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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for pou4f3_pou4f1+pou4f4
Z-value: 2.75
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Transcription factors associated with pou4f3_pou4f1+pou4f4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| pou4f1 | dr11_v1_chr6_+_4539953_4539953 | 0.93 | 1.7e-40 | Click! |
| zgc:158291 | dr11_v1_chr21_+_38312549_38312549 | 0.91 | 1.1e-36 | Click! |
| pou4f3 | dr11_v1_chr9_+_54290896_54290896 | 0.12 | 2.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_-_21688176 Show fit | 76.22 |
ENSDART00000063825
|
shadow of prion protein |
|
| chr23_-_27345425 Show fit | 59.43 |
ENSDART00000022042
ENSDART00000191870 |
sodium channel, voltage gated, type VIII, alpha subunit a |
|
| chr20_+_9355912 Show fit | 48.65 |
ENSDART00000142337
|
si:dkey-174m14.3 |
|
| chr4_+_12111154 Show fit | 48.06 |
ENSDART00000036779
|
transmembrane protein 178B |
|
| chr16_-_12953739 Show fit | 47.72 |
ENSDART00000103894
|
calcium channel, voltage-dependent, gamma subunit 8b |
|
| chr24_+_14713776 Show fit | 46.20 |
ENSDART00000134475
|
ganglioside induced differentiation associated protein 1 |
|
| chr23_-_29376859 Show fit | 44.31 |
ENSDART00000146411
|
somatostatin 6 |
|
| chr23_-_24195519 Show fit | 42.56 |
ENSDART00000112370
ENSDART00000180377 |
anoctamin 11 |
|
| chr24_-_3419998 Show fit | 42.50 |
ENSDART00000066839
|
solute carrier family 35, member G2b |
|
| chr16_+_10318893 Show fit | 40.74 |
ENSDART00000055380
|
tubulin, beta 5 |
Network of associatons between targets according to the STRING database.
First level regulatory network of pou4f3_pou4f1+pou4f4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.9 | 79.1 | GO:0061588 | calcium activated phospholipid scrambling(GO:0061588) |
| 14.9 | 59.4 | GO:0007638 | mechanosensory behavior(GO:0007638) |
| 2.9 | 48.7 | GO:0098962 | regulation of postsynaptic neurotransmitter receptor activity(GO:0098962) |
| 2.8 | 47.7 | GO:0098943 | neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943) |
| 2.9 | 46.2 | GO:0008053 | mitochondrial fusion(GO:0008053) |
| 0.7 | 38.9 | GO:0006636 | unsaturated fatty acid biosynthetic process(GO:0006636) |
| 0.1 | 38.1 | GO:0030334 | regulation of cell migration(GO:0030334) |
| 12.6 | 37.8 | GO:0031630 | regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630) |
| 1.5 | 35.6 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 0.7 | 33.8 | GO:0007019 | microtubule depolymerization(GO:0007019) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 86.5 | GO:0034706 | voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706) |
| 1.3 | 84.6 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 79.6 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 1.6 | 69.0 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.4 | 58.7 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 3.6 | 46.2 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.7 | 35.6 | GO:0097517 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.1 | 30.5 | GO:0005874 | microtubule(GO:0005874) |
| 0.1 | 25.8 | GO:0031410 | cytoplasmic vesicle(GO:0031410) |
| 0.1 | 23.2 | GO:0009897 | external side of plasma membrane(GO:0009897) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 103.6 | GO:0005254 | chloride channel activity(GO:0005254) |
| 4.3 | 103.4 | GO:1905030 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
| 0.7 | 51.1 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.1 | 51.1 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.7 | 40.7 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 37.5 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.2 | 35.8 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.3 | 34.1 | GO:0005179 | hormone activity(GO:0005179) |
| 0.1 | 33.8 | GO:0015631 | tubulin binding(GO:0015631) |
| 3.3 | 32.6 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 34.7 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.4 | 15.7 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.3 | 14.9 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.3 | 12.3 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.3 | 11.2 | PID ATM PATHWAY | ATM pathway |
| 0.6 | 7.2 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 7.0 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.2 | 6.6 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.2 | 6.5 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 6.3 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 43.2 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 3.0 | 30.3 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 1.5 | 22.9 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 1.0 | 21.0 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.5 | 17.8 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.6 | 14.9 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 0.5 | 12.3 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.2 | 11.6 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 1.7 | 8.6 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.2 | 7.8 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |