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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for pou3f1

Z-value: 0.88

Motif logo

Transcription factors associated with pou3f1

Gene Symbol Gene ID Gene Info
ENSDARG00000009823 POU class 3 homeobox 1
ENSDARG00000112302 POU class 3 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
pou3f1dr11_v1_chr16_+_33593116_335931160.586.4e-10Click!

Activity profile of pou3f1 motif

Sorted Z-values of pou3f1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr21_+_30563115 15.13 ENSDART00000028566
si:ch211-200p22.4
chr19_-_30562648 14.19 ENSDART00000171006
hippocalcin like 4
chr22_+_20195280 12.83 ENSDART00000088603
ENSDART00000135692
si:dkey-110c1.7
chr10_+_22003750 11.32 ENSDART00000109420
Kv channel interacting protein 1 b
chr22_+_5106751 11.21 ENSDART00000138967
ataxia, cerebellar, Cayman type a
chr16_-_12173554 10.80 ENSDART00000110567
ENSDART00000155935
calsyntenin 3
chr6_+_4539953 10.57 ENSDART00000025031
POU class 4 homeobox 1
chr23_+_28731379 10.28 ENSDART00000047378
cortistatin
chr7_+_40228422 9.48 ENSDART00000052222
protein tyrosine phosphatase, receptor type, N polypeptide 2
chr16_-_43971258 9.29 ENSDART00000141941
zinc finger protein, FOG family member 2a
chr9_-_18877597 9.13 ENSDART00000099446
potassium channel tetramerization domain containing 4
chr7_-_38633867 9.11 ENSDART00000137424
C1q and TNF related 4
chr17_-_15528597 8.59 ENSDART00000150232
FYN proto-oncogene, Src family tyrosine kinase a
chr6_-_13187168 8.53 ENSDART00000193286
ENSDART00000188350
ENSDART00000150036
ENSDART00000149940
ADAM metallopeptidase domain 23a
chr21_-_27185915 7.78 ENSDART00000135052
solute carrier family 8 (sodium/calcium exchanger), member 4a
chr19_-_28367413 7.76 ENSDART00000079092
si:dkey-261i16.5
chr7_-_24699985 7.62 ENSDART00000052802
calbindin 2b
chr18_-_36135799 7.55 ENSDART00000059344
beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) a
chr5_-_24000211 7.55 ENSDART00000188865
MAP7 domain containing 2a
chr23_+_44307996 7.29 ENSDART00000042430
discs, large homolog 4b (Drosophila)
chr2_-_34555945 7.18 ENSDART00000056671
bone morphogenetic protein/retinoic acid inducible neural-specific 2
chr3_+_33345348 7.08 ENSDART00000059262
membrane protein, palmitoylated 2a (MAGUK p55 subfamily member 2)
chr18_+_38749547 7.04 ENSDART00000143735
si:ch211-215d8.2
chr2_+_24203229 7.02 ENSDART00000138088
microtubule associated protein 4 like
chr23_-_31372639 6.84 ENSDART00000179908
ENSDART00000135620
ENSDART00000053367
high mobility group nucleosomal binding domain 3
chr13_+_33117528 6.82 ENSDART00000085719
si:ch211-10a23.2
chr6_-_13188667 6.78 ENSDART00000191654
ADAM metallopeptidase domain 23a
chr16_+_39159752 6.74 ENSDART00000122081
syntabulin (syntaxin-interacting)
chr23_+_36771593 6.63 ENSDART00000078240
membrane-associated ring finger (C3HC4) 9
chr6_-_13308813 6.42 ENSDART00000065372
potassium inwardly-rectifying channel, subfamily J, member 3b
chr23_+_28582865 5.98 ENSDART00000020296
L1 cell adhesion molecule, paralog a
chr21_+_41743493 5.83 ENSDART00000192669
protein phosphatase 2, regulatory subunit B, beta b
chr16_+_43152727 5.70 ENSDART00000125590
ENSDART00000154493
ADAM metallopeptidase domain 22
chr1_+_1599979 5.70 ENSDART00000097626
urotensin II-related peptide
chr20_+_27298783 5.66 ENSDART00000013861
protein phosphatase 4, regulatory subunit 4
chr4_-_8903240 5.50 ENSDART00000129983
metallophosphoesterase domain containing 1
chr18_+_7286788 5.43 ENSDART00000022998
si:ch73-86n2.1
chr5_-_16996482 5.35 ENSDART00000144501
polypeptide N-acetylgalactosaminyltransferase 9
chr21_+_26390549 5.34 ENSDART00000185643
thymosin, beta
chr16_-_12173399 5.15 ENSDART00000142574
calsyntenin 3
chr25_-_15045338 4.96 ENSDART00000161165
ENSDART00000165774
ENSDART00000172538
paired box 6a
chr2_+_2563192 4.81 ENSDART00000055713

chr1_+_46194333 4.66 ENSDART00000010894
SRY (sex determining region Y)-box 1b
chr8_-_15398760 4.62 ENSDART00000162011
ATP/GTP binding protein-like 4
chr7_+_61050329 4.61 ENSDART00000115355
NACHT and WD repeat domain containing 2
chr25_-_25736958 4.60 ENSDART00000166308
calcium and integrin binding family member 2
chr22_+_18389271 4.54 ENSDART00000088270
YjeF N-terminal domain containing 3
chr1_+_7679328 4.45 ENSDART00000163488
ENSDART00000190070
engrailed homeobox 1b
chr9_-_31915423 4.35 ENSDART00000060051
fibroblast growth factor 14
chr7_+_31074636 4.11 ENSDART00000173805
tight junction protein 1a
chr13_+_28705143 4.09 ENSDART00000183338
LIM domain binding 1a
chr5_+_30624183 4.09 ENSDART00000141444
ATP-binding cassette, sub-family G (WHITE), member 4a
chr3_-_6519691 3.90 ENSDART00000165273
ENSDART00000179882
ENSDART00000172292
si:ch73-157i16.3
chr14_-_40389699 3.80 ENSDART00000181581
ENSDART00000173398
protocadherin 19
chr12_+_28986308 3.71 ENSDART00000153178
si:rp71-1c10.8
chr17_+_15882533 3.68 ENSDART00000164124
gamma-aminobutyric acid (GABA) A receptor, rho 2a
chr15_-_30815826 3.63 ENSDART00000156160
ENSDART00000145918
musashi RNA-binding protein 2b
chr18_-_12957451 3.59 ENSDART00000140403
SLIT-ROBO Rho GTPase activating protein 1a
chr14_-_48939560 3.57 ENSDART00000021736
short coiled-coil protein b
chr3_-_5964557 3.49 ENSDART00000184738

chr24_+_41931585 3.48 ENSDART00000130310
erythrocyte membrane protein band 4.1-like 3a
chr20_-_39188476 3.45 ENSDART00000152858
regulator of calcineurin 2
chr14_+_23874062 3.44 ENSDART00000172149
SH3 domain containing ring finger 2
chr1_+_31725154 3.43 ENSDART00000112333
ENSDART00000189801
cyclin and CBS domain divalent metal cation transport mediator 2b
chr17_-_37052622 3.34 ENSDART00000186408
DNA (cytosine-5-)-methyltransferase 3 alpha b
chr5_-_46896541 3.15 ENSDART00000133240
EGF-like repeats and discoidin I-like domains 3a
chr21_-_25573064 3.12 ENSDART00000134310

chr7_-_40738774 3.11 ENSDART00000084179
ring finger protein 32
chr6_+_45692026 2.98 ENSDART00000164759
contactin 4
chr16_+_45746549 2.97 ENSDART00000190403
progestin and adipoQ receptor family member VI
chr11_-_35575791 2.97 ENSDART00000031441
ENSDART00000188513
ENSDART00000183609
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fb
chr17_+_33719415 2.96 ENSDART00000132294
fucosyltransferase 8a (alpha (1,6) fucosyltransferase)
chr22_-_11729350 2.94 ENSDART00000105813
keratin 222
chr19_-_19556778 2.93 ENSDART00000164060
Tax1 (human T-cell leukemia virus type I) binding protein 1a
chr24_-_37484123 2.93 ENSDART00000111623
clusterin associated protein 1
chr25_+_25737386 2.91 ENSDART00000108476
leucine rich repeat containing 61
chr11_+_21586335 2.71 ENSDART00000091182
zgc:101564
chr17_-_42213822 2.65 ENSDART00000187904
ENSDART00000180029
NK2 homeobox 2a
chr6_+_18418651 2.57 ENSDART00000171097
ENSDART00000167798
RAB11 family interacting protein 4 (class II) b
chr16_+_25074029 2.55 ENSDART00000155465
si:dkeyp-84f3.9
chr17_-_4245311 2.52 ENSDART00000055379
growth differentiation factor 3
chr11_+_25634041 2.47 ENSDART00000033657
glutamate receptor, metabotropic 6b
chr13_+_29778610 2.47 ENSDART00000132004
paired box 2a
chr12_+_48480632 2.47 ENSDART00000158157
Rho GTPase activating protein 44
chr7_+_60396957 2.45 ENSDART00000121545
breast cancer metastasis suppressor 1
chr7_+_25920792 2.41 ENSDART00000026295
arrestin, beta 2b
chr9_-_18735256 2.41 ENSDART00000143165
TSC22 domain family, member 1
chr15_-_5157572 2.41 ENSDART00000174192
odorant receptor, family E, subfamily 128, member 10
chr1_+_54013457 2.39 ENSDART00000012104
ENSDART00000126339
deltaA
chr22_-_18491813 2.36 ENSDART00000105419
si:ch211-212d10.2
chr2_+_52847049 2.34 ENSDART00000121980
cAMP responsive element binding protein 3-like 3b
chr3_-_50998577 2.29 ENSDART00000157735
CDC42 effector protein (Rho GTPase binding) 4a
chr24_-_8730913 2.23 ENSDART00000187228
ENSDART00000082349
ENSDART00000186660
transcription factor AP-2 alpha
chr6_-_16406210 2.22 ENSDART00000012023
Fas apoptotic inhibitory molecule b
chr23_-_3409140 2.20 ENSDART00000002309
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Ba
chr22_+_18786797 2.14 ENSDART00000141864
calcium channel, voltage-dependent, beta subunit associated regulatory protein b
chr12_+_16087077 2.13 ENSDART00000141898
zinc finger protein 281b
chr5_+_69733096 2.10 ENSDART00000169013
ADP-ribosylation factor-like 6 interacting protein 4
chr13_+_29773153 2.09 ENSDART00000144443
ENSDART00000133796
ENSDART00000141310
ENSDART00000139782
paired box 2a
chr21_-_30254185 2.06 ENSDART00000101054
DnaJ (Hsp40) homolog, subfamily C, member 18
chr20_+_18225329 1.96 ENSDART00000144172
potassium channel tetramerization domain containing 1
chr23_+_20518504 1.95 ENSDART00000114246
activity-dependent neuroprotector homeobox b
chr6_-_19381993 1.94 ENSDART00000164114
growth factor receptor-bound protein 2a
chr8_+_28469054 1.92 ENSDART00000062716
solute carrier family 52 (riboflavin transporter), member 3
chr7_-_4036184 1.89 ENSDART00000019949
NDRG family member 2
chr8_-_43574935 1.88 ENSDART00000051139
nuclear receptor corepressor 2
chr1_+_8984068 1.84 ENSDART00000122568
toll-like receptor 2
chr15_+_39096736 1.84 ENSDART00000129511
ENSDART00000014877
roundabout, axon guidance receptor, homolog 2 (Drosophila)
chr9_-_21507083 1.84 ENSDART00000137922
AF4/FMR2 family, member 3
chr14_-_34700633 1.82 ENSDART00000150358
actin binding LIM protein family, member 3
chr1_+_27825980 1.81 ENSDART00000160524
paraspeckle component 1
chr22_+_14051894 1.78 ENSDART00000142548
aldehyde oxidase 6
chr5_-_25406807 1.75 ENSDART00000089748
RAR-related orphan receptor B
chr23_+_2825940 1.74 ENSDART00000135781
phospholipase C, gamma 1
chr19_-_26769867 1.68 ENSDART00000043776
ENSDART00000159489
ENSDART00000138675
proline-rich coiled-coil 2A
chr6_+_41096058 1.62 ENSDART00000028373
FK506 binding protein 5
chr10_+_39304422 1.56 ENSDART00000019267
potassium inwardly-rectifying channel, subfamily J, member 1b
chr21_-_32467099 1.56 ENSDART00000186354
zgc:123105
chr20_+_48782068 1.55 ENSDART00000159275
NK2 homeobox 2b
chr22_-_7400471 1.55 ENSDART00000161215
si:dkey-57c15.1
chr19_-_26770083 1.54 ENSDART00000193811
ENSDART00000174455
proline-rich coiled-coil 2A
chr1_-_20593778 1.52 ENSDART00000124770
UDP glycosyltransferase 8
chr2_-_56131312 1.50 ENSDART00000097755
JunD proto-oncogene, AP-1 transcription factor subunit
chr7_-_26497947 1.49 ENSDART00000058910
SRY (sex determining region Y)-box 19b
chr25_+_14694876 1.49 ENSDART00000050478
ENSDART00000188093
metallophosphoesterase domain containing 2b
chr9_-_30502010 1.48 ENSDART00000149483
si:dkey-229b18.3
chr5_+_63785339 1.47 ENSDART00000050871
regulator of G protein signaling 3b
chr10_+_26972755 1.46 ENSDART00000042162
transmembrane 7 superfamily member 2
chr18_-_47103131 1.43 ENSDART00000188553

chr15_+_34592215 1.43 ENSDART00000099776
tetraspanin 13a
chr11_-_41130239 1.41 ENSDART00000173268
DnaJ (Hsp40) homolog, subfamily C, member 11b
chr5_+_63302660 1.40 ENSDART00000142131
si:ch73-376l24.2
chr24_-_40009446 1.38 ENSDART00000087422
amine oxidase, copper containing 1
chr8_+_31777633 1.38 ENSDART00000142519
3-oxoacid CoA transferase 1a
chr7_+_69470442 1.35 ENSDART00000189593
GABA(A) receptor-associated protein b
chr25_-_26673570 1.35 ENSDART00000154917
circadian associated repressor of transcription b
chr13_-_33822550 1.34 ENSDART00000143703
fibronectin leucine rich transmembrane 3
chr12_-_33579873 1.33 ENSDART00000184661
tudor and KH domain containing
chr2_-_39036604 1.32 ENSDART00000129963
retinol binding protein 1b, cellular
chr25_+_5604512 1.31 ENSDART00000042781
plexin b2b
chr17_-_25831569 1.31 ENSDART00000148743
hedgehog acyltransferase
chr10_-_5821584 1.29 ENSDART00000166388
interleukin 6 signal transducer
chr22_+_17784414 1.28 ENSDART00000188189
ENSDART00000145260
transmembrane 6 superfamily member 2
chr5_+_9147497 1.24 ENSDART00000003273
ring finger and CHY zinc finger domain containing 1
chr23_+_21473103 1.23 ENSDART00000142921
si:ch73-21g5.7
chr24_+_25467465 1.22 ENSDART00000189933
small muscle protein, X-linked
chr2_-_37684641 1.20 ENSDART00000012191
hippocampus abundant transcript 1a
chr3_+_30190419 1.17 ENSDART00000157320
AKT1 substrate 1 (proline-rich)
chr15_-_734203 1.17 ENSDART00000177867
ENSDART00000154918
si:dkey-7i4.21

chr1_-_16394814 1.16 ENSDART00000013024
fibroblast growth factor 20a
chr14_+_6991142 1.16 ENSDART00000157635
ENSDART00000059918
heterogeneous nuclear ribonucleoprotein H1
chr17_+_43013171 1.13 ENSDART00000055541
gsk3b interacting protein
chr22_-_11954861 1.11 ENSDART00000131611
si:dkeyp-4h4.1
chr10_+_26973063 1.11 ENSDART00000143162
ENSDART00000186210
transmembrane 7 superfamily member 2
chr10_+_42521943 1.11 ENSDART00000010420
ENSDART00000075303
ARP1 actin related protein 1, centractin
chr1_-_17587552 1.08 ENSDART00000039917
acyl-CoA synthetase long chain family member 1a
chr9_+_12444494 1.03 ENSDART00000102430
transmembrane protein 41aa
chr14_+_37545639 1.03 ENSDART00000173192
protocadherin 1b
chr4_-_3353595 1.03 ENSDART00000009076
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
chr1_-_40411944 1.03 ENSDART00000144135
mastermind-like transcriptional coactivator 3
chr12_+_36092218 1.00 ENSDART00000168694
BTB (POZ) domain containing 17a
chr18_-_44359726 1.00 ENSDART00000166935
PR domain containing 10
chr20_-_45060241 0.98 ENSDART00000185227
kelch-like family member 29
chr21_+_8427059 0.98 ENSDART00000143151
DENN/MADD domain containing 1A
chr2_-_24317240 0.98 ENSDART00000078975
tRNA selenocysteine 1 associated protein 1b
chr13_-_48756036 0.96 ENSDART00000035018
ENSDART00000132895
nucleoside-triphosphatase, cancer-related
chr23_-_6765653 0.96 ENSDART00000192310

chr10_+_44940693 0.94 ENSDART00000157515
cyclin and CBS domain divalent metal cation transport mediator 4a
chr9_-_25444091 0.94 ENSDART00000002428
activin A receptor type 2Aa
chr22_-_10397600 0.93 ENSDART00000181964
ENSDART00000142886
nischarin
chr13_-_24877577 0.89 ENSDART00000182705
K(lysine) acetyltransferase 6B
chr11_+_25257022 0.88 ENSDART00000156052
tumor protein p53 inducible nuclear protein 2
chr20_+_20751425 0.88 ENSDART00000177048
protein phosphatase 1, regulatory subunit 13Bb
chr22_+_413349 0.87 ENSDART00000082453
cadherin, EGF LAG seven-pass G-type receptor 2
chr16_-_21620947 0.87 ENSDART00000115011
ENSDART00000183125
ENSDART00000188856
ENSDART00000189460
discoidin domain receptor tyrosine kinase 1
chr11_-_44876005 0.86 ENSDART00000192006
opsin 6, group member a
chr10_+_33895315 0.84 ENSDART00000142881
furry homolog b (Drosophila)
chr8_+_8238727 0.83 ENSDART00000144838
plexin B3
chr16_+_25107344 0.83 ENSDART00000033211
zgc:66448
chr2_+_32835679 0.82 ENSDART00000132767
PX domain containing 1a
chr7_+_20965880 0.81 ENSDART00000062003
ephrin-B3b
chr12_-_19151708 0.81 ENSDART00000057124
thyrotrophic embryonic factor a
chr12_+_46960579 0.81 ENSDART00000149032
ornithine aminotransferase
chr10_+_33744098 0.79 ENSDART00000147775
relaxin/insulin-like family peptide receptor 2a
chr7_+_22792895 0.76 ENSDART00000184407
RNA binding motif protein 4.3
chr3_+_26223376 0.76 ENSDART00000128284
nudix (nucleoside diphosphate linked moiety X)-type motif 9
chr23_-_3408777 0.75 ENSDART00000193245
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Ba
chr17_-_4245902 0.73 ENSDART00000151851
growth differentiation factor 3
chr15_+_29727799 0.73 ENSDART00000182006
zgc:153372
chr2_-_3616363 0.71 ENSDART00000144699
phosphotriesterase related
chr4_+_12292274 0.70 ENSDART00000061070
ENSDART00000150786
makorin, ring finger protein, 1
chr2_-_51290607 0.69 ENSDART00000171693
si:ch211-215e19.3
chr4_+_12013043 0.66 ENSDART00000130692
cryptochrome circadian clock 1aa
chr1_-_24918686 0.66 ENSDART00000148076
F-box and WD repeat domain containing 7
chr7_+_10701938 0.66 ENSDART00000158162
aryl-hydrocarbon receptor nuclear translocator 2
chr17_-_30473374 0.65 ENSDART00000155021
si:ch211-175f11.5
chr10_-_26225548 0.64 ENSDART00000132019
ENSDART00000079194
ADP-ribosylation factor interacting protein 2b
chr22_-_32392252 0.64 ENSDART00000148681
ENSDART00000137945
poly(rC) binding protein 4
chr16_+_38350704 0.63 ENSDART00000140761
elongator acetyltransferase complex subunit 6
chr21_+_5888641 0.62 ENSDART00000091331
proline dehydrogenase (oxidase) 1a

Network of associatons between targets according to the STRING database.

First level regulatory network of pou3f1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 7.3 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
2.3 6.8 GO:0061178 insulin secretion involved in cellular response to glucose stimulus(GO:0035773) regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
2.1 12.8 GO:0099525 synaptic vesicle docking(GO:0016081) presynaptic dense core granule exocytosis(GO:0099525)
1.9 7.6 GO:1900271 regulation of presynaptic cytosolic calcium ion concentration(GO:0099509) regulation of long-term synaptic potentiation(GO:1900271)
1.8 16.0 GO:0051965 positive regulation of synapse assembly(GO:0051965)
1.7 6.7 GO:0060074 synapse maturation(GO:0060074)
1.3 5.3 GO:0043152 induction of bacterial agglutination(GO:0043152)
1.1 4.6 GO:0007638 mechanosensory behavior(GO:0007638)
1.1 4.5 GO:0010874 regulation of cholesterol efflux(GO:0010874)
1.1 8.6 GO:0034334 adherens junction maintenance(GO:0034334)
1.0 11.2 GO:0006798 polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
0.9 2.6 GO:0021530 spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.7 3.0 GO:0021742 abducens nucleus development(GO:0021742)
0.7 7.2 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.7 5.0 GO:0060221 retinal rod cell differentiation(GO:0060221)
0.7 5.7 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.7 3.5 GO:0051963 regulation of synapse assembly(GO:0051963)
0.7 0.7 GO:0042989 sequestering of actin monomers(GO:0042989)
0.7 3.3 GO:0038107 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.6 7.8 GO:0042044 fluid transport(GO:0042044)
0.6 1.8 GO:0034134 toll-like receptor 2 signaling pathway(GO:0034134)
0.6 2.4 GO:0060300 regulation of cytokine activity(GO:0060300) regulation of receptor binding(GO:1900120) regulation of chemokine activity(GO:1900136)
0.6 5.8 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.6 1.7 GO:0035477 regulation of angioblast cell migration involved in selective angioblast sprouting(GO:0035477)
0.6 4.6 GO:0021588 cerebellum formation(GO:0021588)
0.5 6.3 GO:0060385 axonogenesis involved in innervation(GO:0060385)
0.5 3.6 GO:0061635 regulation of protein complex stability(GO:0061635)
0.5 15.1 GO:0048268 clathrin coat assembly(GO:0048268)
0.5 1.4 GO:0046677 response to antibiotic(GO:0046677)
0.4 2.4 GO:0055016 hypochord development(GO:0055016)
0.4 4.4 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.3 3.8 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.3 1.3 GO:0048680 positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.3 1.9 GO:0032218 riboflavin transport(GO:0032218)
0.3 4.4 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.3 2.1 GO:1903306 negative regulation of calcium ion-dependent exocytosis(GO:0045955) negative regulation of regulated secretory pathway(GO:1903306)
0.3 1.2 GO:0048011 neurotrophin TRK receptor signaling pathway(GO:0048011)
0.3 7.6 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.3 1.4 GO:0046952 ketone body catabolic process(GO:0046952)
0.3 4.2 GO:0021772 olfactory bulb development(GO:0021772) olfactory lobe development(GO:0021988)
0.3 6.0 GO:0045773 positive regulation of axon extension(GO:0045773)
0.2 0.7 GO:0018872 arsonoacetate metabolic process(GO:0018872)
0.2 0.5 GO:0001954 positive regulation of cell-matrix adhesion(GO:0001954)
0.2 2.4 GO:0071941 nitrogen cycle metabolic process(GO:0071941)
0.2 2.3 GO:0031274 pseudopodium organization(GO:0031268) pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.2 2.5 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.2 0.7 GO:0031642 negative regulation of myelination(GO:0031642) negative regulation of neurological system process(GO:0031645)
0.2 1.0 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.2 4.1 GO:0033344 cholesterol efflux(GO:0033344)
0.2 2.2 GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902041) negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
0.2 0.6 GO:0006585 dopamine biosynthetic process from tyrosine(GO:0006585) dopamine biosynthetic process(GO:0042416)
0.2 2.2 GO:0014036 neural crest cell fate commitment(GO:0014034) neural crest cell fate specification(GO:0014036)
0.2 0.5 GO:0008344 adult locomotory behavior(GO:0008344)
0.2 2.4 GO:0036065 fucosylation(GO:0036065)
0.1 1.2 GO:0046850 regulation of bone remodeling(GO:0046850)
0.1 0.6 GO:0033119 negative regulation of RNA splicing(GO:0033119) negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.1 0.5 GO:0061113 pancreas morphogenesis(GO:0061113)
0.1 0.6 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.1 0.5 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.1 1.4 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.1 0.4 GO:0099625 regulation of membrane repolarization(GO:0060306) regulation of ventricular cardiac muscle cell membrane repolarization(GO:0060307) regulation of cardiac muscle cell membrane repolarization(GO:0099623) ventricular cardiac muscle cell membrane repolarization(GO:0099625)
0.1 6.1 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091)
0.1 8.4 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.1 3.3 GO:0006305 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.1 2.1 GO:1902287 semaphorin-plexin signaling pathway involved in neuron projection guidance(GO:1902285) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.1 2.6 GO:0006695 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.1 1.5 GO:0033505 floor plate formation(GO:0021508) floor plate morphogenesis(GO:0033505)
0.1 2.9 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.1 1.4 GO:0042407 cristae formation(GO:0042407)
0.1 11.1 GO:0051260 protein homooligomerization(GO:0051260)
0.1 3.2 GO:0048854 brain morphogenesis(GO:0048854)
0.1 2.1 GO:0071218 response to misfolded protein(GO:0051788) cellular response to misfolded protein(GO:0071218)
0.1 0.8 GO:0055129 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.1 0.3 GO:1990868 response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869) negative regulation of lymphocyte migration(GO:2000402) negative regulation of T cell migration(GO:2000405)
0.1 0.9 GO:0021754 facial nucleus development(GO:0021754)
0.1 5.7 GO:0008217 regulation of blood pressure(GO:0008217)
0.1 1.4 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.1 2.0 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 3.7 GO:1902476 chloride transmembrane transport(GO:1902476)
0.1 0.8 GO:0030816 activation of adenylate cyclase activity(GO:0007190) positive regulation of cyclic nucleotide metabolic process(GO:0030801) positive regulation of cyclic nucleotide biosynthetic process(GO:0030804) positive regulation of nucleotide biosynthetic process(GO:0030810) positive regulation of cAMP metabolic process(GO:0030816) positive regulation of cAMP biosynthetic process(GO:0030819) positive regulation of cyclase activity(GO:0031281) positive regulation of adenylate cyclase activity(GO:0045762) positive regulation of lyase activity(GO:0051349) positive regulation of purine nucleotide biosynthetic process(GO:1900373)
0.1 1.3 GO:0030032 lamellipodium assembly(GO:0030032)
0.1 0.5 GO:0032228 regulation of synaptic transmission, GABAergic(GO:0032228) synaptic transmission, GABAergic(GO:0051932)
0.1 0.7 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.1 1.0 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.1 3.4 GO:0046328 regulation of JNK cascade(GO:0046328)
0.1 3.0 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.1 1.6 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 2.3 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.1 2.6 GO:0032465 regulation of cytokinesis(GO:0032465)
0.0 0.8 GO:0021654 rhombomere boundary formation(GO:0021654)
0.0 3.0 GO:0030336 negative regulation of cell migration(GO:0030336)
0.0 1.3 GO:0032922 circadian regulation of gene expression(GO:0032922)
0.0 1.5 GO:0072015 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0 1.1 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 1.8 GO:0042752 regulation of circadian rhythm(GO:0042752)
0.0 11.8 GO:0000122 negative regulation of transcription from RNA polymerase II promoter(GO:0000122)
0.0 6.7 GO:0030334 regulation of cell migration(GO:0030334)
0.0 0.3 GO:0042661 regulation of mesodermal cell fate specification(GO:0042661)
0.0 0.3 GO:0032481 positive regulation of type I interferon production(GO:0032481)
0.0 0.5 GO:0050919 negative chemotaxis(GO:0050919)
0.0 0.6 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.0 1.0 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 13.4 GO:0000226 microtubule cytoskeleton organization(GO:0000226)
0.0 1.6 GO:0071482 cellular response to light stimulus(GO:0071482)
0.0 0.4 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.0 0.4 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 0.5 GO:0008272 sulfate transport(GO:0008272)
0.0 1.3 GO:0019216 regulation of lipid metabolic process(GO:0019216)
0.0 1.3 GO:0007224 smoothened signaling pathway(GO:0007224)
0.0 1.5 GO:0035725 sodium ion transmembrane transport(GO:0035725)
0.0 3.8 GO:0043413 protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)
0.0 0.3 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.0 0.1 GO:0006382 adenosine to inosine editing(GO:0006382)
0.0 0.8 GO:0010469 regulation of receptor activity(GO:0010469)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 15.1 GO:0098835 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894)
0.8 20.4 GO:0043195 terminal bouton(GO:0043195)
0.5 6.0 GO:0044295 axonal growth cone(GO:0044295)
0.3 7.3 GO:0031594 neuromuscular junction(GO:0031594)
0.2 1.2 GO:0043034 costamere(GO:0043034)
0.2 1.8 GO:0032783 ELL-EAF complex(GO:0032783)
0.2 5.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.2 6.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.2 2.9 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 5.2 GO:1903293 protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.1 11.6 GO:0030141 secretory granule(GO:0030141)
0.1 0.5 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.1 3.6 GO:0005844 polysome(GO:0005844)
0.1 3.7 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 1.0 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 2.1 GO:0002116 semaphorin receptor complex(GO:0002116)
0.1 1.8 GO:0016363 nuclear matrix(GO:0016363)
0.1 2.2 GO:0070822 Sin3-type complex(GO:0070822)
0.1 7.8 GO:0042383 sarcolemma(GO:0042383)
0.1 7.8 GO:0043025 neuronal cell body(GO:0043025)
0.1 2.6 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 0.9 GO:0048179 activin receptor complex(GO:0048179)
0.1 13.6 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 0.3 GO:0060171 stereocilium membrane(GO:0060171)
0.1 0.6 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 2.6 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 7.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 0.7 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.7 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 2.4 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 1.4 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.9 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 3.9 GO:0016607 nuclear speck(GO:0016607)
0.0 0.6 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 10.6 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 7.5 GO:0005874 microtubule(GO:0005874)
0.0 0.4 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.8 GO:0030427 site of polarized growth(GO:0030427)
0.0 6.9 GO:0000139 Golgi membrane(GO:0000139)
0.0 2.0 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 2.0 GO:0005911 cell-cell junction(GO:0005911)
0.0 1.0 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 3.0 GO:0005938 cell cortex(GO:0005938)
0.0 0.3 GO:0032039 integrator complex(GO:0032039)
0.0 3.7 GO:0000785 chromatin(GO:0000785)
0.0 0.1 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 7.6 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
1.2 6.0 GO:0008046 axon guidance receptor activity(GO:0008046)
1.2 15.1 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
1.0 11.2 GO:0004309 exopolyphosphatase activity(GO:0004309)
0.8 2.4 GO:0031701 angiotensin receptor binding(GO:0031701)
0.7 6.4 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.6 8.1 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.6 1.8 GO:0016623 aldehyde oxidase activity(GO:0004031) oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.6 4.1 GO:0030274 LIM domain binding(GO:0030274)
0.6 3.5 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.5 19.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.5 11.7 GO:0005246 calcium channel regulator activity(GO:0005246)
0.4 1.6 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.4 2.5 GO:0001642 group III metabotropic glutamate receptor activity(GO:0001642)
0.3 2.4 GO:0098809 nitrite reductase activity(GO:0098809)
0.3 1.9 GO:0032217 riboflavin transporter activity(GO:0032217)
0.3 6.1 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.3 1.4 GO:0008131 primary amine oxidase activity(GO:0008131)
0.3 1.4 GO:0008260 3-oxoacid CoA-transferase activity(GO:0008260)
0.3 5.1 GO:0003785 actin monomer binding(GO:0003785)
0.3 3.3 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.2 0.7 GO:0030791 arsenite methyltransferase activity(GO:0030791) methylarsonite methyltransferase activity(GO:0030792)
0.2 3.0 GO:0038191 neuropilin binding(GO:0038191)
0.2 4.5 GO:0016854 racemase and epimerase activity(GO:0016854)
0.2 4.4 GO:0017080 sodium channel regulator activity(GO:0017080)
0.2 0.6 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.1 2.4 GO:0008417 fucosyltransferase activity(GO:0008417)
0.1 2.9 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 2.3 GO:0035497 cAMP response element binding(GO:0035497)
0.1 1.5 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.1 4.3 GO:0042826 histone deacetylase binding(GO:0042826)
0.1 0.5 GO:0046556 alpha-L-arabinofuranosidase activity(GO:0046556)
0.1 8.4 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 0.6 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.1 0.5 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.1 11.5 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.1 1.6 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 3.7 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 2.6 GO:0031267 small GTPase binding(GO:0031267)
0.1 16.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 16.0 GO:0005179 hormone activity(GO:0005179)
0.1 2.6 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.1 1.1 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.1 0.9 GO:0038064 protein tyrosine kinase collagen receptor activity(GO:0038062) collagen receptor activity(GO:0038064)
0.1 1.0 GO:0052812 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.1 7.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 1.9 GO:0050811 GABA receptor binding(GO:0050811)
0.1 0.5 GO:0070888 E-box binding(GO:0070888)
0.1 2.1 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 0.3 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 1.7 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.1 0.9 GO:0017002 activin-activated receptor activity(GO:0017002)
0.1 0.8 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.1 1.3 GO:0005112 Notch binding(GO:0005112)
0.0 0.9 GO:0002039 p53 binding(GO:0002039)
0.0 0.4 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0 11.7 GO:0030246 carbohydrate binding(GO:0030246)
0.0 2.1 GO:0044325 ion channel binding(GO:0044325)
0.0 1.2 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.8 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.5 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 1.1 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.5 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.2 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 0.5 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0 0.6 GO:0008483 transaminase activity(GO:0008483)
0.0 0.8 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 15.5 GO:0005509 calcium ion binding(GO:0005509)
0.0 5.6 GO:0008017 microtubule binding(GO:0008017)
0.0 1.8 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.0 0.5 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 2.5 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 1.3 GO:0019955 cytokine binding(GO:0019955)
0.0 0.5 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.1 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.5 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.2 1.7 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 10.0 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 1.3 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.1 1.8 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 8.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.3 PID IL27 PATHWAY IL27-mediated signaling events
0.1 1.0 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.1 12.8 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 1.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 0.6 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.0 2.2 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 1.5 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 1.1 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 1.2 PID LKB1 PATHWAY LKB1 signaling events
0.0 1.6 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 3.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.5 PID MYC PATHWAY C-MYC pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.4 1.8 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.2 1.8 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.1 5.4 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.1 1.3 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.1 2.6 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 1.0 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 0.8 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 1.2 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 2.5 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.8 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.6 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 1.8 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.5 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.5 REACTOME KINESINS Genes involved in Kinesins