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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for pou6f2

Z-value: 0.83

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Transcription factors associated with pou6f2

Gene Symbol Gene ID Gene Info
pou6f2
ENSDARG00000086362 POU class 6 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
pou6f2dr11_v1_chr24_+_10039165_100391650.733.9e-17Click!

Activity profile of pou6f2 motif

Sorted Z-values of pou6f2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_-_1185772 26.62 ENSDART00000143245
nptnb
neuroplastin b
chr15_-_16098531 15.73 ENSDART00000080377
aldoca
aldolase C, fructose-bisphosphate, a
chr7_+_38717624 12.32 ENSDART00000132522
syt13
synaptotagmin XIII
chr11_+_39672874 11.53 ENSDART00000046663
ENSDART00000157659
camta1b
calmodulin binding transcription activator 1b
chr19_+_30662529 10.87 ENSDART00000175662
fam49al
family with sequence similarity 49, member A-like
chr4_+_12615836 10.77 ENSDART00000003583
lmo3
LIM domain only 3
chr6_+_27146671 10.51 ENSDART00000156792
kif1aa
kinesin family member 1Aa
chr4_+_22365061 10.35 ENSDART00000039277
lhfpl3
LHFPL tetraspan subfamily member 3
chr12_-_10275320 10.09 ENSDART00000170078
mpp2b
membrane protein, palmitoylated 2b (MAGUK p55 subfamily member 2)
chr23_+_28731379 9.58 ENSDART00000047378
cort
cortistatin
chr16_+_46111849 9.52 ENSDART00000172232
sv2a
synaptic vesicle glycoprotein 2A
chr19_-_32641725 9.03 ENSDART00000165006
ENSDART00000188185
hpca
hippocalcin
chr1_+_40023640 8.89 ENSDART00000101623
lgi2b
leucine-rich repeat LGI family, member 2b
chr10_+_3507861 8.78 ENSDART00000092684
rph3aa
rabphilin 3A homolog (mouse), a
chr3_-_43356082 8.19 ENSDART00000171213
uncx
UNC homeobox
chr12_-_35787801 7.97 ENSDART00000171682
aatkb
apoptosis-associated tyrosine kinase b
chr21_-_26918901 7.82 ENSDART00000100685
lrfn4a
leucine rich repeat and fibronectin type III domain containing 4a
chr9_-_32753535 7.73 ENSDART00000060006
olig2
oligodendrocyte lineage transcription factor 2
chr21_-_39177564 7.47 ENSDART00000065143
unc119b
unc-119 homolog b (C. elegans)
chr3_-_28250722 7.28 ENSDART00000165936
rbfox1
RNA binding fox-1 homolog 1
chr24_+_32411753 7.13 ENSDART00000058530
neurod6a
neuronal differentiation 6a
chr14_-_31465905 6.93 ENSDART00000173108
gpc3
glypican 3
chr8_+_21588067 6.81 ENSDART00000172190
ajap1
adherens junctions associated protein 1
chr13_-_31435137 6.80 ENSDART00000057441
rtn1a
reticulon 1a
chr9_+_42063906 6.67 ENSDART00000048893
pcbp3
poly(rC) binding protein 3
chr16_-_12173554 6.67 ENSDART00000110567
ENSDART00000155935
clstn3
calsyntenin 3
chr3_+_33341640 6.64 ENSDART00000186352
pyya
peptide YYa
chr13_+_24552254 6.62 ENSDART00000147907
lgalslb
lectin, galactoside-binding-like b
chr4_-_17629444 6.52 ENSDART00000108814
nrip2
nuclear receptor interacting protein 2
chr18_+_7283283 6.32 ENSDART00000141493
ANO2 (1 of many)
si:ch73-86n2.1
chr16_+_50741154 6.24 ENSDART00000101627
IGLON5
zgc:110372
chr7_-_39203799 6.24 ENSDART00000173727
chrm4a
cholinergic receptor, muscarinic 4a
chr5_-_35953472 6.22 ENSDART00000143448
rxfp2l
relaxin/insulin-like family peptide receptor 2, like
chr22_+_9472814 6.15 ENSDART00000112125
ENSDART00000138850
cacna2d2b
calcium channel, voltage-dependent, alpha 2/delta subunit 2b
chr16_+_29303971 6.02 ENSDART00000087149
hapln2
hyaluronan and proteoglycan link protein 2
chr23_-_28141419 5.85 ENSDART00000133039
tac3a
tachykinin 3a
chr24_-_21923930 5.83 ENSDART00000131944
tagln3b
transgelin 3b
chr7_-_27686021 5.82 ENSDART00000079112
ENSDART00000100989
calca
calcitonin/calcitonin-related polypeptide, alpha
chr21_+_25231160 5.73 ENSDART00000063089
ENSDART00000139127
gng8
guanine nucleotide binding protein (G protein), gamma 8
chr20_-_9436521 5.73 ENSDART00000133000
zgc:101840
zgc:101840
chr8_+_29267093 5.57 ENSDART00000077647
grid2
glutamate receptor, ionotropic, delta 2
chr16_+_43152727 5.50 ENSDART00000125590
ENSDART00000154493
adam22
ADAM metallopeptidase domain 22
chr19_-_5103313 5.45 ENSDART00000037007
tpi1a
triosephosphate isomerase 1a
chr19_-_26869103 5.40 ENSDART00000089699
prrt1
proline-rich transmembrane protein 1
chr12_+_32729470 5.30 ENSDART00000175712
rbfox3a
RNA binding fox-1 homolog 3a
chr5_-_50641129 5.25 ENSDART00000190090
mctp1a
multiple C2 domains, transmembrane 1a
chr5_-_23362602 5.22 ENSDART00000137120
gria3a
glutamate receptor, ionotropic, AMPA 3a
chr1_+_25801648 5.03 ENSDART00000129471
gucy1b1
guanylate cyclase 1 soluble subunit beta 1
chr15_-_13208607 5.02 ENSDART00000184151
zgc:172282
zgc:172282
chr22_-_354592 4.93 ENSDART00000155769
tmem240b
transmembrane protein 240b
chr19_-_31402429 4.47 ENSDART00000137292
tmem106bb
transmembrane protein 106Bb
chr9_+_11034314 4.43 ENSDART00000032695
asic4a
acid-sensing (proton-gated) ion channel family member 4a
chr16_+_30301539 4.40 ENSDART00000186018
LO017848.1

chr13_+_1089942 4.28 ENSDART00000054322
cnrip1b
cannabinoid receptor interacting protein 1b
chr13_-_37545487 4.24 ENSDART00000131269
syt16
synaptotagmin XVI
chr3_-_46817499 4.19 ENSDART00000013717
elavl3
ELAV like neuron-specific RNA binding protein 3
chr3_-_21288202 4.18 ENSDART00000191766
ENSDART00000187319
fam171a2a
family with sequence similarity 171, member A2a
chr4_-_16124417 4.12 ENSDART00000128079
ENSDART00000077664
atp2b1a
ATPase plasma membrane Ca2+ transporting 1a
chr9_-_43538328 4.09 ENSDART00000140526
znf385b
zinc finger protein 385B
chr10_-_26738209 4.06 ENSDART00000188590
fgf13b
fibroblast growth factor 13b
chr10_-_34870667 4.03 ENSDART00000161272
dclk1a
doublecortin-like kinase 1a
chr15_+_22722684 3.93 ENSDART00000156760
grik4
glutamate receptor, ionotropic, kainate 4
chr12_+_41697664 3.88 ENSDART00000162302
bnip3
BCL2 interacting protein 3
chr21_-_27185915 3.86 ENSDART00000135052
slc8a4a
solute carrier family 8 (sodium/calcium exchanger), member 4a
chr13_+_24662238 3.84 ENSDART00000014176
msx3
muscle segment homeobox 3
chr18_-_2433011 3.77 ENSDART00000181922
ENSDART00000193276
CR769778.1

chr20_-_48485354 3.72 ENSDART00000124040
ENSDART00000148437
insm1a
insulinoma-associated 1a
chr2_+_12302527 3.67 ENSDART00000091298
ENSDART00000182569
arhgap21b
Rho GTPase activating protein 21b
chr2_+_29249204 3.66 ENSDART00000168957
cdh18a
cadherin 18, type 2a
chr19_+_9459050 3.62 ENSDART00000186419
si:ch211-288g17.3
si:ch211-288g17.3
chr11_+_24620742 3.54 ENSDART00000182471
ENSDART00000048365
syt6b
synaptotagmin VIb
chr15_+_24704798 3.53 ENSDART00000192470
LRRC75A
si:dkey-151p21.7
chr16_-_12173399 3.52 ENSDART00000142574
clstn3
calsyntenin 3
chr12_+_35654749 3.43 ENSDART00000169889
ENSDART00000167873
baiap2b
BAI1-associated protein 2b
chr22_+_2830703 3.42 ENSDART00000145463
ENSDART00000144785
si:dkey-20i20.8
si:dkey-20i20.8
chr7_-_27685365 3.39 ENSDART00000188342
calca
calcitonin/calcitonin-related polypeptide, alpha
chr5_+_44064764 3.35 ENSDART00000143843
si:dkey-84j12.1
si:dkey-84j12.1
chr24_+_29449690 3.33 ENSDART00000105743
ENSDART00000193556
ENSDART00000145816
ntng1a
netrin g1a
chr1_+_34203817 3.24 ENSDART00000191432
ENSDART00000046094
arl6
ADP-ribosylation factor-like 6
chr6_+_3004972 3.18 ENSDART00000186750
ENSDART00000183862
ENSDART00000191485
ENSDART00000171014
ptprfa
protein tyrosine phosphatase, receptor type, f, a
chr17_-_37052622 3.01 ENSDART00000186408
dnmt3ab
DNA (cytosine-5-)-methyltransferase 3 alpha b
chr2_-_50372467 2.98 ENSDART00000108900
cntnap2b
contactin associated protein like 2b
chr3_-_30434016 2.93 ENSDART00000150958
lrrc4ba
leucine rich repeat containing 4Ba
chr25_-_21716326 2.92 ENSDART00000152011
DOCK4 (1 of many)
si:dkey-81e3.1
chr20_+_40457599 2.85 ENSDART00000017553
serinc1
serine incorporator 1
chr9_+_17982737 2.70 ENSDART00000192569
akap11
A kinase (PRKA) anchor protein 11
chr11_-_27702778 2.67 ENSDART00000045942
ENSDART00000125352
phf2
PHD finger protein 2
chr17_+_11675362 2.66 ENSDART00000157911
kif26ba
kinesin family member 26Ba
chr6_+_49021703 2.58 ENSDART00000149394
slc16a1a
solute carrier family 16 (monocarboxylate transporter), member 1a
chr17_-_45150763 2.57 ENSDART00000155043
ENSDART00000156786
ENSDART00000191147
tmed8
transmembrane p24 trafficking protein 8
chr12_+_9183626 2.51 ENSDART00000020192
tubgcp2
tubulin, gamma complex associated protein 2
chr22_+_10698549 2.49 ENSDART00000081228
abhd14a
abhydrolase domain containing 14A
chr11_-_37425407 2.44 ENSDART00000160911
erc2
ELKS/RAB6-interacting/CAST family member 2
chr9_+_21793565 2.39 ENSDART00000134915
rev1
REV1, polymerase (DNA directed)
chr15_+_21276735 2.30 ENSDART00000111213
ubash3bb
ubiquitin associated and SH3 domain containing Bb
chr18_-_29962234 2.25 ENSDART00000144996
si:ch73-103b9.2
si:ch73-103b9.2
chr6_-_10740365 2.11 ENSDART00000150942
sp3b
Sp3b transcription factor
chr17_+_51499789 2.02 ENSDART00000187701
CABZ01067581.1

chr10_+_40284003 2.01 ENSDART00000062795
ENSDART00000193825
ENSDART00000113582
git2b
G protein-coupled receptor kinase interacting ArfGAP 2b
chr4_+_2619132 1.99 ENSDART00000128807
gpr22a
G protein-coupled receptor 22a
chr7_-_30174882 1.99 ENSDART00000110409
frmd5
FERM domain containing 5
chr9_-_6624663 1.94 ENSDART00000092537
GPR45
si:dkeyp-118h3.5
chr13_+_30912117 1.93 ENSDART00000133138
drgx
dorsal root ganglia homeobox
chr12_-_17698669 1.91 ENSDART00000191384
pvalb9
parvalbumin 9
chr18_+_34362608 1.91 ENSDART00000131478
kcnab1a
potassium voltage-gated channel, shaker-related subfamily, beta member 1 a
chr3_-_40054615 1.82 ENSDART00000003511
ENSDART00000102540
ENSDART00000146121
llgl1
lethal giant larvae homolog 1 (Drosophila)
chr11_+_38280454 1.81 ENSDART00000171496
CDK18
si:dkey-166c18.1
chr7_+_36898850 1.79 ENSDART00000113342
tox3
TOX high mobility group box family member 3
chr18_+_14529005 1.75 ENSDART00000186379
kcng4a
potassium voltage-gated channel, subfamily G, member 4a
chr12_-_17698517 1.73 ENSDART00000105974
pvalb9
parvalbumin 9
chr3_-_56541723 1.66 ENSDART00000156398
ENSDART00000050576
ENSDART00000184874
si:ch211-189a21.1
cyth1a
si:ch211-189a21.1
cytohesin 1a
chr16_+_25107344 1.56 ENSDART00000033211
zgc:66448
zgc:66448
chr11_+_19433936 1.56 ENSDART00000162081
prickle2b
prickle homolog 2b
chr24_-_21404367 1.45 ENSDART00000152093
atp8a2
ATPase phospholipid transporting 8A2
chr9_-_38036984 1.45 ENSDART00000134574
hacd2
3-hydroxyacyl-CoA dehydratase 2
chr1_+_33634186 1.44 ENSDART00000075626
htr1fb
5-hydroxytryptamine (serotonin) receptor 1Fb
chr3_+_57038033 1.36 ENSDART00000162930
bahcc1a
BAH domain and coiled-coil containing 1a
chr8_-_14080534 1.34 ENSDART00000042867
dedd
death effector domain containing
chr8_+_37755099 1.33 ENSDART00000075708
ENSDART00000140966
got1l1
glutamic-oxaloacetic transaminase 1 like 1
chr23_-_28423048 1.31 ENSDART00000140448
c1ql4a
complement component 1, q subcomponent-like 4
chr12_+_30367079 1.30 ENSDART00000190112
ccdc186
si:ch211-225b10.4
chr9_+_38888025 1.23 ENSDART00000148306
map2
microtubule-associated protein 2
chr13_+_3938526 1.21 ENSDART00000012759
yipf3
Yip1 domain family, member 3
chr7_+_53498152 1.21 ENSDART00000184497
znf609b
zinc finger protein 609b
chr4_-_1801519 1.20 ENSDART00000188604
ENSDART00000135749
nudt4b
nudix (nucleoside diphosphate linked moiety X)-type motif 4b
chr21_-_37790727 1.18 ENSDART00000162907
gabrb4
gamma-aminobutyric acid (GABA) A receptor, beta 4
chr11_-_43226255 1.18 ENSDART00000172929
sptbn1
spectrin, beta, non-erythrocytic 1
chr11_+_7580079 1.17 ENSDART00000091550
ENSDART00000193223
ENSDART00000193386
adgrl2a
adhesion G protein-coupled receptor L2a
chr6_-_40713183 1.12 ENSDART00000157113
ENSDART00000154810
ENSDART00000153702
si:ch211-157b11.12
si:ch211-157b11.12
chr6_-_40722480 1.11 ENSDART00000188187
kbtbd12
kelch repeat and BTB (POZ) domain containing 12
chr13_+_25449681 1.10 ENSDART00000101328
atoh7
atonal bHLH transcription factor 7
chr4_+_5642696 1.07 ENSDART00000028941
mrps18a
mitochondrial ribosomal protein S18A
chr7_-_31759602 1.07 ENSDART00000113467
igdcc4
immunoglobulin superfamily, DCC subclass, member 4
chr12_-_20616160 1.06 ENSDART00000105362
snx11
sorting nexin 11
chr9_+_38502524 1.05 ENSDART00000087229
lmln
leishmanolysin-like (metallopeptidase M8 family)
chr10_+_7593185 1.03 ENSDART00000162617
ENSDART00000162590
ENSDART00000171744
ppp2cb
protein phosphatase 2, catalytic subunit, beta isozyme
chr18_-_8398972 1.02 ENSDART00000136512
BEND7
si:ch211-220f12.4
chr8_+_51050554 1.01 ENSDART00000166249
DISP3
si:dkey-32e23.6
chr23_+_33718602 1.01 ENSDART00000024695
dazap2
DAZ associated protein 2
chr23_-_6660985 0.98 ENSDART00000162405
CR450824.2

chr7_+_31145386 0.93 ENSDART00000075407
ENSDART00000169462
fam189a1
family with sequence similarity 189, member A1
chr4_+_9467049 0.92 ENSDART00000012659
zgc:55888
zgc:55888
chr6_-_32726848 0.91 ENSDART00000155294
zc3h3
zinc finger CCCH-type containing 3
chr13_-_44630111 0.90 ENSDART00000110092
mdga1
MAM domain containing glycosylphosphatidylinositol anchor 1
chr12_+_30367371 0.84 ENSDART00000153364
ccdc186
si:ch211-225b10.4
chr6_+_37754763 0.84 ENSDART00000110770
herc2
HECT and RLD domain containing E3 ubiquitin protein ligase 2
chr17_-_48705993 0.82 ENSDART00000030934
kcnk5a
potassium channel, subfamily K, member 5a
chr15_-_33172246 0.79 ENSDART00000158666
nbeab
neurobeachin b
chr4_+_3980247 0.79 ENSDART00000049194
gpr37b
G protein-coupled receptor 37b
chr18_+_43365890 0.78 ENSDART00000173113
si:ch211-129p13.1
si:ch211-129p13.1
chr1_+_10318089 0.75 ENSDART00000029774
pip4p1b
phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1b
chr11_-_42918971 0.75 ENSDART00000052912
pcdh20
protocadherin 20
chr2_-_27619954 0.75 ENSDART00000144826
tgs1
trimethylguanosine synthase 1
chr9_+_32860345 0.74 ENSDART00000121751
si:dkey-145p14.5
si:dkey-145p14.5
chr9_+_45789887 0.72 ENSDART00000135202
si:dkey-34f9.3
si:dkey-34f9.3
chr13_+_42406883 0.72 ENSDART00000084354
cpeb3
cytoplasmic polyadenylation element binding protein 3
chr7_-_18416741 0.72 ENSDART00000097882
sstr1b
somatostatin receptor 1b
chr6_+_16406723 0.70 ENSDART00000040035
ccdc80l1
coiled-coil domain containing 80 like 1
chr9_-_14504834 0.69 ENSDART00000056103
nrp2b
neuropilin 2b
chr17_-_49438873 0.67 ENSDART00000004424
znf292a
zinc finger protein 292a
chr8_-_10961991 0.67 ENSDART00000139603
trim33
tripartite motif containing 33
chr21_-_37973819 0.66 ENSDART00000133405
ripply1
ripply transcriptional repressor 1
chr25_+_6186823 0.66 ENSDART00000153526
oaz2a
ornithine decarboxylase antizyme 2a
chr23_-_25124783 0.65 ENSDART00000160278
idh3g
isocitrate dehydrogenase 3 (NAD+) gamma
chr18_-_19350792 0.65 ENSDART00000147902
megf11
multiple EGF-like-domains 11
chr18_+_34181655 0.65 ENSDART00000130831
ENSDART00000109535
gmps
guanine monophosphate synthase
chr22_-_30881738 0.64 ENSDART00000059965
si:dkey-49n23.1
si:dkey-49n23.1
chr4_+_72723304 0.64 ENSDART00000186791
ENSDART00000158902
ENSDART00000191925
rab3ip
RAB3A interacting protein (rabin3)
chr5_+_54497730 0.63 ENSDART00000157722
tmem203
transmembrane protein 203
chr9_+_38088331 0.58 ENSDART00000123749
cacnb4a
calcium channel, voltage-dependent, beta 4a subunit
chr6_-_40722200 0.58 ENSDART00000035101
kbtbd12
kelch repeat and BTB (POZ) domain containing 12
chr4_+_12612145 0.51 ENSDART00000181201
lmo3
LIM domain only 3
chr23_+_41912151 0.49 ENSDART00000191115
podn
podocan
chr5_-_41638039 0.49 ENSDART00000144525
epg5
ectopic P-granules autophagy protein 5 homolog (C. elegans)
chr9_+_32859967 0.47 ENSDART00000168992
si:dkey-145p14.5
si:dkey-145p14.5
chr17_-_29902187 0.45 ENSDART00000009104
esrrb
estrogen-related receptor beta
chr7_+_27976448 0.45 ENSDART00000181026
tub
tubby bipartite transcription factor
chr11_-_34219211 0.45 ENSDART00000098472
tmem44
transmembrane protein 44
chr20_+_29209615 0.44 ENSDART00000062350
katnbl1
katanin p80 subunit B-like 1
chr17_-_50472864 0.43 ENSDART00000161066
ENSDART00000156963
si:ch211-235i11.3
si:ch211-235i11.3
chr24_-_28648949 0.42 ENSDART00000180227
tecrl2a
trans-2,3-enoyl-CoA reductase-like 2a
chr11_+_33284837 0.41 ENSDART00000166239
ENSDART00000111412
nkpd1
NTPase, KAP family P-loop domain containing 1
chr15_-_5720583 0.36 ENSDART00000158034
ENSDART00000190332
ENSDART00000109599
urb1
URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
chr5_-_26566435 0.35 ENSDART00000146070
arvcfb
ARVCF, delta catenin family member b
chr20_+_29209767 0.33 ENSDART00000141252
katnbl1
katanin p80 subunit B-like 1
chr22_+_24215007 0.32 ENSDART00000162227
glrx2
glutaredoxin 2
chr5_-_48268049 0.31 ENSDART00000187454
mef2cb
myocyte enhancer factor 2cb
chr15_-_38154616 0.31 ENSDART00000099392
irgq2
immunity-related GTPase family, q2
chr2_-_17044959 0.26 ENSDART00000090260
clcn2a
chloride channel, voltage-sensitive 2a
chr21_-_3853204 0.24 ENSDART00000188829
st6galnac4
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
chr22_-_14696667 0.22 ENSDART00000180379
lrp1ba
low density lipoprotein receptor-related protein 1Ba
chr20_+_29209926 0.21 ENSDART00000152949
ENSDART00000153016
katnbl1
katanin p80 subunit B-like 1
chr4_+_12612723 0.19 ENSDART00000133767
lmo3
LIM domain only 3
chr7_-_19364813 0.18 ENSDART00000173977
ntn4
netrin 4
chr14_+_11290828 0.17 ENSDART00000184078
rlim
ring finger protein, LIM domain interacting
chr11_+_20056732 0.16 ENSDART00000103997
fezf2
FEZ family zinc finger 2
chr7_-_17779644 0.14 ENSDART00000128504
si:dkey-106g10.7
si:dkey-106g10.7
chr5_-_41933912 0.14 ENSDART00000097574
ncor1
nuclear receptor corepressor 1
chr24_+_40473032 0.14 ENSDART00000084238
ENSDART00000178508
CABZ01076968.1

chr7_-_33921366 0.12 ENSDART00000052397
pias1a
protein inhibitor of activated STAT, 1a

Network of associatons between targets according to the STRING database.

First level regulatory network of pou6f2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 7.7 GO:0021742 abducens nucleus development(GO:0021742)
1.4 5.4 GO:0046166 methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
1.3 8.0 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
1.3 5.0 GO:0099548 trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by nitric oxide(GO:0099548)
1.2 5.9 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
1.1 10.2 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.9 7.5 GO:0072584 caveolin-mediated endocytosis(GO:0072584) negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286) negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.9 26.6 GO:0070593 dendrite self-avoidance(GO:0070593)
0.9 2.7 GO:0061187 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
0.9 6.9 GO:0060976 coronary vasculature development(GO:0060976)
0.8 4.1 GO:0034505 tooth mineralization(GO:0034505)
0.7 15.7 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.6 2.4 GO:0070987 error-free translesion synthesis(GO:0070987)
0.6 3.0 GO:0071205 protein localization to juxtaparanode region of axon(GO:0071205) protein localization to axon(GO:0099612)
0.6 6.2 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.5 3.7 GO:0060221 retinal rod cell differentiation(GO:0060221)
0.5 6.2 GO:0045762 activation of adenylate cyclase activity(GO:0007190) positive regulation of cAMP metabolic process(GO:0030816) positive regulation of cAMP biosynthetic process(GO:0030819) positive regulation of adenylate cyclase activity(GO:0045762)
0.5 1.9 GO:1901380 negative regulation of potassium ion transmembrane transporter activity(GO:1901017) negative regulation of potassium ion transmembrane transport(GO:1901380) negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.5 4.3 GO:2000272 negative regulation of receptor activity(GO:2000272)
0.4 3.9 GO:0097345 mitochondrial outer membrane permeabilization(GO:0097345)
0.4 3.4 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.4 3.2 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.3 15.9 GO:0014059 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.3 1.3 GO:0006531 aspartate metabolic process(GO:0006531)
0.3 5.6 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.3 9.2 GO:0055064 chloride ion homeostasis(GO:0055064)
0.3 4.1 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.3 3.3 GO:0042044 fluid transport(GO:0042044)
0.3 4.5 GO:0032418 lysosome localization(GO:0032418)
0.2 1.2 GO:1901909 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.2 2.4 GO:0048790 maintenance of presynaptic active zone structure(GO:0048790) maintenance of synapse structure(GO:0099558)
0.2 7.5 GO:0021854 hypothalamus development(GO:0021854)
0.1 4.1 GO:0007631 feeding behavior(GO:0007631)
0.1 1.8 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.1 3.5 GO:0070831 basement membrane assembly(GO:0070831)
0.1 3.8 GO:0043049 otic placode formation(GO:0043049)
0.1 0.4 GO:0090069 regulation of ribosome biogenesis(GO:0090069)
0.1 2.5 GO:0007020 microtubule nucleation(GO:0007020)
0.1 0.7 GO:0071678 olfactory bulb axon guidance(GO:0071678)
0.1 3.8 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 5.3 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.1 10.3 GO:0007605 sensory perception of sound(GO:0007605)
0.1 4.1 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.1 0.7 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.1 9.5 GO:0006836 neurotransmitter transport(GO:0006836)
0.1 2.0 GO:0071910 determination of liver left/right asymmetry(GO:0071910)
0.1 3.7 GO:0061512 protein localization to cilium(GO:0061512)
0.1 0.7 GO:0048569 post-embryonic organ development(GO:0048569)
0.1 11.9 GO:0030705 cytoskeleton-dependent intracellular transport(GO:0030705)
0.1 0.7 GO:0006102 isocitrate metabolic process(GO:0006102)
0.1 1.4 GO:0007210 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198) serotonin receptor signaling pathway(GO:0007210)
0.1 0.6 GO:0006177 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037)
0.1 1.3 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.1 5.3 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 1.1 GO:0097324 melanocyte migration(GO:0097324)
0.1 1.5 GO:0030497 fatty acid elongation(GO:0030497)
0.1 0.7 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.1 3.9 GO:0035249 synaptic transmission, glutamatergic(GO:0035249)
0.0 0.5 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.0 1.5 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.7 GO:0071385 cellular response to corticosteroid stimulus(GO:0071384) cellular response to glucocorticoid stimulus(GO:0071385)
0.0 6.2 GO:0050769 positive regulation of neurogenesis(GO:0050769)
0.0 1.7 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.7 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.0 2.6 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 0.8 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 2.2 GO:0070121 Kupffer's vesicle development(GO:0070121)
0.0 6.7 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.0 0.8 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.0 3.3 GO:0035725 sodium ion transmembrane transport(GO:0035725)
0.0 0.7 GO:0006595 polyamine metabolic process(GO:0006595)
0.0 1.2 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 2.7 GO:0007018 microtubule-based movement(GO:0007018)
0.0 0.2 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 1.2 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 1.7 GO:0051260 protein homooligomerization(GO:0051260)
0.0 0.4 GO:0006306 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 6.8 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
1.0 3.9 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.8 2.5 GO:0008275 gamma-tubulin small complex(GO:0008275)
0.7 7.5 GO:0045171 intercellular bridge(GO:0045171)
0.4 3.0 GO:0033010 paranodal junction(GO:0033010)
0.3 6.9 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.2 1.2 GO:0008091 spectrin(GO:0008091)
0.2 3.3 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.2 14.8 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.2 51.8 GO:0030424 axon(GO:0030424)
0.2 3.5 GO:0005605 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.2 0.6 GO:0070319 Golgi to plasma membrane transport vesicle(GO:0070319)
0.1 3.2 GO:0060170 ciliary membrane(GO:0060170)
0.1 2.4 GO:0048788 cytoskeleton of presynaptic active zone(GO:0048788) presynaptic active zone cytoplasmic component(GO:0098831)
0.1 5.0 GO:0048786 presynaptic active zone(GO:0048786)
0.1 5.2 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 4.1 GO:0030426 growth cone(GO:0030426)
0.1 3.9 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 6.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 18.1 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 0.7 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 5.2 GO:0031902 late endosome membrane(GO:0031902)
0.1 3.5 GO:0016342 catenin complex(GO:0016342)
0.1 1.8 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.1 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 1.7 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 4.4 GO:0045177 apical part of cell(GO:0045177)
0.0 2.7 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 3.9 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 2.7 GO:0005871 kinesin complex(GO:0005871)
0.0 3.5 GO:0070382 exocytic vesicle(GO:0070382)
0.0 0.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 6.6 GO:0045202 synapse(GO:0045202)
0.0 5.5 GO:0031012 extracellular matrix(GO:0031012)
0.0 1.4 GO:0030425 dendrite(GO:0030425)
0.0 1.9 GO:0043005 neuron projection(GO:0043005)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 9.2 GO:0031716 calcitonin receptor binding(GO:0031716)
2.0 15.7 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
1.4 5.4 GO:0008929 triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929)
1.3 6.6 GO:0031843 neuropeptide Y receptor binding(GO:0031841) type 2 neuropeptide Y receptor binding(GO:0031843)
1.0 3.9 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.9 29.9 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.6 6.2 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.4 4.4 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.4 1.5 GO:0102344 3-hydroxyacyl-CoA dehydratase activity(GO:0018812) 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.3 5.2 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.3 6.5 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.3 1.3 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.3 15.9 GO:0001786 phosphatidylserine binding(GO:0001786)
0.3 10.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.3 3.9 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.3 5.0 GO:0004383 guanylate cyclase activity(GO:0004383)
0.2 1.2 GO:0034431 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.2 3.0 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.2 2.6 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.2 5.6 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.2 6.0 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 2.7 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.2 0.7 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.2 3.3 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.2 2.5 GO:0043015 gamma-tubulin binding(GO:0043015)
0.2 1.1 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.2 4.1 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 4.1 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 2.4 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.1 0.7 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.1 1.8 GO:0045159 myosin II binding(GO:0045159)
0.1 2.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 4.9 GO:0008013 beta-catenin binding(GO:0008013)
0.1 0.8 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.1 1.9 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.1 0.7 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 2.1 GO:0031267 small GTPase binding(GO:0031267)
0.1 5.5 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 2.7 GO:0051018 protein kinase A binding(GO:0051018)
0.1 6.7 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 0.3 GO:0004362 glutathione-disulfide reductase activity(GO:0004362)
0.1 0.4 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
0.1 1.4 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.1 1.2 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 0.7 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.1 19.0 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 6.9 GO:0005179 hormone activity(GO:0005179)
0.0 0.6 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0 6.6 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 3.8 GO:0045296 cadherin binding(GO:0045296)
0.0 1.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 2.7 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.8 GO:0022840 leak channel activity(GO:0022840) potassium ion leak channel activity(GO:0022841) narrow pore channel activity(GO:0022842)
0.0 0.2 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 11.8 GO:0003712 transcription factor activity, transcription factor binding(GO:0000989) transcription cofactor activity(GO:0003712)
0.0 11.8 GO:0046983 protein dimerization activity(GO:0046983)
0.0 4.2 GO:0001664 G-protein coupled receptor binding(GO:0001664)
0.0 1.2 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 3.2 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.3 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 1.0 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 2.1 GO:0001653 peptide receptor activity(GO:0001653) G-protein coupled peptide receptor activity(GO:0008528)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 6.0 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 6.9 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.9 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 2.2 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 1.3 ST FAS SIGNALING PATHWAY Fas Signaling Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 6.9 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.4 9.2 REACTOME AMYLOIDS Genes involved in Amyloids
0.3 5.7 REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR Genes involved in Thromboxane signalling through TP receptor
0.3 3.9 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.2 2.5 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1 1.0 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.1 1.2 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.6 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.7 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.8 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.7 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 1.5 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.2 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 2.4 REACTOME DNA REPAIR Genes involved in DNA Repair
0.0 0.5 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway