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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for pgr
Z-value: 0.71
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Transcription factors associated with pgr
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| pgr | dr11_v1_chr18_+_41820039_41820039 | 0.19 | 7.0e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_7538909 Show fit | 5.04 |
ENSDART00000148276
|
myosin, light polypeptide 3, skeletal muscle |
|
| chr22_-_278328 Show fit | 4.00 |
ENSDART00000098072
|
myosin, heavy polypeptide 1.1, skeletal muscle |
|
| chr9_-_22831836 Show fit | 3.95 |
ENSDART00000142585
|
nebulin |
|
| chr11_+_21076872 Show fit | 3.88 |
ENSDART00000155521
|
proline/arginine-rich end leucine-rich repeat protein |
|
| chr6_-_39764995 Show fit | 3.49 |
ENSDART00000085277
|
phosphofructokinase, muscle b |
|
| chr8_-_18535822 Show fit | 3.34 |
ENSDART00000100558
|
nexilin (F actin binding protein) |
|
| chr4_-_16406737 Show fit | 3.12 |
ENSDART00000013085
|
decorin |
|
| chr18_+_9171778 Show fit | 3.02 |
ENSDART00000101192
|
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D |
|
| chr16_+_47308856 Show fit | 3.01 |
ENSDART00000170103
|
collagen, type XXVIII, alpha 1b |
|
| chr20_-_29483514 Show fit | 2.91 |
ENSDART00000062370
|
actin, alpha, cardiac muscle 1a |
Network of associatons between targets according to the STRING database.
First level regulatory network of pgr
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.3 | GO:0060048 | cardiac muscle contraction(GO:0060048) |
| 0.0 | 9.9 | GO:0043062 | extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062) |
| 0.6 | 6.4 | GO:0061620 | glucose catabolic process(GO:0006007) NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718) |
| 0.4 | 6.4 | GO:0016203 | muscle attachment(GO:0016203) |
| 0.2 | 6.0 | GO:0007379 | somite specification(GO:0001757) segment specification(GO:0007379) |
| 0.9 | 5.6 | GO:0003272 | endocardial cushion formation(GO:0003272) |
| 0.1 | 4.2 | GO:0008016 | regulation of heart contraction(GO:0008016) |
| 0.7 | 3.9 | GO:0071691 | cardiac muscle thin filament assembly(GO:0071691) |
| 1.1 | 3.4 | GO:0032060 | bleb assembly(GO:0032060) slow muscle cell migration(GO:1904969) |
| 0.1 | 3.4 | GO:0030916 | otic vesicle formation(GO:0030916) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 18.8 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 10.5 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 10.4 | GO:0030018 | Z disc(GO:0030018) |
| 0.2 | 8.8 | GO:0005861 | troponin complex(GO:0005861) |
| 0.1 | 6.6 | GO:0016459 | myosin complex(GO:0016459) |
| 0.6 | 6.4 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 0.3 | 5.6 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.2 | 4.8 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 4.2 | GO:0005884 | actin filament(GO:0005884) |
| 0.0 | 3.4 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.4 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 15.5 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.6 | 6.4 | GO:0003872 | 6-phosphofructokinase activity(GO:0003872) |
| 0.1 | 5.6 | GO:0005518 | collagen binding(GO:0005518) |
| 0.3 | 4.8 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.0 | 4.6 | GO:0050839 | cell adhesion molecule binding(GO:0050839) |
| 0.2 | 3.6 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.1 | 3.4 | GO:0051018 | protein kinase A binding(GO:0051018) |
| 0.1 | 3.3 | GO:0098631 | protein binding involved in cell adhesion(GO:0098631) protein binding involved in cell-cell adhesion(GO:0098632) |
| 0.1 | 3.0 | GO:0017147 | Wnt-protein binding(GO:0017147) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.5 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 5.2 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 4.7 | NABA CORE MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
| 0.0 | 3.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 2.9 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 2.6 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 1.5 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.0 | 1.2 | PID AVB3 INTEGRIN PATHWAY | Integrins in angiogenesis |
| 0.0 | 0.9 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.0 | 0.8 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.4 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.4 | 3.9 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.3 | 3.1 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.0 | 2.4 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.2 | 2.2 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.2 | 0.8 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.1 | 0.7 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.1 | 0.7 | REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS | Genes involved in CREB phosphorylation through the activation of Ras |
| 0.0 | 0.7 | REACTOME RNA POL III CHAIN ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.1 | 0.5 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |