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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for rest

Z-value: 6.65

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Transcription factors associated with rest

Gene Symbol Gene ID Gene Info
rest
ENSDARG00000103046 Danio rerio RE1-silencing transcription factor (rest), mRNA.

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
restdr11_v1_chr14_-_52433292_52433292-0.232.6e-02Click!

Activity profile of rest motif

Sorted Z-values of rest motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr20_+_34913069 225.34 ENSDART00000007584
snap25a
synaptosomal-associated protein, 25a
chr17_-_12385308 180.15 ENSDART00000080927
snap25b
synaptosomal-associated protein, 25b
chr25_-_22639133 171.20 ENSDART00000073583
islr2
immunoglobulin superfamily containing leucine-rich repeat 2
chr9_-_34915351 170.95 ENSDART00000100728
ENSDART00000139608
upf3a
UPF3A, regulator of nonsense mediated mRNA decay
chr21_+_11468934 152.82 ENSDART00000126045
ENSDART00000129744
ENSDART00000102368
grin1a
glutamate receptor, ionotropic, N-methyl D-aspartate 1a
chr25_-_19443421 150.07 ENSDART00000067362
cart2
cocaine- and amphetamine-regulated transcript 2
chr20_+_27020201 146.99 ENSDART00000126919
ENSDART00000016014
chga
chromogranin A
chr19_-_19339285 146.92 ENSDART00000158413
ENSDART00000170479
cspg5b
chondroitin sulfate proteoglycan 5b
chr4_-_5302866 146.71 ENSDART00000138590
SNAP91 (1 of many)
si:ch211-214j24.9
chr5_-_29643930 144.40 ENSDART00000161250
grin1b
glutamate receptor, ionotropic, N-methyl D-aspartate 1b
chr7_+_40228422 133.27 ENSDART00000052222
ptprn2
protein tyrosine phosphatase, receptor type, N polypeptide 2
chr5_-_29643381 131.57 ENSDART00000034849
grin1b
glutamate receptor, ionotropic, N-methyl D-aspartate 1b
chr23_+_45579497 128.95 ENSDART00000110381
egr4
early growth response 4
chr7_+_26224211 128.74 ENSDART00000173999
vgf
VGF nerve growth factor inducible
chr20_+_45741566 128.56 ENSDART00000113454
chgb
chromogranin B
chr18_+_26337869 126.74 ENSDART00000109257
RASGRF1
si:ch211-234p18.3
chr20_+_38724575 124.97 ENSDART00000015095
ENSDART00000152972
uts1
urotensin 1
chr6_+_41255485 124.94 ENSDART00000042683
ENSDART00000186013
cadpsb
Ca2+-dependent activator protein for secretion b
chr25_+_35250976 123.48 ENSDART00000003494
slc17a6a
solute carrier family 17 (vesicular glutamate transporter), member 6a
chr7_+_23907692 121.92 ENSDART00000045479
syt4
synaptotagmin IV
chr3_+_33340939 121.88 ENSDART00000128786
pyya
peptide YYa
chr6_-_30210378 121.69 ENSDART00000157359
ENSDART00000113924
lrrc7
leucine rich repeat containing 7
chr15_+_36156986 117.59 ENSDART00000059791
sst1.1
somatostatin 1, tandem duplicate 1
chr10_+_25219728 116.60 ENSDART00000193829
grm5a
glutamate receptor, metabotropic 5a
chr16_+_46148990 115.02 ENSDART00000083919
sv2a
synaptic vesicle glycoprotein 2A
chr21_-_42100471 114.05 ENSDART00000166148
gabra1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr10_+_21588002 113.26 ENSDART00000100596
pcdh1a6
protocadherin 1 alpha 6
chr21_+_11468642 109.18 ENSDART00000041869
grin1a
glutamate receptor, ionotropic, N-methyl D-aspartate 1a
chr4_-_5302162 109.11 ENSDART00000177099
SNAP91 (1 of many)
si:ch211-214j24.9
chr5_-_29750377 108.45 ENSDART00000051474
barhl1a
BarH-like homeobox 1a
chr25_-_31863374 108.41 ENSDART00000028338
scamp5a
secretory carrier membrane protein 5a
chr10_+_23022263 108.22 ENSDART00000138955
si:dkey-175g6.2
si:dkey-175g6.2
chr13_+_23282549 105.14 ENSDART00000101134
khdrbs2
KH domain containing, RNA binding, signal transduction associated 2
chr7_-_52876683 102.96 ENSDART00000172910
map1aa
microtubule-associated protein 1Aa
chr23_+_28693278 102.71 ENSDART00000078148
smc1a
structural maintenance of chromosomes 1A
chr1_+_54911458 102.34 ENSDART00000089603
golga7ba
golgin A7 family, member Ba
chr3_+_33341640 101.19 ENSDART00000186352
pyya
peptide YYa
chr5_-_26093945 101.15 ENSDART00000010199
ENSDART00000145096
fam219ab
family with sequence similarity 219, member Ab
chr19_-_43552252 98.82 ENSDART00000138308
gpr186
G protein-coupled receptor 186
chr20_+_19212962 97.69 ENSDART00000063706
fndc4a
fibronectin type III domain containing 4a
chr1_+_10720294 97.21 ENSDART00000139387
atp1b1b
ATPase Na+/K+ transporting subunit beta 1b
chr19_-_42244358 95.98 ENSDART00000102697
cart4
cocaine- and amphetamine-regulated transcript 4
chr18_+_28988373 93.17 ENSDART00000018685
syt9a
synaptotagmin IXa
chr12_+_24561832 93.03 ENSDART00000088159
nrxn1a
neurexin 1a
chr10_+_21807497 91.08 ENSDART00000164634
pcdh1g32
protocadherin 1 gamma 32
chr14_-_2264494 90.93 ENSDART00000191149
pcdh2ab9
protocadherin 2 alpha b 9
chr12_+_24342303 90.62 ENSDART00000111239
nrxn1a
neurexin 1a
chr17_+_19630272 89.40 ENSDART00000104895
rgs7a
regulator of G protein signaling 7a
chr3_-_37476475 88.82 ENSDART00000148107
si:ch211-278a6.1
si:ch211-278a6.1
chr7_-_32833153 86.73 ENSDART00000099871
ENSDART00000099872
slc17a6b
solute carrier family 17 (vesicular glutamate transporter), member 6b
chr5_-_32092856 86.29 ENSDART00000086181
ENSDART00000181677
cabp7b
calcium binding protein 7b
chr7_-_69521481 86.02 ENSDART00000148465
slc1a1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
chr23_-_17657348 85.09 ENSDART00000054736
bhlhe23
basic helix-loop-helix family, member e23
chr23_+_35759843 80.62 ENSDART00000047082
gdap1l1
ganglioside induced differentiation associated protein 1-like 1
chr7_-_30087048 80.12 ENSDART00000112743
nmbb
neuromedin Bb
chr23_+_41800052 79.04 ENSDART00000141484
pdyn
prodynorphin
chr21_+_6751760 78.46 ENSDART00000135914
olfm1b
olfactomedin 1b
chr22_-_25033105 76.45 ENSDART00000124220
nptxrb
neuronal pentraxin receptor b
chr18_-_44611252 75.88 ENSDART00000173095
spred3
sprouty-related, EVH1 domain containing 3
chr7_+_17229980 73.61 ENSDART00000184910
slc6a5
solute carrier family 6 (neurotransmitter transporter), member 5
chr6_+_43903209 72.56 ENSDART00000006435
gpr27
G protein-coupled receptor 27
chr21_-_17482465 72.29 ENSDART00000004548
barhl1b
BarH-like homeobox 1b
chr19_+_26718074 71.59 ENSDART00000134455
zgc:100906
zgc:100906
chr10_-_36927594 69.07 ENSDART00000162046
sez6a
seizure related 6 homolog a
chr9_-_27649406 68.40 ENSDART00000181270
ENSDART00000187112
stxbp5l
syntaxin binding protein 5-like
chr6_-_43092175 67.89 ENSDART00000084389
lrrn1
leucine rich repeat neuronal 1
chr14_-_2267515 66.54 ENSDART00000180988
ENSDART00000130712
pcdh2aa15
protocadherin 2 alpha a 15
chr21_+_6751405 66.40 ENSDART00000037265
ENSDART00000146371
olfm1b
olfactomedin 1b
chr10_-_26793448 65.92 ENSDART00000141955
mcf2b
MCF.2 cell line derived transforming sequence b
chr1_-_38538284 61.81 ENSDART00000009777
glra3
glycine receptor, alpha 3
chr14_-_2032753 61.66 ENSDART00000111335
pcdh2g5
protocadherin 2 gamma 5
chr7_+_59739164 59.17 ENSDART00000110412
gpr78b
G protein-coupled receptor 78b
chr20_-_35052464 58.71 ENSDART00000037195
kif26bb
kinesin family member 26Bb
chr13_+_25846528 56.46 ENSDART00000087426
bcl11aa
B cell CLL/lymphoma 11Aa
chr9_-_31915423 54.71 ENSDART00000060051
fgf14
fibroblast growth factor 14
chr17_+_19630068 53.64 ENSDART00000182619
rgs7a
regulator of G protein signaling 7a
chr14_-_2193248 52.46 ENSDART00000128659
pcdh2ab10
protocadherin 2 alpha b 10
chr11_+_19780717 48.95 ENSDART00000157394
cadpsa
Ca2+-dependent activator protein for secretion a
chr7_-_31940590 48.08 ENSDART00000131009
bdnf
brain-derived neurotrophic factor
chr15_+_24212847 47.11 ENSDART00000155502
sez6b
seizure related 6 homolog b
chr12_+_19305390 46.92 ENSDART00000183987
ENSDART00000066391
csnk1e
casein kinase 1, epsilon
chr17_-_10249095 45.75 ENSDART00000159963
sstr1a
somatostatin receptor 1a
chr23_-_30785382 43.99 ENSDART00000136156
ENSDART00000131285
myt1a
myelin transcription factor 1a
chr17_-_33552363 42.21 ENSDART00000154400
tmem121aa
transmembrane protein 121Aa
chr14_-_2004291 40.92 ENSDART00000114039
pcdh2g5
protocadherin 2 gamma 5
chr12_-_19862912 40.79 ENSDART00000145788
shisa9a
shisa family member 9a
chr10_-_29892486 40.18 ENSDART00000099983
bsx
brain-specific homeobox
chr2_-_5776030 37.73 ENSDART00000133851
nyap2b
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2b
chr6_-_31336317 36.07 ENSDART00000193927
dnajc6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr14_-_1987121 35.76 ENSDART00000135733
pcdh2g5
protocadherin 2 gamma 5
chr7_+_17229282 35.38 ENSDART00000097982
slc6a5
solute carrier family 6 (neurotransmitter transporter), member 5
chr11_+_19781053 34.96 ENSDART00000029680
ENSDART00000182743
cadpsa
Ca2+-dependent activator protein for secretion a
chr20_+_41640687 32.30 ENSDART00000138686
fam184a
family with sequence similarity 184, member A
chr11_+_33426510 30.83 ENSDART00000163106
cntnap5l
contactin associated protein-like 5 like
chr14_-_1998501 28.22 ENSDART00000189052
pcdh2g5
protocadherin 2 gamma 5
chr18_+_50089000 25.97 ENSDART00000058936
scamp5b
secretory carrier membrane protein 5b
chr10_+_36441124 25.02 ENSDART00000185626
uspl1
ubiquitin specific peptidase like 1
chr23_+_30859086 23.45 ENSDART00000053661
zgc:198371
zgc:198371
chr14_-_32486757 23.25 ENSDART00000148830
mcf2a
MCF.2 cell line derived transforming sequence a
chr14_-_1963369 23.11 ENSDART00000125521
pcdh2g5
protocadherin 2 gamma 5
chr15_-_22147860 21.91 ENSDART00000149784
scn3b
sodium channel, voltage-gated, type III, beta
chr6_+_21740672 21.55 ENSDART00000193734
lhfpl4a
lipoma HMGIC fusion partner-like 4a
chr18_+_36806545 21.18 ENSDART00000098958
ttc9b
tetratricopeptide repeat domain 9B
chr17_-_21617618 18.31 ENSDART00000109031
gpr26
G protein-coupled receptor 26
chr15_-_47841259 17.15 ENSDART00000155384
kbtbd3
kelch repeat and BTB (POZ) domain containing 3
chr11_+_33426254 15.81 ENSDART00000111193
cntnap5l
contactin associated protein-like 5 like
chr1_-_201004 14.63 ENSDART00000188956
FO681286.1

chr1_+_12348213 12.78 ENSDART00000144920
ENSDART00000138759
ENSDART00000067082
clta
clathrin, light chain A
chr13_-_45811137 9.40 ENSDART00000190512
fndc5a
fibronectin type III domain containing 5a
chr16_-_40727455 8.75 ENSDART00000162331
si:dkey-22o22.2
si:dkey-22o22.2
chr4_-_17391091 8.37 ENSDART00000056002
th2
tyrosine hydroxylase 2
chr4_+_357810 6.62 ENSDART00000163436
ENSDART00000103645
tmem181
transmembrane protein 181
chr20_-_39391833 5.94 ENSDART00000135149
si:dkey-217m5.8
si:dkey-217m5.8
chr3_-_44753325 5.65 ENSDART00000074543
hs3st4
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr3_-_20721064 5.04 ENSDART00000193532
spop
speckle-type POZ protein
chr12_-_16524727 2.73 ENSDART00000166645
FO704724.1

chr1_+_40794395 2.52 ENSDART00000111656
gpr78a
G protein-coupled receptor 78a
chr4_-_76488581 2.16 ENSDART00000174291
ftr51
finTRIM family, member 51
chr1_+_19515228 0.10 ENSDART00000103091
clrn2
clarin 2

Network of associatons between targets according to the STRING database.

First level regulatory network of rest

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
49.0 147.0 GO:0002792 negative regulation of peptide secretion(GO:0002792) negative regulation of peptide hormone secretion(GO:0090278)
38.9 116.6 GO:0099552 trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553)
29.9 538.0 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
26.3 210.2 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
22.8 114.1 GO:0070208 protein heterotrimerization(GO:0070208)
21.0 146.9 GO:0099550 trans-synaptic signalling, modulating synaptic transmission(GO:0099550)
18.8 150.1 GO:0008343 adult feeding behavior(GO:0008343)
16.2 405.5 GO:0016082 synaptic vesicle priming(GO:0016082)
16.1 208.9 GO:1990504 dense core granule exocytosis(GO:1990504)
14.1 56.5 GO:2000171 negative regulation of dendrite development(GO:2000171)
13.6 109.0 GO:0043092 amino acid import(GO:0043090) L-amino acid import(GO:0043092)
12.6 75.9 GO:0010801 regulation of peptidyl-threonine phosphorylation(GO:0010799) negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
10.1 223.1 GO:0007631 feeding behavior(GO:0007631)
8.7 121.7 GO:0032088 negative regulation of NF-kappaB transcription factor activity(GO:0032088)
8.5 67.9 GO:0021627 olfactory nerve development(GO:0021553) olfactory nerve morphogenesis(GO:0021627) olfactory nerve formation(GO:0021628)
7.2 36.1 GO:0016191 synaptic vesicle uncoating(GO:0016191)
5.9 88.8 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
5.7 40.2 GO:0021982 pineal gland development(GO:0021982)
5.7 170.9 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
5.5 21.9 GO:0086005 ventricular cardiac muscle cell action potential(GO:0086005)
5.4 21.6 GO:0097112 gamma-aminobutyric acid receptor clustering(GO:0097112)
5.1 97.2 GO:0030007 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
5.0 80.1 GO:0046887 positive regulation of hormone secretion(GO:0046887)
5.0 25.0 GO:1990173 nuclear body organization(GO:0030575) Cajal body organization(GO:0030576) protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) protein localization to nucleoplasm(GO:1990173)
4.8 61.8 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
4.7 215.1 GO:0050433 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059) catecholamine secretion(GO:0050432) regulation of catecholamine secretion(GO:0050433)
4.6 45.7 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
4.5 40.8 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
4.2 108.4 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
4.0 48.1 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
4.0 103.0 GO:0031114 regulation of microtubule depolymerization(GO:0031114)
4.0 102.7 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
3.9 54.7 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
2.8 8.4 GO:0042416 dopamine biosynthetic process from tyrosine(GO:0006585) dopamine biosynthetic process(GO:0042416)
2.8 102.3 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
2.4 612.7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
2.4 68.4 GO:0050708 regulation of protein secretion(GO:0050708)
2.1 128.6 GO:0031290 retinal ganglion cell axon guidance(GO:0031290)
2.0 72.6 GO:0042593 carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593)
1.2 105.1 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
1.2 115.0 GO:0006836 neurotransmitter transport(GO:0006836)
1.1 183.7 GO:0002040 sprouting angiogenesis(GO:0002040)
1.0 79.0 GO:0007218 neuropeptide signaling pathway(GO:0007218)
1.0 178.8 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.9 46.9 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.4 22.5 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)
0.4 133.3 GO:0006470 protein dephosphorylation(GO:0006470)
0.4 117.6 GO:0030334 regulation of cell migration(GO:0030334)
0.4 12.8 GO:0048268 clathrin coat assembly(GO:0048268)
0.2 58.7 GO:0007018 microtubule-based movement(GO:0007018)
0.2 96.3 GO:0009968 negative regulation of signal transduction(GO:0009968)
0.2 44.0 GO:1904888 cranial skeletal system development(GO:1904888)
0.1 376.2 GO:0006357 regulation of transcription from RNA polymerase II promoter(GO:0006357)
0.1 94.5 GO:0007399 nervous system development(GO:0007399)
0.0 89.2 GO:0035556 intracellular signal transduction(GO:0035556)
0.0 5.0 GO:0030162 regulation of proteolysis(GO:0030162)
0.0 26.0 GO:0015031 protein transport(GO:0015031)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
67.6 405.5 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
35.9 538.0 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
14.7 147.0 GO:0042583 chromaffin granule(GO:0042583)
14.0 210.2 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
13.3 93.2 GO:0031045 dense core granule(GO:0031045)
9.7 97.2 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
8.6 102.7 GO:0030893 meiotic cohesin complex(GO:0030893)
7.2 21.6 GO:0060077 inhibitory synapse(GO:0060077)
6.8 102.3 GO:0002178 palmitoyltransferase complex(GO:0002178)
6.7 134.4 GO:0032588 trans-Golgi network membrane(GO:0032588)
5.0 208.9 GO:0098978 glutamatergic synapse(GO:0098978)
3.7 154.8 GO:0032589 neuron projection membrane(GO:0032589) dendrite membrane(GO:0032590)
3.5 252.9 GO:0030141 secretory granule(GO:0030141)
2.8 116.6 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
2.4 79.0 GO:0043679 axon terminus(GO:0043679) neuron projection terminus(GO:0044306)
2.3 127.8 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
1.4 25.0 GO:0015030 Cajal body(GO:0015030)
1.4 68.4 GO:0031201 SNARE complex(GO:0031201)
1.3 121.7 GO:0016323 basolateral plasma membrane(GO:0016323)
1.2 61.8 GO:0034707 chloride channel complex(GO:0034707)
1.2 170.0 GO:0099503 secretory vesicle(GO:0099503)
1.1 124.9 GO:0014069 postsynaptic density(GO:0014069)
1.0 111.3 GO:0043025 neuronal cell body(GO:0043025)
1.0 21.9 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.7 58.7 GO:0005871 kinesin complex(GO:0005871)
0.6 232.4 GO:0045202 synapse(GO:0045202)
0.5 166.1 GO:0005730 nucleolus(GO:0005730)
0.5 923.5 GO:0005576 extracellular region(GO:0005576)
0.4 534.2 GO:0005887 integral component of plasma membrane(GO:0005887)
0.2 5.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 931.3 GO:0016021 integral component of membrane(GO:0016021)
0.1 476.2 GO:0005634 nucleus(GO:0005634)
0.0 75.9 GO:0016020 membrane(GO:0016020)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
44.6 223.1 GO:0031843 neuropeptide Y receptor binding(GO:0031841) type 2 neuropeptide Y receptor binding(GO:0031843)
26.9 538.0 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
16.7 116.6 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
16.2 210.2 GO:0005326 neurotransmitter transporter activity(GO:0005326)
13.4 80.1 GO:0031705 bombesin receptor binding(GO:0031705)
11.4 387.0 GO:0005184 neuropeptide hormone activity(GO:0005184)
10.1 405.5 GO:0017075 syntaxin-1 binding(GO:0017075)
8.1 114.1 GO:0008503 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
7.8 109.0 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
6.9 61.8 GO:0016934 inhibitory extracellular ligand-gated ion channel activity(GO:0005237) extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
6.1 79.0 GO:0031628 opioid receptor binding(GO:0031628)
5.7 45.7 GO:0004994 somatostatin receptor activity(GO:0004994)
5.2 170.9 GO:0042162 telomeric DNA binding(GO:0042162)
5.0 105.1 GO:0008143 poly(A) binding(GO:0008143)
5.0 25.0 GO:0032183 SUMO binding(GO:0032183)
4.9 97.2 GO:0001671 ATPase activator activity(GO:0001671)
4.5 215.1 GO:0001786 phosphatidylserine binding(GO:0001786)
4.0 68.4 GO:0045159 myosin II binding(GO:0045159)
3.7 48.1 GO:0005165 nerve growth factor receptor binding(GO:0005163) neurotrophin receptor binding(GO:0005165)
2.8 76.6 GO:0017080 sodium channel regulator activity(GO:0017080)
2.2 242.6 GO:0005179 hormone activity(GO:0005179)
2.2 102.3 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
1.7 8.4 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
1.0 21.6 GO:0050811 GABA receptor binding(GO:0050811)
0.9 12.8 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.7 699.0 GO:0005509 calcium ion binding(GO:0005509)
0.7 133.3 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.6 5.6 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.5 36.1 GO:0030276 clathrin binding(GO:0030276)
0.5 58.7 GO:0003777 microtubule motor activity(GO:0003777)
0.5 86.0 GO:0015293 symporter activity(GO:0015293)
0.4 103.0 GO:0008017 microtubule binding(GO:0008017)
0.4 75.9 GO:0019901 protein kinase binding(GO:0019901)
0.3 197.6 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.3 89.2 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.3 96.6 GO:0003682 chromatin binding(GO:0003682)
0.2 533.5 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.1 121.7 GO:0005102 receptor binding(GO:0005102)
0.1 394.7 GO:0046872 metal ion binding(GO:0046872)
0.1 78.2 GO:0030234 enzyme regulator activity(GO:0030234)
0.1 5.0 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.1 140.9 GO:0005515 protein binding(GO:0005515)
0.0 28.3 GO:0004674 protein serine/threonine kinase activity(GO:0004674)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 126.7 PID RAS PATHWAY Regulation of Ras family activation
5.0 128.9 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
2.9 102.7 PID ATM PATHWAY ATM pathway
2.9 46.9 PID CIRCADIAN PATHWAY Circadian rhythm pathway
1.2 48.1 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.6 12.8 PID ARF 3PATHWAY Arf1 pathway
0.2 21.9 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 5.0 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 12.9 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
31.7 126.7 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
12.3 86.0 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
7.6 114.1 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
7.3 109.0 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
4.4 44.2 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
3.3 79.0 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
3.1 102.7 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
2.1 12.8 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
1.4 21.9 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
1.3 36.1 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
1.3 170.9 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
1.1 46.9 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock
0.4 5.6 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis