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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for pdx1_pbx4

Z-value: 1.48

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Transcription factors associated with pdx1_pbx4

Gene Symbol Gene ID Gene Info
pdx1
ENSDARG00000002779 pancreatic and duodenal homeobox 1
pdx1
ENSDARG00000109275 pancreatic and duodenal homeobox 1
pbx4
ENSDARG00000052150 pre-B-cell leukemia transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
pbx4dr11_v1_chr3_+_52999962_52999962-0.197.2e-02Click!
pdx1dr11_v1_chr24_+_21684189_21684189-0.161.2e-01Click!

Activity profile of pdx1_pbx4 motif

Sorted Z-values of pdx1_pbx4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr24_+_38301080 271.69 ENSDART00000105672
mybpc2b
myosin binding protein C, fast type b
chr11_+_36243774 24.48 ENSDART00000023323
zgc:172270
zgc:172270
chr18_+_13792490 20.10 ENSDART00000136754
cdh13
cadherin 13, H-cadherin (heart)
chr3_-_32818607 16.36 ENSDART00000075465
mylpfa
myosin light chain, phosphorylatable, fast skeletal muscle a
chr1_+_17676745 12.12 ENSDART00000030665
slc25a4
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
chr7_+_29952719 11.79 ENSDART00000173737
tpma
alpha-tropomyosin
chr3_+_33300522 10.54 ENSDART00000114023
hspb9
heat shock protein, alpha-crystallin-related, 9
chr9_-_22834860 9.91 ENSDART00000146486
neb
nebulin
chr20_-_29420713 9.17 ENSDART00000147464
ryr3
ryanodine receptor 3
chr2_+_47623202 8.16 ENSDART00000154465
si:ch211-165b10.3
si:ch211-165b10.3
chr14_+_51056605 7.64 ENSDART00000159639
CABZ01078593.1

chr7_-_20453661 7.49 ENSDART00000174001
ntn5
netrin 5
chr17_+_27434626 7.31 ENSDART00000052446
vgll2b
vestigial-like family member 2b
chr5_-_23280098 6.80 ENSDART00000126540
ENSDART00000051533
plp1b
proteolipid protein 1b
chr13_+_22480496 6.72 ENSDART00000136863
ENSDART00000131870
ENSDART00000078720
ENSDART00000078740
ENSDART00000139218
ldb3a
LIM domain binding 3a
chr13_+_22479988 6.66 ENSDART00000188182
ENSDART00000192972
ENSDART00000178372
ldb3a
LIM domain binding 3a
chr13_+_24842857 6.61 ENSDART00000123866
dusp13a
dual specificity phosphatase 13a
chr18_-_36135799 6.07 ENSDART00000059344
b3gat1a
beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) a
chr12_-_26064480 5.81 ENSDART00000158215
ENSDART00000171206
ENSDART00000171212
ENSDART00000182956
ENSDART00000186779
ldb3b
LIM domain binding 3b
chr23_+_6077503 5.81 ENSDART00000081714
ENSDART00000139834
mybpha
myosin binding protein Ha
chr12_-_26406323 5.69 ENSDART00000131896
myoz1b
myozenin 1b
chr24_-_4973765 5.64 ENSDART00000127597
zic1
zic family member 1 (odd-paired homolog, Drosophila)
chr6_-_46875310 5.57 ENSDART00000154442
igfn1.3
immunoglobulin-like and fibronectin type III domain containing 1, tandem duplicate 3
chr24_-_6898302 5.54 ENSDART00000158646
dpp6a
dipeptidyl-peptidase 6a
chr13_+_22249636 5.45 ENSDART00000108472
ENSDART00000173123
synpo2la
synaptopodin 2-like a
chr24_-_6897884 5.40 ENSDART00000080766
dpp6a
dipeptidyl-peptidase 6a
chr10_-_39011514 5.38 ENSDART00000075123
pcp4a
Purkinje cell protein 4a
chr5_-_7834582 5.11 ENSDART00000162626
ENSDART00000157661
pdlim5a
PDZ and LIM domain 5a
chr10_-_17745345 5.04 ENSDART00000132690
ENSDART00000135376
si:dkey-200l5.4
si:dkey-200l5.4
chr15_+_4632782 5.03 ENSDART00000156012
si:dkey-35i13.1
si:dkey-35i13.1
chr20_-_29418620 5.02 ENSDART00000172634
ryr3
ryanodine receptor 3
chr22_+_3223489 4.99 ENSDART00000082011
lim2.2
lens intrinsic membrane protein 2.2
chr16_+_32736588 4.79 ENSDART00000075191
ENSDART00000168358
zgc:172323
zgc:172323
chr4_+_842010 4.59 ENSDART00000067461
si:ch211-152c2.3
si:ch211-152c2.3
chr3_-_62380146 4.56 ENSDART00000155853
gprc5ba
G protein-coupled receptor, class C, group 5, member Ba
chr12_+_48634927 4.51 ENSDART00000168441
zgc:165653
zgc:165653
chr20_+_15015557 4.39 ENSDART00000039345
myoc
myocilin
chr13_+_38990939 4.37 ENSDART00000145979
col19a1
collagen, type XIX, alpha 1
chr13_+_17468161 4.35 ENSDART00000008906
znf503
zinc finger protein 503
chr1_-_23557877 4.30 ENSDART00000145942
fam184b
family with sequence similarity 184, member B
chr4_-_25485404 4.13 ENSDART00000041402
pfkfb3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr7_+_74150839 4.11 ENSDART00000160195
ppp1cbl
protein phosphatase 1, catalytic subunit, beta isoform, like
chr25_+_20215964 4.06 ENSDART00000139235
tnnt2d
troponin T2d, cardiac
chr1_-_26023678 4.04 ENSDART00000054202
si:ch211-145b13.5
si:ch211-145b13.5
chr20_-_8443425 3.78 ENSDART00000083908
dab1a
Dab, reelin signal transducer, homolog 1a (Drosophila)
chr13_-_24447332 3.78 ENSDART00000043004
slc1a4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr17_-_49800869 3.72 ENSDART00000156264
col12a1a
collagen, type XII, alpha 1a
chr16_-_18960333 3.71 ENSDART00000143185
fhod3b
formin homology 2 domain containing 3b
chr17_-_6399920 3.63 ENSDART00000022010
hivep2b
human immunodeficiency virus type I enhancer binding protein 2b
chr25_+_20216159 3.63 ENSDART00000048642
tnnt2d
troponin T2d, cardiac
chr20_-_54381034 3.61 ENSDART00000136779
entpd5b
ectonucleoside triphosphate diphosphohydrolase 5b
chr19_-_25149034 3.54 ENSDART00000148432
ENSDART00000175266
ptp4a3
protein tyrosine phosphatase type IVA, member 3
chr3_-_16227490 3.50 ENSDART00000057159
ENSDART00000130611
ENSDART00000012835
cacnb1
calcium channel, voltage-dependent, beta 1 subunit
chr23_+_36095260 3.47 ENSDART00000127384
hoxc9a
homeobox C9a
chr14_+_12316581 3.43 ENSDART00000170115
ENSDART00000149757
si:ch211-125c23.3
cx31.7
si:ch211-125c23.3
connexin 31.7
chr15_+_21882419 3.42 ENSDART00000157216
si:dkey-103g5.4
si:dkey-103g5.4
chr21_-_43079161 3.33 ENSDART00000144151
jakmip2
janus kinase and microtubule interacting protein 2
chr22_+_15438513 3.33 ENSDART00000010846
gpc5b
glypican 5b
chr4_-_4261673 3.30 ENSDART00000150694
cd9b
CD9 molecule b
chr21_-_23307653 3.26 ENSDART00000140284
ENSDART00000134103
zbtb16a
zinc finger and BTB domain containing 16a
chr1_-_46981134 3.22 ENSDART00000130607
pknox1.2
pbx/knotted 1 homeobox 1.2
chr19_+_9790806 3.15 ENSDART00000155948
cacng6a
calcium channel, voltage-dependent, gamma subunit 6a
chr18_+_783936 3.05 ENSDART00000193357
rpp25b
ribonuclease P and MRP subunit p25, b
chr4_-_4387012 3.04 ENSDART00000191836
CU468826.3
Danio rerio U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1-like (LOC100331497), mRNA.
chr25_-_16818978 3.02 ENSDART00000104140
dyrk4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr15_-_33925851 3.01 ENSDART00000187807
ENSDART00000187780
mag
myelin associated glycoprotein
chr14_-_6666854 2.93 ENSDART00000133031
si:dkeyp-44a8.4
si:dkeyp-44a8.4
chr19_-_10395683 2.87 ENSDART00000109488
zgc:194578
zgc:194578
chr1_-_9277986 2.80 ENSDART00000146065
ENSDART00000114876
ENSDART00000132812
ubn1
ubinuclein 1
chr2_+_45068366 2.80 ENSDART00000142175
si:dkey-76d14.2
si:dkey-76d14.2
chr25_+_13406069 2.78 ENSDART00000010495
znrf1
zinc and ring finger 1
chr8_-_34052019 2.74 ENSDART00000040126
ENSDART00000159208
ENSDART00000048994
ENSDART00000098822
pbx3b
pre-B-cell leukemia homeobox 3b
chr14_+_5385855 2.72 ENSDART00000031508
lbx2
ladybird homeobox 2
chr19_+_28256076 2.71 ENSDART00000133354
irx4b
iroquois homeobox 4b
chr16_-_18960613 2.71 ENSDART00000183197
fhod3b
formin homology 2 domain containing 3b
chr7_+_29863548 2.70 ENSDART00000136555
ENSDART00000134068
tln2a
talin 2a
chr16_-_54498109 2.64 ENSDART00000083713
clk2b
CDC-like kinase 2b
chr24_+_34113424 2.56 ENSDART00000105572
gbx1
gastrulation brain homeobox 1
chr6_+_149405 2.54 ENSDART00000161154
fdx1l
ferredoxin 1-like
chr12_+_38770654 2.53 ENSDART00000155367
kif19
kinesin family member 19
chr3_-_16227683 2.50 ENSDART00000111707
cacnb1
calcium channel, voltage-dependent, beta 1 subunit
chr3_-_16068236 2.48 ENSDART00000157315
si:dkey-81l17.6
si:dkey-81l17.6
chr9_-_23217196 2.48 ENSDART00000083567
kif5c
kinesin family member 5C
chr18_-_46010 2.35 ENSDART00000052641
gatm
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr19_+_43119698 2.30 ENSDART00000167847
ENSDART00000186962
ENSDART00000187305
eef1a1l1
eukaryotic translation elongation factor 1 alpha 1, like 1
chr1_-_7917062 2.30 ENSDART00000177068
mmd2b
monocyte to macrophage differentiation-associated 2b
chr19_-_10425140 2.29 ENSDART00000145319
si:ch211-171h4.3
si:ch211-171h4.3
chr6_-_49510553 2.27 ENSDART00000166238
rplp2
ribosomal protein, large P2
chr3_+_32443395 2.24 ENSDART00000188447
prr12b
proline rich 12b
chr6_-_53143667 2.21 ENSDART00000079694
gnai2b
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b
chr25_+_11456696 2.20 ENSDART00000171408
AGBL1
si:ch73-141f14.1
chr18_-_38088099 2.19 ENSDART00000146120
luzp2
leucine zipper protein 2
chr6_+_14301214 2.17 ENSDART00000129491
tmem182b
transmembrane protein 182b
chr21_-_23308286 2.15 ENSDART00000184419
zbtb16a
zinc finger and BTB domain containing 16a
chr2_-_10188598 2.12 ENSDART00000189122
dmbx1a
diencephalon/mesencephalon homeobox 1a
chr2_+_42724404 2.11 ENSDART00000075392
basp1
brain abundant, membrane attached signal protein 1
chr10_-_27741793 2.10 ENSDART00000129369
ENSDART00000192440
ENSDART00000189808
ENSDART00000138149
auts2a
si:dkey-33o22.1
autism susceptibility candidate 2a
si:dkey-33o22.1
chr4_+_13810811 2.10 ENSDART00000067168
pdzrn4
PDZ domain containing ring finger 4
chr2_+_2223837 2.09 ENSDART00000101038
ENSDART00000129354
tmie
transmembrane inner ear
chr7_-_69983948 2.07 ENSDART00000185827
KCNIP4
potassium voltage-gated channel interacting protein 4
chr18_+_26899316 2.06 ENSDART00000050230
tspan3a
tetraspanin 3a
chr11_-_1509773 2.05 ENSDART00000050762
phactr3b
phosphatase and actin regulator 3b
chr13_+_30912117 2.03 ENSDART00000133138
drgx
dorsal root ganglia homeobox
chr14_-_2199573 2.01 ENSDART00000124485
pcdh2ab8
protocadherin 2 alpha b 8
chr9_+_42066030 1.99 ENSDART00000185311
ENSDART00000015267
pcbp3
poly(rC) binding protein 3
chr13_+_23282549 1.93 ENSDART00000101134
khdrbs2
KH domain containing, RNA binding, signal transduction associated 2
chr14_-_32403554 1.93 ENSDART00000172873
ENSDART00000173408
ENSDART00000173114
ENSDART00000185594
ENSDART00000186762
ENSDART00000010982
fgf13a
fibroblast growth factor 13a
chr5_+_23622177 1.90 ENSDART00000121504
cx27.5
connexin 27.5
chr9_-_23156908 1.88 ENSDART00000135461
lypd6b
LY6/PLAUR domain containing 6B
chr15_+_30917282 1.85 ENSDART00000129474
omgb
oligodendrocyte myelin glycoprotein b
chr8_-_22157301 1.83 ENSDART00000158383
nphp4
nephronophthisis 4
chr15_-_10341048 1.82 ENSDART00000171013
tenm4
teneurin transmembrane protein 4
chr13_+_30912385 1.81 ENSDART00000182642
drgx
dorsal root ganglia homeobox
chr19_-_26869103 1.79 ENSDART00000089699
prrt1
proline-rich transmembrane protein 1
chr21_+_25181003 1.79 ENSDART00000169700
si:dkey-183i3.9
si:dkey-183i3.9
chr17_+_50127648 1.79 ENSDART00000156460
galnt16
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16
chr16_+_14707960 1.76 ENSDART00000137912
col14a1a
collagen, type XIV, alpha 1a
chr2_+_35240764 1.75 ENSDART00000015827
tnr
tenascin R (restrictin, janusin)
chr4_+_5317483 1.72 ENSDART00000150366
si:ch211-214j24.10
si:ch211-214j24.10
chr5_-_18961694 1.72 ENSDART00000142531
ENSDART00000090521
ankle2
ankyrin repeat and LEM domain containing 2
chr13_-_31435137 1.72 ENSDART00000057441
rtn1a
reticulon 1a
chr12_+_39685485 1.72 ENSDART00000163403
LO017650.1

chr13_-_31296358 1.71 ENSDART00000030946
prdm8
PR domain containing 8
chr15_-_27710513 1.71 ENSDART00000005641
ENSDART00000134373
lhx1a
LIM homeobox 1a
chr20_-_52846212 1.71 ENSDART00000040265
tbc1d7
TBC1 domain family, member 7
chr13_-_11536951 1.69 ENSDART00000018155
adss
adenylosuccinate synthase
chr2_-_23778180 1.68 ENSDART00000136782
si:dkey-24c2.7
si:dkey-24c2.7
chr8_-_16697912 1.67 ENSDART00000076542
rpe65b
retinal pigment epithelium-specific protein 65b
chr6_-_47246948 1.67 ENSDART00000162435
grm4
glutamate receptor, metabotropic 4
chr1_-_494280 1.65 ENSDART00000144406
ercc5
excision repair cross-complementation group 5
chr17_+_23937262 1.65 ENSDART00000113276
si:ch211-189k9.2
si:ch211-189k9.2
chr4_-_27301356 1.65 ENSDART00000100444
fam19a5a
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5a
chr23_+_40460333 1.63 ENSDART00000184658
soga3b
SOGA family member 3b
chr14_+_5383060 1.61 ENSDART00000187825
lbx2
ladybird homeobox 2
chr7_+_46252993 1.61 ENSDART00000167149
znf536
zinc finger protein 536
chr3_-_61116258 1.60 ENSDART00000009194
ENSDART00000156978
aimp2
aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
chr20_-_54924593 1.58 ENSDART00000151522
si:dkey-15f23.1
si:dkey-15f23.1
chr13_-_16191674 1.57 ENSDART00000147868
vwc2
von Willebrand factor C domain containing 2
chr11_-_25538341 1.54 ENSDART00000171560
si:dkey-245f22.3
si:dkey-245f22.3
chr18_-_42172101 1.54 ENSDART00000124211
cntn5
contactin 5
chr2_-_54039293 1.53 ENSDART00000166013
abhd8a
abhydrolase domain containing 8a
chr2_+_27010439 1.53 ENSDART00000030547
cdh7a
cadherin 7a
chr24_+_39186940 1.52 ENSDART00000155817
spsb3b
splA/ryanodine receptor domain and SOCS box containing 3b
chr6_+_45347219 1.51 ENSDART00000188240
LO017951.1

chr8_+_49778756 1.51 ENSDART00000083790
ntrk2a
neurotrophic tyrosine kinase, receptor, type 2a
chr21_+_43669943 1.51 ENSDART00000136025
tmlhe
trimethyllysine hydroxylase, epsilon
chr24_+_32472155 1.50 ENSDART00000098859
neurod6a
neuronal differentiation 6a
chr8_+_49778486 1.50 ENSDART00000131732
ntrk2a
neurotrophic tyrosine kinase, receptor, type 2a
chr13_+_50375800 1.50 ENSDART00000099537
cox5b2
cytochrome c oxidase subunit Vb 2
chr25_-_13842618 1.49 ENSDART00000160258
mapk8ip1a
mitogen-activated protein kinase 8 interacting protein 1a
chr6_-_53144336 1.48 ENSDART00000154429
gnai2b
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b
chr21_+_30194904 1.47 ENSDART00000137023
ENSDART00000078403
BRD8
si:ch211-59d17.3
chr25_+_15354095 1.47 ENSDART00000090397
kiaa1549la
KIAA1549-like a
chr17_+_19626479 1.46 ENSDART00000044993
ENSDART00000131863
rgs7a
regulator of G protein signaling 7a
chr23_-_3721444 1.46 ENSDART00000141682
nudt3a
nudix (nucleoside diphosphate linked moiety X)-type motif 3a
chr5_-_30535327 1.46 ENSDART00000040328
h2afx
H2A histone family, member X
chr22_-_38543630 1.45 ENSDART00000172029
si:ch211-126j24.1
si:ch211-126j24.1
chr12_+_22404108 1.45 ENSDART00000153055
hdlbpb
high density lipoprotein binding protein b
chr3_-_59981476 1.45 ENSDART00000035878
ENSDART00000124038
cdr2l
cerebellar degeneration-related protein 2-like
chr8_+_31777633 1.44 ENSDART00000142519
oxct1a
3-oxoacid CoA transferase 1a
chr3_-_28857195 1.44 ENSDART00000114319
si:ch211-76l23.7
si:ch211-76l23.7
chr8_+_22931427 1.43 ENSDART00000063096
sypa
synaptophysin a
chr17_+_31914877 1.43 ENSDART00000177801
FAM196A (1 of many)
family with sequence similarity 196 member A
chr21_+_20715020 1.43 ENSDART00000015224
gadd45gb.1
growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1
chr11_-_13341483 1.43 ENSDART00000164978
mast3b
microtubule associated serine/threonine kinase 3b
chr19_-_3973567 1.41 ENSDART00000167580
map7d1b
MAP7 domain containing 1b
chr10_-_74408 1.41 ENSDART00000100073
ENSDART00000141723
dyrk1aa
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, a
chr19_-_10243148 1.41 ENSDART00000148073
shisa7b
shisa family member 7
chr17_-_12385308 1.39 ENSDART00000080927
snap25b
synaptosomal-associated protein, 25b
chr25_+_33002963 1.38 ENSDART00000187366
CABZ01046980.1

chr23_-_11870962 1.38 ENSDART00000143481
si:dkey-178k16.1
si:dkey-178k16.1
chr13_+_31177934 1.37 ENSDART00000144568
ptpn20
protein tyrosine phosphatase, non-receptor type 20
chr22_-_24313301 1.34 ENSDART00000161480
uts2d
urotensin 2 domain containing
chr21_-_24632778 1.32 ENSDART00000132533
ENSDART00000058370
arhgap32b
Rho GTPase activating protein 32b
chr1_-_51266394 1.31 ENSDART00000164016
kif16ba
kinesin family member 16Ba
chr13_+_38302665 1.30 ENSDART00000145777
adgrb3
adhesion G protein-coupled receptor B3
chr13_-_37254777 1.30 ENSDART00000139734
syne2b
spectrin repeat containing, nuclear envelope 2b
chr1_+_40023640 1.29 ENSDART00000101623
lgi2b
leucine-rich repeat LGI family, member 2b
chr6_+_42693288 1.28 ENSDART00000155010
si:ch211-207d10.2
si:ch211-207d10.2
chr24_-_40009446 1.28 ENSDART00000087422
aoc1
amine oxidase, copper containing 1
chr2_+_7818368 1.28 ENSDART00000007068
kcnmb2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr17_-_8976307 1.27 ENSDART00000092113
zranb1b
zinc finger, RAN-binding domain containing 1b
chr9_+_50000504 1.26 ENSDART00000164409
ENSDART00000165451
ENSDART00000166509
slc38a11
solute carrier family 38, member 11
chr24_-_24881996 1.26 ENSDART00000145712
crhb
corticotropin releasing hormone b
chr11_-_6048490 1.25 ENSDART00000066164
plvapb
plasmalemma vesicle associated protein b
chr21_+_31151197 1.25 ENSDART00000137728
st6gal1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr10_-_36207737 1.24 ENSDART00000159366
or109-13
odorant receptor, family D, subfamily 109, member 13
chr2_+_17451656 1.23 ENSDART00000163620
BX640408.1

chr7_+_51774502 1.23 ENSDART00000007767
got2b
glutamic-oxaloacetic transaminase 2b, mitochondrial
chr11_+_41243094 1.22 ENSDART00000191782
ENSDART00000169817
ENSDART00000162157
pax7a
paired box 7a
chr3_-_32902138 1.22 ENSDART00000144026
ENSDART00000083874
ENSDART00000145443
ENSDART00000148239
ENSDART00000134917
kat7a
K(lysine) acetyltransferase 7a
chr2_+_24199276 1.22 ENSDART00000140575
map4l
microtubule associated protein 4 like
chr8_-_16712111 1.22 ENSDART00000184147
ENSDART00000180419
ENSDART00000076600
rpe65c
retinal pigment epithelium-specific protein 65c
chr16_-_16152199 1.21 ENSDART00000012718
fabp11b
fatty acid binding protein 11b
chr11_+_13528437 1.21 ENSDART00000011362
arrdc2
arrestin domain containing 2
chr17_-_26507289 1.21 ENSDART00000155616
ccser2a
coiled-coil serine-rich protein 2a
chr25_-_7925269 1.19 ENSDART00000014274
glcea
glucuronic acid epimerase a
chr20_-_2667902 1.19 ENSDART00000036373
cfap206
cilia and flagella associated protein 206
chr19_+_37925616 1.19 ENSDART00000148348
nxph1
neurexophilin 1
chr13_-_8776474 1.18 ENSDART00000122371
STPG4
si:ch211-93n23.7

Network of associatons between targets according to the STRING database.

First level regulatory network of pdx1_pbx4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 12.1 GO:0051503 intracellular nucleoside transport(GO:0015859) purine nucleoside transmembrane transport(GO:0015860) purine nucleotide transport(GO:0015865) ATP transport(GO:0015867) purine ribonucleotide transport(GO:0015868) adenine nucleotide transport(GO:0051503) mitochondrial ATP transmembrane transport(GO:1990544)
2.5 20.1 GO:1902262 apoptotic process involved in patterning of blood vessels(GO:1902262)
2.4 24.5 GO:0070836 membrane raft assembly(GO:0001765) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
1.7 9.9 GO:0071691 cardiac muscle thin filament assembly(GO:0071691)
1.0 7.3 GO:0021534 cell proliferation in hindbrain(GO:0021534)
1.0 3.0 GO:0099540 synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551) cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
1.0 3.8 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
0.9 2.8 GO:0006600 creatine metabolic process(GO:0006600) creatine biosynthetic process(GO:0006601)
0.9 4.3 GO:1904105 positive regulation of convergent extension involved in gastrulation(GO:1904105)
0.8 283.4 GO:0060537 muscle tissue development(GO:0060537)
0.7 2.9 GO:0016108 tetraterpenoid metabolic process(GO:0016108) tetraterpenoid biosynthetic process(GO:0016109) carotenoid metabolic process(GO:0016116) carotenoid biosynthetic process(GO:0016117) xanthophyll metabolic process(GO:0016122) xanthophyll biosynthetic process(GO:0016123) zeaxanthin metabolic process(GO:1901825) zeaxanthin biosynthetic process(GO:1901827)
0.6 3.1 GO:0061577 calcium ion transmembrane transport via high voltage-gated calcium channel(GO:0061577) regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
0.6 1.7 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.5 3.8 GO:0097476 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
0.5 2.7 GO:0032877 regulation of DNA endoreduplication(GO:0032875) positive regulation of DNA endoreduplication(GO:0032877) DNA endoreduplication(GO:0042023)
0.5 13.7 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)
0.5 3.0 GO:0060827 regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827)
0.5 1.0 GO:0033292 T-tubule organization(GO:0033292)
0.5 2.5 GO:0098937 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.4 0.9 GO:1903779 regulation of cardiac conduction(GO:1903779)
0.4 1.3 GO:0035902 response to immobilization stress(GO:0035902)
0.4 5.4 GO:0032481 positive regulation of type I interferon production(GO:0032481)
0.4 8.2 GO:0022010 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.4 11.5 GO:1901379 regulation of potassium ion transmembrane transport(GO:1901379)
0.4 1.8 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.3 3.8 GO:0001973 adenosine receptor signaling pathway(GO:0001973) purinergic receptor signaling pathway(GO:0035587) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.3 3.1 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.3 1.2 GO:0001774 microglial cell activation(GO:0001774)
0.3 1.2 GO:0006531 aspartate metabolic process(GO:0006531)
0.3 1.5 GO:1901910 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.3 1.4 GO:0046952 ketone body catabolic process(GO:0046952)
0.3 1.0 GO:0019532 oxalate transport(GO:0019532)
0.3 1.3 GO:0016322 neuron remodeling(GO:0016322)
0.3 4.4 GO:0001952 regulation of cell-matrix adhesion(GO:0001952)
0.3 4.1 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.3 0.5 GO:0044246 regulation of collagen metabolic process(GO:0010712) regulation of collagen biosynthetic process(GO:0032965) regulation of multicellular organismal metabolic process(GO:0044246)
0.3 1.3 GO:0046677 response to antibiotic(GO:0046677)
0.3 1.3 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.3 2.3 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.3 6.5 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.2 1.0 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186) peptidyl-glutamine modification(GO:0018199)
0.2 1.2 GO:0050938 regulation of xanthophore differentiation(GO:0050938)
0.2 1.0 GO:0010226 response to lithium ion(GO:0010226)
0.2 1.6 GO:0003311 pancreatic D cell differentiation(GO:0003311) pancreatic epsilon cell differentiation(GO:0090104)
0.2 0.9 GO:2001204 regulation of osteoclast development(GO:2001204)
0.2 6.1 GO:0045214 sarcomere organization(GO:0045214)
0.2 4.5 GO:0048679 regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.2 1.3 GO:0005513 detection of calcium ion(GO:0005513)
0.2 3.0 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.2 3.6 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
0.2 0.6 GO:0000212 meiotic spindle organization(GO:0000212)
0.2 1.4 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.2 1.0 GO:1903146 regulation of mitophagy(GO:1903146)
0.2 1.2 GO:0003356 regulation of cilium beat frequency(GO:0003356)
0.2 2.3 GO:0030210 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.2 1.1 GO:0098957 neurotrophin TRK receptor signaling pathway(GO:0048011) anterograde axonal transport of mitochondrion(GO:0098957)
0.2 0.7 GO:0060415 muscle tissue morphogenesis(GO:0060415)
0.2 0.7 GO:1903385 dendrite guidance(GO:0070983) regulation of homophilic cell adhesion(GO:1903385)
0.2 3.2 GO:0061074 regulation of neural retina development(GO:0061074)
0.2 1.0 GO:0021767 mammillary body development(GO:0021767)
0.2 1.0 GO:0042723 thiamine metabolic process(GO:0006772) thiamine-containing compound metabolic process(GO:0042723)
0.2 6.3 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.2 1.9 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.2 0.5 GO:0021661 rhombomere 4 development(GO:0021570) rhombomere 4 morphogenesis(GO:0021661)
0.2 1.4 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.2 0.8 GO:0048903 anterior lateral line neuromast hair cell differentiation(GO:0048903)
0.1 0.7 GO:0010159 specification of organ position(GO:0010159)
0.1 0.5 GO:0046144 alanine metabolic process(GO:0006522) alanine catabolic process(GO:0006524) pyruvate family amino acid metabolic process(GO:0009078) pyruvate family amino acid catabolic process(GO:0009080) D-alanine family amino acid metabolic process(GO:0046144) D-alanine metabolic process(GO:0046436) D-alanine catabolic process(GO:0055130)
0.1 4.3 GO:0060037 pharyngeal system development(GO:0060037)
0.1 0.5 GO:0060092 regulation of synaptic transmission, glycinergic(GO:0060092)
0.1 1.6 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 0.5 GO:0051876 pigment granule dispersal(GO:0051876)
0.1 1.5 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.7 GO:1900028 wound healing, spreading of epidermal cells(GO:0035313) negative regulation of ruffle assembly(GO:1900028)
0.1 1.3 GO:0043114 regulation of vascular permeability(GO:0043114)
0.1 2.1 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.1 0.4 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
0.1 0.8 GO:0035627 ceramide transport(GO:0035627)
0.1 1.7 GO:0014003 oligodendrocyte development(GO:0014003)
0.1 10.1 GO:0061515 myeloid cell development(GO:0061515)
0.1 0.5 GO:0030326 embryonic limb morphogenesis(GO:0030326)
0.1 0.4 GO:0061549 sympathetic ganglion development(GO:0061549)
0.1 6.3 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.1 1.1 GO:0000710 meiotic mismatch repair(GO:0000710)
0.1 0.7 GO:0021535 cell migration in hindbrain(GO:0021535)
0.1 2.1 GO:0021884 forebrain neuron development(GO:0021884)
0.1 0.4 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.1 0.5 GO:1904031 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.1 3.9 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.1 1.0 GO:0097369 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 0.9 GO:0034394 protein localization to cell surface(GO:0034394)
0.1 0.4 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.1 1.5 GO:0060034 notochord cell differentiation(GO:0060034)
0.1 0.6 GO:0003321 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996) positive regulation of blood pressure by epinephrine-norepinephrine(GO:0003321) positive regulation of heart rate(GO:0010460)
0.1 1.1 GO:0099560 synaptic membrane adhesion(GO:0099560)
0.1 0.7 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.1 6.9 GO:0048846 axon extension involved in axon guidance(GO:0048846) neuron projection extension involved in neuron projection guidance(GO:1902284)
0.1 1.6 GO:0051351 positive regulation of ligase activity(GO:0051351)
0.1 2.8 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.1 2.3 GO:0019835 cytolysis(GO:0019835)
0.1 0.5 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.1 0.3 GO:0072673 lamellipodium morphogenesis(GO:0072673) regulation of lamellipodium morphogenesis(GO:2000392)
0.1 0.5 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.1 1.5 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.1 7.6 GO:0016358 dendrite development(GO:0016358)
0.1 4.3 GO:0048596 embryonic camera-type eye morphogenesis(GO:0048596)
0.1 0.3 GO:2000677 histone H3-K79 methylation(GO:0034729) regulation of transcription regulatory region DNA binding(GO:2000677)
0.1 2.3 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.1 0.2 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.1 1.0 GO:0051968 positive regulation of synaptic transmission, glutamatergic(GO:0051968)
0.1 0.4 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.1 1.8 GO:0070831 basement membrane assembly(GO:0070831)
0.1 1.1 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1 0.8 GO:0042026 protein refolding(GO:0042026)
0.1 3.7 GO:0006414 translational elongation(GO:0006414)
0.1 0.4 GO:0060017 parathyroid gland development(GO:0060017)
0.1 0.8 GO:1903963 icosanoid secretion(GO:0032309) arachidonic acid secretion(GO:0050482) icosanoid transport(GO:0071715) fatty acid derivative transport(GO:1901571) arachidonate transport(GO:1903963)
0.1 0.3 GO:0045685 regulation of glial cell differentiation(GO:0045685)
0.1 3.7 GO:0090263 positive regulation of canonical Wnt signaling pathway(GO:0090263)
0.0 0.3 GO:1902093 positive regulation of sperm motility(GO:1902093)
0.0 0.4 GO:0044211 CTP salvage(GO:0044211)
0.0 1.7 GO:0071696 ectodermal placode development(GO:0071696)
0.0 0.6 GO:0070307 lens fiber cell development(GO:0070307) lens fiber cell morphogenesis(GO:0070309)
0.0 0.2 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.0 0.6 GO:0021984 adenohypophysis development(GO:0021984)
0.0 2.3 GO:0000187 activation of MAPK activity(GO:0000187)
0.0 0.4 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.6 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.0 0.8 GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway(GO:0071880)
0.0 0.3 GO:0097010 eukaryotic translation initiation factor 4F complex assembly(GO:0097010)
0.0 0.3 GO:0031048 chromatin silencing by small RNA(GO:0031048)
0.0 0.3 GO:0032367 intracellular cholesterol transport(GO:0032367)
0.0 0.3 GO:0015697 quaternary ammonium group transport(GO:0015697)
0.0 7.2 GO:0061061 muscle structure development(GO:0061061)
0.0 0.9 GO:0031102 neuron projection regeneration(GO:0031102)
0.0 0.2 GO:0035988 chondrocyte proliferation(GO:0035988)
0.0 0.6 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 1.3 GO:0046785 microtubule polymerization(GO:0046785)
0.0 1.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.3 GO:0030878 thyroid gland development(GO:0030878)
0.0 0.6 GO:0035803 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.0 0.4 GO:0051256 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231) mitotic spindle midzone assembly(GO:0051256)
0.0 0.6 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 0.4 GO:0050909 sensory perception of taste(GO:0050909)
0.0 0.3 GO:0097345 mitochondrial outer membrane permeabilization(GO:0097345)
0.0 0.5 GO:0036065 fucosylation(GO:0036065)
0.0 0.3 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 1.6 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.9 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.4 GO:0030819 activation of adenylate cyclase activity(GO:0007190) positive regulation of cAMP metabolic process(GO:0030816) positive regulation of cAMP biosynthetic process(GO:0030819) positive regulation of adenylate cyclase activity(GO:0045762)
0.0 0.7 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.1 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.0 0.2 GO:0050932 regulation of pigment cell differentiation(GO:0050932)
0.0 0.6 GO:0006491 N-glycan processing(GO:0006491)
0.0 1.2 GO:0007338 single fertilization(GO:0007338)
0.0 1.4 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 0.5 GO:0016233 telomere capping(GO:0016233)
0.0 0.5 GO:0051932 synaptic transmission, GABAergic(GO:0051932)
0.0 1.3 GO:0010842 retina layer formation(GO:0010842)
0.0 0.3 GO:0016198 axon choice point recognition(GO:0016198) axon midline choice point recognition(GO:0016199)
0.0 0.3 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.0 1.3 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.3 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.3 GO:0032088 negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.0 0.3 GO:0046549 retinal cone cell development(GO:0046549)
0.0 0.4 GO:1901663 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 4.2 GO:0007018 microtubule-based movement(GO:0007018)
0.0 0.7 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 1.6 GO:0010506 regulation of autophagy(GO:0010506)
0.0 0.6 GO:0046328 regulation of JNK cascade(GO:0046328)
0.0 0.2 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 0.2 GO:0007254 JNK cascade(GO:0007254)
0.0 0.4 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.6 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.1 GO:0032218 riboflavin transport(GO:0032218)
0.0 0.7 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 3.8 GO:0006470 protein dephosphorylation(GO:0006470)
0.0 0.3 GO:0007634 optokinetic behavior(GO:0007634)
0.0 0.2 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.0 0.3 GO:1990798 pancreas regeneration(GO:1990798)
0.0 0.5 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.5 GO:0043113 receptor clustering(GO:0043113)
0.0 0.1 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.0 0.1 GO:0032917 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.0 0.4 GO:0050868 negative regulation of homotypic cell-cell adhesion(GO:0034111) negative regulation of T cell activation(GO:0050868) negative regulation of leukocyte cell-cell adhesion(GO:1903038)
0.0 1.6 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 14.2 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.8 4.6 GO:0070062 extracellular exosome(GO:0070062)
0.6 24.5 GO:0005901 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.4 3.1 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.4 43.4 GO:0030018 Z disc(GO:0030018)
0.4 3.1 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.4 6.8 GO:0043209 myelin sheath(GO:0043209)
0.4 1.2 GO:0001534 radial spoke(GO:0001534)
0.4 20.5 GO:0016342 catenin complex(GO:0016342)
0.2 1.0 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.2 1.4 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.2 1.8 GO:0005614 interstitial matrix(GO:0005614)
0.2 1.3 GO:0043083 synaptic cleft(GO:0043083)
0.2 1.3 GO:0001650 fibrillar center(GO:0001650)
0.2 10.8 GO:0005865 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.2 1.7 GO:0042788 polysomal ribosome(GO:0042788)
0.2 12.7 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.2 0.6 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.1 4.4 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 3.2 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 7.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 1.0 GO:0030315 T-tubule(GO:0030315)
0.1 10.1 GO:0005884 actin filament(GO:0005884)
0.1 4.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 1.8 GO:0097546 ciliary base(GO:0097546)
0.1 8.2 GO:0005604 basement membrane(GO:0005604)
0.1 1.5 GO:0005844 polysome(GO:0005844)
0.1 5.4 GO:0005581 collagen trimer(GO:0005581)
0.1 0.3 GO:0032433 filopodium tip(GO:0032433)
0.1 6.6 GO:0005871 kinesin complex(GO:0005871)
0.1 0.9 GO:0044295 axonal growth cone(GO:0044295)
0.1 0.8 GO:0008180 COP9 signalosome(GO:0008180)
0.1 3.0 GO:0030426 growth cone(GO:0030426)
0.1 1.1 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 2.1 GO:0043679 axon terminus(GO:0043679)
0.1 3.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 5.6 GO:0005882 intermediate filament(GO:0005882)
0.0 0.5 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.6 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.3 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.8 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.4 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 1.3 GO:1902711 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 2.7 GO:0001726 ruffle(GO:0001726)
0.0 0.9 GO:0000795 synaptonemal complex(GO:0000795)
0.0 0.9 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.1 GO:1990745 EARP complex(GO:1990745)
0.0 0.5 GO:0070187 telosome(GO:0070187)
0.0 1.6 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 9.9 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.1 GO:0098554 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553) cytoplasmic side of endoplasmic reticulum membrane(GO:0098554) lumenal side of membrane(GO:0098576)
0.0 0.2 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.3 GO:0030427 site of polarized growth(GO:0030427)
0.0 6.3 GO:0031012 extracellular matrix(GO:0031012)
0.0 1.0 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.7 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.5 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.5 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.0 GO:0005925 focal adhesion(GO:0005925)
0.0 1.6 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 8.2 GO:0043005 neuron projection(GO:0043005)
0.0 0.1 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.4 GO:0014069 postsynaptic density(GO:0014069)
0.0 0.3 GO:0008305 integrin complex(GO:0008305)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 12.1 GO:0005471 ATP:ADP antiporter activity(GO:0005471)
2.8 14.2 GO:0048763 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
1.5 6.1 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
1.1 22.0 GO:0051393 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
1.0 3.0 GO:0060175 brain-derived neurotrophic factor binding(GO:0048403) brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
0.7 2.9 GO:0052885 retinol isomerase activity(GO:0050251) all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity(GO:0052885)
0.7 7.7 GO:0030172 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.6 10.9 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.6 2.3 GO:0047464 heparosan-N-sulfate-glucuronate 5-epimerase activity(GO:0047464)
0.6 5.7 GO:0031433 telethonin binding(GO:0031433) FATZ binding(GO:0051373)
0.5 7.0 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.3 2.7 GO:0001130 bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.3 1.9 GO:0030548 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.3 1.2 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.3 4.1 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.3 1.5 GO:0034432 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.3 1.4 GO:0008260 3-oxoacid CoA-transferase activity(GO:0008260)
0.3 1.0 GO:0050333 thiamin-triphosphatase activity(GO:0050333)
0.2 34.6 GO:0042803 protein homodimerization activity(GO:0042803)
0.2 1.0 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.2 0.9 GO:0008459 chondroitin 6-sulfotransferase activity(GO:0008459)
0.2 0.9 GO:0031781 type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.2 6.7 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.2 3.6 GO:0045134 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.2 1.0 GO:0070004 cysteine-type exopeptidase activity(GO:0070004)
0.2 6.3 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.2 8.1 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.2 3.0 GO:0033691 sialic acid binding(GO:0033691)
0.2 2.1 GO:0031628 opioid receptor binding(GO:0031628)
0.2 1.2 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.2 0.8 GO:1902388 ceramide transporter activity(GO:0035620) ceramide 1-phosphate binding(GO:1902387) ceramide 1-phosphate transporter activity(GO:1902388)
0.1 3.7 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 0.5 GO:0030116 glial cell-derived neurotrophic factor receptor binding(GO:0030116)
0.1 0.5 GO:0031697 adrenergic receptor binding(GO:0031690) beta-1 adrenergic receptor binding(GO:0031697) type II activin receptor binding(GO:0070699)
0.1 1.9 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.1 0.5 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.1 0.5 GO:0003884 D-amino-acid oxidase activity(GO:0003884)
0.1 3.1 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 0.7 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 4.8 GO:0070491 repressing transcription factor binding(GO:0070491)
0.1 3.0 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 19.6 GO:0060090 binding, bridging(GO:0060090)
0.1 1.4 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.1 2.3 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) G-protein coupled glutamate receptor activity(GO:0098988)
0.1 1.9 GO:0008143 poly(A) binding(GO:0008143)
0.1 1.0 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.1 0.7 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.1 2.4 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.1 1.3 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 6.6 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 0.5 GO:0043914 NADPH:sulfur oxidoreductase activity(GO:0043914)
0.1 5.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 0.3 GO:0051059 NF-kappaB binding(GO:0051059)
0.1 0.6 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.1 1.7 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 0.6 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 0.3 GO:0031151 histone methyltransferase activity (H3-K79 specific)(GO:0031151)
0.1 1.0 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 0.9 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 5.4 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 3.6 GO:0030295 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.1 1.3 GO:0048038 quinone binding(GO:0048038)
0.1 0.7 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.1 1.0 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.1 2.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 1.1 GO:0030983 mismatched DNA binding(GO:0030983)
0.1 0.9 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 1.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 0.6 GO:0035804 structural constituent of egg coat(GO:0035804)
0.1 1.5 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.6 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.1 1.1 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.1 0.8 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 4.1 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 2.3 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.3 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.2 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 0.4 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.3 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
0.0 2.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.6 GO:0005537 mannose binding(GO:0005537)
0.0 0.7 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.7 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 1.9 GO:0044325 ion channel binding(GO:0044325)
0.0 0.3 GO:0034057 RNA strand annealing activity(GO:0033592) RNA strand-exchange activity(GO:0034057)
0.0 0.6 GO:0045503 dynein light chain binding(GO:0045503)
0.0 6.8 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.5 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.0 1.0 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 1.3 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 1.6 GO:0017022 myosin binding(GO:0017022)
0.0 0.5 GO:0005223 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 0.5 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 0.5 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.2 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.6 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 1.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.4 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 1.6 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.1 GO:0001607 neuromedin U receptor activity(GO:0001607)
0.0 1.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.7 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.0 0.1 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.7 GO:0004659 prenyltransferase activity(GO:0004659)
0.0 1.3 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.4 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.2 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.0 0.2 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.2 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.0 0.6 GO:0004623 phospholipase A2 activity(GO:0004623)
0.0 0.4 GO:0050811 GABA receptor binding(GO:0050811)
0.0 2.1 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.0 1.0 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.1 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.2 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 2.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.5 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.2 GO:0015250 water channel activity(GO:0015250)
0.0 0.4 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.1 GO:0032217 riboflavin transporter activity(GO:0032217)
0.0 2.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.2 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.3 GO:0048185 activin binding(GO:0048185)
0.0 5.4 GO:0015631 tubulin binding(GO:0015631)
0.0 0.6 GO:0005109 frizzled binding(GO:0005109)
0.0 2.2 GO:0000287 magnesium ion binding(GO:0000287)
0.0 1.2 GO:0030276 clathrin binding(GO:0030276)
0.0 0.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.1 GO:0070728 leucine binding(GO:0070728)
0.0 0.1 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.3 GO:0019003 GDP binding(GO:0019003)
0.0 0.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.3 GO:0042043 neurexin family protein binding(GO:0042043)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.4 NABA COLLAGENS Genes encoding collagen proteins
0.2 0.6 PID NECTIN PATHWAY Nectin adhesion pathway
0.1 7.5 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 3.0 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.1 4.5 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 1.8 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 1.5 PID ATM PATHWAY ATM pathway
0.0 3.4 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.5 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.7 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.8 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.9 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.5 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.6 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.6 PID P53 REGULATION PATHWAY p53 pathway
0.0 0.5 WNT SIGNALING Genes related to Wnt-mediated signal transduction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 20.1 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.4 9.9 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.3 12.8 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.2 3.0 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.2 1.7 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 1.0 REACTOME AMYLOIDS Genes involved in Amyloids
0.2 4.1 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.2 7.1 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.2 1.6 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.2 4.4 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.2 3.8 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 1.7 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 0.6 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.1 1.5 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 1.8 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 0.9 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 1.0 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 0.6 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 0.7 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.1 0.9 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.1 0.5 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.1 1.6 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 1.4 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 0.3 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.5 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 1.0 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.3 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.4 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 1.1 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 2.3 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.0 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.2 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.8 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.4 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 1.5 REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.0 0.3 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 1.8 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives