrs13a.2
dehydrogenase/reductase (SDR family) member 13a, tandem duplicate 2
chr25_+_3327071 11.11 ENSDART00000136131
ENSDART00000133243
ldhbb
lactate dehydrogenase Bb
chr8_-_2153147 11.10 ENSDART00000124093
si:dkeyp-117b11.1
si:dkeyp-117b11.1
chr5_-_41834999 10.96 ENSDART00000135772
si:dkey-65b12.6
si:dkey-65b12.6
chr22_-_17781213 10.94 ENSDART00000137984
si:ch73-63e15.2
si:ch73-63e15.2
chr18_-_26854959 10.88 ENSDART00000057553
ch25hl1.1
cholesterol 25-hydroxylase like 1, tandem duplicate 1
chr8_+_44478294 10.87 ENSDART00000006898
si:ch73-211l2.3
si:ch73-211l2.3
chr22_+_25086567 10.84 ENSDART00000192114
ENSDART00000177284
ENSDART00000180296
ENSDART00000190384
rrbp1b
ribosome binding protein 1b
chr10_-_1733937 10.63 ENSDART00000144216
gal3st1b
galactose-3-O-sulfotransferase 1b
chr24_-_25256230 10.48 ENSDART00000155780
hhla2b.1
HERV-H LTR-associating 2b, tandem duplicate 1
chr9_+_24088062 10.39 ENSDART00000126198
lrrfip1a
leucine rich repeat (in FLII) interacting protein 1a
chr15_+_26600611 10.30 ENSDART00000155352
slc47a3
solute carrier family 47 (multidrug and toxin extrusion), member 3
chr5_+_9434288 10.18 ENSDART00000162089
ugt2a7
UDP glucuronosyltransferase 2 family, polypeptide A7
chr8_-_14091886 10.13 ENSDART00000137857
si:ch211-229n2.7
si:ch211-229n2.7
chr25_-_13202208 10.06 ENSDART00000168155
si:ch211-194m7.4
si:ch211-194m7.4
chr16_-_12319822 10.02 ENSDART00000127453
ENSDART00000184526
trpv6
transient receptor potential cation channel, subfamily V, member 6
chr3_+_12484008 9.98 ENSDART00000182229
vasnb
vasorin b
chr3_+_31662126 9.87 ENSDART00000113441
mylk5
myosin, light chain kinase 5
chr22_-_22337382 9.85 ENSDART00000144684
si:ch211-129c21.1
si:ch211-129c21.1
chr3_+_30921246 9.71 ENSDART00000076850
cldni
claudin i
chr16_-_46567344 9.66 ENSDART00000127721
si:dkey-152b24.7
si:dkey-152b24.7
chr19_+_32855139 9.63 ENSDART00000052082
rpl30
ribosomal protein L30
chr6_+_42338309 9.48 ENSDART00000015277
gpx1b
glutathione peroxidase 1b
chr7_-_60831082 9.47 ENSDART00000073654
ENSDART00000136999
pcxb
pyruvate carboxylase b
chr5_-_50992690 9.31 ENSDART00000149553
ENSDART00000097460
ENSDART00000192021
hmgcra
3-hydroxy-3-methylglutaryl-CoA reductase a
chr8_-_45759137 9.18 ENSDART00000123878
ppiaa
peptidylprolyl isomerase Aa (cyclophilin A)
chr9_+_42270043 9.12 ENSDART00000137435
si:dkey-10c21.1
si:dkey-10c21.1
chr3_+_4346854 8.83 ENSDART00000004273
si:dkey-73p2.3
si:dkey-73p2.3
chr18_+_36631923 8.71 ENSDART00000098980
znf296
zinc finger protein 296
chr25_+_3326885 8.69 ENSDART00000104866
ldhbb
lactate dehydrogenase Bb
chr7_+_35268054 8.68 ENSDART00000113842
dpep2
dipeptidase 2
chr25_+_7492663 8.64 ENSDART00000166496
cat
catalase
chr4_+_77948517 8.61 ENSDART00000149305
pacsin2
protein kinase C and casein kinase substrate in neurons 2
chr10_-_22497980 8.42 ENSDART00000185549
CT573337.2

chr4_+_76973771 8.40 ENSDART00000142978
si:dkey-240n22.3
si:dkey-240n22.3
chr19_-_37154436 8.39 ENSDART00000103155
cx39.4
connexin 39.4
chr2_-_42492201 8.29 ENSDART00000180762
ENSDART00000009093
esyt2a
extended synaptotagmin-like protein 2a
chr21_-_5879897 8.14 ENSDART00000184034
rpl35
ribosomal protein L35
chr6_+_39506043 8.11 ENSDART00000086260
CR388364.1

chr11_-_42750626 7.98 ENSDART00000130640
si:ch73-106k19.5
si:ch73-106k19.5
chr9_-_48701035 7.94 ENSDART00000178332
rdh1
retinol dehydrogenase 1
chr9_-_14055959 7.90 ENSDART00000146675
fer1l6
fer-1-like family member 6
chr4_-_75795899 7.89 ENSDART00000157925
si:dkey-261j11.1
si:dkey-261j11.1
chr5_+_9428876 7.88 ENSDART00000081791
ugt2a7
UDP glucuronosyltransferase 2 family, polypeptide A7
chr23_-_10175898 7.88 ENSDART00000146185
krt5
keratin 5
chr21_-_17956416 7.71 ENSDART00000026737
stx2a
syntaxin 2a
chr4_+_9478500 7.65 ENSDART00000030738
lmf2b
lipase maturation factor 2b
chr2_+_52232630 7.64 ENSDART00000006216
plpp2a
phospholipid phosphatase 2a
chr24_-_25096199 7.46 ENSDART00000185076
phldb2b
pleckstrin homology-like domain, family B, member 2b
chr25_+_18587338 7.34 ENSDART00000180287
met
MET proto-oncogene, receptor tyrosine kinase
chr3_-_7656059 7.26 ENSDART00000170917
junbb
JunB proto-oncogene, AP-1 transcription factor subunit b
chr17_+_22956427 7.13 ENSDART00000155145
ltbp1
latent transforming growth factor beta binding protein 1
chr21_+_5580948 7.10 ENSDART00000160373
ly6m7
lymphocyte antigen 6 family member M7
chr19_+_4038589 7.05 ENSDART00000169271
btr23
bloodthirsty-related gene family, member 23
chr8_-_29713595 6.92 ENSDART00000131988
ENSDART00000077637
mpeg1.1
macrophage expressed 1, tandem duplicate 1
chr3_-_36823643 6.88 ENSDART00000131340
ENSDART00000185075
abcc6b.2
ATP-binding cassette, sub-family C (CFTR/MRP), member 6b, tandem duplicate 2
chr18_+_8340886 6.73 ENSDART00000081132
cpt1b
carnitine palmitoyltransferase 1B (muscle)
chr14_-_1538600 6.71 ENSDART00000180925
CABZ01109480.1

chr16_+_21790870 6.69 ENSDART00000155039
trim108
tripartite motif containing 108
chr10_+_7719796 6.67 ENSDART00000191795
ggcx
gamma-glutamyl carboxylase
chr2_-_20120904 6.42 ENSDART00000186002
ENSDART00000124724
dpydb
dihydropyrimidine dehydrogenase b
chr12_+_33395748 6.41 ENSDART00000129458
fasn
fatty acid synthase
chr18_+_8912113 6.36 ENSDART00000147467
tmem243a
transmembrane protein 243, mitochondrial a
chr24_+_17334682 6.34 ENSDART00000018868
pdia4
protein disulfide isomerase family A, member 4
chr7_+_17096281 6.26 ENSDART00000035558
htatip2
HIV-1 Tat interactive protein 2
chr14_+_16034447 6.24 ENSDART00000161348
prelid1a
PRELI domain containing 1a
chr4_+_2092683 6.17 ENSDART00000067423
frs2a
fibroblast growth factor receptor substrate 2a
chr7_-_15370042 6.08 ENSDART00000128183
ANPEP
si:ch211-276a23.5
chr7_+_24523017 6.03 ENSDART00000077047
btr09
bloodthirsty-related gene family, member 9
chr5_+_45000597 5.93 ENSDART00000051146
dmrt3a
doublesex and mab-3 related transcription factor 3a
chr18_+_40471826 5.83 ENSDART00000098806
ugt5c3
UDP glucuronosyltransferase 5 family, polypeptide C3
chr6_-_42949184 5.76 ENSDART00000147208
edem1
ER degradation enhancer, mannosidase alpha-like 1
chr21_+_43702016 5.70 ENSDART00000017176
dkc1
dyskeratosis congenita 1, dyskerin
chr4_-_71214516 5.62 ENSDART00000169997
si:ch211-205a14.7
si:ch211-205a14.7
chr4_+_8680767 5.61 ENSDART00000182726
adipor2
adiponectin receptor 2
chr10_+_43117661 5.48 ENSDART00000024644
ENSDART00000186932
xrcc4
X-ray repair complementing defective repair in Chinese hamster cells 4
chr14_+_46216703 5.28 ENSDART00000136045
ENSDART00000142317
mgst2
microsomal glutathione S-transferase 2
chr24_+_11381400 5.25 ENSDART00000058703
ackr4b
atypical chemokine receptor 4b
chr15_+_22014029 5.21 ENSDART00000079504
ankk1
ankyrin repeat and kinase domain containing 1
chr7_-_41013575 5.15 ENSDART00000150139
insig1
insulin induced gene 1
chr4_+_43245188 5.15 ENSDART00000150310
si:dkey-29j8.1
si:dkey-29j8.1
chr3_-_36824190 5.11 ENSDART00000172943
abcc6b.2
ATP-binding cassette, sub-family C (CFTR/MRP), member 6b, tandem duplicate 2
chr17_+_38255105 4.98 ENSDART00000005296
nkx2.9
NK2 transcription factor related, locus 9 (Drosophila)
chr15_-_28082310 4.96 ENSDART00000152620
dhrs13a.3
dehydrogenase/reductase (SDR family) member 13a, duplicate 3
chr22_+_10163901 4.93 ENSDART00000190468
rpp14
ribonuclease P/MRP 14 subunit
chr22_-_17462895 4.93 ENSDART00000160415
si:ch211-197g15.6
si:ch211-197g15.6
chr19_+_7878122 4.92 ENSDART00000131917
si:dkeyp-85e10.2
si:dkeyp-85e10.2
chr5_+_50879545 4.92 ENSDART00000128402
nol6
nucleolar protein 6 (RNA-associated)
chr7_-_37917517 4.92 ENSDART00000173795
heatr3
HEAT repeat containing 3
chr24_-_17029374 4.86 ENSDART00000039267
ptgdsb.1
prostaglandin D2 synthase b, tandem duplicate 1
chr24_+_20960216 4.80 ENSDART00000133008
si:ch211-161h7.8
si:ch211-161h7.8
chr9_+_41156818 4.80 ENSDART00000105764
ENSDART00000147052
stat4
signal transducer and activator of transcription 4
chr17_+_6538733 4.79 ENSDART00000193712
slc5a6b
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
chr17_+_24843401 4.78 ENSDART00000110179
cx34.4
connexin 34.4
chr23_+_36653376 4.73 ENSDART00000053189
gpr182
G protein-coupled receptor 182
chr3_+_23697997 4.70 ENSDART00000184299
ENSDART00000078466
hoxb3a
homeobox B3a
chr12_-_17024079 4.65 ENSDART00000129027
ifit11
interferon-induced protein with tetratricopeptide repeats 11
chr5_-_41124241 4.64 ENSDART00000083561
mtmr12
myotubularin related protein 12
chr8_+_42717005 4.64 ENSDART00000181656
ENSDART00000180320
ENSDART00000181293
zgc:194007
zgc:194007
chr8_-_20245892 4.56 ENSDART00000136911
acer1
alkaline ceramidase 1
chr21_-_43636595 4.53 ENSDART00000151115
ENSDART00000151486
ENSDART00000151778
si:ch1073-263o8.2
si:ch1073-263o8.2
chr17_+_450956 4.49 ENSDART00000183022
ENSDART00000171386
zgc:194887
zgc:194887
chr4_-_39487825 4.48 ENSDART00000161855
si:dkey-261o4.6
si:dkey-261o4.6
chr4_-_71470455 4.48 ENSDART00000172685
si:ch211-76m11.5
si:ch211-76m11.5
chr15_+_11840311 4.43 ENSDART00000167671
prkd2
protein kinase D2
chr11_+_45219558 4.42 ENSDART00000167828
tmc6b
transmembrane channel-like 6b
chr1_-_7998493 4.40 ENSDART00000185901
si:dkey-79f11.5
si:dkey-79f11.5
chr5_-_3889047 4.39 ENSDART00000185817
mlxipl
MLX interacting protein like
chr14_+_30272891 4.38 ENSDART00000017122
asah1a
N-acylsphingosine amidohydrolase (acid ceramidase) 1a
chr16_-_46558708 4.38 ENSDART00000128037
si:dkey-152b24.8
si:dkey-152b24.8
chr4_+_60428812 4.38 ENSDART00000162049
si:dkey-16p6.1
si:dkey-16p6.1
chr4_+_58668661 4.37 ENSDART00000188815
CR388148.2

chr5_-_16405651 4.34 ENSDART00000163942
slc39a14
solute carrier family 39 (zinc transporter), member 14
chr24_+_19986432 4.33 ENSDART00000184402
CR381686.5

chr22_+_21152847 4.32 ENSDART00000007321
crlf1b
cytokine receptor-like factor 1b
chr4_-_39479644 4.32 ENSDART00000183332
si:dkey-261o4.6
si:dkey-261o4.6
chr4_-_71554068 4.28 ENSDART00000167414
si:dkey-27n6.1
si:dkey-27n6.1
chr25_-_34512102 4.26 ENSDART00000087450
klf13
Kruppel-like factor 13
chr21_-_40174647 4.22 ENSDART00000183738
ENSDART00000076840
ENSDART00000145109
slco2b1
solute carrier organic anion transporter family, member 2B1
chr19_-_42571829 4.19 ENSDART00000102606
zgc:103438
zgc:103438
chr5_+_9259971 4.17 ENSDART00000163060
susd1
sushi domain containing 1
chr8_-_8489886 4.17 ENSDART00000183334
abt1
activator of basal transcription 1
chr25_-_12804450 4.15 ENSDART00000169717
ca5a
carbonic anhydrase Va
chr7_+_21272833 4.12 ENSDART00000052942
serpinh2
serine (or cysteine) peptidase inhibitor, clade H, member 2
chr12_-_30583668 4.11 ENSDART00000153406
casp7
caspase 7, apoptosis-related cysteine peptidase
chr3_-_3448095 4.11 ENSDART00000078886
A2ML1 (1 of many)
si:dkey-46g23.5
chr4_+_70341246 4.09 ENSDART00000123408
si:ch211-76m11.3
si:ch211-76m11.3
chr24_-_26484298 4.08 ENSDART00000140647
eif5a
eukaryotic translation initiation factor 5A
chr4_-_76184243 4.07 ENSDART00000180937
si:ch211-106j21.4
si:ch211-106j21.4
chr17_-_45733401 4.03 ENSDART00000185727
arf6b
ADP-ribosylation factor 6b
chr3_-_39627412 4.00 ENSDART00000123292
si:dkey-27o4.1
si:dkey-27o4.1
chr3_+_32112004 3.99 ENSDART00000105272
zgc:173593
zgc:173593
chr1_+_52632856 3.99 ENSDART00000011725
slc44a1a
solute carrier family 44 (choline transporter), member 1a
chr16_-_12809873 3.98 ENSDART00000146997
ENSDART00000178291
ENSDART00000007842
isoc2
isochorismatase domain containing 2
chr20_+_23007470 3.97 ENSDART00000134639
ENSDART00000132916
si:ch73-249k16.4
si:ch73-249k16.4
chr4_-_52783184 3.97 ENSDART00000172283
si:dkey-4j21.2
si:dkey-4j21.2
chr3_-_32957702 3.96 ENSDART00000146586
casp6l1
caspase 6, apoptosis-related cysteine peptidase, like 1
chr14_+_10596628 3.95 ENSDART00000115177
gpr174
G protein-coupled receptor 174
chr16_+_49249669 3.94 ENSDART00000181899
LO018128.1

chr25_+_34576067 3.93 ENSDART00000157519
trpm1b
transient receptor potential cation channel, subfamily M, member 1b
chr24_+_19542323 3.88 ENSDART00000140379
ENSDART00000142830
sulf1
sulfatase 1
chr4_+_54639187 3.85 ENSDART00000131869
si:ch211-227e10.1
si:ch211-227e10.1
chr5_-_41841675 3.85 ENSDART00000141683
si:dkey-65b12.6
si:dkey-65b12.6
chr3_+_24612191 3.70 ENSDART00000190998
zgc:171506
zgc:171506
chr1_-_8652648 3.68 ENSDART00000138324
ENSDART00000141407
ENSDART00000054987
actb1
actin, beta 1
chr25_+_14092871 3.67 ENSDART00000067239
guca1g
guanylate cyclase activator 1g
chr22_-_5518117 3.66 ENSDART00000164613
CABZ01064972.1

chr10_-_11383900 3.63 ENSDART00000101045
plac8.1
placenta-specific 8, tandem duplicate 1

Network of associatons between targets according to the STRING database.

First level regulatory network of nr6a1a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
16.1 48.3 GO:0071831 chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830) intermediate-density lipoprotein particle clearance(GO:0071831)
11.3 34.0 GO:0009595 detection of biotic stimulus(GO:0009595) detection of bacterium(GO:0016045) detection of other organism(GO:0098543) detection of external biotic stimulus(GO:0098581)
8.6 60.3 GO:0046294 formaldehyde metabolic process(GO:0046292) formaldehyde catabolic process(GO:0046294)
5.3 15.9 GO:0000256 allantoin catabolic process(GO:0000256)
3.9 23.2 GO:0032367 intracellular cholesterol transport(GO:0032367)
3.9 19.3 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
2.9 14.3 GO:0033499 galactose catabolic process(GO:0019388) galactose catabolic process via UDP-galactose(GO:0033499)
2.8 34.0 GO:1902222 L-phenylalanine metabolic process(GO:0006558) L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
2.8 11.3 GO:0009957 epidermal cell fate specification(GO:0009957)
2.8 8.3 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
2.5 7.6 GO:0033212 iron assimilation(GO:0033212)
2.5 10.0 GO:0070316 G0 to G1 transition(GO:0045023) regulation of G0 to G1 transition(GO:0070316) negative regulation of G0 to G1 transition(GO:0070317)
2.1 6.4 GO:0046125 deoxyribonucleoside metabolic process(GO:0009120) thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
2.0 10.1 GO:0070292 N-acylphosphatidylethanolamine metabolic process(GO:0070292)
2.0 38.1 GO:0042574 retinal metabolic process(GO:0042574)
2.0 9.8 GO:0010692 regulation of alkaline phosphatase activity(GO:0010692) negative regulation of alkaline phosphatase activity(GO:0010693)
1.9 5.7 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
1.7 5.2 GO:0036314 response to sterol(GO:0036314) cellular response to sterol(GO:0036315) SREBP-SCAP complex retention in endoplasmic reticulum(GO:0036316) regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
1.6 9.5 GO:0010269 response to selenium ion(GO:0010269)
1.5 10.6 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
1.4 125.9 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
1.4 4.2 GO:0034471 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000472) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480) rRNA 5'-end processing(GO:0000967) ncRNA 5'-end processing(GO:0034471)
1.2 7.3 GO:0089700 protein kinase D signaling(GO:0089700)
1.2 4.8 GO:0051182 biotin transport(GO:0015878) pantothenate transmembrane transport(GO:0015887) coenzyme transport(GO:0051182)
1.1 5.7 GO:0051103 DNA ligation(GO:0006266) DNA ligation involved in DNA repair(GO:0051103)
1.1 6.7 GO:0017187 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
1.1 5.3 GO:0006691 leukotriene metabolic process(GO:0006691) leukotriene biosynthetic process(GO:0019370)
1.0 3.0 GO:0071236 cellular response to antibiotic(GO:0071236) cellular response to toxic substance(GO:0097237)
1.0 10.5 GO:0031295 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.9 8.6 GO:0001765 membrane raft assembly(GO:0001765) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.8 40.0 GO:0042737 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.8 12.2 GO:0050728 negative regulation of inflammatory response(GO:0050728)
0.8 3.0 GO:0072673 lamellipodium morphogenesis(GO:0072673) regulation of lamellipodium morphogenesis(GO:2000392)
0.7 2.9 GO:2000171 negative regulation of dendrite development(GO:2000171)
0.7 13.4 GO:0015936 coenzyme A metabolic process(GO:0015936)
0.7 13.1 GO:0043171 peptide catabolic process(GO:0043171)
0.7 7.3 GO:0021681 cerebellar granular layer development(GO:0021681) cerebellar granular layer morphogenesis(GO:0021683) cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.7 16.6 GO:0048844 artery morphogenesis(GO:0048844)
0.6 2.6 GO:0051645 Golgi localization(GO:0051645) maintenance of centrosome location(GO:0051661)
0.6 0.6 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.6 3.1 GO:0045448 regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448)
0.6 20.1 GO:0007340 acrosome reaction(GO:0007340)
0.6 4.1 GO:0045901 positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.6 1.7 GO:0002566 somatic diversification of immune receptors via somatic mutation(GO:0002566) somatic hypermutation of immunoglobulin genes(GO:0016446)
0.6 5.6 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.5 5.9 GO:0046661 male sex differentiation(GO:0046661)
0.5 17.2 GO:0032355 response to estradiol(GO:0032355)
0.5 1.5 GO:0035376 sterol import(GO:0035376) recognition of apoptotic cell(GO:0043654) cholesterol import(GO:0070508)
0.5 17.4 GO:0050821 protein stabilization(GO:0050821)
0.5 8.6 GO:0042542 response to hydrogen peroxide(GO:0042542)
0.5 9.5 GO:0046686 response to cadmium ion(GO:0046686)
0.5 12.3 GO:0050727 regulation of inflammatory response(GO:0050727)
0.5 3.4 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.5 3.9 GO:2000290 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910) regulation of myotome development(GO:2000290)
0.5 8.1 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.4 1.3 GO:0019860 uracil catabolic process(GO:0006212) beta-alanine metabolic process(GO:0019482) beta-alanine biosynthetic process(GO:0019483) uracil metabolic process(GO:0019860)
0.4 12.7 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.4 1.3 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.4 4.6 GO:0046512 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.4 2.1 GO:1901842 regulation of high voltage-gated calcium channel activity(GO:1901841) negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.4 2.8 GO:0090594 inflammatory response to wounding(GO:0090594)
0.4 10.0 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.4 57.5 GO:0042742 defense response to bacterium(GO:0042742)
0.4 5.2 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.4 4.8 GO:0043550 regulation of lipid kinase activity(GO:0043550) regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.4 1.8 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.4 2.1 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.3 1.7 GO:0016037 light absorption(GO:0016037)
0.3 1.7 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.3 9.3 GO:0006749 glutathione metabolic process(GO:0006749)
0.3 3.6 GO:0002031 G-protein coupled receptor internalization(GO:0002031)
0.3 4.2 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.3 6.7 GO:0015909 long-chain fatty acid transport(GO:0015909)
0.3 10.9 GO:0016126 sterol biosynthetic process(GO:0016126)
0.3 1.1 GO:0071675 regulation of macrophage chemotaxis(GO:0010758) positive regulation of macrophage chemotaxis(GO:0010759) regulation of odontogenesis(GO:0042481) mononuclear cell migration(GO:0071674) regulation of mononuclear cell migration(GO:0071675)
0.2 0.9 GO:0070255 regulation of mucus secretion(GO:0070255) positive regulation of mucus secretion(GO:0070257)
0.2 13.5 GO:0006730 one-carbon metabolic process(GO:0006730)
0.2 2.1 GO:1901998 toxin transport(GO:1901998)
0.2 3.0 GO:0006689 ganglioside catabolic process(GO:0006689)
0.2 0.9 GO:0006562 proline catabolic process(GO:0006562)
0.2 1.5 GO:1901673 regulation of mitotic spindle assembly(GO:1901673)
0.2 12.6 GO:0006414 translational elongation(GO:0006414)
0.2 9.7 GO:0070830 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.2 2.9 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.2 4.0 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.2 4.1 GO:0097194 execution phase of apoptosis(GO:0097194)
0.2 2.5 GO:0070527 platelet aggregation(GO:0070527)
0.2 9.0 GO:0015914 phospholipid transport(GO:0015914)
0.2 1.1 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.2 2.4 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.2 4.8 GO:0097696 JAK-STAT cascade(GO:0007259) STAT cascade(GO:0097696)
0.1 0.9 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.1 1.0 GO:0003262 endocardial progenitor cell migration to the midline involved in heart field formation(GO:0003262)
0.1 5.0 GO:0021514 ventral spinal cord interneuron differentiation(GO:0021514)
0.1 2.2 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.1 15.1 GO:0031101 fin regeneration(GO:0031101)
0.1 1.0 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.1 5.3 GO:0002224 toll-like receptor signaling pathway(GO:0002224)
0.1 3.2 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 2.6 GO:0035723 interleukin-15-mediated signaling pathway(GO:0035723) response to interleukin-15(GO:0070672) cellular response to interleukin-15(GO:0071350)
0.1 2.4 GO:0019471 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.1 1.4 GO:1902299 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.1 2.9 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.1 1.3 GO:0030719 P granule organization(GO:0030719)
0.1 7.6 GO:0051170 nuclear import(GO:0051170)
0.1 1.4 GO:0030311 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.1 14.2 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.1 3.9 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025) positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.1 1.1 GO:0071219 cellular response to molecule of bacterial origin(GO:0071219) cellular response to lipopolysaccharide(GO:0071222)
0.1 7.7 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.1 3.9 GO:0051262 protein tetramerization(GO:0051262)
0.1 7.7 GO:0007605 sensory perception of sound(GO:0007605)
0.1 2.2 GO:0009648 photoperiodism(GO:0009648)
0.1 0.6 GO:0071459 protein localization to kinetochore(GO:0034501) protein localization to chromosome, centromeric region(GO:0071459)
0.1 2.8 GO:0032456 endocytic recycling(GO:0032456)
0.1 11.4 GO:0072594 establishment of protein localization to organelle(GO:0072594)
0.1 0.8 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.1 1.9 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.1 5.2 GO:0060326 cell chemotaxis(GO:0060326)
0.1 1.3 GO:0021522 spinal cord motor neuron differentiation(GO:0021522)
0.1 21.8 GO:0006955 immune response(GO:0006955)
0.0 1.3 GO:0051923 sulfation(GO:0051923)
0.0 1.3 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)
0.0 1.0 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.0 1.7 GO:0048821 erythrocyte development(GO:0048821)
0.0 0.9 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.0 6.8 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 2.4 GO:0050919 negative chemotaxis(GO:0050919)
0.0 0.9 GO:0030223 neutrophil differentiation(GO:0030223)
0.0 7.4 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.0 2.2 GO:0007131 reciprocal meiotic recombination(GO:0007131)
0.0 5.2 GO:0034976 response to endoplasmic reticulum stress(GO:0034976)
0.0 0.2 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.8 GO:0021884 forebrain neuron development(GO:0021884)
0.0 5.5 GO:0006869 lipid transport(GO:0006869)
0.0 3.8 GO:0008033 tRNA processing(GO:0008033)
0.0 1.9 GO:0006954 inflammatory response(GO:0006954)
0.0 2.0 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.5 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 60.1 GO:0035556 intracellular signal transduction(GO:0035556)
0.0 0.1 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211)
0.0 3.6 GO:0051604 protein maturation(GO:0051604)
0.0 0.6 GO:0007548 sex differentiation(GO:0007548)
0.0 0.7 GO:0030050 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.0 16.5 GO:0015031 protein transport(GO:0015031)
0.0 4.9 GO:0009952 anterior/posterior pattern specification(GO:0009952)
0.0 0.9 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.0 2.1 GO:0006821 chloride transport(GO:0006821)
0.0 2.0 GO:0006631 fatty acid metabolic process(GO:0006631)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
12.1 48.3 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
2.5 7.6 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
2.0 13.8 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
1.8 5.5 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
1.7 5.2 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
1.6 4.9 GO:0034456 CURI complex(GO:0032545) UTP-C complex(GO:0034456)
1.4 5.7 GO:0031429 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.8 20.1 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.7 3.7 GO:0097433 dense body(GO:0097433)
0.7 7.9 GO:0045095 keratin filament(GO:0045095)
0.6 3.0 GO:0032433 filopodium tip(GO:0032433)
0.5 1.6 GO:0031213 RSF complex(GO:0031213)
0.5 1.8 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.4 2.2 GO:1990513 CLOCK-BMAL transcription complex(GO:1990513)
0.4 1.3 GO:0033391 chromatoid body(GO:0033391)
0.3 7.3 GO:0009925 basal plasma membrane(GO:0009925)
0.3 1.7 GO:0008091 spectrin(GO:0008091)
0.3 2.0 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.3 2.6 GO:0031616 spindle pole centrosome(GO:0031616)
0.3 19.2 GO:0031901 early endosome membrane(GO:0031901)
0.3 17.8 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.3 2.1 GO:0035060 brahma complex(GO:0035060)
0.3 8.6 GO:0055038 recycling endosome membrane(GO:0055038)
0.2 2.8 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.2 2.5 GO:0005675 holo TFIIH complex(GO:0005675)
0.2 13.1 GO:0031902 late endosome membrane(GO:0031902)
0.2 9.3 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.2 30.4 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.2 3.4 GO:0016363 nuclear matrix(GO:0016363)
0.2 3.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.2 4.7 GO:0045178 basal part of cell(GO:0045178) basal cortex(GO:0045180)
0.2 0.9 GO:1990071 TRAPPII protein complex(GO:1990071)
0.2 9.2 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 1.5 GO:0042788 polysomal ribosome(GO:0042788)
0.1 196.7 GO:0005615 extracellular space(GO:0005615)
0.1 0.9 GO:0034399 nuclear periphery(GO:0034399)
0.1 23.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 0.9 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.1 1.0 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 6.6 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 4.0 GO:0030141 secretory granule(GO:0030141)
0.1 4.8 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 0.9 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 3.0 GO:0031105 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.1 9.7 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.1 1.4 GO:0042555 MCM complex(GO:0042555)
0.1 7.4 GO:0016324 apical plasma membrane(GO:0016324)
0.1 4.1 GO:0005643 nuclear pore(GO:0005643)
0.1 3.3 GO:0048786 presynaptic active zone(GO:0048786)
0.1 1.7 GO:0035861 site of double-strand break(GO:0035861)
0.1 13.4 GO:0030659 cytoplasmic vesicle membrane(GO:0030659)
0.1 5.6 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 1.5 GO:0044853 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0 1.3 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 14.5 GO:0000139 Golgi membrane(GO:0000139)
0.0 1.7 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 2.1 GO:0034707 chloride channel complex(GO:0034707)
0.0 41.2 GO:0005829 cytosol(GO:0005829)
0.0 0.6 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 4.2 GO:0098562 cytoplasmic side of plasma membrane(GO:0009898) cytoplasmic side of membrane(GO:0098562)
0.0 0.7 GO:0005902 microvillus(GO:0005902)
0.0 3.5 GO:0031012 extracellular matrix(GO:0031012)
0.0 0.6 GO:0000777 condensed chromosome kinetochore(GO:0000777)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
16.1 48.3 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
12.1 60.3 GO:0051903 alcohol dehydrogenase activity, zinc-dependent(GO:0004024) S-(hydroxymethyl)glutathione dehydrogenase activity(GO:0051903)
11.3 34.0 GO:0016019 peptidoglycan receptor activity(GO:0016019)
5.9 23.4 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
4.6 36.7 GO:0004745 retinol dehydrogenase activity(GO:0004745)
4.4 17.4 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
3.8 34.0 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
3.4 10.1 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
3.2 9.5 GO:0004736 pyruvate carboxylase activity(GO:0004736)
2.8 19.8 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
2.5 7.6 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086)
2.5 17.2 GO:0045735 nutrient reservoir activity(GO:0045735)
1.8 15.9 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
1.7 8.7 GO:0070573 metallodipeptidase activity(GO:0070573)
1.7 6.7 GO:0008488 gamma-glutamyl carboxylase activity(GO:0008488)
1.7 10.0 GO:0050431 transforming growth factor beta binding(GO:0050431)
1.6 16.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
1.6 10.9 GO:0000254 C-4 methylsterol oxidase activity(GO:0000254)
1.5 7.7 GO:0017113 uracil binding(GO:0002058) pyrimidine nucleobase binding(GO:0002061) dihydropyrimidine dehydrogenase (NADP+) activity(GO:0017113)
1.5 4.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
1.5 8.9 GO:0017040 ceramidase activity(GO:0017040)
1.3 5.3 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
1.2 4.8 GO:0008523 sodium-dependent multivitamin transmembrane transporter activity(GO:0008523)
1.2 10.6 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
1.1 123.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
1.0 6.8 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
1.0 8.6 GO:0004096 catalase activity(GO:0004096)
0.9 8.3 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.9 6.2 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.9 3.5 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.9 5.2 GO:0008142 oxysterol binding(GO:0008142)
0.8 8.1 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.8 22.3 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.8 9.9 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.7 3.7 GO:0098973 structural constituent of postsynaptic actin cytoskeleton(GO:0098973)
0.7 14.3 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.6 10.3 GO:0042910 xenobiotic transporter activity(GO:0042910)
0.6 36.2 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.6 1.8 GO:0003985 acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.6 40.0 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.6 15.2 GO:0005112 Notch binding(GO:0005112)
0.6 4.9 GO:0001972 retinoic acid binding(GO:0001972)
0.6 5.8 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.6 9.2 GO:0016018 cyclosporin A binding(GO:0016018)
0.6 2.8 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.5 6.3 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.5 2.8 GO:0070568 guanylyltransferase activity(GO:0070568)
0.5 3.7 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.5 2.3 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.4 1.7 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.4 1.3 GO:0003875 ADP-ribosylarginine hydrolase activity(GO:0003875)
0.4 4.9 GO:0004526 ribonuclease P activity(GO:0004526)
0.4 13.1 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.4 2.7 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.4 1.5 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.4 13.3 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.4 16.7 GO:0003746 translation elongation factor activity(GO:0003746)
0.4 4.2 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.3 7.1 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.3 35.6 GO:0019955 cytokine binding(GO:0019955)
0.3 1.9 GO:0004594 pantothenate kinase activity(GO:0004594)
0.3 1.9 GO:0004960 thromboxane receptor activity(GO:0004960)
0.3 9.3 GO:0004364 glutathione transferase activity(GO:0004364)
0.3 5.7 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.3 7.6 GO:0042577 lipid phosphatase activity(GO:0042577)
0.3 1.7 GO:0016793 dGTPase activity(GO:0008832) triphosphoric monoester hydrolase activity(GO:0016793)
0.3 20.1 GO:0005484 SNAP receptor activity(GO:0005484)
0.3 1.4 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140) single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity(GO:1990518)
0.3 7.3 GO:0004698 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.3 2.0 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.3 2.8 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.2 2.2 GO:0003834 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.2 55.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 0.9 GO:0003884 D-amino-acid oxidase activity(GO:0003884)
0.2 2.2 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.2 6.4 GO:0017154 semaphorin receptor activity(GO:0017154)
0.2 4.6 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.2 9.3 GO:0050661 NADP binding(GO:0050661)
0.2 6.8 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.2 9.8 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 10.7 GO:0031490 chromatin DNA binding(GO:0031490)
0.2 2.4 GO:0048495 Roundabout binding(GO:0048495)
0.1 0.6 GO:0033765 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765) enone reductase activity(GO:0035671) cholestenone 5-alpha-reductase activity(GO:0047751)
0.1 4.4 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1 2.6 GO:0042289 MHC class II protein binding(GO:0042289)
0.1 0.9 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995)
0.1 0.5 GO:0004968 gonadotropin-releasing hormone receptor activity(GO:0004968)
0.1 2.4 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.1 5.3 GO:0000049 tRNA binding(GO:0000049)
0.1 1.4 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.1 16.1 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 0.2 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.1 1.2 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.1 0.6 GO:0015057 thrombin receptor activity(GO:0015057)
0.1 17.1 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.1 1.5 GO:0001671 ATPase activator activity(GO:0001671)
0.1 12.4 GO:0005262 calcium channel activity(GO:0005262)
0.1 4.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 1.1 GO:0004177 aminopeptidase activity(GO:0004177)
0.1 0.9 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 1.0 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 3.6 GO:0003724 RNA helicase activity(GO:0003724)
0.0 15.2 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 7.6 GO:0008134 transcription factor binding(GO:0008134)
0.0 1.7 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 20.4 GO:0005525 GTP binding(GO:0005525)
0.0 0.7 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.0 0.8 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 3.9 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 11.9 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 4.0 GO:0019901 protein kinase binding(GO:0019901)
0.0 4.5 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 2.1 GO:0005254 chloride channel activity(GO:0005254)
0.0 3.3 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 1.3 GO:0008201 heparin binding(GO:0008201)
0.0 1.3 GO:0008146 sulfotransferase activity(GO:0008146)
0.0 3.6 GO:0001664 G-protein coupled receptor binding(GO:0001664)
0.0 0.2 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.1 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0 0.7 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.8 GO:0016209 antioxidant activity(GO:0016209)
0.0 0.1 GO:0030504 inorganic diphosphate transmembrane transporter activity(GO:0030504)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 21.6 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.9 31.5 PID HNF3A PATHWAY FOXA1 transcription factor network
0.4 7.6 PID IL23 PATHWAY IL23-mediated signaling events
0.4 11.5 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.3 11.9 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.3 19.0 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.3 3.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.3 14.3 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 5.5 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.2 31.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 6.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 2.2 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 4.9 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 0.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 1.0 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 4.9 PID CMYB PATHWAY C-MYB transcription factor network
0.1 0.6 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 1.4 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 1.1 PID FOXO PATHWAY FoxO family signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 8.6 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.9 5.5 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.8 17.4 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.8 10.5 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.8 2.4 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.7 6.7 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.5 4.2 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.5 33.8 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.5 4.1 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.5 5.0 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.4 6.7 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.4 5.3 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.3 4.1 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.3 5.8 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.3 7.3 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.3 1.4 REACTOME DEFENSINS Genes involved in Defensins
0.2 2.3 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.2 2.8 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.2 4.1 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.2 3.5 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.2 3.1 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.2 5.9 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.2 4.7 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.2 4.6 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 23.8 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 16.3 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.1 1.7 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 1.5 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 2.5 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.1 0.6 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.1 0.6 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.1 2.0 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.1 1.4 REACTOME SPHINGOLIPID METABOLISM Genes involved in Sphingolipid metabolism
0.1 5.0 REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE Genes involved in MyD88:Mal cascade initiated on plasma membrane
0.1 2.3 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.1 4.4 REACTOME INTEGRATION OF ENERGY METABOLISM Genes involved in Integration of energy metabolism
0.0 2.8 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 1.4 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 1.0 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.0 1.5 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.0 0.2 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 1.0 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.5 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes