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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for phox2a

Z-value: 0.49

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Transcription factors associated with phox2a

Gene Symbol Gene ID Gene Info
phox2a
ENSDARG00000007406 paired like homeobox 2A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
phox2adr11_v1_chr15_+_47440477_474404770.414.3e-05Click!

Activity profile of phox2a motif

Sorted Z-values of phox2a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_16025554 7.86 ENSDART00000110171
elavl4
ELAV like neuron-specific RNA binding protein 4
chr4_+_21129752 7.56 ENSDART00000169764
syt1a
synaptotagmin Ia
chr2_+_50608099 5.77 ENSDART00000185805
ENSDART00000111135
neurod6b
neuronal differentiation 6b
chr20_+_41756996 5.09 ENSDART00000186393
fam184a
family with sequence similarity 184, member A
chr10_-_22918214 4.77 ENSDART00000163908
rnasekb
ribonuclease, RNase K b
chr21_-_42100471 4.41 ENSDART00000166148
gabra1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr17_+_15433671 4.15 ENSDART00000149568
fabp7a
fatty acid binding protein 7, brain, a
chr9_-_43538328 3.86 ENSDART00000140526
znf385b
zinc finger protein 385B
chr7_-_30174882 3.77 ENSDART00000110409
frmd5
FERM domain containing 5
chr17_+_15433518 3.75 ENSDART00000026180
fabp7a
fatty acid binding protein 7, brain, a
chr5_+_37903790 3.54 ENSDART00000162470
tmprss4b
transmembrane protease, serine 4b
chr12_-_33357655 3.17 ENSDART00000066233
ENSDART00000148165
slc16a3
solute carrier family 16 (monocarboxylate transporter), member 3
chr16_-_25568512 3.08 ENSDART00000149411
atxn1b
ataxin 1b
chr5_+_4054704 2.74 ENSDART00000140537
dhrs11a
dehydrogenase/reductase (SDR family) member 11a
chr20_-_29864390 2.68 ENSDART00000161834
ENSDART00000132278
rnf144ab
ring finger protein 144ab
chr1_-_19502322 2.44 ENSDART00000181888
ENSDART00000044030
kitb
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog b
chr2_+_2223837 2.44 ENSDART00000101038
ENSDART00000129354
tmie
transmembrane inner ear
chr18_+_28106139 2.19 ENSDART00000089615
kiaa1549lb
KIAA1549-like b
chr3_-_20040636 2.11 ENSDART00000104118
atxn7l3
ataxin 7-like 3
chr11_-_42554290 1.99 ENSDART00000130573
atp6ap1la
ATPase H+ transporting accessory protein 1 like a
chr21_-_13123176 1.75 ENSDART00000144866
ENSDART00000024616
fam219aa
family with sequence similarity 219, member Aa
chr6_+_13117598 1.72 ENSDART00000104744
casp8l1
caspase 8, apoptosis-related cysteine peptidase, like 1
chr1_-_44704261 1.70 ENSDART00000133210
si:dkey-28b4.8
si:dkey-28b4.8
chr5_+_60590796 1.63 ENSDART00000159859
tmem132e
transmembrane protein 132E
chr17_-_200316 1.56 ENSDART00000190561
CABZ01083778.1

chr20_-_28642061 1.53 ENSDART00000135513
rgs6
regulator of G protein signaling 6
chr6_-_35779348 1.43 ENSDART00000191159
brinp3a.1
bone morphogenetic protein/retinoic acid inducible neural-specific 3a, tandem duplicate 1
chr21_+_32820175 1.40 ENSDART00000076903
adra2db
adrenergic, alpha-2D-, receptor b
chr21_+_28478663 1.37 ENSDART00000077887
ENSDART00000134150
slc22a6l
solute carrier family 22 (organic anion transporter), member 6, like
chr3_-_56541723 1.33 ENSDART00000156398
ENSDART00000050576
ENSDART00000184874
si:ch211-189a21.1
cyth1a
si:ch211-189a21.1
cytohesin 1a
chr13_+_22476742 1.32 ENSDART00000078759
ENSDART00000130101
ENSDART00000137220
ENSDART00000133065
ENSDART00000147348
ldb3a
LIM domain binding 3a
chr1_-_15797663 1.27 ENSDART00000177122
SGCZ
sarcoglycan zeta
chr15_-_14552101 1.25 ENSDART00000171169
numbl
numb homolog (Drosophila)-like
chr15_-_22074315 1.21 ENSDART00000149830
drd2a
dopamine receptor D2a
chr18_+_34362608 1.10 ENSDART00000131478
kcnab1a
potassium voltage-gated channel, shaker-related subfamily, beta member 1 a
chr19_+_2631565 1.05 ENSDART00000171487
fam126a
family with sequence similarity 126, member A
chr9_-_32177117 0.83 ENSDART00000078568
sf3b1
splicing factor 3b, subunit 1
chr11_-_2838699 0.79 ENSDART00000066189
lhfpl5a
LHFPL tetraspan subfamily member 5a
chr12_+_26877381 0.71 ENSDART00000087329
znf438
zinc finger protein 438
chr24_+_28953089 0.63 ENSDART00000153761
rnpc3
RNA-binding region (RNP1, RRM) containing 3
chr19_+_5480327 0.62 ENSDART00000148794
jupb
junction plakoglobin b
chr3_+_23692462 0.61 ENSDART00000145934
hoxb7a
homeobox B7a
chr2_-_7845110 0.60 ENSDART00000091987
si:ch211-38m6.7
si:ch211-38m6.7
chr13_+_31211050 0.50 ENSDART00000111705
ptpn20
protein tyrosine phosphatase, non-receptor type 20
chr17_+_49281597 0.49 ENSDART00000155599
zgc:113176
zgc:113176
chr22_-_8725768 0.43 ENSDART00000189873
ENSDART00000181819
si:ch73-27e22.1
si:ch73-27e22.8
si:ch73-27e22.1
si:ch73-27e22.8
chr4_-_1801519 0.40 ENSDART00000188604
ENSDART00000135749
nudt4b
nudix (nucleoside diphosphate linked moiety X)-type motif 4b
chr2_-_9818640 0.36 ENSDART00000139499
ENSDART00000165548
ENSDART00000012442
ENSDART00000046587
ap2m1b
adaptor-related protein complex 2, mu 1 subunit, b
chr10_+_42423318 0.33 ENSDART00000134282
npy8ar
neuropeptide Y receptor Y8a
chr21_-_43616586 0.17 ENSDART00000036537
htr2cl2
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 2
chr5_-_30620625 0.07 ENSDART00000098273
tcnl
transcobalamin like
chr14_+_17376940 0.07 ENSDART00000054590
ENSDART00000010148
spon2b
spondin 2b, extracellular matrix protein
chr7_-_17412559 0.06 ENSDART00000163020
nitr3a
novel immune-type receptor 3a

Network of associatons between targets according to the STRING database.

First level regulatory network of phox2a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.4 GO:0070208 protein heterotrimerization(GO:0070208)
0.6 2.4 GO:0038093 Fc receptor signaling pathway(GO:0038093)
0.3 7.6 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.3 1.4 GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway(GO:0071881)
0.3 1.1 GO:1903817 negative regulation of potassium ion transmembrane transporter activity(GO:1901017) negative regulation of potassium ion transmembrane transport(GO:1901380) negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.1 1.6 GO:0035677 posterior lateral line neuromast hair cell development(GO:0035677)
0.1 1.4 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.1 2.4 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.1 0.6 GO:0002159 desmosome assembly(GO:0002159)
0.1 0.6 GO:0005513 detection of calcium ion(GO:0005513)
0.1 3.9 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.1 1.2 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481) negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1 0.4 GO:0015961 diadenosine polyphosphate metabolic process(GO:0015959) diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.0 2.7 GO:1901800 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.0 0.8 GO:0060122 inner ear receptor stereocilium organization(GO:0060122)
0.0 4.8 GO:0090305 nucleic acid phosphodiester bond hydrolysis(GO:0090305)
0.0 1.2 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 3.2 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 2.0 GO:0030641 regulation of cellular pH(GO:0030641)
0.0 1.3 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 9.2 GO:0008380 RNA splicing(GO:0008380)
0.0 3.8 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 1.1 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.5 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 1.5 GO:0007626 locomotory behavior(GO:0007626)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 7.6 GO:0042584 chromaffin granule membrane(GO:0042584)
0.3 2.0 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.2 7.9 GO:0043204 perikaryon(GO:0043204)
0.1 4.4 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 1.1 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 1.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 1.5 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.4 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.6 GO:0030057 desmosome(GO:0030057)
0.0 1.2 GO:0098978 glutamatergic synapse(GO:0098978)
0.0 1.3 GO:0031941 filamentous actin(GO:0031941)
0.0 1.4 GO:0043025 neuronal cell body(GO:0043025)
0.0 0.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 7.9 GO:0005504 fatty acid binding(GO:0005504)
0.3 4.4 GO:0008503 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.3 3.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.2 1.4 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
0.2 7.6 GO:0001786 phosphatidylserine binding(GO:0001786)
0.2 0.6 GO:0030626 U12 snRNA binding(GO:0030626)
0.1 1.7 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 1.2 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.1 0.4 GO:0034432 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.1 4.8 GO:0004521 endoribonuclease activity(GO:0004521)
0.1 2.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 0.6 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 1.3 GO:0051371 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.1 3.5 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 1.1 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.0 0.5 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 0.6 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 2.4 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 0.3 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 0.4 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 1.7 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.4 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.2 3.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.8 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 1.5 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events