ISMARA results: pou2f1b

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for pou2f1b

Z-value: 1.07

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Transcription factors associated with pou2f1b

Gene Symbol	Gene ID	Gene Info
pou2f1b NCBI UniProt	ENSDARG00000007996	POU class 2 homeobox 1b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
pou2f1b	dr11_v1_chr9_+_34334156_34334156	-0.46	3.5e-06	Click!

Activity profile of pou2f1b motif

Sorted Z-values of pou2f1b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr5_+_35458190 Show fit	19.22	ENSDART00000051313	fbp1b NCBI UniProt Show fit	fructose-1,6-bisphosphatase 1b
chr20_+_10538025 Show fit	12.60	ENSDART00000129762	serpina1l NCBI UniProt Show fit	serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, like
chr24_+_23959487 Show fit	12.27	ENSDART00000080487	hgd NCBI UniProt Show fit	homogentisate 1,2-dioxygenase
chr19_+_2835240 Show fit	11.79	ENSDART00000190838	CDCP1 NCBI UniProt Show fit	CUB domain containing protein 1
chr24_-_21150100 Show fit	11.40	ENSDART00000154249 ENSDART00000193256	gramd1c NCBI UniProt Show fit	GRAM domain containing 1c
chr20_+_10544100 Show fit	10.38	ENSDART00000113927	serpina1 NCBI UniProt Show fit	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr1_-_56080112 Show fit	9.94	ENSDART00000075469 ENSDART00000161473	c3a.6 NCBI UniProt Show fit	complement component c3a, duplicate 6
chr18_-_6742287 Show fit	9.73	ENSDART00000140752	miox NCBI UniProt Show fit	myo-inositol oxygenase
chr4_-_8043839 Show fit	8.84	ENSDART00000190047 ENSDART00000057567	si:ch211-240l19.5 NCBI UniProt Show fit	si:ch211-240l19.5
chr1_-_10071422 Show fit	8.59	ENSDART00000135522 ENSDART00000033118	fga NCBI UniProt Show fit	fibrinogen alpha chain

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of pou2f1b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	23.0	GO:0010951	negative regulation of endopeptidase activity(GO:0010951)
6.4	19.2	GO:0005985	sucrose metabolic process(GO:0005985) sucrose biosynthetic process(GO:0005986) disaccharide biosynthetic process(GO:0046351)
0.0	16.6	GO:0006508	proteolysis(GO:0006508)
1.0	12.3	GO:1902222	L-phenylalanine metabolic process(GO:0006558) L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.1	12.2	GO:0006956	complement activation(GO:0006956)
0.7	9.7	GO:0006020	inositol metabolic process(GO:0006020)
0.6	8.6	GO:0072378	blood coagulation, fibrin clot formation(GO:0072378)
0.1	8.1	GO:0006414	translational elongation(GO:0006414)
2.5	7.5	GO:0009120	deoxyribonucleoside metabolic process(GO:0009120) thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.4	7.4	GO:2001235	positive regulation of apoptotic signaling pathway(GO:2001235)

Showing 1 to 10 of 198 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	87.0	GO:0005615	extracellular space(GO:0005615)
0.0	25.5	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.0	9.3	GO:0005840	ribosome(GO:0005840)
2.9	8.6	GO:0005577	fibrinogen complex(GO:0005577)
0.1	8.3	GO:0005871	kinesin complex(GO:0005871)
0.1	7.1	GO:0019814	immunoglobulin complex(GO:0019814)
0.1	7.1	GO:0005777	peroxisome(GO:0005777) microbody(GO:0042579)
0.6	7.0	GO:0005665	DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1	5.6	GO:0032587	ruffle membrane(GO:0032587)
0.0	5.5	GO:0048471	perinuclear region of cytoplasm(GO:0048471)

Showing 1 to 10 of 70 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	24.0	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
6.4	19.2	GO:0042132	fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.1	12.6	GO:0003735	structural constituent of ribosome(GO:0003735)
0.2	12.3	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.2	9.9	GO:0004866	endopeptidase inhibitor activity(GO:0004866)
0.8	9.7	GO:0008199	ferric iron binding(GO:0008199)
0.0	9.6	GO:0030246	carbohydrate binding(GO:0030246)
0.1	8.7	GO:0031625	ubiquitin protein ligase binding(GO:0031625)
0.1	8.3	GO:0003777	microtubule motor activity(GO:0003777)
1.5	7.5	GO:0002061	uracil binding(GO:0002058) pyrimidine nucleobase binding(GO:0002061) dihydropyrimidine dehydrogenase (NADP+) activity(GO:0017113)

Showing 1 to 10 of 141 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	10.4	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.3	10.0	NABA COLLAGENS	Genes encoding collagen proteins
0.5	8.6	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.2	7.9	PID PLK1 PATHWAY	PLK1 signaling events
0.0	5.1	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	4.9	PID E2F PATHWAY	E2F transcription factor network
0.2	3.7	PID CONE PATHWAY	Visual signal transduction: Cones
0.1	3.5	PID ENDOTHELIN PATHWAY	Endothelins
0.1	2.5	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.1	2.3	PID AURORA B PATHWAY	Aurora B signaling

Showing 1 to 10 of 29 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	11.4	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
0.2	10.4	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.8	8.6	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.2	8.0	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.1	8.0	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.2	7.2	REACTOME PRE NOTCH EXPRESSION AND PROCESSING	Genes involved in Pre-NOTCH Expression and Processing
0.6	7.1	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.5	7.0	REACTOME VIRAL MESSENGER RNA SYNTHESIS	Genes involved in Viral Messenger RNA Synthesis
1.4	5.5	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.3	5.3	REACTOME KINESINS	Genes involved in Kinesins

Showing 1 to 10 of 45 entries

Results for pou2f1b

Z-value: 1.07

Motif logo

Transcription factors associated with pou2f1b

Activity-expression correlation:

Activity profile of pou2f1b motif

Sorted Z-values of pou2f1b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of pou2f1b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: