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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for rfx1a+rfx1b

Z-value: 0.87

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Transcription factors associated with rfx1a+rfx1b

Gene Symbol Gene ID Gene Info
rfx1a
ENSDARG00000005883 regulatory factor X, 1a (influences HLA class II expression)
rfx1b
ENSDARG00000075904 regulatory factor X, 1b (influences HLA class II expression)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
rfx1bdr11_v1_chr1_-_54107321_541073210.447.8e-06Click!
rfx1adr11_v1_chr3_-_19200571_192006510.322.0e-03Click!

Activity profile of rfx1a+rfx1b motif

Sorted Z-values of rfx1a+rfx1b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_58085444 8.05 ENSDART00000166395
fcer1gl
Fc receptor, IgE, high affinity I, gamma polypeptide like
chr8_-_36469117 6.96 ENSDART00000111240
mhc2dab
major histocompatibility complex class II DAB gene
chr7_-_34192834 6.84 ENSDART00000125131
smad6a
SMAD family member 6a
chr20_+_31076488 6.60 ENSDART00000136255
ENSDART00000008840
otofa
otoferlin a
chr2_+_68789 6.25 ENSDART00000058569
cldn1
claudin 1
chr8_-_36370552 5.18 ENSDART00000097932
ENSDART00000148323
si:busm1-104n07.3
si:busm1-104n07.3
chr8_+_32402441 5.02 ENSDART00000191451
epgn
epithelial mitogen homolog (mouse)
chr19_+_3849378 4.98 ENSDART00000166218
ENSDART00000159228
oscp1a
organic solute carrier partner 1a
chr1_-_45633955 4.85 ENSDART00000044057
sept3
septin 3
chr17_+_33767890 4.13 ENSDART00000193177
fut8a
fucosyltransferase 8a (alpha (1,6) fucosyltransferase)
chr25_+_5039050 4.10 ENSDART00000154700
parvb
parvin, beta
chr14_-_9199968 4.10 ENSDART00000146113
arhgef9b
Cdc42 guanine nucleotide exchange factor (GEF) 9b
chr13_+_33117528 4.05 ENSDART00000085719
si:ch211-10a23.2
si:ch211-10a23.2
chr19_-_12324514 4.03 ENSDART00000122192
ncaldb
neurocalcin delta b
chr17_-_33716688 3.95 ENSDART00000043651
dnal1
dynein, axonemal, light chain 1
chr1_+_604127 3.86 ENSDART00000133165
jam2a
junctional adhesion molecule 2a
chr8_+_36142734 3.82 ENSDART00000159361
ENSDART00000161194
mhc2b
major histocompatibility complex class II integral membrane beta chain gene
chr9_+_6009077 3.73 ENSDART00000057484
st6gal2a
ST6 beta-galactosamide alpha-2,6-sialyltranferase 2a
chr3_+_49021079 3.57 ENSDART00000162012
zgc:163083
zgc:163083
chr19_+_17400283 3.56 ENSDART00000127353
nr1d2b
nuclear receptor subfamily 1, group D, member 2b
chr10_-_29744921 3.35 ENSDART00000088605
ift46
intraflagellar transport 46 homolog (Chlamydomonas)
chr6_+_18418651 3.22 ENSDART00000171097
ENSDART00000167798
rab11fip4b
RAB11 family interacting protein 4 (class II) b
chr3_-_57425961 3.19 ENSDART00000033716
socs3a
suppressor of cytokine signaling 3a
chr25_+_35942867 3.13 ENSDART00000066985
hsd17b2
hydroxysteroid (17-beta) dehydrogenase 2
chr11_+_7528599 3.09 ENSDART00000171813
adgrl2a
adhesion G protein-coupled receptor L2a
chr2_-_58183499 3.04 ENSDART00000172281
ENSDART00000186262
si:ch1073-185p12.2
si:ch1073-185p12.2
chr10_-_10864331 3.03 ENSDART00000122657
nrarpa
NOTCH regulated ankyrin repeat protein a
chr8_-_30242706 3.02 ENSDART00000139864
ENSDART00000143809
zgc:162939
zgc:162939
chr24_+_25467465 3.00 ENSDART00000189933
smpx
small muscle protein, X-linked
chr5_+_43807003 2.98 ENSDART00000097625
zgc:158640
zgc:158640
chr23_+_28374458 2.98 ENSDART00000140058
ENSDART00000144240
zgc:153867
zgc:153867
chr10_-_10863936 2.96 ENSDART00000180568
nrarpa
NOTCH regulated ankyrin repeat protein a
chr5_-_52243424 2.89 ENSDART00000159078
erap2
endoplasmic reticulum aminopeptidase 2
chr5_-_26566435 2.79 ENSDART00000146070
arvcfb
ARVCF, delta catenin family member b
chr19_-_12315693 2.77 ENSDART00000151158
ncaldb
neurocalcin delta b
chr17_+_44756247 2.75 ENSDART00000153773
cipca
CLOCK-interacting pacemaker a
chr8_-_49345388 2.66 ENSDART00000053203
plp2
proteolipid protein 2
chr4_+_19534833 2.65 ENSDART00000140028
lrrc4.1
leucine rich repeat containing 4.1
chr18_-_2727764 2.64 ENSDART00000160841
ARHGEF17
si:ch211-248g20.5
chr16_-_9869056 2.61 ENSDART00000149312
ncalda
neurocalcin delta a
chr14_+_24283915 2.59 ENSDART00000172868
klhl3
kelch-like family member 3
chr8_+_7144066 2.53 ENSDART00000146306
slc6a6a
solute carrier family 6 (neurotransmitter transporter), member 6a
chr22_-_16270071 2.52 ENSDART00000171823
cdc14ab
cell division cycle 14Ab
chr1_+_8662530 2.52 ENSDART00000054989
fscn1b
fascin actin-bundling protein 1b
chr22_-_16270462 2.51 ENSDART00000105681
cdc14ab
cell division cycle 14Ab
chr21_+_13387965 2.49 ENSDART00000134347
zgc:113162
zgc:113162
chr23_+_6272638 2.46 ENSDART00000190366
syt2a
synaptotagmin IIa
chr5_-_38384755 2.46 ENSDART00000188573
ENSDART00000051233
mink1
misshapen-like kinase 1
chr19_+_29337789 2.45 ENSDART00000021396
ldlrap1a
low density lipoprotein receptor adaptor protein 1a
chr13_+_9368621 2.36 ENSDART00000109126
alms1
Alstrom syndrome protein 1
chr18_-_31051847 2.31 ENSDART00000170982
gas8
growth arrest-specific 8
chr24_-_205275 2.30 ENSDART00000108762
vopp1
VOPP1, WBP1/VOPP1 family member
chr6_+_18251140 2.27 ENSDART00000169752
ccdc40
coiled-coil domain containing 40
chr25_+_25453571 2.27 ENSDART00000112330
rassf7a
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7a
chr17_-_10838434 2.25 ENSDART00000064597
lgals3b
lectin, galactoside binding soluble 3b
chr2_-_7696287 2.20 ENSDART00000190769
CABZ01055306.1

chr14_+_24277556 2.19 ENSDART00000122660
hnrnpa0a
heterogeneous nuclear ribonucleoprotein A0a
chr12_+_4971515 2.19 ENSDART00000161076
arhgap27
Rho GTPase activating protein 27
chr13_-_36911118 2.18 ENSDART00000048739
trim9
tripartite motif containing 9
chr22_+_980290 2.15 ENSDART00000065377
def6b
differentially expressed in FDCP 6b homolog (mouse)
chr8_+_23639124 2.15 ENSDART00000083108
nt5dc2
5'-nucleotidase domain containing 2
chr2_-_12502495 2.14 ENSDART00000186781
dpp6b
dipeptidyl-peptidase 6b
chr8_+_29749017 2.14 ENSDART00000185144
mapk4
mitogen-activated protein kinase 4
chr4_-_23858900 2.13 ENSDART00000123199
usp6nl
USP6 N-terminal like
chr8_-_36412936 2.12 ENSDART00000159276
si:zfos-2070c2.3
si:zfos-2070c2.3
chr3_+_60044780 2.12 ENSDART00000080437
zgc:113030
zgc:113030
chr4_+_4079418 2.09 ENSDART00000028016
waslb
Wiskott-Aldrich syndrome-like b
chr19_+_27589201 2.09 ENSDART00000182060
si:dkeyp-46h3.1
si:dkeyp-46h3.1
chr3_+_32933663 2.09 ENSDART00000112742
nbr1b
neighbor of brca1 gene 1b
chr21_-_22317920 1.97 ENSDART00000191083
ENSDART00000108701
gdpd4b
glycerophosphodiester phosphodiesterase domain containing 4b
chr13_-_18691041 1.97 ENSDART00000057867
sfxn3
sideroflexin 3
chr3_+_21189766 1.97 ENSDART00000078807
zgc:123295
zgc:123295
chr10_+_8101729 1.97 ENSDART00000138875
ENSDART00000123447
ENSDART00000185333
pstpip2
proline-serine-threonine phosphatase interacting protein 2
chr2_+_16449627 1.96 ENSDART00000005381
zgc:110269
zgc:110269
chr15_+_22267847 1.95 ENSDART00000110665
spa17
sperm autoantigenic protein 17
chr13_-_7767548 1.95 ENSDART00000158720
ENSDART00000121952
h2afy2
H2A histone family, member Y2
chr9_-_40873934 1.94 ENSDART00000066424
pofut2
protein O-fucosyltransferase 2
chr19_+_21266008 1.91 ENSDART00000024639
tshz1
teashirt zinc finger homeobox 1
chr11_-_18800299 1.90 ENSDART00000156276
pfkfb2b
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2b
chr8_+_36288261 1.90 ENSDART00000191281
CU929676.1

chr11_-_18799827 1.88 ENSDART00000185438
ENSDART00000189116
ENSDART00000180504
pfkfb2b
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2b
chr21_+_17005737 1.87 ENSDART00000101246
vps29
vacuolar protein sorting 29 homolog (S. cerevisiae)
chr6_+_52350443 1.87 ENSDART00000151612
ENSDART00000151349
si:ch211-239j9.1
si:ch211-239j9.1
chr19_-_40186328 1.86 ENSDART00000087474
efcab1
EF-hand calcium binding domain 1
chr15_+_37589698 1.84 ENSDART00000076066
ENSDART00000153894
ENSDART00000156298
lin37
lin-37 DREAM MuvB core complex component
chr1_-_49498116 1.84 ENSDART00000137357
zgc:175214
zgc:175214
chr15_-_47892583 1.84 ENSDART00000192584
DMWD
zmp:0000000529
chr11_-_36341189 1.83 ENSDART00000159752
sort1a
sortilin 1a
chr4_+_10616626 1.82 ENSDART00000067251
ENSDART00000143690
cped1
cadherin-like and PC-esterase domain containing 1
chr4_-_18939338 1.81 ENSDART00000132081
ENSDART00000042250
rap1b
RAP1B, member of RAS oncogene family
chr5_+_13394543 1.81 ENSDART00000051669
ENSDART00000135921
tctn2
tectonic family member 2
chr8_-_36327328 1.79 ENSDART00000183333
zgc:103700
zgc:103700
chr8_-_19216180 1.78 ENSDART00000146162
si:ch73-222f22.2
si:ch73-222f22.2
chr6_-_7711349 1.78 ENSDART00000032494
ttc26
tetratricopeptide repeat domain 26
chr6_-_33978622 1.78 ENSDART00000151725
ENSDART00000124917
mpl
MPL proto-oncogene, thrombopoietin receptor
chr23_+_44665230 1.77 ENSDART00000144958
camta2
calmodulin binding transcription activator 2
chr8_+_2487250 1.77 ENSDART00000081325
dynll1
dynein, light chain, LC8-type 1
chr17_+_23937262 1.73 ENSDART00000113276
si:ch211-189k9.2
si:ch211-189k9.2
chr2_+_55914699 1.72 ENSDART00000157905
atcayb
ataxia, cerebellar, Cayman type b
chr2_-_7696503 1.71 ENSDART00000169709
CABZ01055306.1

chr11_-_1291012 1.69 ENSDART00000158390
atp2b2
ATPase plasma membrane Ca2+ transporting 2
chr24_+_25822999 1.69 ENSDART00000109809
sh3kbp1
SH3-domain kinase binding protein 1
chr13_+_28854438 1.68 ENSDART00000193407
ENSDART00000189554
CU639469.1

chr15_-_1534232 1.68 ENSDART00000056763
ENSDART00000133943
ift80
intraflagellar transport 80 homolog (Chlamydomonas)
chr7_-_41881177 1.66 ENSDART00000174258
ENSDART00000018972
zgc:92818
zgc:92818
chr17_-_11329959 1.61 ENSDART00000015418
irf2bpl
interferon regulatory factor 2 binding protein-like
chr16_+_46111849 1.61 ENSDART00000172232
sv2a
synaptic vesicle glycoprotein 2A
chr21_+_22124736 1.60 ENSDART00000130179
ENSDART00000172573
cul5b
cullin 5b
chr10_-_43721530 1.60 ENSDART00000025366
cetn3
centrin 3
chr23_+_21638258 1.57 ENSDART00000104188
igsf21b
immunoglobin superfamily, member 21b
chr19_-_43639331 1.55 ENSDART00000138009
ENSDART00000086138
fam83hb
family with sequence similarity 83, member Hb
chr11_+_43661735 1.54 ENSDART00000017912
gli2b
GLI family zinc finger 2b
chr18_-_17531483 1.54 ENSDART00000061000
bbs2
Bardet-Biedl syndrome 2
chr9_-_443451 1.53 ENSDART00000165642
si:dkey-11f4.14
si:dkey-11f4.14
chr2_-_7246848 1.52 ENSDART00000146434
zgc:153115
zgc:153115
chr20_-_12642685 1.52 ENSDART00000173257
si:dkey-97l20.6
si:dkey-97l20.6
chr19_+_43123331 1.48 ENSDART00000187836
CABZ01101996.1

chr12_-_36521767 1.48 ENSDART00000110290
unc13d
unc-13 homolog D (C. elegans)
chr12_+_13405445 1.48 ENSDART00000089042
kcnh4b
potassium voltage-gated channel, subfamily H (eag-related), member 4b
chr14_-_24277805 1.45 ENSDART00000054243
dpf2l
D4, zinc and double PHD fingers family 2, like
chr14_+_35892802 1.41 ENSDART00000135079
zgc:63568
zgc:63568
chr10_+_24678092 1.41 ENSDART00000159270
thsd1
thrombospondin, type I, domain containing 1
chr2_+_6126638 1.40 ENSDART00000153916
fzr1b
fizzy/cell division cycle 20 related 1b
chr10_-_24648228 1.40 ENSDART00000081834
ENSDART00000132830
stoml3b
stomatin (EPB72)-like 3b
chr10_-_24753715 1.35 ENSDART00000192401
ilk
integrin-linked kinase
chr1_-_21538673 1.34 ENSDART00000131257
wdr19
WD repeat domain 19
chr17_+_27176243 1.34 ENSDART00000162527
si:ch211-160f23.7
si:ch211-160f23.7
chr18_+_30028637 1.33 ENSDART00000139750
si:ch211-220f16.1
si:ch211-220f16.1
chr1_-_21538329 1.33 ENSDART00000182798
ENSDART00000193518
ENSDART00000183873
ENSDART00000183376
wdr19
WD repeat domain 19
chr21_+_27297145 1.32 ENSDART00000146588
si:dkey-175m17.6
si:dkey-175m17.6
chr9_+_9112159 1.32 ENSDART00000165932
sik1
salt-inducible kinase 1
chr11_-_24428237 1.31 ENSDART00000189107
ENSDART00000103752
dvl1b
dishevelled segment polarity protein 1b
chr4_-_12795436 1.31 ENSDART00000131026
ENSDART00000075127
b2m
beta-2-microglobulin
chr3_-_29941357 1.30 ENSDART00000147732
ENSDART00000137973
ENSDART00000103523
grna
granulin a
chr11_+_24800156 1.30 ENSDART00000131976
adipor1a
adiponectin receptor 1a
chr8_+_25267903 1.28 ENSDART00000093090
ampd2b
adenosine monophosphate deaminase 2b
chr6_-_41138854 1.28 ENSDART00000128723
ENSDART00000151055
ENSDART00000132484
slc6a22.1
solute carrier family 6 member 22, tandem duplicate 1
chr20_-_46554440 1.27 ENSDART00000043298
ENSDART00000060680
fosab
v-fos FBJ murine osteosarcoma viral oncogene homolog Ab
chr8_-_9570511 1.26 ENSDART00000044000
plxna3
plexin A3
chr17_-_31695217 1.25 ENSDART00000104332
ENSDART00000143090
lin52
lin-52 DREAM MuvB core complex component
chr24_-_9960290 1.24 ENSDART00000143390
ENSDART00000092975
ENSDART00000184953
vps41
vacuolar protein sorting 41 homolog (S. cerevisiae)
chr21_-_40562705 1.24 ENSDART00000158289
ENSDART00000171997
taok1b
TAO kinase 1b
chr1_-_46718353 1.23 ENSDART00000074514
spryd7a
SPRY domain containing 7a
chr19_-_8604429 1.23 ENSDART00000151165
trim46b
tripartite motif containing 46b
chr13_+_669177 1.22 ENSDART00000190085
CU462915.1

chr2_+_41526904 1.22 ENSDART00000127520
acvr1l
activin A receptor, type 1 like
chr20_+_36682051 1.22 ENSDART00000130513
ncoa1
nuclear receptor coactivator 1
chr3_+_60034194 1.21 ENSDART00000189858
ENSDART00000153642
CR352258.1

chr17_-_8173380 1.21 ENSDART00000148520
syne1b
spectrin repeat containing, nuclear envelope 1b
chr2_-_59247811 1.18 ENSDART00000141384
ftr32
finTRIM family, member 32
chr3_-_36210344 1.16 ENSDART00000025326
csnk1da
casein kinase 1, delta a
chr4_-_3145359 1.15 ENSDART00000112210
plekha5
pleckstrin homology domain containing, family A member 5
chr10_+_7585928 1.15 ENSDART00000166686
tex15
testis expressed 15
chr5_-_38384289 1.15 ENSDART00000135260
mink1
misshapen-like kinase 1
chr16_+_9726038 1.13 ENSDART00000192988
ENSDART00000020859
pip5k1ab
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, b
chr10_-_44482911 1.12 ENSDART00000085556
hip1ra
huntingtin interacting protein 1 related a
chr21_-_435466 1.12 ENSDART00000110297
klf4
Kruppel-like factor 4
chr7_+_20247871 1.10 ENSDART00000173499
ENSDART00000173722
si:ch73-335l21.3
si:ch73-335l21.2
si:ch73-335l21.3
si:ch73-335l21.2
chr20_-_31075972 1.10 ENSDART00000122927
si:ch211-198b3.4
si:ch211-198b3.4
chr11_+_44723019 1.09 ENSDART00000168531
irf2bp2b
interferon regulatory factor 2 binding protein 2b
chr1_+_50538839 1.08 ENSDART00000020412
pkd2
polycystic kidney disease 2
chr6_+_46320693 1.08 ENSDART00000128621
ENSDART00000155917
si:dkeyp-67f1.2
si:dkeyp-67f1.2
chr17_-_12758171 1.08 ENSDART00000131564
brms1la
breast cancer metastasis-suppressor 1-like a
chr14_+_6954579 1.07 ENSDART00000060998
nme5
NME/NM23 family member 5
chr14_+_30413312 1.07 ENSDART00000186864
cnot7
CCR4-NOT transcription complex, subunit 7
chr4_+_30363474 1.06 ENSDART00000168421
si:dkey-199m13.7
si:dkey-199m13.7
chr15_+_36115955 1.05 ENSDART00000032702
sst1.2
somatostatin 1, tandem duplicate 2
chr17_+_21964472 1.03 ENSDART00000063704
ENSDART00000188904
crip3
cysteine-rich protein 3
chr13_-_31470439 1.03 ENSDART00000076574
rtn1a
reticulon 1a
chr17_-_14451718 1.02 ENSDART00000039438
jkamp
jnk1/mapk8 associated membrane protein
chr13_-_6218248 1.02 ENSDART00000159052
si:zfos-1056e6.1
si:zfos-1056e6.1
chr25_+_3868438 1.02 ENSDART00000156438
tmem138
transmembrane protein 138
chr5_+_37087583 1.01 ENSDART00000049900
tagln2
transgelin 2
chr19_+_27970292 1.01 ENSDART00000103887
ENSDART00000145549
med10
mediator complex subunit 10
chr17_+_33296436 1.00 ENSDART00000123114
dnajc27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr6_-_40842768 0.98 ENSDART00000076160
mustn1a
musculoskeletal, embryonic nuclear protein 1a
chr7_-_50395059 0.98 ENSDART00000191150
vps33b
vacuolar protein sorting 33B
chr18_-_50579629 0.97 ENSDART00000188252
zgc:158464
zgc:158464
chr12_-_48168135 0.96 ENSDART00000186624
pald1a
phosphatase domain containing, paladin 1a
chr14_-_52542928 0.94 ENSDART00000075749
ppp2r2ba
protein phosphatase 2, regulatory subunit B, beta a
chr6_+_13933464 0.94 ENSDART00000109144
ptprnb
protein tyrosine phosphatase, receptor type, Nb
chr4_-_30362840 0.93 ENSDART00000165929
znf1083
zinc finger protein 1083
chr14_+_1351214 0.93 ENSDART00000007091
bbs12
Bardet-Biedl syndrome 12
chr7_-_18554603 0.92 ENSDART00000108938
msantd1
Myb/SANT-like DNA-binding domain containing 1
chr15_-_12113045 0.92 ENSDART00000159879
dscaml1
Down syndrome cell adhesion molecule like 1
chr6_-_8264751 0.92 ENSDART00000091628
ccdc151
coiled-coil domain containing 151
chr1_+_594584 0.91 ENSDART00000135944
jam2a
junctional adhesion molecule 2a
chr4_-_1801519 0.90 ENSDART00000188604
ENSDART00000135749
nudt4b
nudix (nucleoside diphosphate linked moiety X)-type motif 4b
chr10_-_7988396 0.89 ENSDART00000141445
ENSDART00000024282
ewsr1a
EWS RNA-binding protein 1a
chr7_+_23515966 0.89 ENSDART00000186893
ENSDART00000186189
zgc:109889
zgc:109889
chr12_+_11650146 0.84 ENSDART00000150191
waplb
WAPL cohesin release factor b
chr18_+_29950233 0.84 ENSDART00000146431
atmin
ATM interactor
chr9_+_40874194 0.84 ENSDART00000141548
hibch
3-hydroxyisobutyryl-CoA hydrolase
chr17_-_14451405 0.81 ENSDART00000146786
jkamp
jnk1/mapk8 associated membrane protein
chr16_-_16590780 0.80 ENSDART00000059841
si:ch211-257p13.3
si:ch211-257p13.3
chr6_+_13787855 0.78 ENSDART00000182899
tmem198b
transmembrane protein 198b
chr12_+_33361948 0.78 ENSDART00000124982
fasn
fatty acid synthase
chr2_-_16449504 0.77 ENSDART00000144801
atr
ATR serine/threonine kinase
chr20_-_35706379 0.77 ENSDART00000152847
si:dkey-30j22.1
si:dkey-30j22.1
chr10_+_25204626 0.76 ENSDART00000024514
chordc1b
cysteine and histidine-rich domain (CHORD) containing 1b

Network of associatons between targets according to the STRING database.

First level regulatory network of rfx1a+rfx1b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 6.8 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.9 2.6 GO:0072156 distal tubule morphogenesis(GO:0072156)
0.7 2.8 GO:0042754 negative regulation of circadian rhythm(GO:0042754)
0.6 5.0 GO:2000273 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) positive regulation of receptor activity(GO:2000273)
0.5 6.0 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.5 16.8 GO:0019882 antigen processing and presentation(GO:0019882)
0.5 2.4 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.5 4.6 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.5 2.3 GO:0072677 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677) positive regulation of calcium ion import(GO:0090280)
0.4 5.8 GO:0010996 response to auditory stimulus(GO:0010996)
0.4 3.2 GO:0048681 negative regulation of axon regeneration(GO:0048681) negative regulation of neuron projection regeneration(GO:0070571)
0.4 2.3 GO:0035889 otolith tethering(GO:0035889)
0.4 1.1 GO:0045649 regulation of macrophage differentiation(GO:0045649)
0.4 1.8 GO:0046929 negative regulation of neurotransmitter secretion(GO:0046929) response to cAMP(GO:0051591) cellular response to cAMP(GO:0071320) negative regulation of synaptic vesicle transport(GO:1902804) negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.4 1.1 GO:0071498 cellular response to fluid shear stress(GO:0071498)
0.4 1.1 GO:0090278 negative regulation of peptide secretion(GO:0002792) negative regulation of peptide hormone secretion(GO:0090278)
0.4 1.1 GO:1902176 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902175) negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902176)
0.4 1.8 GO:0008594 photoreceptor cell morphogenesis(GO:0008594)
0.3 1.0 GO:1905072 cardiac jelly development(GO:1905072)
0.3 1.9 GO:0006004 fucose metabolic process(GO:0006004)
0.3 1.5 GO:0048855 adenohypophysis morphogenesis(GO:0048855)
0.3 1.2 GO:0035124 embryonic caudal fin morphogenesis(GO:0035124)
0.3 1.8 GO:2000576 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.3 0.8 GO:0060623 regulation of chromosome condensation(GO:0060623)
0.3 3.9 GO:0036158 outer dynein arm assembly(GO:0036158)
0.3 4.1 GO:0036065 fucosylation(GO:0036065)
0.3 9.0 GO:0042073 intraciliary transport(GO:0042073)
0.2 3.8 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.2 1.4 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.2 1.8 GO:0006895 Golgi to endosome transport(GO:0006895)
0.2 1.4 GO:0035989 tendon development(GO:0035989)
0.2 3.4 GO:2000601 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.2 0.9 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.2 0.6 GO:0014014 negative regulation of gliogenesis(GO:0014014)
0.2 1.3 GO:0048755 branching morphogenesis of a nerve(GO:0048755)
0.2 1.0 GO:0035988 chondrocyte proliferation(GO:0035988)
0.2 1.3 GO:0090178 establishment of planar polarity of embryonic epithelium(GO:0042249) establishment of planar polarity involved in neural tube closure(GO:0090177) regulation of establishment of planar polarity involved in neural tube closure(GO:0090178) planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.2 4.8 GO:0007520 myoblast fusion(GO:0007520)
0.2 0.9 GO:1901907 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.2 1.1 GO:0036372 opsin transport(GO:0036372)
0.2 4.1 GO:0030032 lamellipodium assembly(GO:0030032)
0.2 1.3 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.2 1.7 GO:0006798 polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
0.2 1.2 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.2 0.8 GO:1901207 regulation of heart looping(GO:1901207)
0.2 1.5 GO:0051877 pigment granule aggregation in cell center(GO:0051877)
0.1 0.8 GO:0006574 valine catabolic process(GO:0006574)
0.1 0.9 GO:0097107 postsynaptic density assembly(GO:0097107) modulation of excitatory postsynaptic potential(GO:0098815) positive regulation of excitatory postsynaptic potential(GO:2000463)
0.1 1.3 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.1 5.1 GO:0032456 endocytic recycling(GO:0032456)
0.1 2.5 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 5.1 GO:0043297 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.1 0.7 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.1 1.7 GO:0072554 endothelial tube morphogenesis(GO:0061154) blood vessel lumenization(GO:0072554)
0.1 0.5 GO:0043393 regulation of protein binding(GO:0043393)
0.1 6.8 GO:0048841 regulation of axon extension involved in axon guidance(GO:0048841)
0.1 1.1 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.1 1.3 GO:0030311 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.1 1.8 GO:0002574 thrombocyte differentiation(GO:0002574)
0.1 0.6 GO:0048823 nucleate erythrocyte development(GO:0048823)
0.1 1.3 GO:0032264 IMP salvage(GO:0032264)
0.1 1.3 GO:0061026 cardiac muscle tissue regeneration(GO:0061026)
0.1 1.2 GO:0007140 male meiosis(GO:0007140)
0.1 0.7 GO:0097476 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
0.1 2.8 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 2.8 GO:0046847 filopodium assembly(GO:0046847)
0.1 2.1 GO:1901379 regulation of potassium ion transmembrane transport(GO:1901379)
0.1 0.9 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.1 3.3 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.1 2.5 GO:0072348 sulfur compound transport(GO:0072348)
0.1 1.9 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1 0.3 GO:0032877 regulation of DNA endoreduplication(GO:0032875) positive regulation of DNA endoreduplication(GO:0032877) DNA endoreduplication(GO:0042023)
0.1 0.6 GO:1901970 positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.0 4.9 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 1.2 GO:0040023 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 2.8 GO:0016575 histone deacetylation(GO:0016575)
0.0 1.0 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.0 0.7 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 1.2 GO:0097194 execution phase of apoptosis(GO:0097194)
0.0 0.8 GO:0010824 regulation of centrosome duplication(GO:0010824)
0.0 2.3 GO:0003146 heart jogging(GO:0003146)
0.0 0.5 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.0 1.5 GO:0042752 regulation of circadian rhythm(GO:0042752)
0.0 1.1 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0006919)
0.0 1.3 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 2.5 GO:0051017 actin filament bundle assembly(GO:0051017)
0.0 0.6 GO:0031952 regulation of protein autophosphorylation(GO:0031952)
0.0 0.9 GO:0070593 dendrite self-avoidance(GO:0070593)
0.0 1.5 GO:0045104 intermediate filament-based process(GO:0045103) intermediate filament cytoskeleton organization(GO:0045104)
0.0 0.4 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.0 0.8 GO:0045879 negative regulation of smoothened signaling pathway(GO:0045879)
0.0 1.8 GO:0006986 response to unfolded protein(GO:0006986)
0.0 0.5 GO:0007020 microtubule nucleation(GO:0007020)
0.0 0.5 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.0 2.0 GO:1990542 mitochondrial transmembrane transport(GO:1990542)
0.0 2.6 GO:0009755 hormone-mediated signaling pathway(GO:0009755)
0.0 0.2 GO:0045899 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.0 1.8 GO:0007224 smoothened signaling pathway(GO:0007224)
0.0 0.2 GO:0007525 somatic muscle development(GO:0007525)
0.0 0.2 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.2 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.0 0.4 GO:0006265 DNA topological change(GO:0006265)
0.0 0.1 GO:0014060 mating(GO:0007618) copulation(GO:0007620) regulation of epinephrine secretion(GO:0014060) positive regulation of epinephrine secretion(GO:0032812) positive regulation of catecholamine secretion(GO:0033605) penile erection(GO:0043084) negative regulation of potassium ion transport(GO:0043267) epinephrine transport(GO:0048241) epinephrine secretion(GO:0048242) positive regulation of amine transport(GO:0051954) regulation of penile erection(GO:0060405) positive regulation of penile erection(GO:0060406) prolactin secretion(GO:0070459)
0.0 0.6 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 1.5 GO:0031018 endocrine pancreas development(GO:0031018)
0.0 0.3 GO:0050927 regulation of positive chemotaxis(GO:0050926) positive regulation of positive chemotaxis(GO:0050927) induction of positive chemotaxis(GO:0050930)
0.0 2.1 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.1 GO:0000022 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231) spindle midzone assembly(GO:0051255) mitotic spindle midzone assembly(GO:0051256)
0.0 0.7 GO:0051262 protein tetramerization(GO:0051262)
0.0 0.3 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 1.6 GO:0006836 neurotransmitter transport(GO:0006836)
0.0 1.7 GO:0016236 macroautophagy(GO:0016236)
0.0 1.6 GO:0060042 retina morphogenesis in camera-type eye(GO:0060042)
0.0 0.6 GO:0018108 peptidyl-tyrosine phosphorylation(GO:0018108)
0.0 2.8 GO:0051480 regulation of cytosolic calcium ion concentration(GO:0051480)
0.0 2.2 GO:0043087 regulation of GTPase activity(GO:0043087)
0.0 1.1 GO:0008285 negative regulation of cell proliferation(GO:0008285)
0.0 1.8 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.0 0.8 GO:0090263 positive regulation of canonical Wnt signaling pathway(GO:0090263)
0.0 1.3 GO:0035725 sodium ion transmembrane transport(GO:0035725)
0.0 0.6 GO:0048484 enteric nervous system development(GO:0048484)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 8.1 GO:0032997 Fc receptor complex(GO:0032997) Fc-epsilon receptor I complex(GO:0032998)
1.6 12.6 GO:0042613 MHC class II protein complex(GO:0042613)
0.8 4.6 GO:1902636 kinociliary basal body(GO:1902636)
0.6 3.0 GO:0043034 costamere(GO:0043034)
0.6 10.3 GO:0030992 intraciliary transport particle B(GO:0030992)
0.5 1.6 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.5 2.5 GO:0042584 chromaffin granule membrane(GO:0042584)
0.3 6.8 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.3 2.7 GO:0030990 intraciliary transport particle(GO:0030990)
0.3 2.3 GO:0001772 immunological synapse(GO:0001772)
0.3 6.6 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.2 1.2 GO:0030897 HOPS complex(GO:0030897)
0.2 1.2 GO:0070724 BMP receptor complex(GO:0070724)
0.2 1.3 GO:0042611 MHC protein complex(GO:0042611)
0.2 1.0 GO:0033263 CORVET complex(GO:0033263)
0.2 1.5 GO:0034464 BBSome(GO:0034464)
0.2 2.9 GO:0036038 MKS complex(GO:0036038)
0.2 1.9 GO:0030904 retromer complex(GO:0030904)
0.2 0.5 GO:0001534 radial spoke(GO:0001534)
0.2 9.7 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.2 4.9 GO:0099569 presynaptic cytoskeleton(GO:0099569)
0.1 1.5 GO:0045095 keratin filament(GO:0045095)
0.1 2.7 GO:0090568 nuclear transcriptional repressor complex(GO:0090568)
0.1 1.8 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 3.2 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 4.3 GO:0098636 protein complex involved in cell adhesion(GO:0098636)
0.1 9.2 GO:0030027 lamellipodium(GO:0030027)
0.1 1.1 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 2.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 1.2 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 2.1 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 2.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 0.9 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 2.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 0.6 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 1.3 GO:0002116 semaphorin receptor complex(GO:0002116)
0.1 1.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 3.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 1.4 GO:0071565 nBAF complex(GO:0071565)
0.1 1.1 GO:0070822 Sin3-type complex(GO:0070822)
0.0 2.3 GO:0030286 dynein complex(GO:0030286)
0.0 5.4 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 0.3 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.7 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.0 4.1 GO:0005884 actin filament(GO:0005884)
0.0 2.0 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.2 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 2.3 GO:0005814 centriole(GO:0005814)
0.0 0.5 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 3.7 GO:0014069 postsynaptic density(GO:0014069)
0.0 2.1 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 6.2 GO:0005912 adherens junction(GO:0005912)
0.0 1.6 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 1.1 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 0.2 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.0 4.0 GO:0030424 axon(GO:0030424)
0.0 1.0 GO:0016592 mediator complex(GO:0016592)
0.0 0.4 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.1 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 0.7 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.4 GO:0071011 precatalytic spliceosome(GO:0071011)
0.0 0.4 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 1.1 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 0.9 GO:0005911 cell-cell junction(GO:0005911)
0.0 1.2 GO:0005769 early endosome(GO:0005769)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 8.1 GO:0019767 immunoglobulin receptor activity(GO:0019763) IgE receptor activity(GO:0019767)
0.8 3.1 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.5 6.6 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.5 3.7 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.5 2.3 GO:0019865 IgE binding(GO:0019863) immunoglobulin binding(GO:0019865)
0.4 6.1 GO:0008417 fucosyltransferase activity(GO:0008417)
0.3 6.8 GO:0070411 I-SMAD binding(GO:0070411)
0.3 4.0 GO:0043014 alpha-tubulin binding(GO:0043014)
0.3 2.0 GO:0022889 serine transmembrane transporter activity(GO:0022889)
0.3 1.4 GO:0010997 anaphase-promoting complex binding(GO:0010997) ubiquitin ligase activator activity(GO:1990757)
0.3 2.0 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.3 3.8 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.2 0.6 GO:0005128 erythropoietin receptor binding(GO:0005128)
0.2 5.0 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.2 0.9 GO:0034431 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.2 1.7 GO:0004309 exopolyphosphatase activity(GO:0004309)
0.1 1.2 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1 1.3 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 1.2 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 0.9 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.1 3.2 GO:0031267 small GTPase binding(GO:0031267)
0.1 2.7 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 2.1 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 1.3 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 1.7 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 1.1 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 0.3 GO:0015228 coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.1 3.8 GO:0005343 organic acid:sodium symporter activity(GO:0005343)
0.1 1.2 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 1.6 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 3.2 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 1.3 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.1 1.8 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 2.7 GO:0004707 MAP kinase activity(GO:0004707)
0.1 1.1 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.1 0.4 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.1 0.3 GO:0042609 CD4 receptor binding(GO:0042609)
0.1 1.7 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 1.4 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 2.5 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 4.6 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.7 GO:0070740 protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)
0.0 8.1 GO:0060090 binding, bridging(GO:0060090)
0.0 1.3 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.3 GO:0001130 bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.0 0.7 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 1.2 GO:0016307 phosphatidylinositol phosphate kinase activity(GO:0016307)
0.0 0.6 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.8 GO:0016289 CoA hydrolase activity(GO:0016289)
0.0 1.3 GO:0005109 frizzled binding(GO:0005109)
0.0 1.1 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.6 GO:0019211 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.0 3.6 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.0 2.8 GO:0045296 cadherin binding(GO:0045296)
0.0 0.9 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.4 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.0 0.7 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 1.6 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 2.1 GO:0043130 ubiquitin binding(GO:0043130)
0.0 4.5 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 0.7 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 0.8 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.7 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 11.6 GO:0003779 actin binding(GO:0003779)
0.0 0.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 1.3 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 1.9 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 3.5 GO:0000989 transcription factor activity, transcription factor binding(GO:0000989) transcription cofactor activity(GO:0003712)
0.0 1.9 GO:0005516 calmodulin binding(GO:0005516)
0.0 3.5 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 1.3 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 9.0 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 1.1 GO:0003730 mRNA 3'-UTR binding(GO:0003730)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 8.1 PID NECTIN PATHWAY Nectin adhesion pathway
0.1 4.6 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 1.2 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 2.6 PID RHOA REG PATHWAY Regulation of RhoA activity
0.1 2.5 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 0.8 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 1.3 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 2.0 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.6 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 1.2 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.6 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 4.6 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.3 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 1.3 PID P73PATHWAY p73 transcription factor network
0.0 1.1 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.6 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.5 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.9 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 6.3 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.4 5.5 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.3 1.3 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.2 0.7 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.2 1.8 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.2 1.8 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.1 1.3 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 0.9 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.1 3.1 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.1 0.8 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.1 1.1 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 1.7 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 3.0 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 1.1 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 0.8 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 1.7 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.1 0.6 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 1.2 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 2.6 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 1.8 REACTOME PLATELET AGGREGATION PLUG FORMATION Genes involved in Platelet Aggregation (Plug Formation)
0.1 0.8 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 0.6 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.1 0.7 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.8 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.6 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.6 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.8 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 3.1 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 1.0 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.3 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism