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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for phf21ab+rfx5

Z-value: 1.12

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Transcription factors associated with phf21ab+rfx5

Gene Symbol Gene ID Gene Info
phf21ab
ENSDARG00000021378 PHD finger protein 21Ab
rfx5
ENSDARG00000063258 regulatory factor X, 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
rfx5dr11_v1_chr19_-_7495006_7495006-0.481.2e-06Click!
phf21abdr11_v1_chr25_-_7764083_7764083-0.363.5e-04Click!

Activity profile of phf21ab+rfx5 motif

Sorted Z-values of phf21ab+rfx5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_36142734 20.98 ENSDART00000159361
ENSDART00000161194
mhc2b
major histocompatibility complex class II integral membrane beta chain gene
chr7_+_66822229 18.19 ENSDART00000112109
lyve1a
lymphatic vessel endothelial hyaluronic receptor 1a
chr3_-_19561058 18.00 ENSDART00000079323
zgc:163079
zgc:163079
chr10_-_22797959 17.75 ENSDART00000183269
pcolcea
procollagen C-endopeptidase enhancer a
chr19_-_7110617 16.90 ENSDART00000104838
psmb8a
proteasome subunit beta 8A
chr8_-_36370552 15.77 ENSDART00000097932
ENSDART00000148323
si:busm1-104n07.3
si:busm1-104n07.3
chr8_-_36412936 14.78 ENSDART00000159276
si:zfos-2070c2.3
si:zfos-2070c2.3
chr18_+_8340886 12.63 ENSDART00000081132
cpt1b
carnitine palmitoyltransferase 1B (muscle)
chr8_+_36288261 12.45 ENSDART00000191281
CU929676.1

chr7_-_3011514 11.70 ENSDART00000169589
zgc:171695
zgc:171695
chr21_+_33459524 11.52 ENSDART00000053205
cd74b
CD74 molecule, major histocompatibility complex, class II invariant chain b
chr16_+_40301056 9.70 ENSDART00000058578
rspo3
R-spondin 3
chr11_-_24458786 8.73 ENSDART00000089713
mxra8a
matrix-remodelling associated 8a
chr19_+_43297546 8.51 ENSDART00000168002
laptm5
lysosomal protein transmembrane 5
chr13_+_233482 8.48 ENSDART00000102511
cfap36
cilia and flagella associated protein 36
chr4_-_76370630 8.03 ENSDART00000168831
ENSDART00000174313
si:ch73-158p21.3
si:ch73-158p21.3
chr3_-_29941357 6.92 ENSDART00000147732
ENSDART00000137973
ENSDART00000103523
grna
granulin a
chr21_-_45920 6.37 ENSDART00000040422
bhmt
betaine-homocysteine methyltransferase
chr1_-_23274393 6.08 ENSDART00000147800
ENSDART00000130277
ENSDART00000054340
ENSDART00000054338
rpl9
ribosomal protein L9
chr12_+_14084291 5.77 ENSDART00000189734
si:ch211-217a12.1
si:ch211-217a12.1
chr1_-_7570181 5.73 ENSDART00000103588
mxa
myxovirus (influenza) resistance A
chr7_-_26049282 5.59 ENSDART00000136389
ENSDART00000101124
rnaseka
ribonuclease, RNase K a
chr16_-_13516745 5.58 ENSDART00000145410
si:dkeyp-69b9.3
si:dkeyp-69b9.3
chr4_-_49982134 5.46 ENSDART00000186050
si:dkey-156k2.4
si:dkey-156k2.4
chr21_-_32097908 5.45 ENSDART00000147387
si:ch211-160j14.3
si:ch211-160j14.3
chr2_-_37862380 5.43 ENSDART00000186005
si:ch211-284o19.8
si:ch211-284o19.8
chr9_+_20780813 5.43 ENSDART00000142787
fam46c
family with sequence similarity 46, member C
chr7_-_55051692 5.24 ENSDART00000170637
tpcn2
two pore segment channel 2
chr17_-_45040813 5.23 ENSDART00000075514
entpd5a
ectonucleoside triphosphate diphosphohydrolase 5a
chr9_-_31090593 5.16 ENSDART00000089136
gpr18
G protein-coupled receptor 18
chr4_+_30788743 5.11 ENSDART00000184557
si:dkey-178j11.5
si:dkey-178j11.5
chr20_-_29787192 5.05 ENSDART00000125348
ENSDART00000048759
id2b
inhibitor of DNA binding 2b
chr2_+_16173999 4.87 ENSDART00000177639
ENSDART00000157601
ENSDART00000190186
ENSDART00000045933
sh3glb1b
SH3-domain GRB2-like endophilin B1b
chr4_+_68939595 4.86 ENSDART00000168331
ENSDART00000193212
si:dkey-264f17.2
si:dkey-264f17.2
chr3_-_7912661 4.04 ENSDART00000161400
trim35-21
tripartite motif containing 35-21
chr8_-_32878228 3.93 ENSDART00000110897
si:dkey-56i24.1
si:dkey-56i24.1
chr7_+_26049818 3.71 ENSDART00000173611
si:dkey-6n21.12
si:dkey-6n21.12
chr4_-_75678082 3.65 ENSDART00000180201
si:dkey-165o8.1
si:dkey-165o8.1
chr15_-_17619306 3.48 ENSDART00000184011
adamts15b
ADAM metallopeptidase with thrombospondin type 1 motif, 15b
chr21_-_17290941 2.85 ENSDART00000147993
gfi1b
growth factor independent 1B transcription repressor
chr4_+_7822773 2.72 ENSDART00000171391
si:ch1073-67j19.2
si:ch1073-67j19.2
chr15_-_38129845 2.71 ENSDART00000057095
si:dkey-24p1.1
si:dkey-24p1.1
chr4_-_36033377 2.66 ENSDART00000164348
ENSDART00000187058
zgc:174180
zgc:174180
chr7_-_56606752 2.53 ENSDART00000138714
sult5a1
sulfotransferase family 5A, member 1
chr7_-_26924903 2.47 ENSDART00000124363
alx4a
ALX homeobox 4a
chr4_-_43613424 2.43 ENSDART00000171524
si:dkey-16p6.4
si:dkey-16p6.4
chr23_+_45025909 2.40 ENSDART00000188105
hmgb2b
high mobility group box 2b
chr8_-_11077230 2.39 ENSDART00000143844
dennd2c
DENN/MADD domain containing 2C
chr19_-_45534392 2.28 ENSDART00000163920
trps1
trichorhinophalangeal syndrome I
chr4_-_36032177 2.11 ENSDART00000170143
zgc:174180
zgc:174180
chr4_+_76906112 1.92 ENSDART00000180696
si:dkey-240n22.6
si:dkey-240n22.6
chr7_+_56889879 1.90 ENSDART00000039810
myo9aa
myosin IXAa
chr16_-_47301376 1.76 ENSDART00000169697
mios
missing oocyte, meiosis regulator, homolog (Drosophila)
chr20_+_43396318 1.68 ENSDART00000060910
pimr138
Pim proto-oncogene, serine/threonine kinase, related 138
chr6_-_54348568 1.66 ENSDART00000156501
zgc:101577
zgc:101577
chr13_-_17860307 1.56 ENSDART00000135920
ENSDART00000054579
march8
membrane-associated ring finger (C3HC4) 8
chr4_-_330748 1.49 ENSDART00000067488
mrps10
mitochondrial ribosomal protein S10
chr2_-_42958619 1.30 ENSDART00000144317
oc90
otoconin 90
chr10_-_16028082 1.28 ENSDART00000122540
aldh7a1
aldehyde dehydrogenase 7 family, member A1
chr6_+_26309968 1.27 ENSDART00000153805
dzip1l
DAZ interacting zinc finger protein 1-like
chr10_-_36618674 1.21 ENSDART00000135302
rsf1b.1
remodeling and spacing factor 1b, tandem duplicate 1
chr8_+_20415824 1.16 ENSDART00000009081
ENSDART00000145444
mob3a
MOB kinase activator 3A
chr11_+_45448212 1.10 ENSDART00000173341
sos1
son of sevenless homolog 1 (Drosophila)
chr3_-_8873716 1.03 ENSDART00000171798
znf1150
zinc finger protein 1150
chr20_-_28931901 0.91 ENSDART00000153082
ENSDART00000046042
susd6
sushi domain containing 6
chr20_+_39416729 0.53 ENSDART00000099993
ENSDART00000144133
pimr128
Pim proto-oncogene, serine/threonine kinase, related 128
chr18_-_21047007 0.49 ENSDART00000162702
igf1ra
insulin-like growth factor 1a receptor
chr18_-_21640389 0.45 ENSDART00000100857
slc38a8a
solute carrier family 38, member 8a
chr1_+_24366110 0.38 ENSDART00000139913
pimr178
Pim proto-oncogene, serine/threonine kinase, related 178
chr8_-_22273819 0.36 ENSDART00000121513
nphp4
nephronophthisis 4
chr15_+_32411660 0.28 ENSDART00000113443
si:dkey-285b23.4
si:dkey-285b23.4
chr20_+_39394308 0.25 ENSDART00000142554
pimr136
Pim proto-oncogene, serine/threonine kinase, related 136
chr2_+_37837249 0.22 ENSDART00000113337
parp2
poly (ADP-ribose) polymerase 2
chr23_+_21964325 0.17 ENSDART00000140208
ENSDART00000135690
lactbl1a
lactamase, beta-like 1a
chr25_-_893464 0.17 ENSDART00000159321
znf609a
zinc finger protein 609a
chr20_+_39373480 0.14 ENSDART00000136714
pimr131
Pim proto-oncogene, serine/threonine kinase, related 131
chr8_-_22274222 0.14 ENSDART00000131805
nphp4
nephronophthisis 4
chr4_+_33095657 0.07 ENSDART00000150647
znf1112
zinc finger protein 1112
chr1_-_494280 0.03 ENSDART00000144406
ercc5
excision repair cross-complementation group 5

Network of associatons between targets according to the STRING database.

First level regulatory network of phf21ab+rfx5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 11.5 GO:0010934 macrophage cytokine production(GO:0010934) regulation of macrophage cytokine production(GO:0010935) positive regulation of macrophage cytokine production(GO:0060907) negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
2.4 9.7 GO:0060829 negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060829)
1.1 5.6 GO:0051145 smooth muscle cell differentiation(GO:0051145)
0.9 6.9 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.9 19.0 GO:0006577 amino-acid betaine metabolic process(GO:0006577)
0.7 5.7 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.7 22.5 GO:0019882 antigen processing and presentation(GO:0019882)
0.7 5.2 GO:2000290 regulation of myotome development(GO:2000290)
0.6 3.7 GO:0035332 positive regulation of hippo signaling(GO:0035332)
0.5 16.9 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.5 5.2 GO:0072506 phosphate ion homeostasis(GO:0055062) trivalent inorganic anion homeostasis(GO:0072506)
0.4 1.9 GO:0098529 neuromuscular junction development, skeletal muscle fiber(GO:0098529)
0.3 18.2 GO:0001946 lymphangiogenesis(GO:0001946)
0.1 5.2 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.1 5.0 GO:0032922 circadian regulation of gene expression(GO:0032922)
0.1 1.3 GO:0032309 icosanoid secretion(GO:0032309) arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.1 2.5 GO:0051923 sulfation(GO:0051923)
0.1 1.8 GO:0032008 positive regulation of TOR signaling(GO:0032008) cellular response to amino acid starvation(GO:0034198)
0.1 5.6 GO:0090305 nucleic acid phosphodiester bond hydrolysis(GO:0090305)
0.0 2.9 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 0.5 GO:0048009 insulin-like growth factor receptor signaling pathway(GO:0048009)
0.0 0.2 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 7.6 GO:0006412 translation(GO:0006412)
0.0 1.3 GO:0032880 regulation of protein localization(GO:0032880)
0.0 3.5 GO:0030198 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.1 32.5 GO:0042613 MHC class II protein complex(GO:0042613)
0.6 16.9 GO:0005839 proteasome core complex(GO:0005839)
0.4 1.2 GO:0031213 RSF complex(GO:0031213)
0.4 7.7 GO:0097546 ciliary base(GO:0097546)
0.3 5.7 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.2 17.5 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 6.1 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 15.5 GO:0005765 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1 0.5 GO:0005899 insulin receptor complex(GO:0005899)
0.1 1.5 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 1.6 GO:0031902 late endosome membrane(GO:0031902)
0.0 1.9 GO:0030426 growth cone(GO:0030426)
0.0 56.8 GO:0005576 extracellular region(GO:0005576)
0.0 1.3 GO:0036064 ciliary basal body(GO:0036064)
0.0 1.1 GO:0000786 nucleosome(GO:0000786)
0.0 2.7 GO:0005911 cell-cell junction(GO:0005911)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 12.6 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.9 16.9 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.7 5.2 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.6 6.4 GO:0008172 S-methyltransferase activity(GO:0008172)
0.5 11.5 GO:0042289 MHC class II protein binding(GO:0042289)
0.5 17.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.3 5.2 GO:0045134 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.2 1.6 GO:0042287 MHC protein binding(GO:0042287)
0.1 2.4 GO:0008301 DNA binding, bending(GO:0008301)
0.1 6.1 GO:0019843 rRNA binding(GO:0019843)
0.1 0.5 GO:0005009 insulin-activated receptor activity(GO:0005009) insulin receptor substrate binding(GO:0043560)
0.1 9.7 GO:0008201 heparin binding(GO:0008201)
0.1 5.6 GO:0004521 endoribonuclease activity(GO:0004521)
0.1 5.8 GO:0030170 pyridoxal phosphate binding(GO:0030170)
0.1 18.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 1.3 GO:0004623 phospholipase A2 activity(GO:0004623)
0.0 2.5 GO:0008146 sulfotransferase activity(GO:0008146)
0.0 1.3 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.0 3.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 13.4 GO:0005525 GTP binding(GO:0005525)
0.0 0.2 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.0 2.0 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 6.2 GO:0046983 protein dimerization activity(GO:0046983)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 9.7 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 1.1 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 12.6 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.3 6.4 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 1.1 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
0.1 6.1 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 5.2 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events