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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for otpa+otpb

Z-value: 0.69

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Transcription factors associated with otpa+otpb

Gene Symbol Gene ID Gene Info
otpa
ENSDARG00000014201 orthopedia homeobox a
otpb
ENSDARG00000058379 orthopedia homeobox b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
otpbdr11_v1_chr5_-_51619742_516197420.204.9e-02Click!
otpadr11_v1_chr21_+_7582036_75820590.065.6e-01Click!

Activity profile of otpa+otpb motif

Sorted Z-values of otpa+otpb motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_31713239 11.60 ENSDART00000122379
habp2
hyaluronan binding protein 2
chr5_+_2815021 9.61 ENSDART00000020472
hpda
4-hydroxyphenylpyruvate dioxygenase a
chr17_+_15433518 8.77 ENSDART00000026180
fabp7a
fatty acid binding protein 7, brain, a
chr17_+_15433671 8.65 ENSDART00000149568
fabp7a
fatty acid binding protein 7, brain, a
chr10_+_26747755 8.14 ENSDART00000100329
f9b
coagulation factor IXb
chr9_+_34127005 7.27 ENSDART00000167384
ENSDART00000078065
f5
coagulation factor V
chr15_-_21014270 5.65 ENSDART00000154019
si:ch211-212c13.10
si:ch211-212c13.10
chr2_-_17392799 4.95 ENSDART00000136470
ENSDART00000141188
st3gal3b
ST3 beta-galactoside alpha-2,3-sialyltransferase 3b
chr11_+_40812590 4.75 ENSDART00000186690
errfi1a
ERBB receptor feedback inhibitor 1a
chr2_-_17393216 4.51 ENSDART00000123137
st3gal3b
ST3 beta-galactoside alpha-2,3-sialyltransferase 3b
chr6_+_612594 4.04 ENSDART00000150903
kynu
kynureninase
chr17_+_16564921 3.69 ENSDART00000151904
foxn3
forkhead box N3
chr17_+_50524573 3.68 ENSDART00000187974
CR382385.1

chr3_+_3681116 3.59 ENSDART00000109618
art4
ADP-ribosyltransferase 4 (Dombrock blood group)
chr18_+_41527877 2.57 ENSDART00000146972
selenot1b
selenoprotein T, 1b
chr13_-_52089003 2.53 ENSDART00000187600
tmem254
transmembrane protein 254
chr4_-_9891874 2.49 ENSDART00000067193
adm2a
adrenomedullin 2a
chr14_-_33481428 2.42 ENSDART00000147059
ENSDART00000140001
ENSDART00000124242
ENSDART00000164836
ENSDART00000190104
ENSDART00000186833
ENSDART00000180873
lamp2
lysosomal-associated membrane protein 2
chr22_+_19552987 2.27 ENSDART00000105315
hsd11b1la
hydroxysteroid (11-beta) dehydrogenase 1-like a
chr7_-_34448076 2.24 ENSDART00000170935
nr1h3
nuclear receptor subfamily 1, group H, member 3
chr22_-_21897203 2.12 ENSDART00000158501
ENSDART00000105566
ENSDART00000136795
gna11a
guanine nucleotide binding protein (G protein), alpha 11a (Gq class)
chr9_+_48761455 2.06 ENSDART00000139631
abcb11a
ATP-binding cassette, sub-family B (MDR/TAP), member 11a
chr10_-_27049170 2.03 ENSDART00000143451
cnih2
cornichon family AMPA receptor auxiliary protein 2
chr4_-_1801519 2.03 ENSDART00000188604
ENSDART00000135749
nudt4b
nudix (nucleoside diphosphate linked moiety X)-type motif 4b
chr25_+_21833287 2.00 ENSDART00000187606
ckmt1
creatine kinase, mitochondrial 1
chr16_+_40024883 1.94 ENSDART00000110100
hint3
histidine triad nucleotide binding protein 3
chr2_+_50608099 1.82 ENSDART00000185805
ENSDART00000111135
neurod6b
neuronal differentiation 6b
chr21_-_20939488 1.77 ENSDART00000039043
rgs7bpb
regulator of G protein signaling 7 binding protein b
chr21_-_2814709 1.73 ENSDART00000097664
SEMA4D
semaphorin 4D
chr8_-_44926077 1.73 ENSDART00000084417
timm17b
translocase of inner mitochondrial membrane 17 homolog B (yeast)
chr14_-_48765262 1.72 ENSDART00000166463
cnot6b
CCR4-NOT transcription complex, subunit 6b
chr5_+_67390115 1.60 ENSDART00000193255
ebf2
early B cell factor 2
chr9_+_2574122 1.59 ENSDART00000166326
ENSDART00000191822
CIR1
si:ch73-167c12.2
chr6_-_11768198 1.59 ENSDART00000183463
march7
membrane-associated ring finger (C3HC4) 7
chr12_-_35830625 1.53 ENSDART00000180028
CU459056.1

chr22_-_16154771 1.52 ENSDART00000009464
slc30a7
solute carrier family 30 (zinc transporter), member 7
chr4_+_9669717 1.51 ENSDART00000004604
si:dkey-153k10.9
si:dkey-153k10.9
chr21_+_22840246 1.50 ENSDART00000151621
birc2
baculoviral IAP repeat containing 2
chr7_-_52388734 1.48 ENSDART00000174186
wdr93
WD repeat domain 93
chr15_+_5360407 1.45 ENSDART00000110420
or112-1
odorant receptor, family A, subfamily 112, member 1
chr20_+_25586099 1.40 ENSDART00000063122
ENSDART00000134047
cyp2p10
cytochrome P450, family 2, subfamily P, polypeptide 10
chr11_-_1509773 1.34 ENSDART00000050762
phactr3b
phosphatase and actin regulator 3b
chr16_+_46111849 1.33 ENSDART00000172232
sv2a
synaptic vesicle glycoprotein 2A
chr13_-_29420885 1.32 ENSDART00000024225
chata
choline O-acetyltransferase a
chr7_-_30174882 1.31 ENSDART00000110409
frmd5
FERM domain containing 5
chr4_-_5019113 1.24 ENSDART00000189321
ENSDART00000081990
strip2
striatin interacting protein 2
chr3_-_16039619 1.22 ENSDART00000143324
spsb3a
splA/ryanodine receptor domain and SOCS box containing 3a
chr6_+_25261297 1.19 ENSDART00000162824
ENSDART00000163490
ENSDART00000157790
ENSDART00000160978
ENSDART00000161545
ENSDART00000159978
kyat3
kynurenine aminotransferase 3
chr6_+_39905021 1.17 ENSDART00000064904
endou
endonuclease, polyU-specific
chr7_+_38811800 1.17 ENSDART00000052322
zgc:110699
zgc:110699
chr9_+_28598577 1.14 ENSDART00000142623
ENSDART00000135947
si:ch73-7i4.1
si:ch73-7i4.1
chr6_+_25257728 1.14 ENSDART00000162581
kyat3
kynurenine aminotransferase 3
chr14_-_7207961 1.14 ENSDART00000167994
ENSDART00000166532
stox2b
storkhead box 2b
chr12_+_20587179 1.12 ENSDART00000170127
arsg
arylsulfatase G
chr11_+_44617021 1.11 ENSDART00000158887
rbm34
RNA binding motif protein 34
chr6_+_11250316 1.11 ENSDART00000137122
atg9a
ATG9 autophagy related 9 homolog A (S. cerevisiae)
chr22_+_508290 1.11 ENSDART00000135403
nuak2
NUAK family, SNF1-like kinase, 2
chr7_+_23515966 1.10 ENSDART00000186893
ENSDART00000186189
zgc:109889
zgc:109889
chr17_+_24821627 1.10 ENSDART00000112389
wdr43
WD repeat domain 43
chr23_+_16638639 1.09 ENSDART00000143545
snphb
syntaphilin b
chr17_-_25831569 1.08 ENSDART00000148743
hhat
hedgehog acyltransferase
chr12_+_36428052 1.06 ENSDART00000131300
unk
unkempt family zinc finger
chr16_+_25068576 1.06 ENSDART00000125838
im:7147486
im:7147486
chr7_-_57509447 1.04 ENSDART00000051973
ENSDART00000147036
sirt3
sirtuin 3
chr2_+_37140448 1.03 ENSDART00000045016
ENSDART00000142940
pex19
peroxisomal biogenesis factor 19
chr25_-_27722614 1.01 ENSDART00000190154
zgc:153935
zgc:153935
chr5_-_21422390 1.01 ENSDART00000144198
tenm1
teneurin transmembrane protein 1
chr22_+_34784075 1.01 ENSDART00000167538
lcor
ligand dependent nuclear receptor corepressor
chr9_-_27398369 0.99 ENSDART00000186499
tex30
testis expressed 30
chr10_+_11261576 0.98 ENSDART00000155333
hsdl2
hydroxysteroid dehydrogenase like 2
chr17_+_49281597 0.95 ENSDART00000155599
zgc:113176
zgc:113176
chr3_-_48716422 0.94 ENSDART00000164979
si:ch211-114m9.1
si:ch211-114m9.1
chr17_-_40956035 0.93 ENSDART00000124715
si:dkey-16j16.4
si:dkey-16j16.4
chr22_-_36530902 0.91 ENSDART00000056188
polr2h
info polymerase (RNA) II (DNA directed) polypeptide H
chr15_-_40267485 0.91 ENSDART00000152253
kcnj13
potassium inwardly-rectifying channel, subfamily J, member 13
chr24_-_16980337 0.89 ENSDART00000183812
klhl15
kelch-like family member 15
chr1_+_45663727 0.89 ENSDART00000038574
ENSDART00000141144
ENSDART00000149565
trappc5
trafficking protein particle complex 5
chr2_+_2223837 0.89 ENSDART00000101038
ENSDART00000129354
tmie
transmembrane inner ear
chr1_+_51721851 0.88 ENSDART00000040397
prdx2
peroxiredoxin 2
chr5_-_11809710 0.87 ENSDART00000186998
ENSDART00000181363
ENSDART00000180681
nf2a
neurofibromin 2a (merlin)
chr9_+_54039006 0.85 ENSDART00000112441
tlr7
toll-like receptor 7
chr4_+_17655872 0.84 ENSDART00000066999
washc3
WASH complex subunit 3
chr5_-_45877387 0.82 ENSDART00000183714
ENSDART00000041503
slc4a4a
solute carrier family 4 (sodium bicarbonate cotransporter), member 4a
chr4_-_2219705 0.81 ENSDART00000131046
si:ch73-278m9.1
si:ch73-278m9.1
chr16_+_23303859 0.79 ENSDART00000006093
slc50a1
solute carrier family 50 (sugar efflux transporter), member 1
chr17_+_28533102 0.75 ENSDART00000156218
mdga2a
MAM domain containing glycosylphosphatidylinositol anchor 2a
chr5_-_45876908 0.74 ENSDART00000188229
slc4a4a
solute carrier family 4 (sodium bicarbonate cotransporter), member 4a
chr7_-_72261721 0.71 ENSDART00000172229
RASGRP2
RAS guanyl releasing protein 2
chr21_+_27513859 0.70 ENSDART00000065420
pacs1a
phosphofurin acidic cluster sorting protein 1a
chr9_-_32177117 0.70 ENSDART00000078568
sf3b1
splicing factor 3b, subunit 1
chr13_-_38730267 0.68 ENSDART00000157524
lmbrd1
LMBR1 domain containing 1
chr24_+_23202545 0.67 ENSDART00000143862
pex2
peroxisomal biogenesis factor 2
chr20_-_9095105 0.65 ENSDART00000140792
oma1
OMA1 zinc metallopeptidase
chr14_-_470505 0.65 ENSDART00000067147
ANKRD50
ankyrin repeat domain 50
chr20_+_34717403 0.64 ENSDART00000034252
pnocb
prepronociceptin b
chr25_-_28674739 0.63 ENSDART00000067073
lrrc10
leucine rich repeat containing 10
chr4_+_76426308 0.59 ENSDART00000180424
ENSDART00000159789
FP074874.1
zgc:172128

zgc:172128
chr1_+_47499888 0.57 ENSDART00000027624
stn1
STN1, CST complex subunit
chr12_-_31794908 0.57 ENSDART00000105583
ENSDART00000153449
nat9
N-acetyltransferase 9 (GCN5-related, putative)
chr17_-_2386569 0.55 ENSDART00000121614
PLCB2
phospholipase C beta 2
chr20_+_23408970 0.53 ENSDART00000144261
fryl
furry homolog, like
chr25_-_21031007 0.50 ENSDART00000138985
gnaia
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a
chr17_+_22577472 0.49 ENSDART00000045099
yipf4
Yip1 domain family, member 4
chr2_+_29842878 0.47 ENSDART00000131376
si:ch211-207d6.2
si:ch211-207d6.2
chr1_-_31534089 0.46 ENSDART00000007770
lbx1b
ladybird homeobox 1b
chr18_-_5527050 0.45 ENSDART00000145400
ENSDART00000132498
ENSDART00000146209
zgc:153317
zgc:153317
chr20_+_11731039 0.44 ENSDART00000152215
ENSDART00000152585
si:ch211-155o21.3
si:ch211-155o21.3
chr20_-_49889111 0.44 ENSDART00000058858
kif13bb
kinesin family member 13Bb
chr8_-_33381430 0.41 ENSDART00000190019
lmx1bb
LIM homeobox transcription factor 1, beta b
chr14_-_26425416 0.40 ENSDART00000088690
lman2
lectin, mannose-binding 2
chr15_-_22074315 0.40 ENSDART00000149830
drd2a
dopamine receptor D2a
chr15_+_22867174 0.39 ENSDART00000035812
grik4
glutamate receptor, ionotropic, kainate 4
chr5_-_12272689 0.38 ENSDART00000099810
nos1
nitric oxide synthase 1 (neuronal)
chr17_-_4245902 0.38 ENSDART00000151851
gdf3
growth differentiation factor 3
chr1_+_9086942 0.36 ENSDART00000055023
cacng3a
calcium channel, voltage-dependent, gamma subunit 3a
chr19_+_31873308 0.36 ENSDART00000146560
ENSDART00000133045
si:dkeyp-34f6.4
si:dkeyp-34f6.4
chr24_-_35282568 0.35 ENSDART00000167406
ENSDART00000088609
sntg1
syntrophin, gamma 1
chr24_-_7995960 0.35 ENSDART00000186594
bloc1s5
biogenesis of lysosomal organelles complex-1, subunit 5, muted
chr21_-_22635245 0.34 ENSDART00000115224
ENSDART00000101782
nectin1a
nectin cell adhesion molecule 1a
chr17_-_21418340 0.32 ENSDART00000007021
atp6v1ba
ATPase, H+ transporting, lysosomal, V1 subunit B, member a
chr4_+_13449775 0.32 ENSDART00000172552
dyrk2
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
chr1_-_45616470 0.32 ENSDART00000150165
atf7ip
activating transcription factor 7 interacting protein
chr11_+_34760628 0.30 ENSDART00000087216
si:dkey-202e22.2
si:dkey-202e22.2
chr10_-_13343831 0.30 ENSDART00000135941
il11ra
interleukin 11 receptor, alpha
chr18_+_14619544 0.29 ENSDART00000010821
utp4
UTP4, small subunit processome component
chr1_-_5455498 0.29 ENSDART00000040368
ENSDART00000114035
mnx2b
motor neuron and pancreas homeobox 2b
chr1_-_669717 0.28 ENSDART00000160564
cyyr1
cysteine/tyrosine-rich 1
chr21_+_38634296 0.28 ENSDART00000114467
AL935199.1

chr3_+_26288981 0.27 ENSDART00000163500
rhot1a
ras homolog family member T1a
chr2_-_30668580 0.26 ENSDART00000087270
ctnnd2b
catenin (cadherin-associated protein), delta 2b
chr14_+_44794936 0.25 ENSDART00000128881
zgc:195212
zgc:195212
chr1_-_9195629 0.25 ENSDART00000143587
ENSDART00000192174
ern2
endoplasmic reticulum to nucleus signaling 2
chr23_+_12406722 0.24 ENSDART00000145008
pigt
phosphatidylinositol glycan anchor biosynthesis, class T
chr25_+_13621563 0.22 ENSDART00000159428
si:ch211-172l8.4
si:ch211-172l8.4
chr10_-_11353469 0.21 ENSDART00000191847
lin54
lin-54 DREAM MuvB core complex component
chr4_+_19700308 0.20 ENSDART00000027919
pax4
paired box 4
chr25_+_22320738 0.17 ENSDART00000073566
cyp11a1
cytochrome P450, family 11, subfamily A, polypeptide 1
chr1_+_52792439 0.16 ENSDART00000123972
smarca5
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
chr1_+_11882186 0.16 ENSDART00000193419
snx8b
sorting nexin 8b
chr12_-_6880694 0.13 ENSDART00000171846
pcdh15b
protocadherin-related 15b
chr6_+_11250033 0.13 ENSDART00000065411
ENSDART00000132677
atg9a
ATG9 autophagy related 9 homolog A (S. cerevisiae)
chr16_+_28994709 0.12 ENSDART00000088023
gon4l
gon-4-like (C. elegans)
chr11_+_17984167 0.12 ENSDART00000020283
ENSDART00000188329
rpusd4
RNA pseudouridylate synthase domain containing 4
chr24_+_28953089 0.10 ENSDART00000153761
rnpc3
RNA-binding region (RNP1, RRM) containing 3
chr23_-_16485190 0.07 ENSDART00000155038
si:dkeyp-100a5.4
si:dkeyp-100a5.4
chr14_+_1170968 0.06 ENSDART00000125203
ENSDART00000193575
hopx
HOP homeobox
chr21_-_36571804 0.06 ENSDART00000138129
wwc1
WW and C2 domain containing 1
chr15_-_14552101 0.05 ENSDART00000171169
numbl
numb homolog (Drosophila)-like
chr5_+_29851433 0.05 ENSDART00000143434
ubash3ba
ubiquitin associated and SH3 domain containing Ba
chr18_+_7456597 0.02 ENSDART00000142270
terb1
telomere repeat binding bouquet formation protein 1
chr18_+_7456888 0.02 ENSDART00000081468
terb1
telomere repeat binding bouquet formation protein 1
chr1_-_15797663 0.01 ENSDART00000177122
SGCZ
sarcoglycan zeta
chr1_+_39482588 0.01 ENSDART00000181790
tenm3
teneurin transmembrane protein 3
chr4_+_54618332 0.01 ENSDART00000171824
si:ch211-227e10.2
si:ch211-227e10.2
chr6_-_35046735 0.01 ENSDART00000143649
uap1
UDP-N-acetylglucosamine pyrophosphorylase 1
chr20_+_32552912 0.00 ENSDART00000009691
scml4
Scm polycomb group protein like 4

Network of associatons between targets according to the STRING database.

First level regulatory network of otpa+otpb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 9.6 GO:0006572 tyrosine catabolic process(GO:0006572)
1.3 4.0 GO:0097053 L-kynurenine metabolic process(GO:0097052) L-kynurenine catabolic process(GO:0097053)
0.7 2.2 GO:1904478 regulation of intestinal absorption(GO:1904478) regulation of intestinal lipid absorption(GO:1904729)
0.7 4.7 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.5 2.1 GO:0015722 canalicular bile acid transport(GO:0015722) bile acid secretion(GO:0032782)
0.4 1.3 GO:0008292 acetylcholine biosynthetic process(GO:0008292) acetate ester biosynthetic process(GO:1900620)
0.4 2.0 GO:0071543 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.4 1.5 GO:0060546 negative regulation of necroptotic process(GO:0060546) negative regulation of necrotic cell death(GO:0060547)
0.3 3.6 GO:0018120 peptidyl-arginine ADP-ribosylation(GO:0018120)
0.3 27.0 GO:0007599 hemostasis(GO:0007599)
0.3 0.8 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
0.3 1.0 GO:0045046 peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)
0.2 0.7 GO:0021611 facial nerve formation(GO:0021611)
0.2 0.9 GO:0099563 modification of synaptic structure(GO:0099563)
0.2 0.9 GO:0051876 pigment granule dispersal(GO:0051876)
0.2 2.4 GO:0006622 protein targeting to lysosome(GO:0006622)
0.2 1.1 GO:0051659 maintenance of mitochondrion location(GO:0051659)
0.2 2.0 GO:0042396 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.1 3.4 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 0.4 GO:0098924 retrograde trans-synaptic signaling by soluble gas(GO:0098923) retrograde trans-synaptic signaling by nitric oxide(GO:0098924)
0.1 1.2 GO:0044805 late nucleophagy(GO:0044805)
0.1 2.5 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.1 0.3 GO:0044650 virion attachment to host cell(GO:0019062) adhesion of symbiont to host(GO:0044406) adhesion of symbiont to host cell(GO:0044650)
0.1 1.7 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 1.2 GO:0055117 regulation of cardiac muscle contraction(GO:0055117)
0.1 0.7 GO:1990845 adaptive thermogenesis(GO:1990845)
0.1 0.7 GO:0061462 protein localization to lysosome(GO:0061462)
0.1 0.4 GO:0038107 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.1 0.8 GO:0034394 protein localization to cell surface(GO:0034394)
0.1 1.1 GO:0051127 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.1 1.6 GO:0015701 bicarbonate transport(GO:0015701)
0.1 2.4 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.1 0.2 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.1 1.5 GO:0006829 zinc II ion transport(GO:0006829)
0.1 0.3 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.0 5.2 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 1.7 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.9 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.6 GO:0061026 cardiac muscle tissue regeneration(GO:0061026)
0.0 0.4 GO:0072386 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0 0.2 GO:0006700 C21-steroid hormone biosynthetic process(GO:0006700)
0.0 1.0 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.3 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.0 0.3 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.0 9.5 GO:0006486 protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)
0.0 1.1 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.3 GO:0097345 mitochondrial outer membrane permeabilization(GO:0097345)
0.0 0.6 GO:0016233 telomere capping(GO:0016233)
0.0 1.4 GO:0017144 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.0 0.3 GO:0031937 methylation-dependent chromatin silencing(GO:0006346) positive regulation of chromatin silencing(GO:0031937) regulation of methylation-dependent chromatin silencing(GO:0090308) positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.0 1.5 GO:0022900 electron transport chain(GO:0022900)
0.0 1.1 GO:0018345 protein palmitoylation(GO:0018345)
0.0 1.8 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 0.8 GO:0008643 carbohydrate transport(GO:0008643)
0.0 0.0 GO:0097240 telomere localization(GO:0034397) telomere tethering at nuclear periphery(GO:0034398) meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic telomere clustering(GO:0045141) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220) chromosome attachment to the nuclear envelope(GO:0097240)
0.0 0.3 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.0 0.3 GO:0070831 basement membrane assembly(GO:0070831)
0.0 0.6 GO:0071696 ectodermal placode development(GO:0071696)
0.0 0.1 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0031166 integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310)
0.3 0.9 GO:1990072 TRAPPIII protein complex(GO:1990072)
0.2 0.6 GO:1990879 CST complex(GO:1990879)
0.2 0.8 GO:0071203 WASH complex(GO:0071203)
0.2 1.7 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.1 0.4 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.1 1.1 GO:0044295 axonal growth cone(GO:0044295)
0.1 0.3 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1 0.9 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 1.7 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 1.1 GO:0031209 SCAR complex(GO:0031209)
0.0 1.2 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 6.0 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.2 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.8 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 1.5 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.4 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.2 GO:0016589 NURF complex(GO:0016589)
0.0 0.3 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 1.0 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 1.7 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 10.8 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.3 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 10.0 GO:0005794 Golgi apparatus(GO:0005794)
0.0 0.6 GO:0043679 axon terminus(GO:0043679) neuron projection terminus(GO:0044306)
0.0 1.3 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.3 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 1.6 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 19.0 GO:0005615 extracellular space(GO:0005615)
0.0 0.3 GO:0005605 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.0 0.9 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.4 GO:0098978 glutamatergic synapse(GO:0098978)
0.0 0.7 GO:0031225 anchored component of membrane(GO:0031225)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 9.6 GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity(GO:0003868)
1.4 9.5 GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity(GO:0008118)
1.2 17.4 GO:0005504 fatty acid binding(GO:0005504)
0.8 4.0 GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.5 2.1 GO:0015432 canalicular bile acid transmembrane transporter activity(GO:0015126) bile acid-exporting ATPase activity(GO:0015432)
0.4 2.0 GO:0034431 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.4 1.1 GO:1990715 mRNA CDS binding(GO:1990715)
0.3 3.6 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.3 2.6 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.3 0.8 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.2 2.1 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.2 2.0 GO:0004111 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.1 0.9 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.1 1.1 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 7.3 GO:0005507 copper ion binding(GO:0005507)
0.1 1.7 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.1 1.5 GO:0043028 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.1 1.7 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 1.6 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 1.3 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.1 0.5 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.1 0.4 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 1.0 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.1 0.7 GO:0031419 cobalamin binding(GO:0031419)
0.1 2.3 GO:0016229 steroid dehydrogenase activity(GO:0016229)
0.1 16.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 1.0 GO:0070403 NAD+ binding(GO:0070403)
0.1 0.6 GO:0031628 opioid receptor binding(GO:0031628)
0.1 0.2 GO:0008386 cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713)
0.1 0.4 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.1 1.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.6 GO:0043047 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0 5.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.4 GO:0005537 mannose binding(GO:0005537)
0.0 0.8 GO:0051119 sugar transmembrane transporter activity(GO:0051119)
0.0 0.4 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 1.1 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.1 GO:0030626 U12 snRNA binding(GO:0030626)
0.0 1.4 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 1.4 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 1.5 GO:0016651 oxidoreductase activity, acting on NAD(P)H(GO:0016651)
0.0 1.1 GO:0016409 palmitoyltransferase activity(GO:0016409)
0.0 0.4 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 2.5 GO:0005179 hormone activity(GO:0005179)
0.0 2.0 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.0 0.7 GO:0044325 ion channel binding(GO:0044325)
0.0 1.4 GO:0042803 protein homodimerization activity(GO:0042803)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 2.2 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 1.5 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 0.5 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 8.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.1 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.0 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 1.7 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.0 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 7.3 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.3 4.0 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 1.7 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 1.5 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 1.1 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 1.0 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 0.7 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 0.8 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 0.9 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.1 0.5 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 1.5 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 2.2 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 2.4 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.4 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.7 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.4 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 0.9 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.2 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols