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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for rorc

Z-value: 0.62

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Transcription factors associated with rorc

Gene Symbol Gene ID Gene Info
rorc
ENSDARG00000087195 RAR-related orphan receptor C

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
rorcdr11_v1_chr16_+_17913936_179139450.232.8e-02Click!

Activity profile of rorc motif

Sorted Z-values of rorc motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr23_-_5683147 9.98 ENSDART00000102766
ENSDART00000067351
tnnt2a
troponin T type 2a (cardiac)
chr19_+_30990129 6.30 ENSDART00000052169
ENSDART00000193376
sync
syncoilin, intermediate filament protein
chr19_+_30990815 6.13 ENSDART00000134645
sync
syncoilin, intermediate filament protein
chr15_-_12360409 5.62 ENSDART00000164596
tmprss13a
transmembrane protease, serine 13a
chr5_+_52167986 5.29 ENSDART00000162256
ENSDART00000073626
slc14a2
solute carrier family 14 (urea transporter), member 2
chr16_+_17715243 4.83 ENSDART00000149437
ENSDART00000149596
si:dkey-87o1.2
si:dkey-87o1.2
chr20_-_9980318 4.75 ENSDART00000080664
ACTC1
zgc:86709
chr14_+_17376940 3.84 ENSDART00000054590
ENSDART00000010148
spon2b
spondin 2b, extracellular matrix protein
chr5_+_70155935 3.73 ENSDART00000165570
rgs3a
regulator of G protein signaling 3a
chr18_+_36631923 3.62 ENSDART00000098980
znf296
zinc finger protein 296
chr19_+_18797623 3.36 ENSDART00000166172
ddah2
dimethylarginine dimethylaminohydrolase 2
chr2_-_8648440 3.15 ENSDART00000135743
si:ch211-71m22.3
si:ch211-71m22.3
chr21_+_27189490 2.95 ENSDART00000125349
bada
BCL2 associated agonist of cell death a
chr22_+_36704764 2.90 ENSDART00000146662
trim35-33
tripartite motif containing 35-33
chr20_+_16750177 2.72 ENSDART00000185357
calm1b
calmodulin 1b
chr8_+_6576940 2.60 ENSDART00000138135
vsig8b
V-set and immunoglobulin domain containing 8b
chr25_-_32888115 2.55 ENSDART00000087586
c2cd4a
C2 calcium dependent domain containing 4A
chr23_-_36316352 2.54 ENSDART00000014840
nfe2
nuclear factor, erythroid 2
chr6_-_8244474 2.45 ENSDART00000151358
rgl3a
ral guanine nucleotide dissociation stimulator-like 3a
chr2_+_48282590 2.45 ENSDART00000035338
lpar5a
lysophosphatidic acid receptor 5a
chr4_+_10616626 2.38 ENSDART00000067251
ENSDART00000143690
cped1
cadherin-like and PC-esterase domain containing 1
chr19_+_43314700 2.37 ENSDART00000049045
ENSDART00000133158
matn1
matrilin 1
chr19_+_2590182 2.21 ENSDART00000162293
si:ch73-345f18.3
si:ch73-345f18.3
chr7_+_19835569 2.21 ENSDART00000149812
ovol1a
ovo-like zinc finger 1a
chr16_-_47426482 2.21 ENSDART00000148631
ENSDART00000149723
sept7b
septin 7b
chr11_-_24458786 2.17 ENSDART00000089713
mxra8a
matrix-remodelling associated 8a
chr11_+_22134540 2.17 ENSDART00000190502
MDFI
si:dkey-91m3.1
chr12_-_7234915 2.15 ENSDART00000048866
ipmkb
inositol polyphosphate multikinase b
chr2_-_56649883 2.07 ENSDART00000191786
gpx4b
glutathione peroxidase 4b
chr6_+_2030703 1.97 ENSDART00000109679
ENSDART00000187502
ENSDART00000191165
ENSDART00000187544
quo
quattro
chr3_+_59935606 1.89 ENSDART00000154157
arhgdia
Rho GDP dissociation inhibitor (GDI) alpha
chr2_+_58841181 1.85 ENSDART00000164102
cirbpa
cold inducible RNA binding protein a
chr2_+_27867830 1.76 ENSDART00000128193
rnf152
ring finger protein 152
chr21_+_40106448 1.74 ENSDART00000100166
serpinf1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr17_-_31044803 1.67 ENSDART00000185941
ENSDART00000152016
eml1
echinoderm microtubule associated protein like 1
chr16_+_30438041 1.66 ENSDART00000137977
pear1
platelet endothelial aggregation receptor 1
chr18_-_15911394 1.62 ENSDART00000091339
plekhg7
pleckstrin homology domain containing, family G (with RhoGef domain) member 7
chr22_-_834106 1.62 ENSDART00000105873
cry4
cryptochrome circadian clock 4
chr11_+_10975012 1.56 ENSDART00000192872
itgb6
integrin, beta 6
chr22_+_8612462 1.56 ENSDART00000114586
CR450686.1

chr10_+_44692272 1.54 ENSDART00000157458
ubc
ubiquitin C
chr11_+_10975481 1.49 ENSDART00000160488
itgb6
integrin, beta 6
chr18_+_7594012 1.48 ENSDART00000062150
zgc:77752
zgc:77752
chr20_+_34320635 1.45 ENSDART00000153207
ivns1abpa
influenza virus NS1A binding protein a
chr2_-_56655769 1.41 ENSDART00000113589
gpx4b
glutathione peroxidase 4b
chr4_-_9780931 1.40 ENSDART00000134280
ENSDART00000150664
ENSDART00000150304
ENSDART00000080744
svopl
SVOP-like
chr7_-_22632518 1.39 ENSDART00000161046
si:dkey-112a7.4
si:dkey-112a7.4
chr5_-_69523816 1.35 ENSDART00000112692
si:ch211-157p22.10
si:ch211-157p22.10
chr22_-_621609 1.35 ENSDART00000137264
ENSDART00000106636
srsf3b
serine/arginine-rich splicing factor 3b
chr25_-_1235457 1.31 ENSDART00000093093
coro2bb
coronin, actin binding protein, 2Bb
chr10_-_25628555 1.30 ENSDART00000143978
tiam1a
T cell lymphoma invasion and metastasis 1a
chr13_+_21768447 1.26 ENSDART00000100941
chchd1
coiled-coil-helix-coiled-coil-helix domain containing 1
chr21_+_19517492 1.19 ENSDART00000123168
ENSDART00000187993
gzmk
granzyme K
chr16_-_27442344 1.18 ENSDART00000027545
erp44
endoplasmic reticulum protein 44
chr11_-_42396302 1.12 ENSDART00000165624
slmapa
sarcolemma associated protein a
chr15_-_43625549 1.11 ENSDART00000168589
ctsc
cathepsin C
chr10_-_44341288 1.11 ENSDART00000166131
zswim6
zinc finger, SWIM-type containing 6
chr5_+_19413838 1.08 ENSDART00000089014
ENSDART00000146215
myo1ha
myosin IHa
chr21_-_5881344 1.04 ENSDART00000009241
rpl35
ribosomal protein L35
chr1_-_49498116 1.03 ENSDART00000137357
zgc:175214
zgc:175214
chr7_-_22632938 1.03 ENSDART00000159867
ENSDART00000165706
si:dkey-112a7.4
si:dkey-112a7.4
chr1_+_17527931 1.02 ENSDART00000131927
casp3a
caspase 3, apoptosis-related cysteine peptidase a
chr8_+_43340995 1.00 ENSDART00000038566
rflna
refilin A
chr16_-_30564319 0.99 ENSDART00000145087
lmna
lamin A
chr1_-_29658721 0.97 ENSDART00000132063
si:dkey-1h24.6
si:dkey-1h24.6
chr5_+_19261687 0.91 ENSDART00000139401
atp8b5a
ATPase phospholipid transporting 8B5a
chr8_+_18463797 0.89 ENSDART00000148958
alkal1
ALK and LTK ligand 1
chr6_-_49159207 0.88 ENSDART00000041942
tspan2a
tetraspanin 2a
chr2_-_38337122 0.87 ENSDART00000076523
ENSDART00000187473
slc7a8b
solute carrier family 7 (amino acid transporter light chain, L system), member 8b
chr8_-_29706882 0.86 ENSDART00000045909
prf1.5
perforin 1.5
chr5_+_19261391 0.84 ENSDART00000089173
atp8b5a
ATPase phospholipid transporting 8B5a
chr25_-_17918536 0.83 ENSDART00000148660
arntl1a
aryl hydrocarbon receptor nuclear translocator-like 1a
chr3_+_32698424 0.83 ENSDART00000055340
fus
FUS RNA binding protein
chr8_+_18464235 0.83 ENSDART00000110571
alkal1
ALK and LTK ligand 1
chr3_+_14641962 0.81 ENSDART00000091070
zgc:158403
zgc:158403
chr3_-_29508959 0.79 ENSDART00000055408
cyth4a
cytohesin 4a
chr8_+_26034623 0.79 ENSDART00000004521
ENSDART00000142555
arih2
ariadne homolog 2 (Drosophila)
chr19_+_42336523 0.77 ENSDART00000151304
anp32e
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr20_-_30377221 0.76 ENSDART00000126229
rps7
ribosomal protein S7
chr2_-_37896965 0.76 ENSDART00000129852
hbl1
hexose-binding lectin 1
chr10_-_1788376 0.74 ENSDART00000123842
epb41l4a
erythrocyte membrane protein band 4.1 like 4A
chr8_-_25771474 0.73 ENSDART00000193883
suv39h1b
suppressor of variegation 3-9 homolog 1b
chr15_-_2841677 0.72 ENSDART00000026145
ENSDART00000180290
AMOTL1
angiomotin like 1
chr1_-_31140096 0.68 ENSDART00000172243
kcnq5b
potassium voltage-gated channel, KQT-like subfamily, member 5b
chr22_-_11124419 0.63 ENSDART00000149634
atp6ap2
ATPase H+ transporting accessory protein 2
chr10_+_15454745 0.62 ENSDART00000129441
ENSDART00000123935
ENSDART00000163446
ENSDART00000087680
ENSDART00000193752
erbin
erbb2 interacting protein
chr17_-_24364527 0.60 ENSDART00000155192
wdpcp
WD repeat containing planar cell polarity effector
chr11_+_26363435 0.60 ENSDART00000088800
ppcs
phosphopantothenoylcysteine synthetase
chr10_+_575929 0.57 ENSDART00000129856
smad4a
SMAD family member 4a
chr8_+_25351863 0.56 ENSDART00000034092
dnase1l1l
deoxyribonuclease I-like 1-like
chr9_-_52598343 0.55 ENSDART00000167922
xrcc5
X-ray repair complementing defective repair in Chinese hamster cells 5
chr7_+_48675347 0.55 ENSDART00000157917
ENSDART00000185580
trpm5
transient receptor potential cation channel, subfamily M, member 5
chr2_+_49864219 0.53 ENSDART00000187744
rpl37
ribosomal protein L37
chr7_+_24573721 0.53 ENSDART00000173938
ENSDART00000173681
si:dkeyp-75h12.7
si:dkeyp-75h12.7
chr1_+_15204633 0.53 ENSDART00000188410
itln1
intelectin 1
chr1_-_12393060 0.49 ENSDART00000079782
sclt1
sodium channel and clathrin linker 1
chr24_+_24809877 0.49 ENSDART00000185117
dnajc5b
DnaJ (Hsp40) homolog, subfamily C, member 5 beta
chr18_+_20225961 0.48 ENSDART00000045679
tle3a
transducin-like enhancer of split 3a
chr25_-_17918810 0.44 ENSDART00000023959
arntl1a
aryl hydrocarbon receptor nuclear translocator-like 1a
chr3_-_5555500 0.43 ENSDART00000176133
ENSDART00000057464
trim35-31
tripartite motif containing 35-31
chr12_+_7399403 0.41 ENSDART00000103526
bicc1b
BicC family RNA binding protein 1b
chr8_+_26254903 0.39 ENSDART00000113763
slc26a6
solute carrier family 26, member 6
chr3_+_60761811 0.38 ENSDART00000053482
tsen54
TSEN54 tRNA splicing endonuclease subunit
chr16_-_24561354 0.36 ENSDART00000193278
ENSDART00000126274
si:ch211-79k12.2
si:ch211-79k12.2
chr17_-_2126517 0.36 ENSDART00000013093
zfyve19
zinc finger, FYVE domain containing 19
chr8_-_2602572 0.35 ENSDART00000110482
zdhhc12a
zinc finger, DHHC-type containing 12a
chr22_-_6420239 0.34 ENSDART00000148385
zgc:171699
zgc:171699
chr22_-_18546241 0.34 ENSDART00000105404
ENSDART00000105405
cirbpb
cold inducible RNA binding protein b
chr10_-_39321367 0.33 ENSDART00000129647
smtlb
somatolactin beta
chr16_+_11242443 0.33 ENSDART00000024935
gsk3ab
glycogen synthase kinase 3 alpha b
chr23_-_36724575 0.32 ENSDART00000159560
agap2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr14_-_29859067 0.29 ENSDART00000136380
sorbs2b
sorbin and SH3 domain containing 2b
chr25_+_3035384 0.29 ENSDART00000184219
ENSDART00000149360
mpi
mannose phosphate isomerase
chr19_+_4990496 0.27 ENSDART00000151050
ENSDART00000017535
zgc:91968
zgc:91968
chr2_-_25120197 0.27 ENSDART00000132549
pccb
propionyl CoA carboxylase, beta polypeptide
chr9_+_13682133 0.23 ENSDART00000175639
mpp4a
membrane protein, palmitoylated 4a (MAGUK p55 subfamily member 4)
chr6_-_43005901 0.20 ENSDART00000161071
si:ch73-361p23.3
si:ch73-361p23.3
chr14_-_34700633 0.20 ENSDART00000150358
ablim3
actin binding LIM protein family, member 3
chr7_-_30227878 0.20 ENSDART00000173514
znf710b
zinc finger protein 710b
chr25_-_37227491 0.20 ENSDART00000156647
glg1a
golgi glycoprotein 1a
chr21_-_25613249 0.19 ENSDART00000137896
fibpb
fibroblast growth factor (acidic) intracellular binding protein b
chr25_+_11389220 0.13 ENSDART00000187787
AGBL1
si:ch73-141f14.1
chr14_+_22297257 0.12 ENSDART00000113676
atp10b
ATPase phospholipid transporting 10B
chr4_-_4129187 0.08 ENSDART00000146889
asb15b
ankyrin repeat and SOCS box containing 15b
chr8_+_43016714 0.07 ENSDART00000142671
rassf2a
Ras association (RalGDS/AF-6) domain family member 2a
chr11_-_39118882 0.04 ENSDART00000113185
ENSDART00000156526
ap5b1
adaptor-related protein complex 5, beta 1 subunit
chr24_-_32408404 0.04 ENSDART00000144157
si:ch211-56a11.2
si:ch211-56a11.2
chr19_+_10860485 0.03 ENSDART00000169962
si:ch73-347e22.4
si:ch73-347e22.4
chr1_-_21287724 0.03 ENSDART00000193900
npy1r
neuropeptide Y receptor Y1
chr25_+_30233638 0.02 ENSDART00000192558
ENSDART00000067057
ENSDART00000147327
ENSDART00000145924
ENSDART00000148250
alkbh3
alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase
chr5_-_7513082 0.01 ENSDART00000158913
bmpr1ba
bone morphogenetic protein receptor, type IBa

Network of associatons between targets according to the STRING database.

First level regulatory network of rorc

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 10.0 GO:0003228 atrial cardiac muscle tissue development(GO:0003228)
1.8 5.3 GO:0071918 urea transmembrane transport(GO:0071918)
0.9 3.6 GO:2000171 negative regulation of dendrite development(GO:2000171)
0.8 3.4 GO:1904407 regulation of nitric oxide biosynthetic process(GO:0045428) positive regulation of nitric oxide biosynthetic process(GO:0045429) positive regulation of reactive oxygen species biosynthetic process(GO:1903428) positive regulation of nitric oxide metabolic process(GO:1904407)
0.7 3.7 GO:0008591 regulation of Wnt signaling pathway, calcium modulating pathway(GO:0008591) negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.3 2.4 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.3 1.0 GO:0097237 cellular response to antibiotic(GO:0071236) cellular response to toxic substance(GO:0097237)
0.3 1.0 GO:0061182 negative regulation of chondrocyte differentiation(GO:0032331) negative regulation of cartilage development(GO:0061037) negative regulation of chondrocyte development(GO:0061182) regulation of bone mineralization involved in bone maturation(GO:1900157) negative regulation of bone mineralization involved in bone maturation(GO:1900158) negative regulation of bone development(GO:1903011)
0.3 2.2 GO:0070285 pigment cell development(GO:0070285)
0.3 1.2 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
0.3 1.7 GO:0070378 ERK5 cascade(GO:0070375) regulation of ERK5 cascade(GO:0070376) positive regulation of ERK5 cascade(GO:0070378)
0.2 2.5 GO:0045646 regulation of erythrocyte differentiation(GO:0045646)
0.2 1.0 GO:0090342 regulation of cell aging(GO:0090342)
0.2 1.7 GO:0036368 cone photoresponse recovery(GO:0036368)
0.1 0.4 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.1 2.2 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.1 0.4 GO:0044878 abscission(GO:0009838) mitotic cytokinesis checkpoint(GO:0044878)
0.1 1.8 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.1 0.5 GO:0071480 response to gamma radiation(GO:0010332) cellular response to gamma radiation(GO:0071480)
0.1 2.2 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.1 2.5 GO:1990798 pancreas regeneration(GO:1990798)
0.1 0.3 GO:0042546 cell wall biogenesis(GO:0042546) cell wall macromolecule biosynthetic process(GO:0044038) cellular component macromolecule biosynthetic process(GO:0070589)
0.1 3.1 GO:0033627 cell adhesion mediated by integrin(GO:0033627)
0.1 3.1 GO:0017121 phospholipid scrambling(GO:0017121)
0.1 0.4 GO:0045852 pH elevation(GO:0045852) intracellular pH elevation(GO:0051454)
0.1 1.0 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.1 1.9 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.5 GO:0050909 sensory perception of taste(GO:0050909)
0.0 0.5 GO:0061056 sclerotome development(GO:0061056)
0.0 0.6 GO:0032088 negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.0 0.6 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 1.3 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.5 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 1.6 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 3.8 GO:0030178 negative regulation of Wnt signaling pathway(GO:0030178)
0.0 0.8 GO:0043486 histone exchange(GO:0043486)
0.0 0.5 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 2.4 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.0 0.3 GO:0051877 pigment granule aggregation in cell center(GO:0051877)
0.0 0.5 GO:0000737 DNA catabolic process, endonucleolytic(GO:0000737)
0.0 0.9 GO:0019835 cytolysis(GO:0019835)
0.0 2.0 GO:0048332 mesoderm morphogenesis(GO:0048332)
0.0 0.6 GO:0048264 determination of ventral identity(GO:0048264)
0.0 0.6 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.0 0.9 GO:0015804 neutral amino acid transport(GO:0015804)
0.0 3.5 GO:0007266 Rho protein signal transduction(GO:0007266)
0.0 2.2 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 1.1 GO:0030050 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.0 1.7 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 1.0 GO:0042129 regulation of T cell proliferation(GO:0042129)
0.0 1.3 GO:0050772 positive regulation of axonogenesis(GO:0050772)
0.0 0.8 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.8 GO:1901800 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.0 1.1 GO:1902667 regulation of axon guidance(GO:1902667)
0.0 0.2 GO:0090382 phagosome maturation(GO:0090382)
0.0 0.8 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.0 0.8 GO:0048675 axon extension(GO:0048675)
0.0 2.4 GO:0051216 cartilage development(GO:0051216)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.1 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.2 10.0 GO:0005861 troponin complex(GO:0005861)
0.2 0.6 GO:0097541 axonemal basal plate(GO:0097541)
0.1 13.3 GO:0005882 intermediate filament(GO:0005882)
0.1 0.4 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.1 0.8 GO:0000812 Swr1 complex(GO:0000812)
0.1 1.1 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.1 2.6 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.7 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.6 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.6 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 1.7 GO:0072686 mitotic spindle(GO:0072686)
0.0 0.8 GO:0032040 small-subunit processome(GO:0032040)
0.0 1.1 GO:0005902 microvillus(GO:0005902)
0.0 1.2 GO:0032432 actin filament bundle(GO:0032432)
0.0 1.3 GO:0000313 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
0.0 1.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.2 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 1.8 GO:0005802 trans-Golgi network(GO:0005802)
0.0 1.3 GO:0016607 nuclear speck(GO:0016607)
0.0 2.2 GO:0005681 spliceosomal complex(GO:0005681)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 10.0 GO:0031013 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.7 2.2 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.7 3.5 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.5 5.3 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.5 1.9 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.4 2.4 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427) calcium-dependent protein kinase regulator activity(GO:0010858)
0.4 3.4 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.3 1.7 GO:0030298 receptor signaling protein tyrosine kinase activator activity(GO:0030298)
0.3 3.1 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.3 1.0 GO:0031005 filamin binding(GO:0031005)
0.2 0.6 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.1 0.3 GO:0005131 growth hormone receptor binding(GO:0005131) growth hormone activity(GO:0070186)
0.1 1.5 GO:0031386 protein tag(GO:0031386)
0.1 0.7 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.1 0.5 GO:0042834 peptidoglycan binding(GO:0042834)
0.1 3.1 GO:0005178 integrin binding(GO:0005178)
0.1 0.5 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.0 1.0 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.0 1.6 GO:0009881 photoreceptor activity(GO:0009881)
0.0 0.6 GO:0070411 I-SMAD binding(GO:0070411)
0.0 4.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.9 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 0.3 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.4 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 1.1 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.8 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.6 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 6.9 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 0.8 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.0 1.5 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.5 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 0.4 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 0.5 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 1.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.3 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 5.8 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 1.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 2.2 GO:0060090 binding, bridging(GO:0060090)
0.0 2.5 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 2.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.5 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.4 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 1.9 GO:0000287 magnesium ion binding(GO:0000287)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.1 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 1.9 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.0 0.6 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.5 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.0 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 2.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.3 PID NETRIN PATHWAY Netrin-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.3 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 0.5 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.0 0.6 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 3.1 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 1.0 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.7 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.2 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 2.5 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.9 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 2.3 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 1.1 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.3 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.3 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis