ISMARA results: plag1+plagx

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for plag1+plagx

Z-value: 0.50

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Transcription factors associated with plag1+plagx

Gene Symbol	Gene ID	Gene Info
plagx NCBI UniProt	ENSDARG00000036855	pleiomorphic adenoma gene X
plag1 NCBI UniProt	ENSDARG00000051926	pleiomorphic adenoma gene 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
plagx	dr11_v1_chr23_+_32011768_32011768	-0.27	8.4e-03	Click!
plag1	dr11_v1_chr7_+_58730201_58730201	-0.25	1.5e-02	Click!

Activity profile of plag1+plagx motif

Sorted Z-values of plag1+plagx motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_-_25916530 Show fit	5.69	ENSDART00000186386	sncgb NCBI UniProt Show fit	synuclein, gamma b (breast cancer-specific protein 1)
chr21_+_7823146 Show fit	5.08	ENSDART00000030579	crhbp NCBI UniProt Show fit	corticotropin releasing hormone binding protein
chr4_+_6572364 Show fit	4.64	ENSDART00000122574	ppp1r3aa NCBI UniProt Show fit	protein phosphatase 1, regulatory subunit 3Aa
chr23_+_44732863 Show fit	4.37	ENSDART00000160044 ENSDART00000172268	atp1b2a NCBI UniProt Show fit	ATPase Na+/K+ transporting subunit beta 2a
chr2_+_2470687 Show fit	3.01	ENSDART00000184024 ENSDART00000061955	myl13 NCBI UniProt Show fit	myosin, light chain 13
chr4_+_19534833 Show fit	2.88	ENSDART00000140028	lrrc4.1 NCBI UniProt Show fit	leucine rich repeat containing 4.1
chr16_-_36798783 Show fit	2.77	ENSDART00000145697	calb1 NCBI UniProt Show fit	calbindin 1
chr7_+_568819 Show fit	2.61	ENSDART00000173716	nrxn2b NCBI UniProt Show fit	neurexin 2b
chr23_+_43954809 Show fit	2.04	ENSDART00000164080	corin NCBI UniProt Show fit	corin, serine peptidase
chr4_+_9400012 Show fit	1.90	ENSDART00000191960	tmtc1 NCBI UniProt Show fit	transmembrane and tetratricopeptide repeat containing 1

Showing 1 to 10 of 48 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of plag1+plagx

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	5.7	GO:0071542	dopaminergic neuron differentiation(GO:0071542)
1.7	5.1	GO:0090278	negative regulation of peptide secretion(GO:0002792) negative regulation of peptide hormone secretion(GO:0090278)
0.2	4.6	GO:0005979	regulation of glycogen biosynthetic process(GO:0005979) regulation of glucan biosynthetic process(GO:0010962)
0.2	4.4	GO:0036376	cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.7	2.8	GO:0099509	regulation of presynaptic cytosolic calcium ion concentration(GO:0099509) regulation of long-term synaptic potentiation(GO:1900271)
0.0	1.4	GO:0045332	phospholipid translocation(GO:0045332)
0.1	1.3	GO:0043486	histone exchange(GO:0043486)
0.3	0.9	GO:0002074	extraocular skeletal muscle development(GO:0002074)
0.0	0.9	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.0	0.8	GO:0010669	epithelial structure maintenance(GO:0010669)

Showing 1 to 10 of 17 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	8.5	GO:0043679	axon terminus(GO:0043679)
0.3	4.6	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.4	4.4	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.1	1.4	GO:0030132	clathrin coat of coated pit(GO:0030132)
0.1	1.3	GO:0000812	Swr1 complex(GO:0000812)
0.0	0.7	GO:0005861	troponin complex(GO:0005861)
0.1	0.4	GO:0016589	NURF complex(GO:0016589)

Showing 1 to 7 of 7 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.9	5.7	GO:1903136	cuprous ion binding(GO:1903136)
0.1	5.1	GO:0017046	peptide hormone binding(GO:0017046)
0.3	4.6	GO:2001069	glycogen binding(GO:2001069)
0.2	4.4	GO:0001671	ATPase activator activity(GO:0001671)
0.9	2.8	GO:0005499	vitamin D binding(GO:0005499)
0.0	2.0	GO:0005044	scavenger receptor activity(GO:0005044)
0.1	1.9	GO:0004169	dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.3	1.5	GO:0070004	cysteine-type exopeptidase activity(GO:0070004)
0.0	1.3	GO:0019212	phosphatase inhibitor activity(GO:0019212)
0.0	0.9	GO:0046332	SMAD binding(GO:0046332)

Showing 1 to 10 of 15 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
5.1	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.9	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.6	PID NOTCH PATHWAY	Notch signaling pathway
0.1	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway

Showing 1 to 4 of 4 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.4	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.0	0.9	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.1	0.6	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0	0.2	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling

Showing 1 to 4 of 4 entries

Results for plag1+plagx

Z-value: 0.50

Motif logo

Transcription factors associated with plag1+plagx

Activity-expression correlation:

Activity profile of plag1+plagx motif

Sorted Z-values of plag1+plagx motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of plag1+plagx

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: