ISMARA results: nrf1

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for nrf1

Z-value: 2.78

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Transcription factors associated with nrf1

Gene Symbol	Gene ID	Gene Info
nrf1 NCBI UniProt	ENSDARG00000000018	nuclear respiratory factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
nrf1	dr11_v1_chr4_-_15103646_15103696	0.74	7.5e-18	Click!

Activity profile of nrf1 motif

Sorted Z-values of nrf1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_-_34801041 Show fit	26.76	ENSDART00000103043	nsfa NCBI UniProt Show fit	N-ethylmaleimide-sensitive factor a
chr12_-_25916530 Show fit	25.84	ENSDART00000186386	sncgb NCBI UniProt Show fit	synuclein, gamma b (breast cancer-specific protein 1)
chr23_+_44732863 Show fit	21.96	ENSDART00000160044 ENSDART00000172268	atp1b2a NCBI UniProt Show fit	ATPase Na+/K+ transporting subunit beta 2a
chr19_-_5254699 Show fit	20.79	ENSDART00000081951	stx1b NCBI UniProt Show fit	syntaxin 1B
chr14_+_22172047 Show fit	20.78	ENSDART00000114750 ENSDART00000148259	gabrb2 NCBI UniProt Show fit	gamma-aminobutyric acid (GABA) A receptor, beta 2
chr6_+_27667359 Show fit	19.02	ENSDART00000159624 ENSDART00000049177	rab6ba NCBI UniProt Show fit	RAB6B, member RAS oncogene family a
chr19_-_19339285 Show fit	18.89	ENSDART00000158413 ENSDART00000170479	cspg5b NCBI UniProt Show fit	chondroitin sulfate proteoglycan 5b
chr8_-_14050758 Show fit	18.64	ENSDART00000133922	atp2b3a NCBI UniProt Show fit	ATPase plasma membrane Ca2+ transporting 3a
chr1_+_53954230 Show fit	17.47	ENSDART00000037729 ENSDART00000159900	ccsapa NCBI UniProt Show fit	centriole, cilia and spindle-associated protein a
chr2_+_22795494 Show fit	17.41	ENSDART00000042255	rab6bb NCBI UniProt Show fit	RAB6B, member RAS oncogene family b

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of nrf1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.6	49.1	GO:0036376	cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
1.1	35.8	GO:0006891	intra-Golgi vesicle-mediated transport(GO:0006891)
7.9	31.5	GO:0048211	Golgi vesicle docking(GO:0048211)
0.2	29.1	GO:0030705	cytoskeleton-dependent intracellular transport(GO:0030705)
1.0	25.8	GO:0071542	dopaminergic neuron differentiation(GO:0071542)
1.6	24.5	GO:0051127	positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.1	23.4	GO:0043087	regulation of GTPase activity(GO:0043087)
1.8	23.2	GO:0006599	phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.3	21.3	GO:0015914	phospholipid transport(GO:0015914)
0.8	21.2	GO:0030497	fatty acid elongation(GO:0030497)

Showing 1 to 10 of 224 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	56.5	GO:0043679	axon terminus(GO:0043679)
4.9	49.1	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.1	44.4	GO:0005794	Golgi apparatus(GO:0005794)
0.0	44.1	GO:0005887	integral component of plasma membrane(GO:0005887)
0.4	36.9	GO:0005795	Golgi stack(GO:0005795)
0.3	26.6	GO:0005871	kinesin complex(GO:0005871)
0.1	25.0	GO:0030424	axon(GO:0030424)
1.5	24.5	GO:0031209	SCAR complex(GO:0031209)
0.7	23.4	GO:1902710	GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.6	21.5	GO:0035869	ciliary transition zone(GO:0035869)

Showing 1 to 10 of 112 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	90.6	GO:0003924	GTPase activity(GO:0003924)
2.5	49.1	GO:0001671	ATPase activator activity(GO:0001671)
0.0	33.5	GO:0004674	protein serine/threonine kinase activity(GO:0004674)
0.1	25.9	GO:0008017	microtubule binding(GO:0008017)
8.6	25.8	GO:1903136	cuprous ion binding(GO:1903136)
0.4	25.8	GO:0003725	double-stranded RNA binding(GO:0003725)
2.7	24.5	GO:0071933	Arp2/3 complex binding(GO:0071933)
1.8	23.2	GO:0004111	creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.6	22.2	GO:0017075	syntaxin-1 binding(GO:0017075)
0.1	21.7	GO:0005096	GTPase activator activity(GO:0005096)

Showing 1 to 10 of 168 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	37.2	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.7	22.3	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.4	16.8	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.2	16.2	PID CXCR4 PATHWAY	CXCR4-mediated signaling events
0.5	16.1	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.2	9.2	PID P53 REGULATION PATHWAY	p53 pathway
0.8	7.4	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.2	6.6	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.2	5.7	ST G ALPHA I PATHWAY	G alpha i Pathway
0.3	4.7	PID ARF 3PATHWAY	Arf1 pathway

Showing 1 to 10 of 26 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.0	44.6	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
1.2	20.8	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.4	15.7	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.4	14.4	REACTOME MRNA SPLICING MINOR PATHWAY	Genes involved in mRNA Splicing - Minor Pathway
0.2	10.7	REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
2.1	10.6	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.1	10.6	REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS	Genes involved in Glycerophospholipid biosynthesis
0.4	10.2	REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER	Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.6	9.5	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.9	8.5	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1

Showing 1 to 10 of 47 entries

Results for nrf1

Z-value: 2.78

Motif logo

Transcription factors associated with nrf1

Activity-expression correlation:

Activity profile of nrf1 motif

Sorted Z-values of nrf1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of nrf1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: