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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for rarga
Z-value: 1.99
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Transcription factors associated with rarga
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| rarga | dr11_v1_chr23_+_35918530_35918530 | -0.88 | 1.4e-31 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_42234484 Show fit | 42.91 |
ENSDART00000132617
ENSDART00000136690 ENSDART00000141358 |
apolipoprotein M |
|
| chr13_-_12660318 Show fit | 31.21 |
ENSDART00000008498
|
alcohol dehydrogenase 8a |
|
| chr5_+_28830388 Show fit | 30.77 |
ENSDART00000149150
|
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 |
|
| chr11_+_37201483 Show fit | 30.70 |
ENSDART00000160930
ENSDART00000173439 ENSDART00000171273 |
zgc:112265 |
|
| chr16_-_17197546 Show fit | 29.83 |
ENSDART00000139939
ENSDART00000135146 ENSDART00000063800 ENSDART00000163606 |
glyceraldehyde-3-phosphate dehydrogenase |
|
| chr4_-_17409533 Show fit | 29.54 |
ENSDART00000011943
|
phenylalanine hydroxylase |
|
| chr5_-_41531629 Show fit | 27.42 |
ENSDART00000051082
|
aldo-keto reductase family 1, member A1a (aldehyde reductase) |
|
| chr7_+_52122224 Show fit | 26.80 |
ENSDART00000174268
|
cytochrome P450, family 2, subfamily X, polypeptide 12 |
|
| chr20_+_31269778 Show fit | 25.36 |
ENSDART00000133353
|
apolipoprotein Bb, tandem duplicate 1 |
|
| chr13_-_22862133 Show fit | 24.34 |
ENSDART00000138563
|
phenazine biosynthesis-like protein domain containing 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of rarga
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 56.8 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
| 0.9 | 45.4 | GO:0042737 | drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) |
| 1.3 | 32.6 | GO:0015986 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 4.5 | 31.2 | GO:0046294 | formaldehyde metabolic process(GO:0046292) formaldehyde catabolic process(GO:0046294) |
| 0.9 | 29.8 | GO:0050821 | protein stabilization(GO:0050821) |
| 2.5 | 29.5 | GO:1902221 | L-phenylalanine metabolic process(GO:0006558) L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222) |
| 0.1 | 29.4 | GO:0046777 | protein autophosphorylation(GO:0046777) |
| 9.6 | 28.8 | GO:0098543 | detection of biotic stimulus(GO:0009595) detection of bacterium(GO:0016045) detection of other organism(GO:0098543) detection of external biotic stimulus(GO:0098581) |
| 2.8 | 27.7 | GO:0072337 | modified amino acid transport(GO:0072337) |
| 5.1 | 25.4 | GO:0006642 | triglyceride mobilization(GO:0006642) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 164.8 | GO:0005576 | extracellular region(GO:0005576) |
| 0.2 | 27.2 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 6.5 | 26.1 | GO:0000275 | mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) |
| 5.1 | 25.4 | GO:0034359 | mature chylomicron(GO:0034359) |
| 0.0 | 21.4 | GO:0005829 | cytosol(GO:0005829) |
| 0.4 | 20.5 | GO:0031941 | filamentous actin(GO:0031941) |
| 2.2 | 15.5 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.9 | 15.3 | GO:0031680 | G-protein beta/gamma-subunit complex(GO:0031680) |
| 0.1 | 13.9 | GO:0016459 | myosin complex(GO:0016459) |
| 0.1 | 10.4 | GO:0030018 | Z disc(GO:0030018) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 54.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.7 | 45.4 | GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712) |
| 6.2 | 31.2 | GO:0051903 | alcohol dehydrogenase activity, zinc-dependent(GO:0004024) S-(hydroxymethyl)glutathione dehydrogenase activity(GO:0051903) |
| 7.5 | 29.8 | GO:0043891 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891) |
| 3.3 | 29.5 | GO:0016714 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714) |
| 9.6 | 28.8 | GO:0016019 | peptidoglycan receptor activity(GO:0016019) |
| 0.0 | 27.6 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 5.5 | 27.4 | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity(GO:0004032) |
| 0.0 | 26.3 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 2.4 | 26.1 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 61.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.5 | 31.8 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.5 | 21.1 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.7 | 15.3 | PID RHODOPSIN PATHWAY | Visual signal transduction: Rods |
| 0.1 | 14.9 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 7.3 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.2 | 5.9 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 5.6 | PID P73PATHWAY | p73 transcription factor network |
| 0.2 | 3.4 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.1 | 3.0 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 39.6 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 1.1 | 22.6 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.9 | 21.3 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 3.8 | 15.3 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.1 | 12.6 | REACTOME MRNA PROCESSING | Genes involved in mRNA Processing |
| 0.5 | 11.5 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 9.6 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.6 | 9.4 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.9 | 9.1 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.6 | 7.3 | REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | Genes involved in Trafficking and processing of endosomal TLR |