ISMARA results: rest

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for rest

Z-value: 6.65

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Transcription factors associated with rest

Gene Symbol	Gene ID	Gene Info
rest NCBI UniProt	ENSDARG00000103046	Danio rerio RE1-silencing transcription factor (rest), mRNA.

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
rest	dr11_v1_chr14_-_52433292_52433292	-0.23	2.6e-02	Click!

Activity profile of rest motif

Sorted Z-values of rest motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr20_+_34913069 Show fit	225.34	ENSDART00000007584	snap25a NCBI UniProt Show fit	synaptosomal-associated protein, 25a
chr17_-_12385308 Show fit	180.15	ENSDART00000080927	snap25b NCBI UniProt Show fit	synaptosomal-associated protein, 25b
chr25_-_22639133 Show fit	171.20	ENSDART00000073583	islr2 NCBI UniProt Show fit	immunoglobulin superfamily containing leucine-rich repeat 2
chr9_-_34915351 Show fit	170.95	ENSDART00000100728 ENSDART00000139608	upf3a NCBI UniProt Show fit	UPF3A, regulator of nonsense mediated mRNA decay
chr21_+_11468934 Show fit	152.82	ENSDART00000126045 ENSDART00000129744 ENSDART00000102368	grin1a NCBI UniProt Show fit	glutamate receptor, ionotropic, N-methyl D-aspartate 1a
chr25_-_19443421 Show fit	150.07	ENSDART00000067362	cart2 NCBI UniProt Show fit	cocaine- and amphetamine-regulated transcript 2
chr20_+_27020201 Show fit	146.99	ENSDART00000126919 ENSDART00000016014	chga NCBI UniProt Show fit	chromogranin A
chr19_-_19339285 Show fit	146.92	ENSDART00000158413 ENSDART00000170479	cspg5b NCBI UniProt Show fit	chondroitin sulfate proteoglycan 5b
chr4_-_5302866 Show fit	146.71	ENSDART00000138590	SNAP91 (1 of many) NCBI UniProt Show fit	si:ch211-214j24.9
chr5_-_29643930 Show fit	144.40	ENSDART00000161250	grin1b NCBI UniProt Show fit	glutamate receptor, ionotropic, N-methyl D-aspartate 1b

Showing 1 to 10 of 119 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of rest

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.4	612.7	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
29.9	538.0	GO:0035235	ionotropic glutamate receptor signaling pathway(GO:0035235)
16.2	405.5	GO:0016082	synaptic vesicle priming(GO:0016082)
0.1	376.2	GO:0006357	regulation of transcription from RNA polymerase II promoter(GO:0006357)
10.1	223.1	GO:0007631	feeding behavior(GO:0007631)
4.7	215.1	GO:0050433	dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059) catecholamine secretion(GO:0050432) regulation of catecholamine secretion(GO:0050433)
26.3	210.2	GO:0098700	neurotransmitter loading into synaptic vesicle(GO:0098700)
16.1	208.9	GO:1990504	dense core granule exocytosis(GO:1990504)
1.1	183.7	GO:0002040	sprouting angiogenesis(GO:0002040)
1.0	178.8	GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)

Showing 1 to 10 of 57 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	931.3	GO:0016021	integral component of membrane(GO:0016021)
0.5	923.5	GO:0005576	extracellular region(GO:0005576)
35.9	538.0	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.4	534.2	GO:0005887	integral component of plasma membrane(GO:0005887)
0.1	476.2	GO:0005634	nucleus(GO:0005634)
67.6	405.5	GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
3.5	252.9	GO:0030141	secretory granule(GO:0030141)
0.6	232.4	GO:0045202	synapse(GO:0045202)
14.0	210.2	GO:0030285	integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
5.0	208.9	GO:0098978	glutamatergic synapse(GO:0098978)

Showing 1 to 10 of 33 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	699.0	GO:0005509	calcium ion binding(GO:0005509)
26.9	538.0	GO:0004972	NMDA glutamate receptor activity(GO:0004972)
0.2	533.5	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
10.1	405.5	GO:0017075	syntaxin-1 binding(GO:0017075)
0.1	394.7	GO:0046872	metal ion binding(GO:0046872)
11.4	387.0	GO:0005184	neuropeptide hormone activity(GO:0005184)
2.2	242.6	GO:0005179	hormone activity(GO:0005179)
44.6	223.1	GO:0031843	neuropeptide Y receptor binding(GO:0031841) type 2 neuropeptide Y receptor binding(GO:0031843)
4.5	215.1	GO:0001786	phosphatidylserine binding(GO:0001786)
16.2	210.2	GO:0005326	neurotransmitter transporter activity(GO:0005326)

Showing 1 to 10 of 43 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.0	128.9	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
5.1	126.7	PID RAS PATHWAY	Regulation of Ras family activation
2.9	102.7	PID ATM PATHWAY	ATM pathway
1.2	48.1	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
2.9	46.9	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.2	21.9	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.1	12.9	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.6	12.8	PID ARF 3PATHWAY	Arf1 pathway
0.1	5.0	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins

Showing 1 to 9 of 9 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	170.9	REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX	Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
31.7	126.7	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
7.6	114.1	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
7.3	109.0	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
3.1	102.7	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
12.3	86.0	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
3.3	79.0	REACTOME G PROTEIN ACTIVATION	Genes involved in G-protein activation
1.1	46.9	REACTOME CIRCADIAN CLOCK	Genes involved in Circadian Clock
4.4	44.2	REACTOME LIGAND GATED ION CHANNEL TRANSPORT	Genes involved in Ligand-gated ion channel transport
1.3	36.1	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis

Showing 1 to 10 of 13 entries

Results for rest

Z-value: 6.65

Motif logo

Transcription factors associated with rest

Activity-expression correlation:

Activity profile of rest motif

Sorted Z-values of rest motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of rest

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: