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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for onecut1+onecutl

Z-value: 2.30

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Transcription factors associated with onecut1+onecutl

Gene Symbol Gene ID Gene Info
onecut1
ENSDARG00000007982 one cut homeobox 1
onecutl
ENSDARG00000040253 one cut domain, family member, like
onecut1
ENSDARG00000112251 one cut homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
onecutldr11_v1_chr16_-_29528198_295281980.752.3e-18Click!
onecut1dr11_v1_chr18_+_38755023_387550240.652.3e-12Click!

Activity profile of onecut1+onecutl motif

Sorted Z-values of onecut1+onecutl motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_7885707 29.52 ENSDART00000029981
ppp3cb
protein phosphatase 3, catalytic subunit, beta isozyme
chr15_+_28202170 20.78 ENSDART00000077736
vtna
vitronectin a
chr1_+_29759678 20.24 ENSDART00000054059
ENSDART00000101856
cpb2
carboxypeptidase B2 (plasma)
chr6_-_32349153 19.77 ENSDART00000140004
angptl3
angiopoietin-like 3
chr24_-_17444067 19.55 ENSDART00000155843
cntnap2a
contactin associated protein like 2a
chr14_+_22172047 19.41 ENSDART00000114750
ENSDART00000148259
gabrb2
gamma-aminobutyric acid (GABA) A receptor, beta 2
chr12_+_24344611 19.23 ENSDART00000093094
nrxn1a
neurexin 1a
chr20_+_3108597 18.44 ENSDART00000133435
CEP170B (1 of many)
si:ch73-212j7.1
chr15_-_21155641 18.20 ENSDART00000061098
ENSDART00000046443
A2ML1 (1 of many)
si:dkey-105h12.2
chr2_+_35240764 17.95 ENSDART00000015827
tnr
tenascin R (restrictin, janusin)
chr1_-_10071422 17.67 ENSDART00000135522
ENSDART00000033118
fga
fibrinogen alpha chain
chr12_-_22524388 17.61 ENSDART00000020942
shbg
sex hormone-binding globulin
chr15_-_21132480 17.60 ENSDART00000078734
ENSDART00000157481
a2ml
alpha-2-macroglobulin-like
chr8_-_31919624 17.53 ENSDART00000085573
rgs7bpa
regulator of G protein signaling 7 binding protein a
chr22_+_37888249 17.48 ENSDART00000076082
fetub
fetuin B
chr25_+_4837915 17.47 ENSDART00000168016
gnb5a
guanine nucleotide binding protein (G protein), beta 5a
chr13_+_16521898 17.27 ENSDART00000122557
kcnma1a
potassium large conductance calcium-activated channel, subfamily M, alpha member 1a
chr15_-_24869826 17.09 ENSDART00000127047
tusc5a
tumor suppressor candidate 5a
chr15_+_26399538 17.09 ENSDART00000159589
rtn4rl1b
reticulon 4 receptor-like 1b
chr19_-_9829965 16.85 ENSDART00000136842
ENSDART00000142766
cacng8a
calcium channel, voltage-dependent, gamma subunit 8a
chr25_-_11088839 16.84 ENSDART00000154748
sv2bb
synaptic vesicle glycoprotein 2Bb
chr15_-_25392589 16.75 ENSDART00000124205
si:dkey-54n8.4
si:dkey-54n8.4
chr23_+_28648864 16.58 ENSDART00000189096
l1cama
L1 cell adhesion molecule, paralog a
chr5_+_55626693 16.54 ENSDART00000168908
ENSDART00000161412
ntrk2b
neurotrophic tyrosine kinase, receptor, type 2b
chr15_+_14854666 16.49 ENSDART00000163066
diabloa
diablo, IAP-binding mitochondrial protein a
chr17_-_20979077 16.35 ENSDART00000006676
phyhipla
phytanoyl-CoA 2-hydroxylase interacting protein-like a
chr12_+_24344963 16.32 ENSDART00000191648
ENSDART00000183180
ENSDART00000088178
ENSDART00000189696
nrxn1a
neurexin 1a
chr21_+_9628854 16.06 ENSDART00000161753
ENSDART00000160711
mapk10
mitogen-activated protein kinase 10
chr9_+_11034314 16.00 ENSDART00000032695
asic4a
acid-sensing (proton-gated) ion channel family member 4a
chr6_+_55174744 15.78 ENSDART00000023562
SYT2
synaptotagmin 2
chr1_-_21409877 15.52 ENSDART00000102782
gria2a
glutamate receptor, ionotropic, AMPA 2a
chr25_+_19954576 15.29 ENSDART00000149335
kcna1a
potassium voltage-gated channel, shaker-related subfamily, member 1a
chr17_-_16133249 15.11 ENSDART00000030919
pnoca
prepronociceptin a
chr7_-_22132265 15.10 ENSDART00000125284
ENSDART00000112978
nlgn2a
neuroligin 2a
chr21_-_27881752 15.08 ENSDART00000132583
nrxn2a
neurexin 2a
chr7_-_52842007 14.82 ENSDART00000182710
map1aa
microtubule-associated protein 1Aa
chr6_-_609880 14.48 ENSDART00000149248
ENSDART00000148867
ENSDART00000149414
ENSDART00000148552
ENSDART00000148391
lgals2b
lectin, galactoside-binding, soluble, 2b
chr19_+_25649626 14.47 ENSDART00000146947
tac1
tachykinin 1
chr10_+_37137464 14.22 ENSDART00000114909
cuedc1a
CUE domain containing 1a
chr6_+_3828560 14.17 ENSDART00000185273
ENSDART00000179091
gad1b
glutamate decarboxylase 1b
chr2_+_35240485 14.15 ENSDART00000179804
tnr
tenascin R (restrictin, janusin)
chr15_-_21239416 14.08 ENSDART00000155787
A2ML1 (1 of many)
si:dkey-105h12.2
chr19_-_9882821 14.04 ENSDART00000147128
cacng7a
calcium channel, voltage-dependent, gamma subunit 7a
chr7_+_32722227 13.95 ENSDART00000126565
si:ch211-150g13.3
si:ch211-150g13.3
chr21_-_41305748 13.95 ENSDART00000170457
nsg2
neuronal vesicle trafficking associated 2
chr2_+_1487118 13.87 ENSDART00000147283
c8a
complement component 8, alpha polypeptide
chr13_+_16522608 13.68 ENSDART00000182838
ENSDART00000143200
kcnma1a
potassium large conductance calcium-activated channel, subfamily M, alpha member 1a
chr5_-_29750377 13.54 ENSDART00000051474
barhl1a
BarH-like homeobox 1a
chr2_+_1486822 13.40 ENSDART00000132500
c8a
complement component 8, alpha polypeptide
chr3_-_18711288 13.33 ENSDART00000183885
grid2ipa
glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein, a
chr9_-_18424844 13.02 ENSDART00000154351
enox1
ecto-NOX disulfide-thiol exchanger 1
chr14_+_8127893 12.97 ENSDART00000169091
psd2
pleckstrin and Sec7 domain containing 2
chr1_-_49932040 12.71 ENSDART00000048281
cyp2u1
cytochrome P450, family 2, subfamily U, polypeptide 1
chr14_-_25985698 12.43 ENSDART00000172909
ENSDART00000123053
atox1
antioxidant 1 copper chaperone
chr12_-_13886952 12.28 ENSDART00000110503
adam11
ADAM metallopeptidase domain 11
chr16_+_52105227 12.23 ENSDART00000150025
ENSDART00000097863
MAN1C1
si:ch73-373m9.1
chr20_+_25581627 12.09 ENSDART00000030229
cyp2p9
cytochrome P450, family 2, subfamily P, polypeptide 9
chr20_+_23440632 11.96 ENSDART00000180685
ENSDART00000042820
si:dkey-90m5.4
si:dkey-90m5.4
chr24_+_24461558 11.78 ENSDART00000182424
bhlhe22
basic helix-loop-helix family, member e22
chr2_-_5475910 11.76 ENSDART00000100954
ENSDART00000172143
ENSDART00000132496
proca
proca
protein C (inactivator of coagulation factors Va and VIIIa), a
protein C (inactivator of coagulation factors Va and VIIIa), a
chr9_-_35557397 11.72 ENSDART00000100681
ncam2
neural cell adhesion molecule 2
chr8_+_7740004 11.67 ENSDART00000170184
ENSDART00000187811
fgd1
FYVE, RhoGEF and PH domain containing 1
chr21_-_31143903 11.11 ENSDART00000111571
rap1gap2b
RAP1 GTPase activating protein 2b
chr12_-_4781801 11.11 ENSDART00000167490
ENSDART00000121718
mapta
microtubule-associated protein tau a
chr15_+_47418565 10.99 ENSDART00000155709
clpb
ClpB homolog, mitochondrial AAA ATPase chaperonin
chr16_-_44649053 10.98 ENSDART00000184807
CR925804.2

chr10_+_1638876 10.96 ENSDART00000184484
ENSDART00000060946
ENSDART00000181251
sgsm1b
small G protein signaling modulator 1b
chr4_-_1147655 10.94 ENSDART00000171561
si:ch211-117i20.2
si:ch211-117i20.2
chr9_+_46644633 10.88 ENSDART00000160285
slc4a3
solute carrier family 4 (anion exchanger), member 3
chr8_+_23916647 10.88 ENSDART00000143152
cpne5a
copine Va
chr3_-_16250527 10.82 ENSDART00000146699
ENSDART00000141181
bckdhbl
branched chain keto acid dehydrogenase E1, beta polypeptide, like
chr2_-_5466708 10.78 ENSDART00000136682
proca
protein C (inactivator of coagulation factors Va and VIIIa), a
chr12_-_3756405 10.67 ENSDART00000150839
fam57bb
family with sequence similarity 57, member Bb
chr18_-_44611252 10.65 ENSDART00000173095
spred3
sprouty-related, EVH1 domain containing 3
chr16_+_10346277 10.64 ENSDART00000081092
si:dkeyp-77h1.4
si:dkeyp-77h1.4
chr7_+_33314925 10.63 ENSDART00000148590
coro2ba
coronin, actin binding protein, 2Ba
chr3_-_28665291 10.59 ENSDART00000151670
fbxl16
F-box and leucine-rich repeat protein 16
chr17_+_8183393 10.25 ENSDART00000155957
tulp4b
tubby like protein 4b
chr4_-_4507761 10.14 ENSDART00000130588
tbc1d30
TBC1 domain family, member 30
chr2_-_31735142 9.92 ENSDART00000130903
ralyl
RALY RNA binding protein like
chr2_-_2096055 9.90 ENSDART00000126566
slc22a23
solute carrier family 22, member 23
chr18_-_26510545 9.89 ENSDART00000135133
FRMD5
si:ch211-69m14.1
chr8_-_19051906 9.86 ENSDART00000089024
sema6bb
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Bb
chr16_-_46393154 9.81 ENSDART00000132154
si:ch73-59c19.1
si:ch73-59c19.1
chr5_+_3501859 9.74 ENSDART00000080486
ywhag1
3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1
chr21_-_10886709 9.72 ENSDART00000134408
si:dkey-277m11.2
si:dkey-277m11.2
chr6_-_38419318 9.64 ENSDART00000138026
gabra5
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr10_+_7182168 9.54 ENSDART00000172766
psd3l
pleckstrin and Sec7 domain containing 3, like
chr4_+_10365857 9.46 ENSDART00000138890
kcnd2
potassium voltage-gated channel, Shal-related subfamily, member 2
chr8_-_45279411 9.17 ENSDART00000175207
adamts13
ADAM metallopeptidase with thrombospondin type 1 motif, 13
chr1_-_44704261 9.04 ENSDART00000133210
si:dkey-28b4.8
si:dkey-28b4.8
chr15_-_5467477 8.77 ENSDART00000123839
arrb1
arrestin, beta 1
chr3_+_43467595 8.68 ENSDART00000188300
galr2b
galanin receptor 2b
chr4_+_20318127 8.65 ENSDART00000028856
ENSDART00000132909
cacna1c
calcium channel, voltage-dependent, L type, alpha 1C subunit
chr14_+_11762991 8.64 ENSDART00000110004
frmpd3
FERM and PDZ domain containing 3
chr15_-_26636826 8.58 ENSDART00000087632
slc47a4
solute carrier family 47 (multidrug and toxin extrusion), member 4
chr8_-_40555340 8.48 ENSDART00000163348
NPC1L1
NPC1 like intracellular cholesterol transporter 1
chr21_-_17482465 8.41 ENSDART00000004548
barhl1b
BarH-like homeobox 1b
chr2_-_51794472 8.40 ENSDART00000186652
BX908782.3

chr19_-_17526735 8.27 ENSDART00000189391
thrb
thyroid hormone receptor beta
chr17_-_35076730 8.22 ENSDART00000146590
mboat2a
membrane bound O-acyltransferase domain containing 2a
chr23_-_44494401 8.21 ENSDART00000114640
ENSDART00000148532
actl6b
actin-like 6B
chr18_+_3498989 8.11 ENSDART00000172373
ompa
olfactory marker protein a
chr7_+_23580082 8.05 ENSDART00000183245
si:dkey-172j4.3
si:dkey-172j4.3
chr7_+_57725708 8.04 ENSDART00000056466
ENSDART00000142259
ENSDART00000166198
camk2d1
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1
chr19_+_27479563 7.95 ENSDART00000049368
ENSDART00000185426
atat1
alpha tubulin acetyltransferase 1
chr7_-_31938938 7.89 ENSDART00000132353
bdnf
brain-derived neurotrophic factor
chr11_-_17713987 7.85 ENSDART00000090401
fam19a4b
family with sequence similarity 19 (chemokine (C-C motif)-like), member A4b
chr3_-_23407720 7.85 ENSDART00000155658
rapgefl1
Rap guanine nucleotide exchange factor (GEF)-like 1
chr15_-_19677511 7.84 ENSDART00000043743
si:dkey-4p15.3
si:dkey-4p15.3
chr5_-_23429228 7.83 ENSDART00000049291
gria3a
glutamate receptor, ionotropic, AMPA 3a
chr9_+_37754845 7.82 ENSDART00000100592
pdia5
protein disulfide isomerase family A, member 5
chr15_-_18429550 7.81 ENSDART00000136208
ncam1b
neural cell adhesion molecule 1b
chr12_+_39685485 7.74 ENSDART00000163403
LO017650.1

chr1_-_25438737 7.72 ENSDART00000134470
fhdc1
FH2 domain containing 1
chr16_+_55168245 7.71 ENSDART00000171109
eomesb
eomesodermin homolog b
chr15_-_14375452 7.61 ENSDART00000160675
ENSDART00000164028
ENSDART00000171642
dpf1
D4, zinc and double PHD fingers family 1
chr19_+_9533008 7.54 ENSDART00000104607
fam131ba
family with sequence similarity 131, member Ba
chr5_-_13835461 7.50 ENSDART00000148297
ENSDART00000114841
add2
adducin 2 (beta)
chr16_+_5184402 7.35 ENSDART00000156685
soga3a
SOGA family member 3a
chr21_+_9576176 7.34 ENSDART00000161289
ENSDART00000159899
ENSDART00000162834
mapk10
mitogen-activated protein kinase 10
chr20_-_44575103 7.31 ENSDART00000192573
ubxn2a
UBX domain protein 2A
chr16_+_25116827 7.11 ENSDART00000163244
si:ch211-261d7.6
si:ch211-261d7.6
chr1_+_19930520 7.10 ENSDART00000158344
apbb2b
amyloid beta (A4) precursor protein-binding, family B, member 2b
chr13_-_23270576 7.08 ENSDART00000132828
si:dkey-103j14.5
si:dkey-103j14.5
chr11_+_25111846 6.99 ENSDART00000128705
ENSDART00000190058
ndrg3a
ndrg family member 3a
chr2_+_38881165 6.97 ENSDART00000141850
carmil3
capping protein regulator and myosin 1 linker 3
chr2_+_38608290 6.95 ENSDART00000159066
cdh24b
cadherin 24, type 2b
chr9_+_22632126 6.95 ENSDART00000139434
etv5a
ets variant 5a
chr10_+_25222367 6.92 ENSDART00000042767
grm5a
glutamate receptor, metabotropic 5a
chr13_+_31070181 6.67 ENSDART00000110560
ENSDART00000146088
si:ch211-223a10.1
si:ch211-223a10.1
chr15_+_17441734 6.45 ENSDART00000153729
snx19b
sorting nexin 19b
chr25_-_3979288 6.41 ENSDART00000157117
myrf
myelin regulatory factor
chr20_+_25575391 6.40 ENSDART00000063108
cyp2p8
cytochrome P450, family 2, subfamily P, polypeptide 8
chr9_+_54417141 6.34 ENSDART00000056810
drd1b
dopamine receptor D1b
chr2_+_47471943 6.34 ENSDART00000141974
acsl3b
acyl-CoA synthetase long chain family member 3b
chr3_-_12890670 6.33 ENSDART00000159934
ENSDART00000188607
btbd17b
BTB (POZ) domain containing 17b
chr7_+_30875273 6.30 ENSDART00000173693
apba2b
amyloid beta (A4) precursor protein-binding, family A, member 2b
chr6_-_18739519 6.29 ENSDART00000170998
tnrc6c2
trinucleotide repeat containing 6C2
chr18_-_42313798 6.27 ENSDART00000098639
cntn5
contactin 5
chr20_+_21268795 6.11 ENSDART00000090016
nudt14
nudix (nucleoside diphosphate linked moiety X)-type motif 14
chr16_+_46453176 6.09 ENSDART00000132793
rpz3
rapunzel 3
chr24_-_21674950 6.06 ENSDART00000123216
ENSDART00000046211
lnx2a
ligand of numb-protein X 2a
chr2_+_32843133 5.94 ENSDART00000018501
opn4.1
opsin 4.1
chr5_-_22952156 5.88 ENSDART00000111146
si:ch211-26b3.4
si:ch211-26b3.4
chr16_-_25607266 5.81 ENSDART00000192602
zgc:110410
zgc:110410
chr23_-_31372639 5.80 ENSDART00000179908
ENSDART00000135620
ENSDART00000053367
hmgn3
high mobility group nucleosomal binding domain 3
chr18_+_48576527 5.79 ENSDART00000167555
kcnj5
potassium inwardly-rectifying channel, subfamily J, member 5
chr16_-_24518027 5.71 ENSDART00000134120
ENSDART00000143761
cadm4
cell adhesion molecule 4
chr15_-_16121496 5.65 ENSDART00000128624
sgk494a
uncharacterized serine/threonine-protein kinase SgK494a
chr20_+_405811 5.49 ENSDART00000149311
gpr63
G protein-coupled receptor 63
chr5_-_28109416 5.46 ENSDART00000042002
si:ch211-48m9.1
si:ch211-48m9.1
chr19_-_8880688 5.40 ENSDART00000039629
celf3a
cugbp, Elav-like family member 3a
chr11_+_6819050 5.35 ENSDART00000104289
rab3ab
RAB3A, member RAS oncogene family, b
chr3_-_62125701 5.33 ENSDART00000097345
TOM1L2
Danio rerio target of myb1 like 2 membrane trafficking protein (tom1l2), mRNA.
chr9_+_22631672 5.32 ENSDART00000101770
ENSDART00000126015
ENSDART00000145005
etv5a
ets variant 5a
chr7_+_36041509 5.25 ENSDART00000162850
irx3a
iroquois homeobox 3a
chr5_+_50788329 5.23 ENSDART00000050979
fam81b
family with sequence similarity 81, member B
chr2_+_47471647 5.22 ENSDART00000184199
acsl3b
acyl-CoA synthetase long chain family member 3b
chr14_-_33083539 5.18 ENSDART00000160173
dlg3
discs, large homolog 3 (Drosophila)
chr16_+_21738194 5.14 ENSDART00000163688
FP085428.1
Danio rerio si:ch211-154o6.4 (si:ch211-154o6.4), mRNA.
chr6_+_296130 5.09 ENSDART00000073985
rbfox2
RNA binding fox-1 homolog 2
chr16_-_21181128 5.05 ENSDART00000133403
pde11al
phosphodiesterase 11a, like
chr3_+_39853788 5.00 ENSDART00000154869
cacna1ha
calcium channel, voltage-dependent, T type, alpha 1H subunit a
chr24_-_30091937 4.97 ENSDART00000148249
plppr4b
phospholipid phosphatase related 4b
chr7_-_53664618 4.91 ENSDART00000166391
chrna7
cholinergic receptor, nicotinic, alpha 7 (neuronal)
chr18_-_12612699 4.83 ENSDART00000090335
hipk2
homeodomain interacting protein kinase 2
chr20_-_36107422 4.82 ENSDART00000146055
ptchd4
patched domain containing 4
chr7_+_36035432 4.76 ENSDART00000179004
irx3a
iroquois homeobox 3a
chr15_+_20543770 4.74 ENSDART00000092357
sgsm2
small G protein signaling modulator 2
chr1_-_52497834 4.73 ENSDART00000136469
ENSDART00000004233
acy3.2
aspartoacylase (aminocyclase) 3, tandem duplicate 2
chr24_-_35707552 4.65 ENSDART00000165199
mapre2
microtubule-associated protein, RP/EB family, member 2
chr17_-_10249095 4.63 ENSDART00000159963
sstr1a
somatostatin receptor 1a
chr10_-_19011934 4.60 ENSDART00000167973
adra1ab
adrenoceptor alpha 1Ab
chr6_-_4214297 4.57 ENSDART00000191433
trak2
trafficking protein, kinesin binding 2
chr13_+_33689740 4.48 ENSDART00000161904
ephx5
epoxide hydrolase 5
chr2_-_26642831 4.46 ENSDART00000132854
ENSDART00000087714
ENSDART00000132651
u2surp
U2 snRNP-associated SURP domain containing
chr19_+_27479838 4.46 ENSDART00000103922
atat1
alpha tubulin acetyltransferase 1
chr13_+_35746440 4.45 ENSDART00000187859
gpr75
G protein-coupled receptor 75
chr15_-_1003553 4.42 ENSDART00000154195
si:dkey-77f5.6
si:dkey-77f5.6
chr19_+_37701450 4.37 ENSDART00000087694
thsd7aa
thrombospondin, type I, domain containing 7Aa
chr16_+_30301539 4.31 ENSDART00000186018
LO017848.1

chr1_+_49814942 4.31 ENSDART00000164936
lef1
lymphoid enhancer-binding factor 1
chr9_+_32358514 4.30 ENSDART00000144608
plcl1
phospholipase C like 1
chr4_-_9764767 4.29 ENSDART00000164328
ENSDART00000147699
mical3b
microtubule associated monooxygenase, calponin and LIM domain containing 3b
chr1_-_52498146 4.28 ENSDART00000122217
acy3.2
aspartoacylase (aminocyclase) 3, tandem duplicate 2
chr7_+_73649686 4.13 ENSDART00000185589
PCP4L1
si:dkey-46i9.1
chr5_-_63515210 4.07 ENSDART00000022348
prdm12b
PR domain containing 12b
chr1_+_44710955 4.01 ENSDART00000131296
ENSDART00000142187
ssrp1b
structure specific recognition protein 1b
chr14_-_33894915 3.98 ENSDART00000143290
urp1
urotensin-related peptide 1
chr8_-_16259063 3.95 ENSDART00000057590
dmrta2
DMRT-like family A2
chr2_+_52065884 3.62 ENSDART00000146418
shda
Src homology 2 domain containing transforming protein D, a
chr7_-_54217547 3.61 ENSDART00000162777
ENSDART00000188268
ENSDART00000165875
csnk1g1
casein kinase 1, gamma 1
chr22_+_110158 3.54 ENSDART00000143698
prkar2ab
protein kinase, cAMP-dependent, regulatory, type II, alpha, B
chr10_-_14536399 3.52 ENSDART00000186501
hdhd2
haloacid dehalogenase-like hydrolase domain containing 2
chr12_-_25065916 3.52 ENSDART00000159167
socs5a
suppressor of cytokine signaling 5a
chr5_-_12093618 3.46 ENSDART00000161542
lrrc74b
leucine rich repeat containing 74B
chr24_+_17069420 3.45 ENSDART00000014787
pip4k2aa
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha a
chr9_+_36356740 3.45 ENSDART00000139033
lrp1bb
low density lipoprotein receptor-related protein 1Bb
chr20_-_50014936 3.42 ENSDART00000148892
extl3
exostosin-like glycosyltransferase 3

Network of associatons between targets according to the STRING database.

First level regulatory network of onecut1+onecutl

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.7 20.2 GO:0042730 fibrinolysis(GO:0042730)
5.5 16.5 GO:0099540 synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551) cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
4.9 19.8 GO:0055091 phospholipid homeostasis(GO:0055091)
4.7 14.2 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
3.9 19.5 GO:0071205 protein localization to juxtaparanode region of axon(GO:0071205) protein localization to axon(GO:0099612)
3.3 16.5 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
2.9 14.5 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
2.6 13.0 GO:0007624 ultradian rhythm(GO:0007624)
2.4 31.0 GO:0010996 response to auditory stimulus(GO:0010996)
2.3 6.9 GO:0099552 trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553)
2.2 8.9 GO:0043374 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
2.2 8.8 GO:0001774 microglial cell activation(GO:0001774) regulation of cytokine activity(GO:0060300) regulation of receptor binding(GO:1900120) regulation of chemokine activity(GO:1900136)
2.1 8.3 GO:0060220 retinal cone cell fate determination(GO:0042671) eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate determination(GO:0043703) retinal cone cell fate commitment(GO:0046551) photoreceptor cell fate commitment(GO:0046552) camera-type eye photoreceptor cell fate commitment(GO:0060220)
2.0 5.9 GO:0016056 rhodopsin mediated signaling pathway(GO:0016056)
2.0 29.5 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
1.9 5.8 GO:0035773 insulin secretion involved in cellular response to glucose stimulus(GO:0035773) regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
1.8 30.9 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
1.8 5.3 GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
1.8 10.6 GO:0010799 regulation of peptidyl-threonine phosphorylation(GO:0010799) negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
1.8 7.1 GO:0033345 asparagine catabolic process(GO:0006530) asparagine catabolic process via L-aspartate(GO:0033345)
1.7 8.7 GO:0014896 muscle hypertrophy(GO:0014896)
1.6 12.4 GO:0006878 cellular copper ion homeostasis(GO:0006878)
1.4 15.1 GO:0097104 presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
1.4 4.1 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
1.2 8.7 GO:0042311 vasodilation(GO:0042311)
1.2 17.7 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
1.1 12.3 GO:0060217 hemangioblast cell differentiation(GO:0060217)
1.0 5.1 GO:0010754 negative regulation of cGMP-mediated signaling(GO:0010754)
1.0 11.0 GO:0034605 cellular response to heat(GO:0034605)
1.0 15.5 GO:0048899 anterior lateral line development(GO:0048899)
1.0 5.7 GO:0003232 bulbus arteriosus development(GO:0003232)
0.9 27.3 GO:0019835 cytolysis(GO:0019835)
0.9 4.3 GO:0060784 regulation of cell proliferation involved in tissue homeostasis(GO:0060784)
0.8 3.2 GO:0061113 endodermal digestive tract morphogenesis(GO:0061031) pancreas morphogenesis(GO:0061113)
0.8 4.6 GO:0010460 regulation of systemic arterial blood pressure by norepinephrine-epinephrine(GO:0001993) positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996) positive regulation of blood pressure by epinephrine-norepinephrine(GO:0003321) positive regulation of heart rate(GO:0010460)
0.8 31.4 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.8 4.6 GO:0098957 anterograde axonal transport of mitochondrion(GO:0098957)
0.7 8.1 GO:0007608 sensory perception of smell(GO:0007608)
0.7 5.1 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.7 6.4 GO:0043217 myelin maintenance(GO:0043217)
0.7 7.9 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.7 33.9 GO:0042738 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.6 5.7 GO:0003315 heart rudiment formation(GO:0003315)
0.6 15.4 GO:0031114 regulation of microtubule depolymerization(GO:0031114)
0.6 13.9 GO:0051932 synaptic transmission, GABAergic(GO:0051932)
0.6 3.4 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.6 13.0 GO:0030537 larval locomotory behavior(GO:0008345) larval behavior(GO:0030537)
0.6 5.6 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.6 2.8 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.5 4.8 GO:0045634 regulation of melanocyte differentiation(GO:0045634)
0.5 2.7 GO:0046416 D-amino acid catabolic process(GO:0019478) D-serine catabolic process(GO:0036088) D-amino acid metabolic process(GO:0046416) D-serine metabolic process(GO:0070178)
0.5 4.7 GO:1904825 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)
0.5 10.9 GO:0015701 bicarbonate transport(GO:0015701)
0.5 7.3 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.5 3.6 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.4 1.3 GO:2000009 regulation of protein localization to cell surface(GO:2000008) negative regulation of protein localization to cell surface(GO:2000009)
0.4 2.0 GO:0060055 larval development(GO:0002164) larval heart development(GO:0007508) angiogenesis involved in wound healing(GO:0060055)
0.4 2.7 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.4 8.9 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.4 1.1 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.4 3.4 GO:0061300 cerebellum vasculature development(GO:0061300)
0.4 6.3 GO:0060213 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213) positive regulation of mRNA catabolic process(GO:0061014) regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153)
0.4 22.5 GO:0007596 blood coagulation(GO:0007596)
0.3 23.1 GO:0050919 negative chemotaxis(GO:0050919)
0.3 2.0 GO:0099525 synaptic vesicle docking(GO:0016081) presynaptic dense core granule exocytosis(GO:0099525)
0.3 11.7 GO:0046847 filopodium assembly(GO:0046847)
0.3 35.1 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.3 3.2 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.3 5.0 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.3 24.6 GO:0007254 JNK cascade(GO:0007254)
0.3 3.3 GO:0006751 glutathione catabolic process(GO:0006751)
0.3 11.6 GO:0035336 long-chain fatty acid metabolic process(GO:0001676) long-chain fatty-acyl-CoA metabolic process(GO:0035336)
0.3 2.0 GO:0046487 glyoxylate metabolic process(GO:0046487)
0.3 42.0 GO:0002040 sprouting angiogenesis(GO:0002040)
0.3 37.0 GO:0090630 activation of GTPase activity(GO:0090630)
0.3 8.2 GO:0043967 histone H4 acetylation(GO:0043967)
0.3 3.5 GO:0043949 regulation of cAMP-mediated signaling(GO:0043949)
0.3 1.6 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.3 4.8 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.3 1.3 GO:1902019 regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
0.3 1.0 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway(GO:2001244)
0.2 3.4 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.2 8.2 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.2 23.8 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.2 0.9 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.2 2.1 GO:0021576 hindbrain formation(GO:0021576)
0.2 5.2 GO:0097120 receptor localization to synapse(GO:0097120)
0.2 24.7 GO:0051260 protein homooligomerization(GO:0051260)
0.2 10.9 GO:0071277 cellular response to calcium ion(GO:0071277)
0.2 4.0 GO:0021984 adenohypophysis development(GO:0021984)
0.2 12.4 GO:0006475 internal protein amino acid acetylation(GO:0006475) internal peptidyl-lysine acetylation(GO:0018393)
0.2 2.5 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044) chondroitin sulfate biosynthetic process(GO:0030206)
0.2 2.0 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.1 10.6 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 4.2 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.1 11.7 GO:0036293 response to hypoxia(GO:0001666) response to decreased oxygen levels(GO:0036293)
0.1 4.5 GO:0009636 response to toxic substance(GO:0009636)
0.1 0.7 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.1 16.8 GO:0006836 neurotransmitter transport(GO:0006836)
0.1 16.0 GO:0035725 sodium ion transmembrane transport(GO:0035725)
0.1 1.6 GO:0099560 synaptic membrane adhesion(GO:0099560)
0.1 18.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 0.7 GO:0021794 thalamus development(GO:0021794)
0.1 3.3 GO:0000187 activation of MAPK activity(GO:0000187)
0.1 10.0 GO:0031018 endocrine pancreas development(GO:0031018)
0.1 1.0 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.1 32.9 GO:0007411 axon guidance(GO:0007411)
0.1 3.0 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1 3.5 GO:0048634 regulation of muscle organ development(GO:0048634)
0.1 2.1 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.1 1.6 GO:0030316 osteoclast differentiation(GO:0030316)
0.1 0.7 GO:0038026 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948) reelin-mediated signaling pathway(GO:0038026)
0.1 3.0 GO:0045055 regulated exocytosis(GO:0045055)
0.1 0.4 GO:0017006 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.1 4.7 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.1 6.3 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.1 4.0 GO:0008217 regulation of blood pressure(GO:0008217)
0.1 0.4 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.1 0.2 GO:2000434 regulation of protein neddylation(GO:2000434)
0.1 2.5 GO:0061512 protein localization to cilium(GO:0061512)
0.1 4.0 GO:1902275 regulation of chromatin organization(GO:1902275)
0.1 1.1 GO:0007032 endosome organization(GO:0007032)
0.1 0.4 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 1.7 GO:0006171 cAMP biosynthetic process(GO:0006171)
0.0 3.6 GO:0090263 positive regulation of canonical Wnt signaling pathway(GO:0090263)
0.0 3.3 GO:0008360 regulation of cell shape(GO:0008360)
0.0 4.6 GO:0010506 regulation of autophagy(GO:0010506)
0.0 0.7 GO:0006998 nuclear envelope organization(GO:0006998)
0.0 3.0 GO:0042074 cell migration involved in gastrulation(GO:0042074)
0.0 3.2 GO:0007281 germ cell development(GO:0007281)
0.0 0.9 GO:0009648 photoperiodism(GO:0009648)
0.0 2.6 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.0 0.3 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.0 10.3 GO:0009968 negative regulation of signal transduction(GO:0009968)
0.0 1.1 GO:0048232 spermatogenesis(GO:0007283) male gamete generation(GO:0048232)
0.0 0.7 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.2 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.0 0.8 GO:0007062 sister chromatid cohesion(GO:0007062)
0.0 1.7 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 4.2 GO:0006874 cellular calcium ion homeostasis(GO:0006874)
0.0 0.3 GO:0048168 regulation of neuronal synaptic plasticity(GO:0048168)
0.0 0.2 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.4 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.0 1.3 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 0.7 GO:0015914 phospholipid transport(GO:0015914)
0.0 0.1 GO:0090398 cellular senescence(GO:0090398)
0.0 0.4 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.9 17.7 GO:0005577 fibrinogen complex(GO:0005577)
5.0 15.1 GO:0060077 inhibitory synapse(GO:0060077)
4.9 29.5 GO:0005955 calcineurin complex(GO:0005955)
2.4 19.5 GO:0033010 paranodal junction(GO:0033010)
1.7 27.3 GO:0005579 membrane attack complex(GO:0005579)
1.5 15.3 GO:0033270 paranode region of axon(GO:0033270)
1.4 16.6 GO:0044295 axonal growth cone(GO:0044295)
1.2 54.2 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.7 4.2 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.5 22.5 GO:0032587 ruffle membrane(GO:0032587)
0.4 17.9 GO:0043679 axon terminus(GO:0043679)
0.4 8.2 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.4 2.4 GO:0005845 mRNA cap binding complex(GO:0005845)
0.4 3.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.3 3.1 GO:0042583 chromaffin granule(GO:0042583)
0.3 7.6 GO:0071565 nBAF complex(GO:0071565)
0.3 9.6 GO:1902711 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.3 17.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.3 13.1 GO:0005905 clathrin-coated pit(GO:0005905)
0.2 3.4 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.2 16.0 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.2 5.2 GO:0008328 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.2 5.0 GO:0001518 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.2 6.9 GO:0099634 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.2 19.5 GO:0008021 synaptic vesicle(GO:0008021)
0.2 25.0 GO:0045177 apical part of cell(GO:0045177)
0.2 4.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.2 4.7 GO:0035371 microtubule plus-end(GO:0035371)
0.2 0.9 GO:0071203 WASH complex(GO:0071203)
0.2 6.3 GO:0031225 anchored component of membrane(GO:0031225)
0.1 2.8 GO:0097546 ciliary base(GO:0097546)
0.1 3.0 GO:0042734 presynaptic membrane(GO:0042734)
0.1 2.0 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 9.4 GO:0044309 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.1 7.0 GO:0016342 catenin complex(GO:0016342)
0.1 4.8 GO:0016605 PML body(GO:0016605)
0.1 10.6 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 7.5 GO:0014069 postsynaptic density(GO:0014069)
0.1 2.1 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1 35.4 GO:0043005 neuron projection(GO:0043005)
0.1 17.8 GO:0005875 microtubule associated complex(GO:0005875)
0.1 16.8 GO:0030424 axon(GO:0030424)
0.1 3.2 GO:0045495 pole plasm(GO:0045495)
0.1 10.0 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 1.3 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.1 6.3 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 3.4 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.1 2.4 GO:0005844 polysome(GO:0005844)
0.1 0.6 GO:0030897 HOPS complex(GO:0030897)
0.1 1.6 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 1.1 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 0.9 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.1 3.5 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 3.6 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 0.5 GO:1990752 microtubule end(GO:1990752)
0.0 7.9 GO:0005874 microtubule(GO:0005874)
0.0 1.1 GO:0008278 cohesin complex(GO:0008278)
0.0 2.1 GO:0016592 mediator complex(GO:0016592)
0.0 6.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 34.9 GO:0005615 extracellular space(GO:0005615)
0.0 1.3 GO:0005811 lipid particle(GO:0005811)
0.0 15.4 GO:0005576 extracellular region(GO:0005576)
0.0 0.2 GO:0008180 COP9 signalosome(GO:0008180)
0.0 2.4 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 5.9 GO:0000785 chromatin(GO:0000785)
0.0 1.8 GO:0005911 cell-cell junction(GO:0005911)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.5 16.5 GO:0060175 brain-derived neurotrophic factor binding(GO:0048403) brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
4.9 29.5 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
4.8 14.5 GO:0031835 neurokinin receptor binding(GO:0031834) substance P receptor binding(GO:0031835)
4.7 14.2 GO:0004351 glutamate decarboxylase activity(GO:0004351)
3.3 16.6 GO:0008046 axon guidance receptor activity(GO:0008046)
2.5 12.4 GO:0016531 copper chaperone activity(GO:0016531)
2.3 23.4 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
2.1 6.3 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
2.1 8.3 GO:0070324 thyroid hormone binding(GO:0070324)
1.8 31.0 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
1.6 9.5 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
1.6 23.3 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
1.5 4.5 GO:0033961 cis-stilbene-oxide hydrolase activity(GO:0033961)
1.4 14.5 GO:0016936 galactoside binding(GO:0016936)
1.4 8.7 GO:0004966 galanin receptor activity(GO:0004966)
1.4 7.1 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
1.4 4.1 GO:1990226 histone methyltransferase binding(GO:1990226)
1.3 16.0 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
1.2 17.5 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
1.2 15.1 GO:0031628 opioid receptor binding(GO:0031628)
1.0 5.1 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
1.0 13.9 GO:0032051 clathrin light chain binding(GO:0032051)
1.0 6.9 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.9 3.5 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.8 3.3 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.8 13.2 GO:0048495 Roundabout binding(GO:0048495)
0.8 9.0 GO:0004046 aminoacylase activity(GO:0004046)
0.8 7.4 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.8 21.9 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.8 20.2 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.8 3.1 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.7 5.0 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.7 9.6 GO:0022851 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.7 4.7 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.7 2.7 GO:0016841 ammonia-lyase activity(GO:0016841)
0.6 2.5 GO:0008459 chondroitin 6-sulfotransferase activity(GO:0008459)
0.6 7.9 GO:0005165 nerve growth factor receptor binding(GO:0005163) neurotrophin receptor binding(GO:0005165)
0.6 3.6 GO:0001784 phosphotyrosine binding(GO:0001784)
0.6 10.8 GO:0033691 sialic acid binding(GO:0033691)
0.6 4.2 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.6 2.4 GO:0051380 norepinephrine binding(GO:0051380)
0.6 4.6 GO:0004994 somatostatin receptor activity(GO:0004994)
0.6 4.6 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.6 13.4 GO:0001540 beta-amyloid binding(GO:0001540)
0.5 8.6 GO:0042910 xenobiotic transporter activity(GO:0042910)
0.5 4.8 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.5 9.0 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.5 41.6 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.5 33.9 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.5 3.5 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.5 10.9 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.4 17.5 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.4 8.9 GO:0050811 GABA receptor binding(GO:0050811)
0.4 11.6 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.4 2.7 GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.4 10.0 GO:0042043 neurexin family protein binding(GO:0042043)
0.4 4.8 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.4 8.9 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.4 5.7 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.3 15.3 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.3 18.6 GO:0042562 hormone binding(GO:0042562)
0.3 2.0 GO:0019992 diacylglycerol binding(GO:0019992)
0.3 1.9 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.3 5.8 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 4.3 GO:0008301 DNA binding, bending(GO:0008301)
0.2 12.4 GO:0061733 peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.2 2.7 GO:0070840 dynein complex binding(GO:0070840)
0.2 5.0 GO:0042577 lipid phosphatase activity(GO:0042577)
0.2 2.1 GO:0043495 protein anchor(GO:0043495)
0.2 8.0 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.2 2.0 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.2 9.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 2.4 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.2 4.7 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 2.8 GO:0015026 coreceptor activity(GO:0015026)
0.1 2.0 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 6.7 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 20.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 5.9 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.1 2.0 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.1 0.2 GO:0005009 insulin-activated receptor activity(GO:0005009) insulin receptor substrate binding(GO:0043560)
0.1 4.5 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.1 3.3 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.1 3.4 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.1 3.5 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 1.3 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 21.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 2.9 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 3.4 GO:0005548 phospholipid transporter activity(GO:0005548)
0.1 8.2 GO:0045296 cadherin binding(GO:0045296)
0.1 24.6 GO:0008017 microtubule binding(GO:0008017)
0.1 1.6 GO:0070411 I-SMAD binding(GO:0070411)
0.1 1.1 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 4.3 GO:0071949 FAD binding(GO:0071949)
0.1 0.4 GO:0004408 holocytochrome-c synthase activity(GO:0004408)
0.1 1.3 GO:0002039 p53 binding(GO:0002039)
0.1 6.6 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 2.5 GO:0019003 GDP binding(GO:0019003)
0.1 1.7 GO:0004016 adenylate cyclase activity(GO:0004016)
0.1 0.4 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.1 6.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 1.5 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 9.5 GO:0001664 G-protein coupled receptor binding(GO:0001664)
0.1 1.9 GO:0005518 collagen binding(GO:0005518)
0.1 0.4 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.1 0.7 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 17.3 GO:0005096 GTPase activator activity(GO:0005096)
0.0 7.0 GO:0005179 hormone activity(GO:0005179)
0.0 21.5 GO:0005102 receptor binding(GO:0005102)
0.0 9.3 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 1.0 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 4.3 GO:0019901 protein kinase binding(GO:0019901)
0.0 0.7 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 1.3 GO:0044325 ion channel binding(GO:0044325)
0.0 6.3 GO:0003682 chromatin binding(GO:0003682)
0.0 0.2 GO:0070740 protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)
0.0 0.1 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.7 GO:0000049 tRNA binding(GO:0000049)
0.0 5.5 GO:0003712 transcription factor activity, transcription factor binding(GO:0000989) transcription cofactor activity(GO:0003712)
0.0 0.9 GO:0043130 ubiquitin binding(GO:0043130)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 29.5 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
1.1 23.4 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
1.1 17.7 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.8 8.8 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.6 17.6 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.5 3.3 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.4 8.3 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.4 5.8 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.4 2.5 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.3 9.2 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.3 3.6 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.2 7.9 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.2 4.8 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.2 8.9 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.1 1.0 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.1 1.6 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 16.7 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 4.8 PID P53 REGULATION PATHWAY p53 pathway
0.1 14.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.7 PID NOTCH PATHWAY Notch signaling pathway
0.1 3.1 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 1.5 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 2.2 PID AURORA B PATHWAY Aurora B signaling
0.0 0.7 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.6 PID AR PATHWAY Coregulation of Androgen receptor activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 23.4 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
1.9 29.0 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
1.7 29.5 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
1.5 17.7 REACTOME COMMON PATHWAY Genes involved in Common Pathway
1.0 27.3 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.8 14.9 REACTOME BOTULINUM NEUROTOXICITY Genes involved in Botulinum neurotoxicity
0.6 2.5 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.5 12.7 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.5 4.9 REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.4 10.5 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.4 5.2 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.3 3.3 REACTOME SHC MEDIATED SIGNALLING Genes involved in SHC-mediated signalling
0.3 5.8 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.3 9.5 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.3 11.7 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.3 11.2 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.2 4.2 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.2 9.0 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.2 1.6 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 2.8 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 5.3 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 8.7 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 8.9 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 2.8 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.1 2.4 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 3.1 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 2.4 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 1.8 REACTOME PI METABOLISM Genes involved in PI Metabolism
0.0 6.8 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 1.5 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.6 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.7 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)