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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for pax3a+pax3b

Z-value: 0.59

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Transcription factors associated with pax3a+pax3b

Gene Symbol Gene ID Gene Info
pax3a
ENSDARG00000010192 paired box 3a
pax3b
ENSDARG00000028348 paired box 3b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
pax3adr11_v1_chr2_-_47431205_47431205-0.637.2e-12Click!
pax3bdr11_v1_chr15_-_42206890_42206890-0.348.8e-04Click!

Activity profile of pax3a+pax3b motif

Sorted Z-values of pax3a+pax3b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_320153 8.01 ENSDART00000161493
akt2l
v-akt murine thymoma viral oncogene homolog 2, like
chr2_-_53481912 7.30 ENSDART00000189610
hsd11b1lb
hydroxysteroid (11-beta) dehydrogenase 1-like b
chr23_+_44611864 5.65 ENSDART00000145905
ENSDART00000132361
eno3
enolase 3, (beta, muscle)
chr1_-_59348118 4.79 ENSDART00000170901
cyp3a65
cytochrome P450, family 3, subfamily A, polypeptide 65
chr18_-_977075 4.73 ENSDART00000032392
dhdhl
dihydrodiol dehydrogenase (dimeric), like
chr2_+_39618951 3.41 ENSDART00000077108
zgc:136870
zgc:136870
chr21_-_19919918 3.23 ENSDART00000137307
ENSDART00000142523
ENSDART00000065670
ppp1r3b
protein phosphatase 1, regulatory subunit 3B
chr24_-_36727922 3.21 ENSDART00000135142
si:ch73-334d15.1
si:ch73-334d15.1
chr7_+_27455321 3.10 ENSDART00000148417
cyp2r1
cytochrome P450, family 2, subfamily R, polypeptide 1
chr25_+_36292057 3.09 ENSDART00000152329
bmb
brambleberry
chr22_-_6941098 3.05 ENSDART00000105864
zgc:171500
zgc:171500
chr3_-_8265158 2.68 ENSDART00000171310
cyp2k6
cytochrome P450, family 2, subfamily K, polypeptide 6
chr5_-_42060121 2.58 ENSDART00000148021
ENSDART00000147407
cenpv
centromere protein V
chr23_-_41651759 2.51 ENSDART00000146808
si:ch73-184c24.1
si:ch73-184c24.1
chr13_+_2908764 2.49 ENSDART00000162362
wu:fj16a03
wu:fj16a03
chr17_+_3128273 2.47 ENSDART00000122453
zgc:136872
zgc:136872
chr23_-_6641223 2.43 ENSDART00000023793
mipb
major intrinsic protein of lens fiber b
chr18_+_45645357 2.41 ENSDART00000010256
eif3m
eukaryotic translation initiation factor 3, subunit M
chr16_-_13516745 2.39 ENSDART00000145410
si:dkeyp-69b9.3
si:dkeyp-69b9.3
chr2_+_17181777 2.35 ENSDART00000112063
ptger4c
prostaglandin E receptor 4 (subtype EP4) c
chr13_-_37653840 2.33 ENSDART00000143806
si:dkey-188i13.11
si:dkey-188i13.11
chr5_-_42059869 2.28 ENSDART00000193984
cenpv
centromere protein V
chr11_-_669558 2.27 ENSDART00000173450
pparg
peroxisome proliferator-activated receptor gamma
chr6_+_34870374 2.12 ENSDART00000149356
il23r
interleukin 23 receptor
chr22_-_10826 2.11 ENSDART00000125700
mrpl20
mitochondrial ribosomal protein L20
chr7_+_20344222 2.11 ENSDART00000141186
ENSDART00000139274
ponzr1
plac8 onzin related protein 1
chr20_+_46660339 2.11 ENSDART00000016530
adcy3b
adenylate cyclase 3b
chr1_-_59313465 2.04 ENSDART00000158067
ENSDART00000159419
txndc11
thioredoxin domain containing 11
chr23_+_2421313 2.03 ENSDART00000126038
tcp1
t-complex 1
chr10_+_16501699 1.99 ENSDART00000121864
slc27a6
solute carrier family 27 (fatty acid transporter), member 6
chr11_-_669270 1.98 ENSDART00000172834
pparg
peroxisome proliferator-activated receptor gamma
chr5_+_22406672 1.93 ENSDART00000141385
si:dkey-27p18.3
si:dkey-27p18.3
chr13_+_13681681 1.91 ENSDART00000057825
cfd
complement factor D (adipsin)
chr25_-_3836597 1.84 ENSDART00000115154
si:ch211-247i17.1
si:ch211-247i17.1
chr7_+_24520518 1.80 ENSDART00000173604
btr09
bloodthirsty-related gene family, member 9
chr2_+_44571200 1.79 ENSDART00000098132
klhl24a
kelch-like family member 24a
chr7_-_39552314 1.78 ENSDART00000134174
slc22a18
solute carrier family 22, member 18
chr3_-_14571514 1.78 ENSDART00000137197
swsap1
SWIM-type zinc finger 7 associated protein 1
chr1_+_12195700 1.77 ENSDART00000040307
tdrd7a
tudor domain containing 7 a
chr25_-_4525081 1.75 ENSDART00000184347
pidd1
p53-induced death domain protein 1
chr8_-_410728 1.74 ENSDART00000151255
trim36
tripartite motif containing 36
chr22_+_336256 1.69 ENSDART00000019155
btg2
B-cell translocation gene 2
chr15_-_33965440 1.65 ENSDART00000163841
lsr
lipolysis stimulated lipoprotein receptor
chr3_-_55121125 1.62 ENSDART00000125092
hbae1
hemoglobin, alpha embryonic 1
chr7_+_20344486 1.61 ENSDART00000134004
ENSDART00000139685
ponzr1
plac8 onzin related protein 1
chr5_+_27440325 1.54 ENSDART00000185815
ENSDART00000144013
loxl2b
lysyl oxidase-like 2b
chr15_+_24588963 1.54 ENSDART00000155075
zgc:198241
zgc:198241
chr16_+_9713850 1.53 ENSDART00000164103
ecm1b
extracellular matrix protein 1b
chr10_+_43406796 1.51 ENSDART00000184337
ENSDART00000183034
ENSDART00000180623
ENSDART00000132486
rasa1b
RAS p21 protein activator (GTPase activating protein) 1b
chr1_-_55262763 1.51 ENSDART00000152769
si:ch211-286b5.4
si:ch211-286b5.4
chr14_-_38878356 1.51 ENSDART00000173082
ENSDART00000039788
uqcrq
ubiquinol-cytochrome c reductase, complex III subunit VII
chr7_+_61764040 1.50 ENSDART00000056745
acox3
acyl-CoA oxidase 3, pristanoyl
chr23_-_40796992 1.49 ENSDART00000145116
si:dkey-194e6.2
si:dkey-194e6.2
chr15_-_41689684 1.48 ENSDART00000143447
spsb4b
splA/ryanodine receptor domain and SOCS box containing 4b
chr20_+_10727022 1.47 ENSDART00000104185
si:ch211-182e10.4
si:ch211-182e10.4
chr18_+_26829086 1.43 ENSDART00000098356
slc28a1
solute carrier family 28 (concentrative nucleoside transporter), member 1
chr19_+_31061718 1.43 ENSDART00000145971
sostdc1b
sclerostin domain containing 1b
chr7_-_24520866 1.39 ENSDART00000077039
faah2b
fatty acid amide hydrolase 2b
chr23_-_18381361 1.39 ENSDART00000016891
hsd17b10
hydroxysteroid (17-beta) dehydrogenase 10
chr21_-_7995994 1.34 ENSDART00000151632
zgc:171965
zgc:171965
chr8_-_25247284 1.33 ENSDART00000132697
gnat2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr14_-_21238046 1.33 ENSDART00000129743
si:ch211-175m2.5
si:ch211-175m2.5
chr21_-_38852860 1.32 ENSDART00000166101
tlr22
toll-like receptor 22
chr23_-_40779334 1.29 ENSDART00000141432
DUPD1 (1 of many)
si:dkeyp-27c8.1
chr13_-_33671694 1.26 ENSDART00000143945
ENSDART00000100504
zgc:163030
zgc:163030
chr23_-_5729484 1.25 ENSDART00000000488
tnni1a
troponin I type 1a (skeletal, slow)
chr23_-_4925131 1.25 ENSDART00000138805
taz
tafazzin
chr21_-_38581903 1.24 ENSDART00000148939
pof1b
POF1B, actin binding protein
chr10_+_9561066 1.19 ENSDART00000136281
si:ch211-243g18.2
si:ch211-243g18.2
chr25_-_16160494 1.19 ENSDART00000146880
si:dkey-80c24.4
si:dkey-80c24.4
chr13_-_3516473 1.19 ENSDART00000146240
prkn
parkin RBR E3 ubiquitin protein ligase
chr4_-_4834347 1.18 ENSDART00000141803
coa6
cytochrome c oxidase assembly factor 6
chr16_-_46558708 1.16 ENSDART00000128037
si:dkey-152b24.8
si:dkey-152b24.8
chr4_-_7869731 1.16 ENSDART00000067339
mcm10
minichromosome maintenance 10 replication initiation factor
chr7_+_6879534 1.15 ENSDART00000157731
zgc:175248
zgc:175248
chr1_+_49668423 1.15 ENSDART00000150880
tsga10
testis specific, 10
chr19_-_3781405 1.14 ENSDART00000170609
btr19
bloodthirsty-related gene family, member 19
chr18_+_26829362 1.14 ENSDART00000132728
slc28a1
solute carrier family 28 (concentrative nucleoside transporter), member 1
chr25_+_35048945 1.12 ENSDART00000155850
hist1h2ba
histone cluster 1, H2ba
chr24_-_41195068 1.12 ENSDART00000121592
acvr2ba
activin A receptor type 2Ba
chr15_-_19681870 1.11 ENSDART00000152266
si:dkey-4p15.4
si:dkey-4p15.4
chr11_+_769623 1.10 ENSDART00000172972
vgll4b
vestigial-like family member 4b
chr22_+_24378064 1.09 ENSDART00000180592
BX649608.2

chr3_-_39208714 1.08 ENSDART00000125730
si:ch211-232p21.6
si:ch211-232p21.6
chr5_-_26181863 1.07 ENSDART00000098500
ccdc125
coiled-coil domain containing 125
chr3_+_32615889 1.04 ENSDART00000028010
unc119.2
unc-119 lipid binding chaperone B homolog 2
chr15_+_19681718 1.02 ENSDART00000164803
si:dkey-4p15.5
si:dkey-4p15.5
chr20_-_52616333 1.00 ENSDART00000138348
ENSDART00000132196
si:ch211-221n20.7
si:ch211-221n20.7
chr25_-_16554757 0.97 ENSDART00000154480
si:ch211-266k8.6
si:ch211-266k8.6
chr20_-_52642504 0.97 ENSDART00000138982
ENSDART00000134999
si:ch211-221n20.2
si:ch211-221n20.2
chr6_+_49095646 0.97 ENSDART00000103385
slc25a55a
solute carrier family 25, member 55a
chr17_+_20569806 0.96 ENSDART00000113936
SAMD8
zgc:162183
chr11_-_24347644 0.96 ENSDART00000089777
si:ch211-15p9.2
si:ch211-15p9.2
chr17_+_2734331 0.96 ENSDART00000067542
kcnk10b
potassium channel, subfamily K, member 10b
chr8_-_45729758 0.96 ENSDART00000189329
BX088696.1

chr20_-_51697437 0.95 ENSDART00000145391
si:ch211-14a11.2
si:ch211-14a11.2
chr8_+_48848200 0.95 ENSDART00000130673
tp73
tumor protein p73
chr11_-_15874974 0.94 ENSDART00000166551
ENSDART00000129526
ENSDART00000165836
rap1ab
RAP1A, member of RAS oncogene family b
chr2_-_5502256 0.93 ENSDART00000193037
saga
S-antigen; retina and pineal gland (arrestin) a
chr24_+_10202718 0.91 ENSDART00000126668
pou6f2
POU class 6 homeobox 2
chr3_-_47294365 0.91 ENSDART00000191039
tnfsf18
TNF superfamily member 18
chr20_-_52603094 0.91 ENSDART00000136945
ENSDART00000133798
si:dkey-235d18.6
si:dkey-235d18.6
chr13_+_52071971 0.91 ENSDART00000184775
CABZ01092745.1

chr11_-_497680 0.90 ENSDART00000154888
cnbpb
CCHC-type zinc finger, nucleic acid binding protein b
chr7_+_16033273 0.90 ENSDART00000187303
immp1l
inner mitochondrial membrane peptidase subunit 1
chr23_-_35483163 0.90 ENSDART00000138660
ENSDART00000113643
ENSDART00000189269
fbxo25
F-box protein 25
chr21_+_15709061 0.89 ENSDART00000065772
ddt
D-dopachrome tautomerase
chr22_+_569565 0.89 ENSDART00000037069
usp49
ubiquitin specific peptidase 49
chr18_+_14684115 0.87 ENSDART00000108469
spata2l
spermatogenesis associated 2-like
chr20_-_2667902 0.85 ENSDART00000036373
cfap206
cilia and flagella associated protein 206
chr1_-_17803614 0.85 ENSDART00000138475
sorbs2a
sorbin and SH3 domain containing 2a
chr15_-_41689981 0.84 ENSDART00000059327
spsb4b
splA/ryanodine receptor domain and SOCS box containing 4b
chr20_+_42563618 0.84 ENSDART00000153441
igf2r
insulin-like growth factor 2 receptor
chr5_-_67499279 0.84 ENSDART00000128050
si:dkey-251i10.3
si:dkey-251i10.3
chr5_-_24154437 0.82 ENSDART00000080609
mrps31
mitochondrial ribosomal protein S31
chr22_+_4513607 0.82 ENSDART00000185696
ctxn1
cortexin 1
chr11_-_6048490 0.81 ENSDART00000066164
plvapb
plasmalemma vesicle associated protein b
chr16_-_46558521 0.81 ENSDART00000189406
si:dkey-152b24.8
si:dkey-152b24.8
chr19_+_31873308 0.79 ENSDART00000146560
ENSDART00000133045
si:dkeyp-34f6.4
si:dkeyp-34f6.4
chr24_-_36175365 0.77 ENSDART00000065338
pak1ip1
PAK1 interacting protein 1
chr2_+_43864575 0.75 ENSDART00000151951
nlrb5
NOD-like receptor family B, member 5
chr15_-_34051457 0.75 ENSDART00000189764
VWDE
si:dkey-30e9.7
chr9_+_22080122 0.74 ENSDART00000065956
ENSDART00000136014
crygm2e
crystallin, gamma M2e
chr19_-_24163845 0.72 ENSDART00000133277
prf1.2
perforin 1.2
chr2_+_11685742 0.72 ENSDART00000138562
greb1l
growth regulation by estrogen in breast cancer-like
chr20_-_52666150 0.71 ENSDART00000146716
ENSDART00000134155
si:ch211-221n20.4
si:ch211-221n20.4
chr5_+_8196264 0.70 ENSDART00000174564
ENSDART00000161261
lmbrd2a
LMBR1 domain containing 2a
chr2_-_4032732 0.68 ENSDART00000158335
rab18b
RAB18B, member RAS oncogene family
chr19_-_10627752 0.65 ENSDART00000081419
si:dkey-211g8.7
si:dkey-211g8.7
chr19_+_4139065 0.64 ENSDART00000172524
si:dkey-218f9.10
si:dkey-218f9.10
chr19_-_20162980 0.64 ENSDART00000184605
fam221a
family with sequence similarity 221, member A
chr9_-_12624622 0.63 ENSDART00000146535
tspearb
thrombospondin-type laminin G domain and EAR repeats b
chr2_-_47039762 0.62 ENSDART00000139389
si:ch211-226f6.1
si:ch211-226f6.1
chr15_+_1440364 0.62 ENSDART00000153685
il12a
interleukin 12a
chr8_+_7316568 0.61 ENSDART00000140874
selenoh
selenoprotein H
chr13_-_3351708 0.59 ENSDART00000042875
si:ch73-193i2.2
si:ch73-193i2.2
chr8_+_26410197 0.56 ENSDART00000145836
ENSDART00000053447
ifrd2
interferon-related developmental regulator 2
chr5_+_28161079 0.55 ENSDART00000141109
tacr1a
tachykinin receptor 1a
chr8_+_15239549 0.54 ENSDART00000132216
paox1
polyamine oxidase (exo-N4-amino) 1
chr4_+_17354670 0.54 ENSDART00000183726
nup37
nucleoporin 37
chr17_-_3815693 0.54 ENSDART00000161207
PLCB4
phospholipase C beta 4
chr5_+_54424592 0.53 ENSDART00000165672
ENSDART00000169531
traf2b
Tnf receptor-associated factor 2b
chr4_-_42014474 0.53 ENSDART00000193544
si:dkey-237m9.1
si:dkey-237m9.1
chr23_+_45734011 0.51 ENSDART00000062415
CABZ01088025.1

chr23_-_4925641 0.50 ENSDART00000140861
ENSDART00000060718
taz
tafazzin
chr9_-_53920959 0.49 ENSDART00000149618
mid1
midline 1
chr23_-_20363261 0.48 ENSDART00000054651
si:rp71-17i16.5
si:rp71-17i16.5
chr14_+_38878482 0.48 ENSDART00000043317
timm8a
translocase of inner mitochondrial membrane 8 homolog A (yeast)
chr18_-_46280578 0.47 ENSDART00000131724
pld3
phospholipase D family, member 3
chr7_+_33130639 0.47 ENSDART00000142450
ENSDART00000173967
ENSDART00000173832
zgc:153219
si:ch211-194p6.7
zgc:153219
si:ch211-194p6.7
chr2_+_45479841 0.47 ENSDART00000151856
si:ch211-66k16.28
si:ch211-66k16.28
chr4_-_53072245 0.46 ENSDART00000169387
ENSDART00000190363
ENSDART00000192904
si:dkey-201g16.5
si:dkey-201g16.5
chr3_+_57820913 0.45 ENSDART00000168101
CU571328.1

chr23_+_44461493 0.45 ENSDART00000149854
si:ch1073-228j22.1
si:ch1073-228j22.1
chr25_-_12923482 0.44 ENSDART00000161754
CR450808.1

chr19_+_4059200 0.44 ENSDART00000161676
ENSDART00000172424
ENSDART00000161804
btr25
bloodthirsty-related gene family, member 25
chr3_-_10970502 0.44 ENSDART00000127500
CR382337.1

chr2_+_35993404 0.44 ENSDART00000170845
lamc2
laminin, gamma 2
chr22_+_11395 0.43 ENSDART00000062264
sdhb
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
chr3_+_6469754 0.43 ENSDART00000185809
NUP85 (1 of many)
nucleoporin 85
chr23_+_4483083 0.42 ENSDART00000092389
nup210
nucleoporin 210
chr22_-_5958066 0.42 ENSDART00000145821
si:rp71-36a1.3
si:rp71-36a1.3
chr7_-_44970870 0.41 ENSDART00000191291
ENSDART00000073734
ENSDART00000124342
fam96b
family with sequence similarity 96, member B
chr10_-_24753715 0.40 ENSDART00000192401
ilk
integrin-linked kinase
chr15_-_17213723 0.40 ENSDART00000156892
itgae.1
integrin, alpha E, tandem duplicate 1
chr15_-_25556074 0.39 ENSDART00000124677
mmp20a
matrix metallopeptidase 20a (enamelysin)
chr20_+_41021054 0.39 ENSDART00000146052
man1a1
mannosidase, alpha, class 1A, member 1
chr13_+_37653851 0.38 ENSDART00000141988
ENSDART00000126902
ENSDART00000100352
phf3
PHD finger protein 3
chr19_+_23932259 0.37 ENSDART00000139040
si:dkey-222b8.1
si:dkey-222b8.1
chr8_-_48847772 0.35 ENSDART00000122458
wrap73
WD repeat containing, antisense to TP73
chr18_+_16053455 0.35 ENSDART00000189163
ENSDART00000188269
FO834850.1

chr4_+_32772213 0.35 ENSDART00000137958
ENSDART00000125835
si:dkey-16p6.1
si:dkey-16p6.1
chr11_+_42587900 0.34 ENSDART00000167529
asb14a
ankyrin repeat and SOCS box containing 14a
chr23_-_33775145 0.34 ENSDART00000132147
ENSDART00000027959
ENSDART00000160116
racgap1
Rac GTPase activating protein 1
chr1_+_51537250 0.32 ENSDART00000152789
etaa1
ETAA1, ATR kinase activator
chr4_-_55227527 0.31 ENSDART00000184323
ENSDART00000148091
si:dkey-61p9.9
si:dkey-61p9.9
chr23_+_33963619 0.31 ENSDART00000140666
ENSDART00000084792
plpbp
pyridoxal phosphate binding protein
chr12_-_48566778 0.29 ENSDART00000063442
cyp4f3
cytochrome P450, family 4, subfamily F, polypeptide 3
chr3_-_5664123 0.28 ENSDART00000145866
si:ch211-106h11.1
si:ch211-106h11.1
chr8_+_49092077 0.25 ENSDART00000032355
zgc:56525
zgc:56525
chr4_-_46946643 0.24 ENSDART00000180392
ENSDART00000184563
si:dkey-16p6.1
si:dkey-16p6.1
chr6_-_31233696 0.23 ENSDART00000079173
lepr
leptin receptor
chr21_-_38582061 0.22 ENSDART00000193891
ENSDART00000124349
pof1b
POF1B, actin binding protein
chr3_-_16010968 0.21 ENSDART00000080672
mrps34
mitochondrial ribosomal protein S34
chr23_+_12406722 0.19 ENSDART00000145008
pigt
phosphatidylinositol glycan anchor biosynthesis, class T
chr18_+_33185819 0.18 ENSDART00000193409
ENSDART00000059497
ENSDART00000179868
ENSDART00000191151
v2rc1
vomeronasal 2 receptor, c1
chr25_-_12935424 0.17 ENSDART00000160217
ccl39.7
chemokine (C-C motif) ligand 39, duplicate 7
chr4_-_31666343 0.17 ENSDART00000190758
ENSDART00000192721
si:dkey-16p6.1
si:dkey-16p6.1
chr23_+_42304602 0.16 ENSDART00000166004
cyp2aa11
cytochrome P450, family 2, subfamily AA, polypeptide 11
chr18_-_5248365 0.16 ENSDART00000082506
ENSDART00000082504
ENSDART00000097960
myef2
myelin expression factor 2
chr18_+_43365890 0.15 ENSDART00000173113
si:ch211-129p13.1
si:ch211-129p13.1
chr18_+_2189211 0.14 ENSDART00000170827
ccpg1
cell cycle progression 1
chr13_-_44997991 0.13 ENSDART00000115360
CR376783.1

chr15_-_25556227 0.13 ENSDART00000156445
mmp20a
matrix metallopeptidase 20a (enamelysin)
chr7_+_24153070 0.08 ENSDART00000076735
lrp10
low density lipoprotein receptor-related protein 10
chr11_-_497854 0.07 ENSDART00000104520
cnbpb
CCHC-type zinc finger, nucleic acid binding protein b
chr25_-_12935065 0.06 ENSDART00000167362
ccl39.7
chemokine (C-C motif) ligand 39, duplicate 7
chr4_+_77076645 0.04 ENSDART00000174346
BX005417.2

chr15_-_23721618 0.03 ENSDART00000109318
zc3h4
zinc finger CCCH-type containing 4
chr2_+_18017000 0.02 ENSDART00000186877
BX511224.1

Network of associatons between targets according to the STRING database.

First level regulatory network of pax3a+pax3b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.2 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.9 2.7 GO:1901376 mycotoxin metabolic process(GO:0043385) aflatoxin metabolic process(GO:0046222) organic heteropentacyclic compound metabolic process(GO:1901376)
0.7 5.6 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
0.6 1.9 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.6 3.1 GO:0007344 karyogamy(GO:0000741) pronuclear fusion(GO:0007344)
0.5 3.1 GO:0071305 vitamin D3 metabolic process(GO:0070640) cellular response to vitamin D(GO:0071305)
0.5 2.4 GO:0051145 smooth muscle cell differentiation(GO:0051145)
0.5 2.3 GO:0034695 response to prostaglandin E(GO:0034695) cellular response to prostaglandin E stimulus(GO:0071380)
0.4 1.5 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
0.4 1.5 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.3 3.7 GO:0061333 renal tubule morphogenesis(GO:0061333) nephron tubule morphogenesis(GO:0072078) nephron epithelium morphogenesis(GO:0072088)
0.3 4.2 GO:0070328 acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328)
0.3 2.4 GO:0006833 water transport(GO:0006833)
0.3 1.8 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.2 1.0 GO:1904184 regulation of pyruvate dehydrogenase activity(GO:1904182) positive regulation of pyruvate dehydrogenase activity(GO:1904184)
0.2 1.0 GO:2000767 positive regulation of cytoplasmic translation(GO:2000767)
0.2 0.9 GO:0071320 negative regulation of neurotransmitter secretion(GO:0046929) response to cAMP(GO:0051591) cellular response to cAMP(GO:0071320) negative regulation of synaptic vesicle transport(GO:1902804) negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.2 0.6 GO:0071314 response to cocaine(GO:0042220) cellular response to alkaloid(GO:0071312) cellular response to cocaine(GO:0071314)
0.2 2.6 GO:0015858 nucleoside transport(GO:0015858) nucleoside transmembrane transport(GO:1901642)
0.2 1.8 GO:0030719 P granule organization(GO:0030719)
0.2 1.8 GO:0046471 cardiolipin metabolic process(GO:0032048) phosphatidylglycerol metabolic process(GO:0046471)
0.2 1.5 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.1 0.9 GO:0003356 regulation of cilium beat frequency(GO:0003356)
0.1 0.5 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.1 1.0 GO:1900186 optomotor response(GO:0071632) caveolin-mediated endocytosis(GO:0072584) negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286) negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.1 0.9 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.1 1.3 GO:0050909 sensory perception of taste(GO:0050909)
0.1 1.2 GO:1900407 regulation of cellular response to oxidative stress(GO:1900407)
0.1 0.7 GO:0034389 lipid particle organization(GO:0034389)
0.1 1.0 GO:0043490 acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490)
0.1 2.4 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
0.1 2.1 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 1.1 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.1 1.5 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.1 0.9 GO:0002031 G-protein coupled receptor internalization(GO:0002031)
0.1 0.4 GO:0035989 tendon development(GO:0035989)
0.1 0.9 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.1 0.3 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 0.5 GO:0072321 chaperone-mediated protein transport(GO:0072321)
0.1 1.2 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.1 2.0 GO:0015908 fatty acid transport(GO:0015908)
0.1 1.5 GO:0070167 regulation of bone mineralization(GO:0030500) regulation of biomineral tissue development(GO:0070167)
0.1 0.6 GO:0043330 response to exogenous dsRNA(GO:0043330)
0.0 0.8 GO:0043114 regulation of vascular permeability(GO:0043114)
0.0 1.1 GO:0035329 hippo signaling(GO:0035329)
0.0 0.2 GO:0010610 regulation of mRNA stability involved in response to stress(GO:0010610) regulation of mRNA stability involved in response to oxidative stress(GO:2000815)
0.0 2.1 GO:0006171 cAMP biosynthetic process(GO:0006171)
0.0 7.9 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 1.2 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.2 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.6 GO:1990035 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.0 0.1 GO:2001106 regulation of guanyl-nucleotide exchange factor activity(GO:1905097) regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.0 1.4 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.0 0.7 GO:0019835 cytolysis(GO:0019835)
0.0 0.5 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 1.3 GO:0002224 toll-like receptor signaling pathway(GO:0002224)
0.0 1.3 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 0.6 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 2.0 GO:0070121 Kupffer's vesicle development(GO:0070121)
0.0 0.4 GO:0072698 protein localization to microtubule cytoskeleton(GO:0072698)
0.0 0.7 GO:0071875 adrenergic receptor signaling pathway(GO:0071875)
0.0 0.9 GO:0007050 cell cycle arrest(GO:0007050)
0.0 1.7 GO:0007492 endoderm development(GO:0007492)
0.0 1.8 GO:0000724 double-strand break repair via homologous recombination(GO:0000724)
0.0 1.7 GO:0045930 negative regulation of mitotic cell cycle(GO:0045930)
0.0 0.4 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.5 GO:0030574 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.0 0.8 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.0 2.4 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.0 0.4 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 1.1 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.4 GO:0032924 activin receptor signaling pathway(GO:0032924)
0.0 1.2 GO:0007283 spermatogenesis(GO:0007283)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 5.6 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.6 2.4 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.3 0.9 GO:0001534 radial spoke(GO:0001534)
0.2 1.2 GO:0031298 replication fork protection complex(GO:0031298)
0.2 3.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.2 2.0 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.2 0.9 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.2 1.5 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.1 1.8 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 1.0 GO:0045171 intercellular bridge(GO:0045171)
0.1 2.3 GO:0001917 photoreceptor inner segment(GO:0001917)
0.1 0.4 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.1 1.1 GO:0048179 activin receptor complex(GO:0048179)
0.1 0.6 GO:0097225 sperm midpiece(GO:0097225)
0.1 1.8 GO:1990391 DNA repair complex(GO:1990391)
0.1 1.8 GO:0043186 P granule(GO:0043186)
0.0 0.5 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.5 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 1.0 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.7 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.2 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 1.3 GO:0005861 troponin complex(GO:0005861)
0.0 2.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.8 GO:0032040 small-subunit processome(GO:0032040)
0.0 2.1 GO:0031965 nuclear membrane(GO:0031965)
0.0 1.5 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.7 GO:0005811 lipid particle(GO:0005811)
0.0 0.3 GO:0043596 nuclear replication fork(GO:0043596)
0.0 0.5 GO:0031970 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0 1.2 GO:0005882 intermediate filament(GO:0005882)
0.0 0.2 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.0 1.3 GO:0005925 focal adhesion(GO:0005925)
0.0 2.1 GO:0005840 ribosome(GO:0005840)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.2 GO:0070644 vitamin D response element binding(GO:0070644)
0.7 5.6 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.4 1.8 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.3 1.5 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.3 1.5 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
0.3 2.0 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.3 2.4 GO:0015250 water channel activity(GO:0015250)
0.3 4.9 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.2 1.0 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.2 2.3 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.2 1.1 GO:0001223 transcription coactivator binding(GO:0001223)
0.2 3.2 GO:2001069 glycogen binding(GO:2001069)
0.2 0.6 GO:0016496 substance P receptor activity(GO:0016496)
0.2 1.4 GO:0036122 BMP binding(GO:0036122)
0.1 1.3 GO:0051920 peroxiredoxin activity(GO:0051920)
0.1 0.4 GO:0000104 succinate dehydrogenase activity(GO:0000104)
0.1 10.7 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.1 0.5 GO:0046592 polyamine oxidase activity(GO:0046592)
0.1 1.5 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 1.0 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.1 2.5 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 2.1 GO:0004016 adenylate cyclase activity(GO:0004016)
0.1 1.1 GO:0017002 activin-activated receptor activity(GO:0017002)
0.1 0.8 GO:0005537 mannose binding(GO:0005537)
0.1 3.2 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 1.2 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 2.6 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 2.1 GO:0019843 rRNA binding(GO:0019843)
0.0 0.4 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0 1.3 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 1.2 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 2.4 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.5 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.9 GO:0019003 GDP binding(GO:0019003)
0.0 1.9 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.5 GO:0070492 oligosaccharide binding(GO:0070492)
0.0 1.0 GO:0045182 translation regulator activity(GO:0045182)
0.0 2.4 GO:0019955 cytokine binding(GO:0019955)
0.0 1.4 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 1.5 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.2 GO:0031726 CCR1 chemokine receptor binding(GO:0031726) CCR4 chemokine receptor binding(GO:0031729)
0.0 1.9 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.7 GO:0005212 structural constituent of eye lens(GO:0005212)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.2 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 2.1 PID IL23 PATHWAY IL23-mediated signaling events
0.1 1.3 PID CONE PATHWAY Visual signal transduction: Cones
0.1 0.6 PID IL27 PATHWAY IL27-mediated signaling events
0.0 0.4 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.6 ST GA12 PATHWAY G alpha 12 Pathway
0.0 0.4 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.0 1.1 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 2.6 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.5 ST G ALPHA I PATHWAY G alpha i Pathway
0.0 0.3 SIG CHEMOTAXIS Genes related to chemotaxis

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.6 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.3 1.8 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.2 4.6 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 1.9 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.1 3.4 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 4.2 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.1 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 1.4 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 1.5 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 1.3 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 2.0 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 2.0 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 1.9 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 1.2 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
0.0 0.4 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.0 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 0.5 REACTOME PLC BETA MEDIATED EVENTS Genes involved in PLC beta mediated events
0.0 0.8 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.3 REACTOME KINESINS Genes involved in Kinesins
0.0 0.4 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization