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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for rfx7a+rfx7b
Z-value: 1.00
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Transcription factors associated with rfx7a+rfx7b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| rfx7a | dr11_v1_chr7_+_34506937_34506937 | 0.47 | 1.4e-06 | Click! |
| rfx7b | dr11_v1_chr25_+_388258_388258 | 0.27 | 8.2e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr15_-_47193564 Show fit | 16.24 |
ENSDART00000172453
|
limbic system-associated membrane protein |
|
| chr19_+_21266008 Show fit | 9.70 |
ENSDART00000024639
|
teashirt zinc finger homeobox 1 |
|
| chr15_+_22267847 Show fit | 9.40 |
ENSDART00000110665
|
sperm autoantigenic protein 17 |
|
| chr1_+_8662530 Show fit | 8.78 |
ENSDART00000054989
|
fascin actin-bundling protein 1b |
|
| chr19_+_2279051 Show fit | 8.64 |
ENSDART00000182103
|
integrin, beta 8 |
|
| chr25_+_34407740 Show fit | 8.53 |
ENSDART00000012677
|
si:dkey-37f18.2 |
|
| chr19_+_2275019 Show fit | 8.51 |
ENSDART00000136138
|
integrin, beta 8 |
|
| chr6_+_12853655 Show fit | 8.31 |
ENSDART00000156341
|
family with sequence similarity 117, member Ba |
|
| chr6_-_33023745 Show fit | 7.74 |
ENSDART00000156211
|
adenylate cyclase activating polypeptide 1b (pituitary) receptor type I |
|
| chr20_-_29475172 Show fit | 7.19 |
ENSDART00000183164
|
secretogranin V |
Network of associatons between targets according to the STRING database.
First level regulatory network of rfx7a+rfx7b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 28.8 | GO:0046883 | regulation of hormone secretion(GO:0046883) |
| 0.0 | 19.3 | GO:0006397 | mRNA processing(GO:0006397) |
| 0.5 | 17.2 | GO:0033627 | cell adhesion mediated by integrin(GO:0033627) |
| 0.2 | 11.3 | GO:0003341 | cilium movement(GO:0003341) |
| 0.1 | 10.1 | GO:0006475 | internal protein amino acid acetylation(GO:0006475) internal peptidyl-lysine acetylation(GO:0018393) |
| 0.3 | 9.9 | GO:0045494 | photoreceptor cell maintenance(GO:0045494) |
| 0.1 | 8.8 | GO:0051017 | actin filament bundle assembly(GO:0051017) |
| 0.1 | 8.3 | GO:0009142 | nucleoside triphosphate biosynthetic process(GO:0009142) |
| 0.2 | 7.7 | GO:0021854 | hypothalamus development(GO:0021854) |
| 0.5 | 7.3 | GO:0018095 | protein polyglutamylation(GO:0018095) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 50.7 | GO:0031514 | motile cilium(GO:0031514) |
| 0.4 | 21.4 | GO:0098636 | protein complex involved in cell adhesion(GO:0098636) |
| 0.0 | 9.7 | GO:0005929 | cilium(GO:0005929) |
| 0.2 | 9.6 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.2 | 8.8 | GO:0030175 | filopodium(GO:0030175) |
| 0.2 | 7.9 | GO:0030286 | dynein complex(GO:0030286) |
| 0.2 | 7.5 | GO:0099569 | presynaptic cytoskeleton(GO:0099569) |
| 1.3 | 6.6 | GO:0042584 | chromaffin granule membrane(GO:0042584) |
| 0.6 | 6.5 | GO:0030990 | intraciliary transport particle(GO:0030990) intraciliary transport particle B(GO:0030992) |
| 1.3 | 6.4 | GO:0005879 | axonemal microtubule(GO:0005879) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 33.5 | GO:0030234 | enzyme regulator activity(GO:0030234) |
| 0.1 | 23.2 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.0 | 18.8 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.3 | 18.4 | GO:0005178 | integrin binding(GO:0005178) |
| 0.2 | 9.6 | GO:0061733 | peptide-lysine-N-acetyltransferase activity(GO:0061733) |
| 0.1 | 9.2 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.1 | 8.8 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 1.6 | 7.9 | GO:0004127 | cytidylate kinase activity(GO:0004127) |
| 0.1 | 7.1 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.3 | 6.9 | GO:0097602 | cullin family protein binding(GO:0097602) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 17.2 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.3 | 7.0 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.2 | 3.7 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.0 | 1.6 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.1 | 1.3 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 1.0 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 0.6 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 0.4 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 17.2 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.3 | 3.7 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.2 | 3.2 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 3.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.3 | 3.0 | REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING | Genes involved in Transferrin endocytosis and recycling |
| 0.1 | 2.8 | REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.1 | 2.3 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.4 | 2.2 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.2 | 1.6 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.1 | 1.6 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |