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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for osr2

Z-value: 0.45

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Transcription factors associated with osr2

Gene Symbol Gene ID Gene Info
osr2
ENSDARG00000038006 odd-skipped related transciption factor 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
osr2dr11_v1_chr16_-_54405976_54405976-0.161.1e-01Click!

Activity profile of osr2 motif

Sorted Z-values of osr2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_-_46010 7.01 ENSDART00000052641
gatm
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr18_-_45736 6.86 ENSDART00000148373
ENSDART00000148950
gatm
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr20_-_29418620 6.25 ENSDART00000172634
ryr3
ryanodine receptor 3
chr23_+_36095260 2.73 ENSDART00000127384
hoxc9a
homeobox C9a
chr23_-_9925568 2.62 ENSDART00000081268
si:ch211-220i18.4
si:ch211-220i18.4
chr23_+_7379728 1.91 ENSDART00000012194
gata5
GATA binding protein 5
chr2_+_5446882 1.75 ENSDART00000083260
dusp28
dual specificity phosphatase 28
chr8_-_4100365 1.40 ENSDART00000142846
cux2b
cut-like homeobox 2b
chr13_-_27621246 1.29 ENSDART00000102232
kcnq5a
potassium voltage-gated channel, KQT-like subfamily, member 5a
chr22_-_5006801 1.27 ENSDART00000106166
rx1
retinal homeobox gene 1
chr7_+_17374560 1.24 ENSDART00000172272
ENSDART00000073467
nitr7a
novel immune-type receptor 7a
chr20_-_26866111 1.23 ENSDART00000077767
mylk4b
myosin light chain kinase family, member 4b
chr18_-_977075 1.15 ENSDART00000032392
dhdhl
dihydrodiol dehydrogenase (dimeric), like
chr2_-_48497175 1.13 ENSDART00000158839
CR391991.5

chr3_-_30384353 1.11 ENSDART00000186832
lrrc4ba
leucine rich repeat containing 4Ba
chr2_-_48448225 1.11 ENSDART00000129826
CR391991.2

chr5_+_6617401 1.05 ENSDART00000060532
zgc:110796
zgc:110796
chr10_+_21899753 1.05 ENSDART00000080155
hrh2b
histamine receptor H2b
chr7_+_42206543 1.04 ENSDART00000112543
phkb
phosphorylase kinase, beta
chr21_+_21679086 0.97 ENSDART00000146225
or125-5
odorant receptor, family E, subfamily 125, member 5
chr7_-_17771166 0.94 ENSDART00000173620
si:dkey-106g10.7
si:dkey-106g10.7
chr14_+_29945070 0.94 ENSDART00000185039
fam149a
family with sequence similarity 149 member A
chr14_+_5383060 0.94 ENSDART00000187825
lbx2
ladybird homeobox 2
chr22_-_11626014 0.90 ENSDART00000063133
ENSDART00000160085
gcga
glucagon a
chr5_-_48307804 0.89 ENSDART00000182831
ENSDART00000186920
ENSDART00000183585
mef2cb
myocyte enhancer factor 2cb
chr15_-_31357634 0.88 ENSDART00000127485
or111-2
odorant receptor, family D, subfamily 111, member 2
chr6_+_19383267 0.80 ENSDART00000166549
mchr1a
melanin-concentrating hormone receptor 1a
chr5_-_61787969 0.77 ENSDART00000112744
gas2l2
growth arrest specific 2 like 2
chr6_+_54576520 0.72 ENSDART00000093199
ENSDART00000127519
ENSDART00000157142
tead3b
TEA domain family member 3 b
chr25_-_19395156 0.57 ENSDART00000155335
map1ab
microtubule-associated protein 1Ab
chr1_+_40199074 0.49 ENSDART00000179679
ENSDART00000136849
si:ch211-113e8.5
si:ch211-113e8.5
chr8_+_48858132 0.38 ENSDART00000124737
ENSDART00000079644
tp73
tumor protein p73
chr21_-_40834413 0.38 ENSDART00000148513
limk1b
LIM domain kinase 1b
chr2_-_48512450 0.37 ENSDART00000160132
CR391991.1

chr12_+_28856151 0.36 ENSDART00000152969
nfe2l1b
nuclear factor, erythroid 2-like 1b
chr13_+_29778610 0.35 ENSDART00000132004
pax2a
paired box 2a
chr1_+_44826593 0.34 ENSDART00000162200
STX3
zgc:165520
chr3_-_10751491 0.29 ENSDART00000016351
zgc:112965
zgc:112965
chr2_+_3986083 0.27 ENSDART00000188979
mkxb
mohawk homeobox b
chr6_+_46431848 0.26 ENSDART00000181056
ENSDART00000144569
ENSDART00000064865
ENSDART00000133992
stau1
staufen double-stranded RNA binding protein 1
chr8_-_22639794 0.23 ENSDART00000188029
iqsec2a
IQ motif and Sec7 domain 2a
chr19_-_25519310 0.22 ENSDART00000089882
C1GALT1 (1 of many)
si:dkey-202e17.1
chr6_-_40884453 0.16 ENSDART00000017968
ENSDART00000154100
sirt4
sirtuin 4
chr14_+_36246726 0.14 ENSDART00000105602
elovl6
ELOVL fatty acid elongase 6
chr23_-_4704938 0.10 ENSDART00000067293
cnbpa
CCHC-type zinc finger, nucleic acid binding protein a
chr19_-_9503473 0.09 ENSDART00000091615
iffo1a
intermediate filament family orphan 1a
chr16_-_13612650 0.07 ENSDART00000080372
dbpb
D site albumin promoter binding protein b
chr23_-_36003282 0.00 ENSDART00000103150
calcoco1a
calcium binding and coiled-coil domain 1a

Network of associatons between targets according to the STRING database.

First level regulatory network of osr2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 13.9 GO:0006601 creatine metabolic process(GO:0006600) creatine biosynthetic process(GO:0006601)
0.7 2.7 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
0.5 1.9 GO:0048618 post-embryonic foregut morphogenesis(GO:0048618)
0.2 6.2 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)
0.2 0.9 GO:1904105 positive regulation of convergent extension involved in gastrulation(GO:1904105)
0.0 2.6 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.3 GO:0021588 cerebellum formation(GO:0021588)
0.0 0.8 GO:0051764 actin crosslink formation(GO:0051764)
0.0 1.3 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0 0.9 GO:0003323 type B pancreatic cell development(GO:0003323)
0.0 0.7 GO:0035329 hippo signaling(GO:0035329)
0.0 0.4 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.0 0.1 GO:2000767 positive regulation of cytoplasmic translation(GO:2000767)
0.0 0.9 GO:0060914 heart formation(GO:0060914)
0.0 1.5 GO:0021782 glial cell development(GO:0021782)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 6.2 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 13.9 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.5 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 1.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 6.2 GO:0048763 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
0.4 13.9 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.3 0.8 GO:0030273 melanin-concentrating hormone receptor activity(GO:0030273)
0.2 0.9 GO:0031769 glucagon receptor binding(GO:0031769)
0.1 1.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.1 1.8 GO:0033549 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.1 0.8 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 1.3 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 1.0 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.0 0.9 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.2 GO:0070403 NAD+ binding(GO:0070403)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 13.9 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.5 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 1.9 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.1 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs