ISMARA results: pax2a+pax5

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for pax2a+pax5

Z-value: 2.87

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Transcription factors associated with pax2a+pax5

Gene Symbol	Gene ID	Gene Info
pax2a NCBI UniProt	ENSDARG00000028148	paired box 2a
pax5 NCBI UniProt	ENSDARG00000037383	paired box 5

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
pax2a	dr11_v1_chr13_+_29773153_29773153	0.49	5.6e-07	Click!
pax5	dr11_v1_chr1_+_21731382_21731382	0.36	4.3e-04	Click!

Activity profile of pax2a+pax5 motif

Sorted Z-values of pax2a+pax5 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr7_+_29952169 Show fit	63.05	ENSDART00000173540 ENSDART00000173940 ENSDART00000173906 ENSDART00000173772 ENSDART00000173506 ENSDART00000039657	tpma NCBI UniProt Show fit	alpha-tropomyosin
chr7_+_29951997 Show fit	61.01	ENSDART00000173453	tpma NCBI UniProt Show fit	alpha-tropomyosin
chr7_+_29952719 Show fit	40.49	ENSDART00000173737	tpma NCBI UniProt Show fit	alpha-tropomyosin
chr7_+_29955368 Show fit	28.90	ENSDART00000173686	tpma NCBI UniProt Show fit	alpha-tropomyosin
chr3_-_61205711 Show fit	27.64	ENSDART00000055062	pvalb1 NCBI UniProt Show fit	parvalbumin 1
chr9_-_12034444 Show fit	27.27	ENSDART00000038651	znf804a NCBI UniProt Show fit	zinc finger protein 804A
chr24_-_40731305 Show fit	23.98	ENSDART00000172073	CU633479.6 NCBI UniProt Show fit
chr12_+_13256415 Show fit	23.52	ENSDART00000144542	atp2a1l NCBI UniProt Show fit	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like
chr3_-_46818001 Show fit	20.15	ENSDART00000166505	elavl3 NCBI UniProt Show fit	ELAV like neuron-specific RNA binding protein 3
chr25_+_33192796 Show fit	19.41	ENSDART00000125892 ENSDART00000121680 ENSDART00000014851	TPM1 (1 of many) NCBI UniProt Show fit	zgc:171719

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of pax2a+pax5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.8	187.9	GO:0061515	myeloid cell development(GO:0061515)
1.4	33.7	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.2	32.6	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.8	32.2	GO:0021761	limbic system development(GO:0021761) hypothalamus development(GO:0021854)
3.1	30.9	GO:1904071	presynaptic active zone assembly(GO:1904071)
0.1	30.9	GO:0050767	regulation of neurogenesis(GO:0050767)
0.2	30.1	GO:0070588	calcium ion transmembrane transport(GO:0070588)
0.2	24.1	GO:0051260	protein homooligomerization(GO:0051260)
2.2	23.8	GO:0030240	skeletal muscle thin filament assembly(GO:0030240)
4.3	21.3	GO:0034653	diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)

Showing 1 to 10 of 355 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.5	180.0	GO:0005884	actin filament(GO:0005884)
0.0	99.9	GO:0005634	nucleus(GO:0005634)
0.1	62.9	GO:0043005	neuron projection(GO:0043005)
0.6	59.5	GO:0043025	neuronal cell body(GO:0043025)
2.7	56.2	GO:0031430	M band(GO:0031430)
0.5	55.6	GO:0005882	intermediate filament(GO:0005882)
0.2	34.0	GO:0070382	exocytic vesicle(GO:0070382)
0.2	31.8	GO:0045211	postsynaptic membrane(GO:0045211)
3.1	30.9	GO:0098982	GABA-ergic synapse(GO:0098982)
1.4	29.9	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)

Showing 1 to 10 of 149 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	186.8	GO:0042803	protein homodimerization activity(GO:0042803)
0.1	84.1	GO:0005509	calcium ion binding(GO:0005509)
0.0	80.7	GO:0003700	nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.2	59.4	GO:0051015	actin filament binding(GO:0051015)
0.2	54.9	GO:0015631	tubulin binding(GO:0015631)
0.1	47.4	GO:0061630	ubiquitin protein ligase activity(GO:0061630)
0.1	42.5	GO:0044822	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0	34.0	GO:0003723	RNA binding(GO:0003723)
1.9	32.7	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.7	32.2	GO:0017022	myosin binding(GO:0017022)

Showing 1 to 10 of 245 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	27.5	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.3	14.1	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.3	13.3	PID ILK PATHWAY	Integrin-linked kinase signaling
0.8	11.3	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.4	9.5	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1	9.4	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.4	9.2	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.2	9.0	PID LKB1 PATHWAY	LKB1 signaling events
0.5	8.1	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.6	8.0	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events

Showing 1 to 10 of 52 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	32.5	REACTOME LIGAND GATED ION CHANNEL TRANSPORT	Genes involved in Ligand-gated ion channel transport
0.5	18.5	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.7	17.9	REACTOME KERATAN SULFATE BIOSYNTHESIS	Genes involved in Keratan sulfate biosynthesis
0.1	17.8	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.9	15.2	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.5	12.9	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
1.0	11.3	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.2	11.0	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.6	10.8	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.7	9.2	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors

Showing 1 to 10 of 65 entries

Results for pax2a+pax5

Z-value: 2.87

Motif logo

Transcription factors associated with pax2a+pax5

Activity-expression correlation:

Activity profile of pax2a+pax5 motif

Sorted Z-values of pax2a+pax5 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of pax2a+pax5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: