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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for pax8

Z-value: 0.76

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Transcription factors associated with pax8

Gene Symbol Gene ID Gene Info
pax8
ENSDARG00000015879 paired box 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
pax8dr11_v1_chr5_-_72415578_72415578-0.009.7e-01Click!

Activity profile of pax8 motif

Sorted Z-values of pax8 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_23487051 14.73 ENSDART00000145496
icn2
ictacalcin 2
chr1_+_9966384 9.32 ENSDART00000132607
si:dkeyp-75b4.8
si:dkeyp-75b4.8
chr10_+_2715548 6.33 ENSDART00000130793
grk5
G protein-coupled receptor kinase 5
chr21_-_22928214 6.21 ENSDART00000182760
dub
duboraya
chr23_+_42813415 5.60 ENSDART00000055577
myl9a
myosin, light chain 9a, regulatory
chr3_+_46444625 5.40 ENSDART00000108686
si:ch211-66e2.3
si:ch211-66e2.3
chr23_+_26733232 5.35 ENSDART00000035080
zgc:158263
zgc:158263
chr2_-_55337585 5.27 ENSDART00000177924
tpm4b
tropomyosin 4b
chr15_-_34892664 5.09 ENSDART00000153787
ENSDART00000099721
rnf183
ring finger protein 183
chr24_-_36727922 4.81 ENSDART00000135142
si:ch73-334d15.1
si:ch73-334d15.1
chr3_+_46444999 4.40 ENSDART00000186530
si:ch211-66e2.3
si:ch211-66e2.3
chr6_-_10927766 4.21 ENSDART00000134327
ccr7
chemokine (C-C motif) receptor 7
chr7_+_2797795 4.09 ENSDART00000161208
si:ch211-217i17.1
si:ch211-217i17.1
chr23_+_32039386 4.05 ENSDART00000133801
mylk2
myosin light chain kinase 2
chr6_+_168962 3.89 ENSDART00000182631
CABZ01066694.1

chr4_+_25630555 3.82 ENSDART00000133425
acot15
acyl-CoA thioesterase 15
chr6_+_25215944 3.68 ENSDART00000165456
si:ch73-97h19.2
si:ch73-97h19.2
chr25_+_13620555 3.51 ENSDART00000163642
si:ch211-172l8.4
si:ch211-172l8.4
chr3_-_3019979 3.48 ENSDART00000111174
zgc:172090
zgc:172090
chr25_+_18475032 3.48 ENSDART00000073564
tes
testis derived transcript (3 LIM domains)
chr20_+_10498704 3.31 ENSDART00000192985
zgc:100997
zgc:100997
chr23_+_6141541 3.26 ENSDART00000105257
zmp:0000001139
zmp:0000001139
chr24_-_25442342 3.24 ENSDART00000177140
ENSDART00000138215
phex
phosphate regulating endopeptidase homolog, X-linked
chr7_-_8981507 2.99 ENSDART00000161422
si:ch211-183d5.2
si:ch211-183d5.2
chr20_+_10498986 2.94 ENSDART00000064114
zgc:100997
zgc:100997
chr9_+_23665777 2.91 ENSDART00000060905
gypc
glycophorin C (Gerbich blood group)
chr6_-_436658 2.87 ENSDART00000191515
grap2b
GRB2-related adaptor protein 2b
chr2_+_45479841 2.76 ENSDART00000151856
si:ch211-66k16.28
si:ch211-66k16.28
chr21_-_45891262 2.76 ENSDART00000169816
galnt10
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)
chr9_+_35014728 2.70 ENSDART00000100700
gabpa
GA binding protein transcription factor, alpha subunit
chr7_-_28549361 2.68 ENSDART00000173918
ENSDART00000054368
ENSDART00000113313
st5
suppression of tumorigenicity 5
chr12_+_4900981 2.61 ENSDART00000171507
cd79b
CD79b molecule, immunoglobulin-associated beta
chr9_+_23765587 2.59 ENSDART00000145120
si:ch211-219a4.3
si:ch211-219a4.3
chr2_-_985417 2.58 ENSDART00000140540
si:ch211-241e1.3
si:ch211-241e1.3
chr23_+_44049509 2.49 ENSDART00000102003
txk
TXK tyrosine kinase
chr7_+_3444473 2.45 ENSDART00000122334
si:ch211-285c6.2
si:ch211-285c6.2
chr7_+_10610791 2.38 ENSDART00000166064
fah
fumarylacetoacetate hydrolase (fumarylacetoacetase)
chr7_+_20019125 2.14 ENSDART00000186391
bcl6b
B-cell CLL/lymphoma 6, member B
chr1_+_51721851 2.03 ENSDART00000040397
prdx2
peroxiredoxin 2
chr22_-_16154771 2.00 ENSDART00000009464
slc30a7
solute carrier family 30 (zinc transporter), member 7
chr20_+_15164482 1.99 ENSDART00000181842
ENSDART00000063877
prdx6
peroxiredoxin 6
chr13_-_36049008 1.88 ENSDART00000189978
lgmn
legumain
chr17_+_20576848 1.81 ENSDART00000183203
SAMD8
zgc:162183
chr3_-_16110351 1.78 ENSDART00000064838
lasp1
LIM and SH3 protein 1
chr3_-_16110100 1.73 ENSDART00000051807
lasp1
LIM and SH3 protein 1
chr16_+_49601838 1.72 ENSDART00000168570
ENSDART00000159236
si:dkey-82o10.4
si:dkey-82o10.4
chr8_+_4809156 1.71 ENSDART00000143720
tmem127
transmembrane protein 127
chr22_+_1751640 1.71 ENSDART00000162093
znf1169
zinc finger protein 1169
chr1_-_30457062 1.68 ENSDART00000185318
ENSDART00000157924
ENSDART00000161380
igf2bp2b
insulin-like growth factor 2 mRNA binding protein 2b
chr16_+_41135018 1.60 ENSDART00000139435
si:ch211-53m15.2
si:ch211-53m15.2
chr21_-_20120543 1.59 ENSDART00000065664
dusp4
dual specificity phosphatase 4
chr23_+_7505943 1.53 ENSDART00000135787
hck
HCK proto-oncogene, Src family tyrosine kinase
chr14_-_1313480 1.43 ENSDART00000097748
il21
interleukin 21
chr20_+_32224405 1.41 ENSDART00000062993
ENSDART00000147448
sesn1
sestrin 1
chr7_+_19374683 1.10 ENSDART00000162700
snrpf
small nuclear ribonucleoprotein polypeptide F
chr4_-_39265279 1.05 ENSDART00000164912
si:ch73-236c18.2
si:ch73-236c18.2
chr22_+_2598998 1.03 ENSDART00000176665
CU570894.1

chr23_+_43255328 0.96 ENSDART00000102712
tgm2a
transglutaminase 2, C polypeptide A
chr25_-_17579701 0.96 ENSDART00000073684
mmp15a
matrix metallopeptidase 15a
chr5_+_4298636 0.92 ENSDART00000100061
prdx4
peroxiredoxin 4
chr9_-_21825913 0.88 ENSDART00000101986
mrpl30
mitochondrial ribosomal protein L30
chr22_-_4813345 0.86 ENSDART00000190650
CU570881.2

chr9_+_39027123 0.79 ENSDART00000004742
cps1
carbamoyl-phosphate synthase 1, mitochondrial
chr6_-_130849 0.72 ENSDART00000108710
LRRC8E
si:zfos-323e3.4
chr5_-_37341044 0.70 ENSDART00000084675
wdr44
WD repeat domain 44
chr10_+_24660225 0.59 ENSDART00000190695
vps36
vacuolar protein sorting 36 homolog (S. cerevisiae)
chr10_-_40352250 0.58 ENSDART00000150821
taar20f
trace amine associated receptor 20f
chr10_+_24660017 0.53 ENSDART00000079597
vps36
vacuolar protein sorting 36 homolog (S. cerevisiae)
chr7_-_29356084 0.53 ENSDART00000075757
gtf2a2
general transcription factor IIA, 2
chr16_+_46695777 0.50 ENSDART00000169767
rab25b
RAB25, member RAS oncogene family b
chr16_-_43011470 0.49 ENSDART00000131898
ENSDART00000142003
ENSDART00000017966
nudt17
nudix (nucleoside diphosphate linked moiety X)-type motif 17
chr5_+_23630384 0.48 ENSDART00000013745
cx39.9
connexin 39.9
chr5_+_20437124 0.41 ENSDART00000159001
tmem119a
transmembrane protein 119a
chr9_+_39027312 0.40 ENSDART00000192258
ENSDART00000164407
cps1
carbamoyl-phosphate synthase 1, mitochondrial
chr6_-_131401 0.34 ENSDART00000151251
LRRC8E
si:zfos-323e3.4
chr7_-_73843720 0.33 ENSDART00000111622
caap1
caspase activity and apoptosis inhibitor 1
chr6_-_47840465 0.33 ENSDART00000141986
lrig2
leucine-rich repeats and immunoglobulin-like domains 2
chr9_+_38712474 0.24 ENSDART00000182874
kansl1l
KAT8 regulatory NSL complex subunit 1-like
chr24_-_21973163 0.23 ENSDART00000131406
acot9.1
acyl-CoA thioesterase 9, tandem duplicate 1
chr13_-_35844961 0.14 ENSDART00000171371
map3k4
mitogen-activated protein kinase kinase kinase 4
chr25_+_37285737 0.12 ENSDART00000126879
tmed6
transmembrane p24 trafficking protein 6
chr21_-_27251112 0.09 ENSDART00000137667
mark2a
MAP/microtubule affinity-regulating kinase 2a
chr5_-_27438812 0.03 ENSDART00000078755
drd7
dopamine receptor D7

Network of associatons between targets according to the STRING database.

First level regulatory network of pax8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.2 GO:0061341 non-canonical Wnt signaling pathway involved in heart development(GO:0061341)
0.5 1.9 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.4 2.5 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.4 2.4 GO:0006572 tyrosine catabolic process(GO:0006572)
0.3 1.7 GO:0032978 protein insertion into membrane from inner side(GO:0032978) protein insertion into mitochondrial membrane from inner side(GO:0032979) protein insertion into mitochondrial membrane(GO:0051204)
0.2 1.2 GO:0097272 ammonia homeostasis(GO:0097272)
0.2 2.0 GO:0000305 response to superoxide(GO:0000303) response to oxygen radical(GO:0000305) removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.2 1.4 GO:1901031 response to leucine(GO:0043201) cellular response to leucine(GO:0071233) regulation of response to reactive oxygen species(GO:1901031)
0.2 0.5 GO:0019677 pyridine nucleotide catabolic process(GO:0019364) NAD catabolic process(GO:0019677) pyridine-containing compound catabolic process(GO:0072526)
0.2 1.6 GO:0070373 negative regulation of ERK1 and ERK2 cascade(GO:0070373)
0.1 0.4 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.1 2.9 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 1.1 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.1 2.6 GO:0030183 B cell differentiation(GO:0030183)
0.1 14.7 GO:0021782 glial cell development(GO:0021782)
0.1 2.0 GO:0006829 zinc II ion transport(GO:0006829)
0.1 6.3 GO:0008016 regulation of heart contraction(GO:0008016)
0.1 5.4 GO:0006672 ceramide metabolic process(GO:0006672)
0.1 4.2 GO:0090090 negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.0 1.7 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 1.0 GO:0018149 peptide cross-linking(GO:0018149)
0.0 6.3 GO:0042157 lipoprotein metabolic process(GO:0042157)
0.0 0.5 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 3.5 GO:0006637 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 1.1 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 1.0 GO:0044243 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.0 2.6 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 3.7 GO:0006936 muscle contraction(GO:0006936)
0.0 0.3 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0 3.2 GO:0016485 protein processing(GO:0016485)
0.0 2.1 GO:0001817 regulation of cytokine production(GO:0001817)
0.0 8.8 GO:0098609 cell-cell adhesion(GO:0098609)
0.0 3.5 GO:0042127 regulation of cell proliferation(GO:0042127)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.6 GO:0019815 B cell receptor complex(GO:0019815)
0.2 1.1 GO:0000814 ESCRT II complex(GO:0000814)
0.2 1.4 GO:0061700 GATOR2 complex(GO:0061700)
0.1 0.5 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.1 9.3 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1 1.1 GO:0005732 small nucleolar ribonucleoprotein complex(GO:0005732)
0.0 5.3 GO:0005884 actin filament(GO:0005884)
0.0 6.2 GO:0005925 focal adhesion(GO:0005925)
0.0 2.9 GO:0030863 cortical cytoskeleton(GO:0030863)
0.0 4.2 GO:0005769 early endosome(GO:0005769)
0.0 2.6 GO:0005604 basement membrane(GO:0005604)
0.0 0.2 GO:0044545 NSL complex(GO:0044545)
0.0 1.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.4 GO:0001729 ceramide kinase activity(GO:0001729)
0.5 4.9 GO:0051920 peroxiredoxin activity(GO:0051920)
0.5 14.7 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.5 2.4 GO:0016823 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.4 1.2 GO:0004087 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087)
0.4 6.3 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.3 4.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.2 1.4 GO:0070728 leucine binding(GO:0070728)
0.1 1.6 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.1 4.2 GO:0019957 C-C chemokine binding(GO:0019957)
0.1 0.5 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.1 2.0 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 4.1 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 3.5 GO:0016790 thiolester hydrolase activity(GO:0016790)
0.0 4.0 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 1.0 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 1.1 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.2 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 1.7 GO:0043022 ribosome binding(GO:0043022)
0.0 0.5 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 4.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 8.8 GO:0051015 actin filament binding(GO:0051015)
0.0 2.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 1.7 GO:0003730 mRNA 3'-UTR binding(GO:0003730)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 7.9 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.2 4.1 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 1.6 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 2.6 PID BCR 5PATHWAY BCR signaling pathway
0.0 1.4 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.2 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.2 1.9 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 2.0 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 1.6 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.1 1.1 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 2.6 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 1.5 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.1 2.8 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.1 6.3 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 1.1 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 3.6 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.5 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening