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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for nr6a1b

Z-value: 0.65

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Transcription factors associated with nr6a1b

Gene Symbol Gene ID Gene Info
nr6a1b
ENSDARG00000014480 nuclear receptor subfamily 6, group A, member 1b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nr6a1bdr11_v1_chr21_+_8198652_81986520.303.1e-03Click!

Activity profile of nr6a1b motif

Sorted Z-values of nr6a1b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr20_+_10539293 5.51 ENSDART00000182265
serpina1l
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, like
chr12_+_33395748 5.19 ENSDART00000129458
fasn
fatty acid synthase
chr16_-_45235947 5.06 ENSDART00000164436
si:dkey-33i11.4
si:dkey-33i11.4
chr5_+_20693724 4.73 ENSDART00000141368
si:ch211-240b21.2
si:ch211-240b21.2
chr3_+_39540014 4.35 ENSDART00000074848
zgc:165423
zgc:165423
chr3_+_12652244 3.96 ENSDART00000165980
abca3b
ATP-binding cassette, sub-family A (ABC1), member 3b
chr5_-_50992690 3.90 ENSDART00000149553
ENSDART00000097460
ENSDART00000192021
hmgcra
3-hydroxy-3-methylglutaryl-CoA reductase a
chr3_-_40976463 3.43 ENSDART00000128450
ENSDART00000018676
cyp3c1
cytochrome P450, family 3, subfamily c, polypeptide 1
chr23_-_19953089 3.39 ENSDART00000153828
atp2b3b
ATPase plasma membrane Ca2+ transporting 3b
chr16_+_23811554 3.27 ENSDART00000114336
si:dkey-7f3.9
si:dkey-7f3.9
chr3_+_19299309 3.26 ENSDART00000046297
ENSDART00000146955
ldlra
low density lipoprotein receptor a
chr9_+_42270043 3.05 ENSDART00000137435
si:dkey-10c21.1
si:dkey-10c21.1
chr23_-_10175898 3.03 ENSDART00000146185
krt5
keratin 5
chr4_-_17409533 3.00 ENSDART00000011943
pah
phenylalanine hydroxylase
chr3_-_40976288 2.80 ENSDART00000193553
cyp3c1
cytochrome P450, family 3, subfamily c, polypeptide 1
chr12_-_18408566 2.66 ENSDART00000078767
ENSDART00000152748
tom1l2
target of myb1 like 2 membrane trafficking protein
chr23_-_24450686 2.47 ENSDART00000189161
spen
spen family transcriptional repressor
chr10_+_29260096 2.44 ENSDART00000088973
sytl2a
synaptotagmin-like 2a
chr20_+_4392687 2.32 ENSDART00000187271
im:7142702
im:7142702
chr17_+_18117029 2.21 ENSDART00000154646
ENSDART00000179739
bcl11ba
B cell CLL/lymphoma 11Ba
chr11_+_15878343 2.16 ENSDART00000167191
ENSDART00000171862
ENSDART00000163992
ENSDART00000170065
pank4
pantothenate kinase 4
chr11_-_5563498 2.10 ENSDART00000160835
pex11g
peroxisomal biogenesis factor 11 gamma
chr16_+_52751445 2.09 ENSDART00000191807
atp6v1c1a
ATPase H+ transporting V1 subunit C1a
chr14_-_25095808 2.08 ENSDART00000184244
matr3l1.1
matrin 3-like 1.1
chr6_+_39836474 2.07 ENSDART00000112637
smarcc2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
chr20_+_9128829 2.04 ENSDART00000064144
ENSDART00000137450
bpnt1
bisphosphate nucleotidase 1
chr12_-_17024079 2.03 ENSDART00000129027
ifit11
interferon-induced protein with tetratricopeptide repeats 11
chr2_+_24700922 1.88 ENSDART00000170467
pik3r2
phosphoinositide-3-kinase, regulatory subunit 2 (beta)
chr24_-_25256230 1.84 ENSDART00000155780
hhla2b.1
HERV-H LTR-associating 2b, tandem duplicate 1
chr4_-_63166758 1.80 ENSDART00000192765
CR450780.1

chr5_+_50879545 1.79 ENSDART00000128402
nol6
nucleolar protein 6 (RNA-associated)
chr7_+_19482084 1.79 ENSDART00000173873
si:ch211-212k18.7
si:ch211-212k18.7
chr8_-_2153147 1.75 ENSDART00000124093
si:dkeyp-117b11.1
si:dkeyp-117b11.1
chr16_+_14216581 1.71 ENSDART00000113093
gba
glucosidase, beta, acid
chr3_+_1749793 1.62 ENSDART00000149308
si:dkeyp-52c3.7
si:dkeyp-52c3.7
chr25_-_29415369 1.60 ENSDART00000110774
ENSDART00000019183
ugt5a2
ugt5a1
UDP glucuronosyltransferase 5 family, polypeptide A2
UDP glucuronosyltransferase 5 family, polypeptide A1
chr6_-_30932078 1.57 ENSDART00000028612
pde4ba
phosphodiesterase 4B, cAMP-specific a
chr15_+_16886196 1.55 ENSDART00000139296
ENSDART00000049196
gdpd1
glycerophosphodiester phosphodiesterase domain containing 1
chr5_+_1079423 1.55 ENSDART00000172231
si:zfos-128g4.2
si:zfos-128g4.2
chr6_+_48618512 1.52 ENSDART00000111190
FAM19A3
si:dkey-238f9.1
chr25_+_7492663 1.51 ENSDART00000166496
cat
catalase
chr17_-_40956035 1.48 ENSDART00000124715
si:dkey-16j16.4
si:dkey-16j16.4
chr17_-_39786222 1.43 ENSDART00000154515
pimr62
Pim proto-oncogene, serine/threonine kinase, related 62
chr17_-_37054959 1.43 ENSDART00000151921
dnmt3ab
DNA (cytosine-5-)-methyltransferase 3 alpha b
chr19_+_5135113 1.42 ENSDART00000151310
si:dkey-89b17.4
si:dkey-89b17.4
chr22_+_24603930 1.41 ENSDART00000180240
ENSDART00000164256
CU655842.1

chr8_-_14091886 1.35 ENSDART00000137857
si:ch211-229n2.7
si:ch211-229n2.7
chr10_+_25219728 1.34 ENSDART00000193829
grm5a
glutamate receptor, metabotropic 5a
chr22_+_10215558 1.33 ENSDART00000063274
kctd6a
potassium channel tetramerization domain containing 6a
chr7_+_35268054 1.32 ENSDART00000113842
dpep2
dipeptidase 2
chr4_+_76973771 1.32 ENSDART00000142978
si:dkey-240n22.3
si:dkey-240n22.3
chr13_-_21688176 1.29 ENSDART00000063825
sprn
shadow of prion protein
chr21_-_32374656 1.28 ENSDART00000112550
mapk9
mitogen-activated protein kinase 9
chr21_+_11401247 1.27 ENSDART00000143952
cel.1
carboxyl ester lipase, tandem duplicate 1
chr14_-_5678457 1.24 ENSDART00000012116
tlx2
T cell leukemia homeobox 2
chr19_+_7878122 1.23 ENSDART00000131917
si:dkeyp-85e10.2
si:dkeyp-85e10.2
chr21_-_43040780 1.18 ENSDART00000187037
jakmip2
janus kinase and microtubule interacting protein 2
chr19_+_5134624 1.18 ENSDART00000151324
si:dkey-89b17.4
si:dkey-89b17.4
chr17_+_18117358 1.18 ENSDART00000144894
bcl11ba
B cell CLL/lymphoma 11Ba
chr8_+_22472584 1.18 ENSDART00000138303
si:dkey-23c22.9
si:dkey-23c22.9
chr19_+_30662529 1.16 ENSDART00000175662
fam49al
family with sequence similarity 49, member A-like
chr4_+_69712223 1.11 ENSDART00000163035
ENSDART00000164475
si:dkey-238o14.1
zgc:174944
si:dkey-238o14.1
zgc:174944
chr23_-_545942 1.08 ENSDART00000105316
samhd1
SAM domain and HD domain 1
chr3_+_22442445 1.08 ENSDART00000190921
wnk4b
WNK lysine deficient protein kinase 4b
chr10_-_22057001 1.05 ENSDART00000016575
tlx3b
T cell leukemia homeobox 3b
chr25_-_225964 1.03 ENSDART00000193424
CABZ01113818.1

chr6_+_41099787 1.00 ENSDART00000186884
fkbp5
FK506 binding protein 5
chr12_+_46605600 0.99 ENSDART00000123533
FADS6
fatty acid desaturase 6
chr6_+_39506043 0.96 ENSDART00000086260
CR388364.1

chr15_-_41720173 0.96 ENSDART00000155585
ENSDART00000075909
ftr76
finTRIM family, member 76
chr22_-_17781213 0.95 ENSDART00000137984
si:ch73-63e15.2
si:ch73-63e15.2
chr10_-_17284055 0.94 ENSDART00000167464
GNAZ
G protein subunit alpha z
chr15_+_11840311 0.94 ENSDART00000167671
prkd2
protein kinase D2
chr12_-_30583668 0.93 ENSDART00000153406
casp7
caspase 7, apoptosis-related cysteine peptidase
chr1_+_17527342 0.90 ENSDART00000139702
ENSDART00000140076
ENSDART00000005593
casp3a
caspase 3, apoptosis-related cysteine peptidase a
chr1_+_17527931 0.89 ENSDART00000131927
casp3a
caspase 3, apoptosis-related cysteine peptidase a
chr7_-_15370042 0.85 ENSDART00000128183
ANPEP
si:ch211-276a23.5
chr25_+_33939728 0.84 ENSDART00000148537
roraa
RAR-related orphan receptor A, paralog a
chr6_+_2030703 0.84 ENSDART00000109679
ENSDART00000187502
ENSDART00000191165
ENSDART00000187544
quo
quattro
chr8_+_25145464 0.83 ENSDART00000136505
gnai3
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
chr3_+_13469704 0.83 ENSDART00000166806
zgc:77748
zgc:77748
chr4_+_9836465 0.82 ENSDART00000004879
hsp90b1
heat shock protein 90, beta (grp94), member 1
chr19_+_20724347 0.79 ENSDART00000090757
kat2b
K(lysine) acetyltransferase 2B
chr4_-_49582758 0.79 ENSDART00000180834
ENSDART00000187608
si:dkey-159n16.2
si:dkey-159n16.2
chr3_-_7656059 0.78 ENSDART00000170917
junbb
JunB proto-oncogene, AP-1 transcription factor subunit b
chr6_+_40671336 0.76 ENSDART00000111639
ENSDART00000186617
rereb
arginine-glutamic acid dipeptide (RE) repeats b
chr3_+_32112004 0.74 ENSDART00000105272
zgc:173593
zgc:173593
chr4_-_71267461 0.70 ENSDART00000161219
ENSDART00000151838
si:dkeyp-51g9.4
si:dkeyp-51g9.4
chr2_+_10771787 0.68 ENSDART00000187782
gfi1aa
growth factor independent 1A transcription repressor a
chr25_+_10830269 0.59 ENSDART00000175736
si:ch211-147g22.5
si:ch211-147g22.5
chr20_+_13175379 0.57 ENSDART00000025644
ppp2r5a
protein phosphatase 2, regulatory subunit B', alpha isoform
chr4_+_7827261 0.57 ENSDART00000129568
phyh
phytanoyl-CoA 2-hydroxylase
chr15_+_44133972 0.54 ENSDART00000157846
ENSDART00000191082
CU655961.2

chr13_+_8306399 0.54 ENSDART00000080339
galm
galactose mutarotase
chr16_-_46558521 0.54 ENSDART00000189406
si:dkey-152b24.8
si:dkey-152b24.8
chr4_-_71470455 0.53 ENSDART00000172685
si:ch211-76m11.5
si:ch211-76m11.5
chr7_-_30639385 0.52 ENSDART00000173618
myo1ea
myosin IE, a
chr8_-_23578660 0.52 ENSDART00000039080
wasb
Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b
chr4_-_34776147 0.50 ENSDART00000167498
si:dkey-146m20.14
si:dkey-146m20.14
chr4_-_47096170 0.47 ENSDART00000161079
si:dkey-26m3.3
si:dkey-26m3.3
chr25_-_210730 0.45 ENSDART00000187580
FP236318.1

chr4_+_9478500 0.43 ENSDART00000030738
lmf2b
lipase maturation factor 2b
chr23_+_27779452 0.41 ENSDART00000134785
kmt2d
lysine (K)-specific methyltransferase 2D
chr9_-_7287375 0.35 ENSDART00000128352
mitd1
MIT, microtubule interacting and transport, domain containing 1
chr9_-_27749936 0.33 ENSDART00000064156
tbccd1
TBCC domain containing 1
chr5_-_3839285 0.32 ENSDART00000122292
mlxipl
MLX interacting protein like
chr15_+_22722684 0.32 ENSDART00000156760
grik4
glutamate receptor, ionotropic, kainate 4
chr3_-_39627412 0.32 ENSDART00000123292
si:dkey-27o4.1
si:dkey-27o4.1
chr4_-_38829098 0.30 ENSDART00000151932
si:dkey-59l11.10
si:dkey-59l11.10
chr1_+_57348756 0.29 ENSDART00000063750
b3gntl1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
chr16_-_46558708 0.24 ENSDART00000128037
si:dkey-152b24.8
si:dkey-152b24.8
chr4_-_70263609 0.17 ENSDART00000163868
si:dkey-3h2.3
si:dkey-3h2.3
chr8_-_54216499 0.16 ENSDART00000193678
mbd4
methyl-CpG binding domain protein 4
chr23_+_23119008 0.15 ENSDART00000132418
samd11
sterile alpha motif domain containing 11
chr1_-_49947290 0.14 ENSDART00000141476
sgms2
sphingomyelin synthase 2
chr1_-_8566567 0.12 ENSDART00000114613
ptcd1
pentatricopeptide repeat domain 1
chr2_+_13694450 0.10 ENSDART00000077259
ENSDART00000189485
ebna1bp2
EBNA1 binding protein 2
chr4_-_47095583 0.09 ENSDART00000183595
ENSDART00000183279
ENSDART00000191638
si:dkey-26m3.3
si:dkey-26m3.3
chr24_+_19542323 0.08 ENSDART00000140379
ENSDART00000142830
sulf1
sulfatase 1
chr12_+_30788912 0.06 ENSDART00000160422
aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr16_+_27224068 0.04 ENSDART00000059013
sec61b
Sec61 translocon beta subunit
chr23_+_17102960 0.02 ENSDART00000053414
commd7
COMM domain containing 7
chr4_-_63559311 0.01 ENSDART00000164415
si:dkey-16p6.1
si:dkey-16p6.1

Network of associatons between targets according to the STRING database.

First level regulatory network of nr6a1b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 1.4 GO:0070292 N-acylphosphatidylethanolamine metabolic process(GO:0070292)
0.6 1.8 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.6 1.8 GO:0071236 cellular response to antibiotic(GO:0071236) cellular response to toxic substance(GO:0097237)
0.6 1.7 GO:0006678 glucosylceramide metabolic process(GO:0006678)
0.5 3.3 GO:0032367 intracellular cholesterol transport(GO:0032367)
0.4 1.3 GO:0099552 trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553)
0.4 1.6 GO:0070291 N-acylethanolamine metabolic process(GO:0070291)
0.4 1.1 GO:0016446 somatic diversification of immune receptors via somatic mutation(GO:0002566) somatic hypermutation of immunoglobulin genes(GO:0016446)
0.3 2.1 GO:0016559 peroxisome fission(GO:0016559)
0.3 6.1 GO:0015936 coenzyme A metabolic process(GO:0015936)
0.3 0.8 GO:0090069 regulation of ribosome biogenesis(GO:0090069)
0.3 3.0 GO:1902221 L-phenylalanine metabolic process(GO:0006558) L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.2 1.1 GO:0003096 renal sodium ion transport(GO:0003096) renal sodium ion absorption(GO:0070294)
0.2 0.9 GO:0003272 endocardial cushion formation(GO:0003272) protein kinase D signaling(GO:0089700)
0.1 1.9 GO:0043550 regulation of lipid kinase activity(GO:0043550) regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.1 0.8 GO:0035889 otolith tethering(GO:0035889)
0.1 1.3 GO:0097105 presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
0.1 0.5 GO:0019388 galactose catabolic process(GO:0019388) galactose catabolic process via UDP-galactose(GO:0033499)
0.1 2.0 GO:0046855 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) inositol phosphate catabolic process(GO:0071545)
0.1 1.5 GO:0046688 response to copper ion(GO:0046688)
0.1 0.3 GO:0051645 Golgi localization(GO:0051645) maintenance of centrosome location(GO:0051661)
0.1 0.6 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.1 1.6 GO:0006198 cAMP catabolic process(GO:0006198)
0.1 5.5 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 0.5 GO:0031295 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0 0.4 GO:0003428 growth plate cartilage morphogenesis(GO:0003422) chondrocyte intercalation involved in growth plate cartilage morphogenesis(GO:0003428)
0.0 1.4 GO:0006306 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0 0.9 GO:0097194 execution phase of apoptosis(GO:0097194)
0.0 0.5 GO:2000601 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 3.8 GO:0031101 fin regeneration(GO:0031101)
0.0 2.1 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.0 1.0 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 2.0 GO:0051607 defense response to virus(GO:0051607)
0.0 0.6 GO:0031952 regulation of protein autophosphorylation(GO:0031952)
0.0 2.1 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.0 0.1 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.0 0.9 GO:0050727 regulation of inflammatory response(GO:0050727)
0.0 0.6 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.7 GO:0060319 primitive erythrocyte differentiation(GO:0060319)
0.0 1.3 GO:0007254 JNK cascade(GO:0007254)
0.0 0.5 GO:0003094 glomerular filtration(GO:0003094)
0.0 3.4 GO:0051480 regulation of cytosolic calcium ion concentration(GO:0051480)
0.0 0.5 GO:0021587 cerebellum morphogenesis(GO:0021587)
0.0 0.8 GO:0048332 mesoderm morphogenesis(GO:0048332)
0.0 1.3 GO:0051260 protein homooligomerization(GO:0051260)
0.0 5.4 GO:0045944 positive regulation of transcription from RNA polymerase II promoter(GO:0045944)
0.0 0.1 GO:0021910 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910) regulation of myotome development(GO:2000290)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0034456 CURI complex(GO:0032545) UTP-C complex(GO:0034456)
0.3 2.1 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.3 3.0 GO:0045095 keratin filament(GO:0045095)
0.3 2.1 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 2.1 GO:0071564 npBAF complex(GO:0071564)
0.1 3.9 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 0.3 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 0.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 2.6 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.1 GO:0035861 site of double-strand break(GO:0035861)
0.0 3.5 GO:0005765 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 1.3 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 0.4 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 1.5 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.6 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 2.4 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 2.4 GO:0070382 exocytic vesicle(GO:0070382)
0.0 0.5 GO:0005902 microvillus(GO:0005902)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.3 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
0.5 1.4 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.4 1.3 GO:0004771 sterol esterase activity(GO:0004771)
0.4 2.2 GO:0004594 pantothenate kinase activity(GO:0004594)
0.3 3.0 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.3 1.3 GO:0070573 metallodipeptidase activity(GO:0070573)
0.2 1.0 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.2 1.3 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.2 1.1 GO:0016793 dGTPase activity(GO:0008832) triphosphoric monoester hydrolase activity(GO:0016793)
0.2 1.5 GO:0004096 catalase activity(GO:0004096)
0.1 2.7 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.1 1.3 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 3.4 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 1.4 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1 2.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 0.8 GO:0004145 diamine N-acetyltransferase activity(GO:0004145)
0.1 6.2 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.1 2.0 GO:0008252 nucleotidase activity(GO:0008252)
0.1 0.3 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 1.6 GO:0004622 lysophospholipase activity(GO:0004622)
0.1 2.1 GO:0036442 hydrogen-exporting ATPase activity(GO:0036442) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 1.1 GO:0019870 chloride channel inhibitor activity(GO:0019869) potassium channel inhibitor activity(GO:0019870)
0.1 3.9 GO:0050661 NADP binding(GO:0050661)
0.1 1.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 5.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 4.0 GO:0042626 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492)
0.0 0.9 GO:0004697 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.0 0.6 GO:0072542 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.0 1.6 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.8 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.5 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 2.7 GO:0030276 clathrin binding(GO:0030276)
0.0 4.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.6 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.2 GO:0000700 mismatch base pair DNA N-glycosylase activity(GO:0000700) pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263)
0.0 0.4 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 2.8 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 3.0 GO:0042393 histone binding(GO:0042393)
0.0 1.7 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.0 0.1 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 0.8 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 8.8 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 1.8 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 2.0 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1 3.2 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 1.2 PID ALK2 PATHWAY ALK2 signaling events
0.1 2.3 PID FOXO PATHWAY FoxO family signaling
0.1 3.1 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.1 0.9 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 2.1 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.8 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 0.8 PID CMYB PATHWAY C-MYB transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 7.4 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.5 2.0 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.3 1.5 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.2 1.9 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 1.3 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 0.9 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 0.8 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 1.8 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.1 0.8 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.6 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.0 1.7 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.6 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.3 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.2 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway