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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for prdm1a
Z-value: 1.67
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Transcription factors associated with prdm1a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| prdm1a | dr11_v1_chr16_-_7443388_7443388 | 0.77 | 7.8e-20 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_+_17776981 Show fit | 21.06 |
ENSDART00000141693
|
chemokine (C-C motif) ligand 19b |
|
| chr6_-_40657653 Show fit | 15.24 |
ENSDART00000154359
|
peptidylprolyl isomerase (cyclophilin)-like 1 |
|
| chr8_-_50259448 Show fit | 15.09 |
ENSDART00000146056
|
NK3 homeobox 1 |
|
| chr25_+_10416583 Show fit | 15.06 |
ENSDART00000073907
|
ets homologous factor |
|
| chr5_+_13373593 Show fit | 14.73 |
ENSDART00000051668
ENSDART00000183883 |
chemokine (C-C motif) ligand 19a, tandem duplicate 2 |
|
| chr6_+_46697710 Show fit | 11.59 |
ENSDART00000154969
|
thymocyte expressed, positive selection associated 1 |
|
| chr19_+_18739085 Show fit | 10.98 |
ENSDART00000188868
|
sperm acrosome associated 4 like |
|
| chr4_-_76370630 Show fit | 10.26 |
ENSDART00000168831
ENSDART00000174313 |
si:ch73-158p21.3 |
|
| chr6_-_39313027 Show fit | 9.79 |
ENSDART00000012644
|
keratin 4 |
|
| chr22_+_36704764 Show fit | 9.67 |
ENSDART00000146662
|
tripartite motif containing 35-33 |
Network of associatons between targets according to the STRING database.
First level regulatory network of prdm1a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 48.0 | GO:0016567 | protein ubiquitination(GO:0016567) |
| 1.0 | 44.1 | GO:0048247 | lymphocyte chemotaxis(GO:0048247) |
| 2.3 | 25.7 | GO:0002483 | antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885) |
| 0.7 | 23.8 | GO:0010499 | proteasomal ubiquitin-independent protein catabolic process(GO:0010499) |
| 4.3 | 17.3 | GO:0050862 | positive regulation of T cell receptor signaling pathway(GO:0050862) |
| 0.5 | 15.2 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.1 | 11.9 | GO:0050673 | epithelial cell proliferation(GO:0050673) |
| 0.4 | 11.0 | GO:0007286 | spermatid development(GO:0007286) |
| 0.9 | 9.3 | GO:0006177 | GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037) |
| 0.4 | 9.3 | GO:0001843 | neural tube closure(GO:0001843) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 63.0 | GO:0005634 | nucleus(GO:0005634) |
| 0.0 | 47.6 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 29.9 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.8 | 23.8 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.0 | 11.1 | GO:0015629 | actin cytoskeleton(GO:0015629) |
| 0.9 | 9.8 | GO:0045095 | keratin filament(GO:0045095) |
| 0.2 | 9.3 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.1 | 9.3 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.0 | 9.1 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 8.2 | GO:0000785 | chromatin(GO:0000785) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 39.2 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.8 | 35.8 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.1 | 34.3 | GO:0005525 | GTP binding(GO:0005525) |
| 0.1 | 19.2 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.9 | 17.0 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.3 | 15.2 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
| 0.0 | 12.2 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.4 | 11.0 | GO:0004675 | transmembrane receptor protein serine/threonine kinase activity(GO:0004675) |
| 0.1 | 10.9 | GO:0030414 | peptidase inhibitor activity(GO:0030414) |
| 0.3 | 10.1 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 13.1 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.4 | 12.0 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.3 | 11.6 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.3 | 6.5 | SIG IL4RECEPTOR IN B LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.1 | 4.9 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.0 | 3.9 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 3.3 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.1 | 3.1 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.1 | 2.5 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 0.1 | 2.4 | PID AURORA B PATHWAY | Aurora B signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 12.6 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 1.4 | 8.4 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS | Genes involved in Synthesis of bile acids and bile salts |
| 0.9 | 8.3 | REACTOME ENDOGENOUS STEROLS | Genes involved in Endogenous sterols |
| 0.1 | 6.5 | REACTOME DOWNSTREAM SIGNAL TRANSDUCTION | Genes involved in Downstream signal transduction |
| 0.1 | 5.2 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 0.3 | 4.4 | REACTOME RNA POL III CHAIN ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.1 | 4.2 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.1 | 3.4 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 3.3 | REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 0.1 | 3.2 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |