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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for rel
Z-value: 1.21
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Transcription factors associated with rel
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| rel | dr11_v1_chr13_-_25819825_25819825 | 0.51 | 1.2e-07 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_16780643 Show fit | 14.33 |
ENSDART00000125647
ENSDART00000108611 ENSDART00000181245 ENSDART00000163194 |
transferrin-a |
|
| chr24_+_26006730 Show fit | 14.12 |
ENSDART00000140384
ENSDART00000139184 |
chemokine (C-C motif) ligand 20b |
|
| chr7_+_45975537 Show fit | 13.44 |
ENSDART00000170253
|
pleckstrin homology domain containing, family F (with FYVE domain) member 1 |
|
| chr7_+_12950507 Show fit | 13.22 |
ENSDART00000067629
ENSDART00000158004 |
serum amyloid A |
|
| chr1_-_49225890 Show fit | 13.03 |
ENSDART00000111598
|
chemokine (C-X-C motif) ligand 18b |
|
| chr25_-_13188214 Show fit | 12.78 |
ENSDART00000187298
|
si:ch211-147m6.1 |
|
| chr2_-_51772438 Show fit | 11.96 |
ENSDART00000170241
|
Danio rerio three-finger protein 5 (LOC100003647), mRNA. |
|
| chr22_+_5478353 Show fit | 11.59 |
ENSDART00000160596
|
tubulin polymerization promoting protein |
|
| chr20_+_16881883 Show fit | 10.82 |
ENSDART00000130107
|
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a |
|
| chr23_+_19701587 Show fit | 10.72 |
ENSDART00000104425
|
deoxyribonuclease I-like 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of rel
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 45.8 | GO:0070098 | chemokine-mediated signaling pathway(GO:0070098) |
| 2.6 | 15.7 | GO:0051883 | killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364) disruption of cells of other organism involved in symbiotic interaction(GO:0051818) killing of cells in other organism involved in symbiotic interaction(GO:0051883) |
| 1.6 | 14.3 | GO:0019731 | antibacterial humoral response(GO:0019731) |
| 4.7 | 14.0 | GO:0002468 | dendritic cell antigen processing and presentation(GO:0002468) |
| 3.6 | 10.8 | GO:1901533 | negative regulation of hematopoietic progenitor cell differentiation(GO:1901533) |
| 0.6 | 10.7 | GO:0000737 | DNA catabolic process, endonucleolytic(GO:0000737) |
| 0.8 | 10.3 | GO:0034121 | regulation of toll-like receptor signaling pathway(GO:0034121) negative regulation of toll-like receptor signaling pathway(GO:0034122) negative regulation of innate immune response(GO:0045824) |
| 0.4 | 9.5 | GO:0050829 | defense response to Gram-negative bacterium(GO:0050829) |
| 0.1 | 9.0 | GO:0045930 | negative regulation of mitotic cell cycle(GO:0045930) |
| 2.8 | 8.4 | GO:0034138 | toll-like receptor 3 signaling pathway(GO:0034138) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 71.1 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 16.2 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 15.1 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.9 | 13.2 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 1.7 | 10.3 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.1 | 10.2 | GO:0009898 | cytoplasmic side of plasma membrane(GO:0009898) |
| 0.6 | 9.1 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.1 | 8.7 | GO:0030018 | Z disc(GO:0030018) |
| 0.1 | 7.5 | GO:0019814 | immunoglobulin complex(GO:0019814) |
| 0.2 | 7.4 | GO:0005861 | troponin complex(GO:0005861) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 32.8 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.1 | 17.1 | GO:0035091 | phosphatidylinositol binding(GO:0035091) |
| 3.7 | 15.0 | GO:0051916 | granulocyte colony-stimulating factor binding(GO:0051916) |
| 0.4 | 13.0 | GO:0017147 | Wnt-protein binding(GO:0017147) |
| 1.8 | 12.6 | GO:0008118 | N-acetyllactosaminide alpha-2,3-sialyltransferase activity(GO:0008118) |
| 1.1 | 10.7 | GO:0004530 | deoxyribonuclease I activity(GO:0004530) |
| 0.0 | 9.6 | GO:0003779 | actin binding(GO:0003779) |
| 0.1 | 9.4 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.3 | 9.1 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.3 | 9.1 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 16.4 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.1 | 15.7 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.4 | 10.3 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.5 | 9.9 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.4 | 9.6 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 0.3 | 8.6 | PID TXA2PATHWAY | Thromboxane A2 receptor signaling |
| 0.2 | 7.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.2 | 5.7 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.2 | 4.8 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.5 | 4.6 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 10.6 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 2.1 | 10.3 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 1.1 | 7.7 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.4 | 6.3 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.4 | 5.2 | REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 0.1 | 5.2 | REACTOME SIGNALING BY ILS | Genes involved in Signaling by Interleukins |
| 0.2 | 4.8 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.4 | 4.6 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.1 | 4.4 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.1 | 4.3 | REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | Genes involved in Activation of NF-kappaB in B Cells |