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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for otx2b

Z-value: 1.07

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Transcription factors associated with otx2b

Gene Symbol Gene ID Gene Info
otx2b
ENSDARG00000011235 orthodenticle homeobox 2b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
otx2bdr11_v1_chr17_-_44249538_442495380.753.7e-18Click!

Activity profile of otx2b motif

Sorted Z-values of otx2b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr22_+_5103349 21.18 ENSDART00000083474
atcaya
ataxia, cerebellar, Cayman type a
chr16_+_32059785 17.88 ENSDART00000134459
si:dkey-40m6.8
si:dkey-40m6.8
chr2_-_30784198 16.31 ENSDART00000182523
ENSDART00000147355
rgs20
regulator of G protein signaling 20
chr14_-_36378494 15.62 ENSDART00000058503
gpm6aa
glycoprotein M6Aa
chr17_-_12389259 12.62 ENSDART00000185724
snap25b
synaptosomal-associated protein, 25b
chr3_+_34919810 12.54 ENSDART00000055264
ca10b
carbonic anhydrase Xb
chr11_-_29082429 12.53 ENSDART00000041443
igsf21a
immunoglobin superfamily, member 21a
chr14_-_4273396 11.78 ENSDART00000127318
frmpd1b
FERM and PDZ domain containing 1b
chr15_+_33070939 11.43 ENSDART00000164928
mab21l1
mab-21-like 1
chr11_-_29082175 11.42 ENSDART00000123245
igsf21a
immunoglobin superfamily, member 21a
chr11_+_39672874 10.09 ENSDART00000046663
ENSDART00000157659
camta1b
calmodulin binding transcription activator 1b
chr3_+_34220194 9.70 ENSDART00000145859
slc25a23b
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23b
chr6_+_36942966 9.26 ENSDART00000028895
negr1
neuronal growth regulator 1
chr12_-_10275320 9.14 ENSDART00000170078
mpp2b
membrane protein, palmitoylated 2b (MAGUK p55 subfamily member 2)
chr5_-_28625515 9.05 ENSDART00000190782
ENSDART00000179736
ENSDART00000131729
tnc
tenascin C
chr7_-_49594995 8.67 ENSDART00000174161
ENSDART00000109147
brsk2b
BR serine/threonine kinase 2b
chr9_+_13714379 8.43 ENSDART00000017593
ENSDART00000145503
tmem237a
transmembrane protein 237a
chr3_+_15296824 7.87 ENSDART00000043801
cabp5b
calcium binding protein 5b
chr17_-_20979077 7.71 ENSDART00000006676
phyhipla
phytanoyl-CoA 2-hydroxylase interacting protein-like a
chr6_-_20875111 7.70 ENSDART00000115118
ENSDART00000159916
tns1a
tensin 1a
chr16_-_33059246 7.51 ENSDART00000171718
ENSDART00000168305
ENSDART00000166401
snap91
synaptosomal-associated protein 91
chr14_+_34966598 7.48 ENSDART00000004550
rnf145a
ring finger protein 145a
chr15_-_26636826 7.45 ENSDART00000087632
slc47a4
solute carrier family 47 (multidrug and toxin extrusion), member 4
chr7_-_52842605 7.36 ENSDART00000083002
map1aa
microtubule-associated protein 1Aa
chr3_+_1492174 7.10 ENSDART00000112979
sox10
SRY (sex determining region Y)-box 10
chr19_-_9503473 7.01 ENSDART00000091615
iffo1a
intermediate filament family orphan 1a
chr17_+_18117029 6.75 ENSDART00000154646
ENSDART00000179739
bcl11ba
B cell CLL/lymphoma 11Ba
chr12_+_15622621 6.66 ENSDART00000079784
plcd3b
phospholipase C, delta 3b
chr2_+_28995776 6.64 ENSDART00000138733
cdh12a
cadherin 12, type 2a (N-cadherin 2)
chr10_-_21054059 6.50 ENSDART00000139733
pcdh1a
protocadherin 1a
chr25_-_19090479 6.39 ENSDART00000027465
ENSDART00000177670
cacna2d4b
calcium channel, voltage-dependent, alpha 2/delta subunit 4b
chr20_-_20821783 6.29 ENSDART00000152577
ENSDART00000027603
ENSDART00000145601
ckbb
creatine kinase, brain b
chr15_-_18574716 6.20 ENSDART00000142010
ENSDART00000019006
ncam1b
neural cell adhesion molecule 1b
chr17_+_35097024 6.17 ENSDART00000026152
asap2a
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2a
chr5_+_43072951 6.12 ENSDART00000193905
ENSDART00000026020
wdr54
WD repeat domain 54
chr2_-_4797512 6.06 ENSDART00000160765
tnk2b
tyrosine kinase, non-receptor, 2b
chr5_-_28606916 6.05 ENSDART00000026107
ENSDART00000137717
tnc
tenascin C
chr21_+_32339158 6.04 ENSDART00000161723
si:ch211-247j9.1
si:ch211-247j9.1
chr21_+_32338897 5.92 ENSDART00000110137
si:ch211-247j9.1
si:ch211-247j9.1
chr20_-_9963713 5.83 ENSDART00000104234
gjd2b
gap junction protein delta 2b
chr21_-_40782393 5.82 ENSDART00000075808
apbb3
amyloid beta (A4) precursor protein-binding, family B, member 3
chr12_+_25640480 5.78 ENSDART00000105608
prkcea
protein kinase C, epsilon a
chr2_+_25929619 5.74 ENSDART00000137746
slc7a14a
solute carrier family 7, member 14a
chr19_-_8880688 5.52 ENSDART00000039629
celf3a
cugbp, Elav-like family member 3a
chr1_-_16507812 5.42 ENSDART00000169081
mtmr7b
myotubularin related protein 7b
chr23_-_7125494 5.33 ENSDART00000111929
slco4a1
solute carrier organic anion transporter family, member 4A1
chr12_+_41991635 5.26 ENSDART00000186161
ENSDART00000192510
TCERG1L
transcription elongation regulator 1 like
chr25_-_7925269 5.18 ENSDART00000014274
glcea
glucuronic acid epimerase a
chr25_-_7925019 5.12 ENSDART00000183309
glcea
glucuronic acid epimerase a
chr3_-_32170850 5.10 ENSDART00000055307
ENSDART00000157366
tnnt1
troponin T type 1 (skeletal, slow)
chr11_+_25010491 5.09 ENSDART00000167285
zgc:92107
zgc:92107
chr5_-_14390445 5.02 ENSDART00000026120
ap3m2
adaptor-related protein complex 3, mu 2 subunit
chr24_+_24923166 4.98 ENSDART00000065288
pcyt1ba
phosphate cytidylyltransferase 1, choline, beta a
chr3_-_28665291 4.90 ENSDART00000151670
fbxl16
F-box and leucine-rich repeat protein 16
chr11_-_29563437 4.88 ENSDART00000163958
arhgef10la
Rho guanine nucleotide exchange factor (GEF) 10-like a
chr17_+_25289431 4.76 ENSDART00000161002
kbtbd11
kelch repeat and BTB (POZ) domain containing 11
chr13_+_1089942 4.66 ENSDART00000054322
cnrip1b
cannabinoid receptor interacting protein 1b
chr14_-_32503363 4.60 ENSDART00000034883
mcf2a
MCF.2 cell line derived transforming sequence a
chr2_-_1569250 4.58 ENSDART00000167202
dab1b
Dab, reelin signal transducer, homolog 1b (Drosophila)
chr1_-_20273227 4.39 ENSDART00000146084
ndst3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr11_-_27702778 4.38 ENSDART00000045942
ENSDART00000125352
phf2
PHD finger protein 2
chr2_-_48171441 4.29 ENSDART00000123040
pfkpb
phosphofructokinase, platelet b
chr7_+_30970045 4.24 ENSDART00000155974
tjp1a
tight junction protein 1a
chr13_-_36525982 4.12 ENSDART00000114744
pacs2
phosphofurin acidic cluster sorting protein 2
chr16_-_37372613 4.11 ENSDART00000124090
si:ch211-208k15.1
si:ch211-208k15.1
chr18_+_7639401 4.11 ENSDART00000092416
rabl2
RAB, member of RAS oncogene family-like 2
chr7_-_18656069 3.99 ENSDART00000021559
coro1b
coronin, actin binding protein, 1B
chr16_+_11151699 3.99 ENSDART00000140674
cicb
capicua transcriptional repressor b
chr12_+_39685485 3.89 ENSDART00000163403
LO017650.1

chr20_-_16156419 3.88 ENSDART00000037420
ralgps2
Ral GEF with PH domain and SH3 binding motif 2
chr6_+_32415132 3.87 ENSDART00000155790
kank4
KN motif and ankyrin repeat domains 4
chr17_-_31058900 3.86 ENSDART00000134998
ENSDART00000104307
ENSDART00000172721
eml1
echinoderm microtubule associated protein like 1
chr5_+_59494079 3.84 ENSDART00000148727
gtf2ird1
GTF2I repeat domain containing 1
chr2_-_16217344 3.84 ENSDART00000152031
arhgef4
Rho guanine nucleotide exchange factor (GEF) 4
chr7_-_64770456 3.67 ENSDART00000192618
zdhhc21
zinc finger, DHHC-type containing 21
chr7_-_41489822 3.66 ENSDART00000006724
smarcd3b
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3b
chr10_-_7988396 3.63 ENSDART00000141445
ENSDART00000024282
ewsr1a
EWS RNA-binding protein 1a
chr5_+_34981584 3.61 ENSDART00000134795
ankra2
ankyrin repeat, family A (RFXANK-like), 2
chr16_+_24684107 3.36 ENSDART00000183920
ywhabl
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like
chr5_-_27994679 3.25 ENSDART00000132740
ppp3cca
protein phosphatase 3, catalytic subunit, gamma isozyme, a
chr19_+_2631565 3.21 ENSDART00000171487
fam126a
family with sequence similarity 126, member A
chr11_-_4235811 3.18 ENSDART00000121716
si:ch211-236d3.4
si:ch211-236d3.4
chr9_-_18568927 3.17 ENSDART00000084668
enox1
ecto-NOX disulfide-thiol exchanger 1
chr3_-_33574576 3.16 ENSDART00000184881
CR847537.1

chr7_-_41489997 3.10 ENSDART00000174300
smarcd3b
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3b
chr2_+_11923824 3.02 ENSDART00000153873
trove2
TROVE domain family, member 2
chr17_+_10593398 3.01 ENSDART00000168897
ENSDART00000193989
ENSDART00000191664
ENSDART00000167188
mapkbp1
mitogen-activated protein kinase binding protein 1
chr8_-_25566347 2.95 ENSDART00000138289
ENSDART00000078022
prex1
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
chr18_+_49969568 2.92 ENSDART00000126916
mob2b
MOB kinase activator 2b
chr16_+_42829735 2.90 ENSDART00000014956
polr3glb
polymerase (RNA) III (DNA directed) polypeptide G like b
chr15_-_15469079 2.87 ENSDART00000132637
ENSDART00000004220
rab34a
RAB34, member RAS oncogene family a
chr18_+_10784730 2.87 ENSDART00000028938
mical3a
microtubule associated monooxygenase, calponin and LIM domain containing 3a
chr10_+_29963518 2.85 ENSDART00000011317
ENSDART00000099964
ENSDART00000182990
ENSDART00000113912
ntm
neurotrimin
chr10_+_4095917 2.80 ENSDART00000114533
mn1a
meningioma 1a
chr25_-_16818195 2.80 ENSDART00000185215
dyrk4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr4_-_9173552 2.75 ENSDART00000042963
chst11
carbohydrate (chondroitin 4) sulfotransferase 11
chr13_+_17468161 2.71 ENSDART00000008906
znf503
zinc finger protein 503
chr5_+_37290260 2.66 ENSDART00000113642
zgc:163098
zgc:163098
chr7_+_38395197 2.66 ENSDART00000138669
cep89
centrosomal protein 89
chr16_+_42830152 2.57 ENSDART00000159730
polr3glb
polymerase (RNA) III (DNA directed) polypeptide G like b
chr17_-_50010121 2.56 ENSDART00000122747
tmem30aa
transmembrane protein 30Aa
chr9_+_26103814 2.52 ENSDART00000026011
efnb2a
ephrin-B2a
chr25_+_33002963 2.49 ENSDART00000187366
CABZ01046980.1

chr7_+_39011355 2.46 ENSDART00000173855
dgkza
diacylglycerol kinase, zeta a
chr1_-_39909985 2.44 ENSDART00000181673
stox2a
storkhead box 2a
chr12_+_11080776 2.43 ENSDART00000079336
raraa
retinoic acid receptor, alpha a
chr5_+_37290586 2.43 ENSDART00000122919
zgc:163098
zgc:163098
chr15_+_37559570 2.41 ENSDART00000085522
hspb6
heat shock protein, alpha-crystallin-related, b6
chr1_-_17650223 2.38 ENSDART00000043484
si:dkey-256e7.5
si:dkey-256e7.5
chr23_-_28294763 2.32 ENSDART00000139537
znf385a
zinc finger protein 385A
chr1_+_33383644 2.25 ENSDART00000187194
dhrsx
dehydrogenase/reductase (SDR family) X-linked
chr13_-_36184701 2.21 ENSDART00000146522
map3k9
mitogen-activated protein kinase kinase kinase 9
chr14_-_30587814 2.19 ENSDART00000144912
ENSDART00000149714
tmem265
transmembrane protein 265
chr24_-_1303935 2.19 ENSDART00000159212
ENSDART00000159267
ENSDART00000164904
nrp1a
neuropilin 1a
chr3_-_61593274 2.14 ENSDART00000154132
ENSDART00000055071
nptx2a
neuronal pentraxin 2a
chr14_-_46395408 2.10 ENSDART00000147537
bbs7
Bardet-Biedl syndrome 7
chr16_+_14710436 2.01 ENSDART00000027982
col14a1a
collagen, type XIV, alpha 1a
chr7_-_12821277 1.99 ENSDART00000091584
zgc:158785
zgc:158785
chr4_+_1722899 1.97 ENSDART00000021139
fgfr1op2
FGFR1 oncogene partner 2
chr1_-_26293203 1.95 ENSDART00000180140
cxxc4
CXXC finger 4
chr14_-_29799993 1.92 ENSDART00000133775
ENSDART00000005568
pdlim3b
PDZ and LIM domain 3b
chr9_-_32343673 1.88 ENSDART00000078499
rftn2
raftlin family member 2
chr3_-_30885250 1.80 ENSDART00000109104
kmt5c
lysine methyltransferase 5C
chr15_-_15468326 1.75 ENSDART00000161192
rab34a
RAB34, member RAS oncogene family a
chr25_-_16818380 1.63 ENSDART00000155401
dyrk4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr8_+_14381272 1.62 ENSDART00000057642
acbd6
acyl-CoA binding domain containing 6
chr1_-_11075403 1.61 ENSDART00000102903
ENSDART00000170290
dmd
dystrophin
chr22_+_30184039 1.60 ENSDART00000049075
add3a
adducin 3 (gamma) a
chr11_-_3860199 1.58 ENSDART00000082420
gata2a
GATA binding protein 2a
chr10_-_25561751 1.55 ENSDART00000147089
grik1a
glutamate receptor, ionotropic, kainate 1a
chrM_+_15308 1.49 ENSDART00000093625
mt-cyb
cytochrome b, mitochondrial
chr3_-_28828242 1.48 ENSDART00000151445
si:ch211-76l23.4
si:ch211-76l23.4
chr25_-_18913336 1.47 ENSDART00000171010
parietopsin
parietopsin
chr18_+_5172848 1.45 ENSDART00000190642
CABZ01080599.1

chr25_+_29688671 1.37 ENSDART00000073478
brd1b
bromodomain containing 1b
chr14_-_32089117 1.36 ENSDART00000158014
si:ch211-69b22.5
si:ch211-69b22.5
chr25_-_35996141 1.36 ENSDART00000149074
sall1b
spalt-like transcription factor 1b
chr5_-_17876709 1.35 ENSDART00000141978
si:dkey-112e17.1
si:dkey-112e17.1
chr21_-_28235361 1.32 ENSDART00000164458
nrxn2a
neurexin 2a
chr2_-_48171112 1.30 ENSDART00000156258
pfkpb
phosphofructokinase, platelet b
chr14_+_14847745 1.29 ENSDART00000189302
ENSDART00000188336
ccdc142
coiled-coil domain containing 142
chr19_+_43884120 1.29 ENSDART00000139684
ENSDART00000142312
lypla2
lysophospholipase II
chr6_-_17999776 1.27 ENSDART00000183048
ENSDART00000181577
ENSDART00000170597
rptor
regulatory associated protein of MTOR, complex 1
chr13_+_31205439 1.26 ENSDART00000132326
ptpn20
protein tyrosine phosphatase, non-receptor type 20
chr11_+_2506516 1.22 ENSDART00000130886
ENSDART00000189767
NABP2
si:ch73-190f16.2
chr15_+_29116063 1.18 ENSDART00000016112
ENSDART00000153609
ENSDART00000155630
capns1b
calpain, small subunit 1 b
chr12_+_17042754 1.10 ENSDART00000066439
ch25h
cholesterol 25-hydroxylase
chr10_-_18468385 1.10 ENSDART00000183302
si:dkey-28o19.1
si:dkey-28o19.1
chr9_-_8454060 1.06 ENSDART00000110158
irs2b
insulin receptor substrate 2b
chr5_-_38107741 1.04 ENSDART00000156853
si:ch211-284e13.14
si:ch211-284e13.14
chr7_+_57866292 1.04 ENSDART00000138757
camk2d1
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1
chr24_-_18877118 0.97 ENSDART00000092783
arfgef1
ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
chr20_-_16548912 0.97 ENSDART00000137601
ches1
checkpoint suppressor 1
chr14_-_2400668 0.96 ENSDART00000172717
ENSDART00000182882
si:ch73-233f7.1
si:ch73-233f7.1
chr24_+_3478871 0.94 ENSDART00000111491
ENSDART00000134598
ENSDART00000142407
wdr37
WD repeat domain 37
chr11_-_40257225 0.94 ENSDART00000139009
TRIM62 (1 of many)
si:ch211-193i15.2
chr9_-_48184823 0.93 ENSDART00000180264
klhl23
kelch-like family member 23
chr14_+_14847304 0.93 ENSDART00000169932
ccdc142
coiled-coil domain containing 142
chr20_-_34768301 0.92 ENSDART00000142482
paqr8
progestin and adipoQ receptor family member VIII
chr20_+_16721933 0.91 ENSDART00000063950
psmc1b
proteasome 26S subunit, ATPase 1b
chr24_-_18876877 0.88 ENSDART00000186269
arfgef1
ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
chr21_-_41369370 0.88 ENSDART00000159290
cpeb4b
cytoplasmic polyadenylation element binding protein 4b
chr4_-_5077158 0.86 ENSDART00000155915
ahcyl2
adenosylhomocysteinase-like 2
chr7_+_39011852 0.82 ENSDART00000093009
dgkza
diacylglycerol kinase, zeta a
chr14_-_2933185 0.81 ENSDART00000161677
ENSDART00000162446
ENSDART00000109378
si:dkey-201i24.6
si:dkey-201i24.6
chr11_-_16215143 0.76 ENSDART00000027014
rab7
RAB7, member RAS oncogene family
chr3_+_23703704 0.74 ENSDART00000024256
hoxb6a
homeobox B6a
chr13_-_47800342 0.73 ENSDART00000121817
fbln7
fibulin 7
chr9_+_11034967 0.72 ENSDART00000152081
asic4a
acid-sensing (proton-gated) ion channel family member 4a
chr2_+_31476065 0.72 ENSDART00000049219
cacnb2b
calcium channel, voltage-dependent, beta 2b
chr16_+_29376751 0.71 ENSDART00000168856
ENSDART00000162502
ENSDART00000050535
rrnad1
ribosomal RNA adenine dimethylase domain containing 1
chr25_+_19753890 0.69 ENSDART00000190268
ENSDART00000128852
celsr1b
cadherin EGF LAG seven-pass G-type receptor 1b
chr23_-_27050083 0.68 ENSDART00000142324
ENSDART00000133249
ENSDART00000138751
ENSDART00000128718
zgc:66440
zgc:66440
chr22_-_35006554 0.67 ENSDART00000138639
kcnip2
Kv channel interacting protein 2
chr13_-_50614639 0.67 ENSDART00000170527
vent
ventral expressed homeobox
chr16_+_16265850 0.66 ENSDART00000181265
setd2
SET domain containing 2
chr16_+_3067134 0.65 ENSDART00000012048
cyb5r4
cytochrome b5 reductase 4
chr11_-_3860534 0.64 ENSDART00000082425
gata2a
GATA binding protein 2a
chr2_+_30878864 0.63 ENSDART00000009326
oprk1
opioid receptor, kappa 1
chr18_+_19006063 0.60 ENSDART00000135729
slc24a1
solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
chr2_-_50272077 0.58 ENSDART00000127623
cul1a
cullin 1a
chr23_-_3759692 0.55 ENSDART00000028885
hmga1a
high mobility group AT-hook 1a
chr1_+_44523516 0.37 ENSDART00000147702
zdhhc5a
zinc finger, DHHC-type containing 5a
chr14_-_25034142 0.34 ENSDART00000000392
pde6a
phosphodiesterase 6A, cGMP-specific, rod, alpha
chr5_-_14344647 0.33 ENSDART00000188456
tet3
tet methylcytosine dioxygenase 3
chr10_+_9222476 0.32 ENSDART00000064973
ENSDART00000145879
paqr3b
progestin and adipoQ receptor family member IIIb
chr7_-_35516251 0.30 ENSDART00000045628
irx6a
iroquois homeobox 6a
chr12_-_35582521 0.28 ENSDART00000162175
ENSDART00000168958
sec24c
SEC24 homolog C, COPII coat complex component
chr7_+_66884291 0.24 ENSDART00000187499
sbf2
SET binding factor 2
chr18_-_19005919 0.24 ENSDART00000129776
ints14
integrator complex subunit 14
chr2_-_9744081 0.18 ENSDART00000097732
dvl3a
dishevelled segment polarity protein 3a
chr17_-_21617618 0.13 ENSDART00000109031
gpr26
G protein-coupled receptor 26
chr6_-_36795111 0.12 ENSDART00000160669
ENSDART00000104256
ENSDART00000187751
ENSDART00000161928
ENSDART00000183264
opa1
optic atrophy 1 (autosomal dominant)
chr17_+_16564921 0.12 ENSDART00000151904
foxn3
forkhead box N3
chr12_-_35582683 0.11 ENSDART00000167933
sec24c
SEC24 homolog C, COPII coat complex component
chr7_-_17780048 0.11 ENSDART00000183336
si:dkey-106g10.7
si:dkey-106g10.7
chr20_-_34754617 0.10 ENSDART00000148066
znf395b
zinc finger protein 395b
chr14_+_21754521 0.09 ENSDART00000111839
kdm2ab
lysine (K)-specific demethylase 2Ab
chr16_+_37876779 0.09 ENSDART00000140148
si:ch211-198c19.1
si:ch211-198c19.1
chr2_-_38337122 0.09 ENSDART00000076523
ENSDART00000187473
slc7a8b
solute carrier family 7 (amino acid transporter light chain, L system), member 8b

Network of associatons between targets according to the STRING database.

First level regulatory network of otx2b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.0 15.1 GO:0014814 regulation of synaptic growth at neuromuscular junction(GO:0008582) axon regeneration at neuromuscular junction(GO:0014814) positive regulation of synaptic growth at neuromuscular junction(GO:0045887)
2.0 12.0 GO:0035313 wound healing, spreading of epidermal cells(GO:0035313) negative regulation of ruffle assembly(GO:1900028)
1.9 21.2 GO:0006798 polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
1.5 4.4 GO:0061188 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
1.2 14.7 GO:0030202 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.9 3.6 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.9 12.6 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.8 6.8 GO:0032986 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.7 2.2 GO:1902895 pri-miRNA transcription from RNA polymerase II promoter(GO:0061614) regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902893) positive regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902895)
0.7 5.1 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.7 24.0 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.6 3.2 GO:0007624 ultradian rhythm(GO:0007624)
0.6 1.8 GO:0034773 histone H4-K20 methylation(GO:0034770) histone H4-K20 trimethylation(GO:0034773)
0.6 4.6 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.6 4.6 GO:0097476 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
0.5 7.1 GO:0050936 xanthophore differentiation(GO:0050936)
0.5 4.7 GO:2000272 negative regulation of receptor activity(GO:2000272)
0.5 5.6 GO:0061621 glucose catabolic process(GO:0006007) NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.5 2.5 GO:0007412 axon target recognition(GO:0007412)
0.5 6.3 GO:0006599 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.4 2.2 GO:0007508 larval development(GO:0002164) larval heart development(GO:0007508) angiogenesis involved in wound healing(GO:0060055)
0.4 4.2 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.4 6.4 GO:0046549 retinal cone cell development(GO:0046549)
0.4 4.9 GO:0071501 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.4 3.9 GO:0036368 cone photoresponse recovery(GO:0036368)
0.3 5.5 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.3 7.4 GO:0031114 regulation of microtubule depolymerization(GO:0031114)
0.3 5.3 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.3 7.5 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.2 12.5 GO:0036269 swimming behavior(GO:0036269)
0.2 8.7 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.2 0.6 GO:0060292 long term synaptic depression(GO:0060292)
0.2 2.1 GO:0051877 pigment granule aggregation in cell center(GO:0051877)
0.2 6.6 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.2 5.5 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.2 2.7 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.2 0.6 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.1 1.5 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.1 2.9 GO:0030042 actin filament depolymerization(GO:0030042)
0.1 3.3 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.1 1.6 GO:0007525 somatic muscle development(GO:0007525)
0.1 4.0 GO:0060319 primitive erythrocyte differentiation(GO:0060319)
0.1 0.7 GO:0097198 histone H3-K36 trimethylation(GO:0097198)
0.1 5.4 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.1 1.3 GO:0098734 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.1 2.9 GO:0038092 nodal signaling pathway(GO:0038092)
0.1 1.4 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.1 3.3 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 6.7 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.1 2.4 GO:0032526 response to retinoic acid(GO:0032526)
0.1 1.7 GO:0043507 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.1 2.6 GO:0045332 phospholipid translocation(GO:0045332)
0.1 5.5 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 2.0 GO:0070831 basement membrane assembly(GO:0070831)
0.1 8.4 GO:0060027 convergent extension involved in gastrulation(GO:0060027)
0.1 4.4 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.1 0.3 GO:0032656 5-methylcytosine catabolic process(GO:0006211) 5-methylcytosine metabolic process(GO:0019857) interleukin-13 production(GO:0032616) regulation of interleukin-13 production(GO:0032656)
0.1 0.7 GO:0042661 regulation of mesodermal cell fate specification(GO:0042661)
0.0 1.3 GO:0071230 cellular response to amino acid stimulus(GO:0071230)
0.0 3.9 GO:0032272 negative regulation of actin filament polymerization(GO:0030837) negative regulation of protein polymerization(GO:0032272)
0.0 1.9 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 3.2 GO:0051017 actin filament bundle assembly(GO:0051017)
0.0 2.2 GO:0046854 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.0 1.1 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.0 4.8 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.0 2.1 GO:0051966 regulation of synaptic transmission, glutamatergic(GO:0051966)
0.0 0.2 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 2.2 GO:0048596 embryonic camera-type eye morphogenesis(GO:0048596)
0.0 1.1 GO:0016126 sterol biosynthetic process(GO:0016126)
0.0 3.1 GO:0006865 amino acid transport(GO:0006865)
0.0 1.3 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 1.1 GO:0035249 synaptic transmission, glutamatergic(GO:0035249)
0.0 0.7 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 0.2 GO:0042249 establishment of planar polarity of embryonic epithelium(GO:0042249) establishment of planar polarity involved in neural tube closure(GO:0090177) regulation of establishment of planar polarity involved in neural tube closure(GO:0090178) planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.0 0.1 GO:0003373 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.0 0.4 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.7 GO:0000154 rRNA modification(GO:0000154)
0.0 0.4 GO:0018345 protein palmitoylation(GO:0018345)
0.0 4.7 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 13.3 GO:0031175 neuron projection development(GO:0031175)
0.0 4.0 GO:0007015 actin filament organization(GO:0007015)
0.0 3.9 GO:0045087 innate immune response(GO:0045087)
0.0 1.7 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 12.6 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
1.3 15.6 GO:0044295 axonal growth cone(GO:0044295)
0.7 7.5 GO:0098833 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894)
0.5 3.2 GO:0005955 calcineurin complex(GO:0005955)
0.5 5.6 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.4 5.8 GO:0005922 connexon complex(GO:0005922)
0.4 6.8 GO:0071564 npBAF complex(GO:0071564)
0.3 2.1 GO:0034464 BBSome(GO:0034464)
0.3 2.0 GO:0005614 interstitial matrix(GO:0005614)
0.2 5.5 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.2 5.0 GO:0030131 clathrin adaptor complex(GO:0030131)
0.2 1.3 GO:0031931 TORC1 complex(GO:0031931)
0.1 1.5 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.1 5.1 GO:0005861 troponin complex(GO:0005861)
0.1 7.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 5.1 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 20.9 GO:0005912 adherens junction(GO:0005912)
0.1 1.4 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1 1.6 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 2.8 GO:0031970 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.1 5.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 5.6 GO:0005882 intermediate filament(GO:0005882)
0.1 3.9 GO:0072686 mitotic spindle(GO:0072686)
0.1 4.4 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.1 7.3 GO:0043025 neuronal cell body(GO:0043025)
0.0 0.3 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 5.7 GO:0005765 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 0.9 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 3.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 9.7 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 2.7 GO:0005923 bicellular tight junction(GO:0005923) apical junction complex(GO:0043296) occluding junction(GO:0070160)
0.0 9.9 GO:0000139 Golgi membrane(GO:0000139)
0.0 2.9 GO:0030658 transport vesicle membrane(GO:0030658)
0.0 8.6 GO:0005794 Golgi apparatus(GO:0005794)
0.0 4.3 GO:0005813 centrosome(GO:0005813)
0.0 5.8 GO:0030054 cell junction(GO:0030054)
0.0 0.2 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 1.6 GO:0014069 postsynaptic density(GO:0014069)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)
0.0 13.3 GO:0005856 cytoskeleton(GO:0005856)
0.0 0.9 GO:0000502 proteasome complex(GO:0000502)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 10.3 GO:0047464 heparosan-N-sulfate-glucuronate 5-epimerase activity(GO:0047464)
1.9 21.2 GO:0004309 exopolyphosphatase activity(GO:0004309)
1.2 5.8 GO:0055077 gap junction hemi-channel activity(GO:0055077)
1.0 5.0 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.6 1.8 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.6 7.5 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.5 2.7 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
0.5 4.4 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.5 3.2 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.5 5.6 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.5 6.3 GO:0016775 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.5 7.4 GO:0042910 xenobiotic transporter activity(GO:0042910)
0.4 12.5 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.4 8.5 GO:0050321 tau-protein kinase activity(GO:0050321)
0.3 12.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.3 1.5 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.3 4.4 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.3 5.3 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.2 10.5 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.2 5.8 GO:0001540 beta-amyloid binding(GO:0001540)
0.2 5.8 GO:0004697 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.2 5.4 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.2 1.7 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.2 6.7 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.2 9.7 GO:0005347 ATP transmembrane transporter activity(GO:0005347)
0.2 2.2 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.2 3.5 GO:0005523 tropomyosin binding(GO:0005523)
0.2 1.1 GO:0000254 C-4 methylsterol oxidase activity(GO:0000254)
0.2 0.9 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.1 0.7 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.1 3.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 1.7 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 2.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 1.4 GO:0010484 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.1 1.3 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.1 11.4 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.1 1.9 GO:0051371 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.1 0.6 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 1.1 GO:0005158 insulin receptor binding(GO:0005158)
0.1 7.1 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 3.7 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 0.9 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.1 4.1 GO:0044325 ion channel binding(GO:0044325)
0.1 0.6 GO:0004985 opioid receptor activity(GO:0004985)
0.1 0.6 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.1 2.7 GO:0070491 repressing transcription factor binding(GO:0070491)
0.1 1.3 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 0.7 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.1 1.6 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.1 2.9 GO:0071949 FAD binding(GO:0071949)
0.1 12.1 GO:0042802 identical protein binding(GO:0042802)
0.1 18.0 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 0.7 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.3 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.0 0.1 GO:1901612 cardiolipin binding(GO:1901612)
0.0 13.9 GO:0005096 GTPase activator activity(GO:0005096)
0.0 1.1 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 11.2 GO:0008017 microtubule binding(GO:0008017)
0.0 12.5 GO:0000989 transcription factor activity, transcription factor binding(GO:0000989) transcription cofactor activity(GO:0003712)
0.0 3.1 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.0 1.5 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.0 0.3 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 3.6 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 1.0 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 2.4 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.0 8.5 GO:0003924 GTPase activity(GO:0003924)
0.0 3.4 GO:0004497 monooxygenase activity(GO:0004497)
0.0 5.7 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 12.9 GO:0008270 zinc ion binding(GO:0008270)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 15.1 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.4 16.3 ST G ALPHA I PATHWAY G alpha i Pathway
0.2 3.8 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.1 3.6 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.1 2.9 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.1 1.9 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.3 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 1.3 PID LKB1 PATHWAY LKB1 signaling events
0.0 1.7 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 2.3 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 5.3 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.4 16.3 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.3 4.4 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.3 3.7 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.2 6.7 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.2 2.7 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 6.8 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 1.3 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 1.1 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS Genes involved in Synthesis of bile acids and bile salts
0.1 2.0 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 3.5 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.3 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.4 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC